JP6796067B2 - スペーサによって分離された液体体積の配列を処理するためのマイクロ流体プローブ・ヘッド - Google Patents
スペーサによって分離された液体体積の配列を処理するためのマイクロ流体プローブ・ヘッド Download PDFInfo
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Description
2 マイクロ流体プローブ・ヘッド
3 ロボット・アーム
4a−4h 付着領域
5a、5b、5c 給液部
6 スペーサ供給部
7 廃棄部
8 底面
9 ペトリ皿
10 浸液
11 本体
12 端面
13 第1の流路
14 第2の流路
15 第1の開口
16 第2の開口
17 流体バイパス
18 第1のバイパス合流部
19 第2のバイパス合流部
20、20a−20c スペーサ
21、21a−21c ブロッキング要素
22、22’ 閉じ込め体積
23a−23c 液体体積
24 バルブ装置
25 流入口
26 流入口制御部
27 スペーサ挿入部
27a 流入口
28 スペーサ合流部
29 制御部
30 流出口
31 第1の検出器
32 第2の検出器
33 第3の流路
34 第3の開口
35 追加の廃棄部
35a 流出口
36 部分流路
37 面
38 面
A1、A2、A3 直径
B1、B2、B3 直径
C、C’ 層流
D 距離
L1、L2、L3 長さ
P1、P2、P3 幅
Q1、Q2、Q3 流量
T1、T2 距離
W 幅
Claims (14)
- スペーサによって分離された個別液体体積の配列を処理するためのマイクロ流体プローブ・ヘッドであって、
流入口および流出口と、
第1の流路および第2の流路と、
前記第1の流路と前記第2の流路とを互いに接続する流体バイパスとを含み、
前記第1の流路は、個別液体体積の前記配列を前記流入口から付着領域に向けて給送するように構成され、
前記流体バイパスは、前記第1の流路から前記スペーサを除去することによってスペーサのない個別液体体積の自由配列が得られるように、前記第1の流路と前記第2の流路とを接続し、
前記第1の流路は、個別液体体積の前記自由配列を前記付着領域に給送するように構成され、
前記第2の流路は、除去された前記スペーサを前記流体バイパスから前記流出口に給送するように構成され、
前記第1の流路と前記第2の流路と前記流体バイパスとを含み、浸液中に浸漬するように構成された端面を有する本体と、
前記端面に形成され、前記第1の流路に流体接続された第1の開口と、
前記端面に形成され、前記第2の流路に流体接続された第2の開口とをさらに含み、
前記流体バイパスは、前記第1の開口の上流で前記第1の流路に接続し、
前記マイクロ流体プローブ・ヘッドは、
個別液体体積の前記自由配列を前記第1の開口と前記第1の流路とを介して第1の流量で給送し、
個別液体体積の前記自由配列を前記付着領域から前記浸液の一部とともに、前記第2の開口と前記第2の流路とを介して第2の流量で吸引するように構成され、
給送された個別液体体積の前記自由配列を前記浸液内に閉じ込めるように、前記第2の流量は前記第1の流量より大きい、マイクロ流体プローブ・ヘッド。 - 個別液体体積の前記配列のうちの後続の2つの個別液体体積を互いに分離するスペーサが、前記個別液体体積とは混合しない、請求項1に記載のマイクロ流体プローブ・ヘッド。
- 前記第2の流路は、個別液体体積の前記自由配列を前記付着領域から前記流出口に給送するように構成された、請求項1または2に記載のマイクロ流体プローブ・ヘッド。
- 追加の流出口と第3の流路とをさらに含み、
前記第3の流路は、個別液体体積の前記自由配列を前記付着領域から前記追加の流出口に給送するように構成された、請求項1ないし3のいずれかに記載のマイクロ流体プローブ・ヘッド。 - 前記本体が前記第3の流路を含み、
前記端面に形成され、前記第3の流路に流体接続された第3の開口をさらに含み、
前記流体バイパスは前記第1の開口の上流で前記第1の流路に接続し、前記マイクロ流体プローブ・ヘッドは、
個別液体体積の前記自由配列を前記第1の開口と前記第1の流路とを介して供給し、
前記浸液の一部を前記付着領域から前記第2の開口と前記第2の流路とを介して吸引し、
個別液体体積の前記自由配列を前記浸液の一部とともに前記付着領域から前記第3の開口と前記第3の流路とを介して吸引するように構成された、請求項4に記載のマイクロ流体プローブ・ヘッド。
- 前記スペーサを前記第1の流路から前記流体バイパスに方向変更するための少なくとも1つのブロッキング要素をさらに含む、請求項1ないし5のいずれかに記載のマイクロ流体プローブ・ヘッド。
- 前記流体バイパスは、前記第1の流路から前記第2の流路に向かって先細りになっている、請求項1ないし6のいずれかに記載のマイクロ流体プローブ・ヘッド。
- 前記第2の流路は、前記流体バイパスが前記第2の流路に流体接続する場所での圧力を増大させるように構成された狭窄部を含む、請求項1ないし7のいずれかに記載のマイクロ流体プローブ・ヘッド。
- 前記スペーサを前記第1の流路に注入するためのスペーサ挿入部をさらに含む、請求項1ないし8のいずれかに記載のマイクロ流体プローブ・ヘッド。
- 前記配列は、生化学物質を含有する少なくとも1つの個別液体体積を含む、請求項1ないし9のいずれかに記載のマイクロ流体プローブ・ヘッド。
- 前記第1の流路への前記スペーサの挿入速度を前記第2の流路への前記スペーサの吸引速度と同期させるように構成された制御部をさらに含む、請求項1ないし10のいずれかに記載のマイクロ流体プローブ・ヘッド。
- スペーサによって分離された個別液体体積の配列を処理するためのマイクロ流体プローブであって、
請求項1ないし11のいずれかのマイクロ流体プローブ・ヘッドと、
前記マイクロ流体プローブ・ヘッドの前記流入口に流体接続可能な複数の給液部と、
前記流入口を前記複数の給液部のうちの1つに選択的に流体接続するための制御部とを含む、マイクロ流体プローブ。 - スペーサによって分離された個別液体体積の配列を処理する方法であって、
個別液体体積の前記配列を第1の流路を介して流入口から付着領域に向けて給送することと、
前記個別液体体積を互いに分離する前記スペーサを、前記第1の流路と第2の流路とを接続する流体バイパスを介して前記第1の流路から除去することによってスペーサのない個別液体体積の自由配列を得ることと、
個別液体体積の前記自由配列を前記付着領域に給送することと、
除去された前記スペーサを前記流体バイパスから前記第2の流路を介して流出口に給送することとを含み、
個別液体体積の前記配列を給送することと、前記スペーサを除去することと、個別液体体積の前記自由配列を給送することと、除去された前記スペーサを給送することとが、請求項1に記載のマイクロ流体プローブ・ヘッドを使用して行われる方法。 - 前記第1の流路を介して給送される個別液体体積の前記配列は、少なくとも2つの異なる液体の個別体積を含む、請求項13に記載の方法。
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US10006838B2 (en) | 2015-08-04 | 2018-06-26 | Adam Tokarski | Sampling device |
US10434510B2 (en) | 2017-05-06 | 2019-10-08 | International Business Machines Corporation | Microfluidic probe with bypass and control channels |
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US10639631B2 (en) | 2020-05-05 |
GB201713658D0 (en) | 2017-10-11 |
DE112016000223T5 (de) | 2017-09-07 |
WO2016128543A1 (en) | 2016-08-18 |
US20200230599A1 (en) | 2020-07-23 |
US20160243549A1 (en) | 2016-08-25 |
JP2018505403A (ja) | 2018-02-22 |
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CN107295796A (zh) | 2017-10-24 |
US10926258B2 (en) | 2021-02-23 |
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