JP6776283B2 - 血管のセグメンテーションの方法および装置 - Google Patents
血管のセグメンテーションの方法および装置 Download PDFInfo
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Description
本出願は、2017年1月19日付のポルトガル国特許出願第109864号の優先権を主張する。
は、局所脈管方向を指す単位ベクトルである。後者の単位ベクトル
は、Agam et al.(非特許文献12)に基づいて、局所勾配ベクトルの解析によって推定される。脈管方向
は、局所勾配ベクトルの二乗投影をvへと最小限に抑えるものである。
式中、nは、局所勾配ベクトルの数、giはi番目の勾配ベクトルである。後者のiは、局所勾配ベクトルの指数を示し、1からnまでである。局所勾配ベクトルの数は、使用されるウィンドウのサイズに応じて決まることが理解されるであろう。例えば、ウィンドウが3×3×3のサイズである場合、ボクセルの近傍を特徴付ける27の局所勾配ベクトルがあることになる。
を表すことによって、上記式はE(v)=vTGGTvとなり、GGTは3×3の相関行列である。Agam et al.(非特許文献12)によって示されるように、E(v)の最小値はその最小固有値に属するGGTの固有ベクトルによって得られる。
の位置を予測した後、中心線地点を含むと共に、脈管方向
に直交する面が得られる(図8を参照)。この面は、脈管の2D断面である、ほぼ円形の明るい領域を含むことが予期される。勾配ベクトル場を計算し(非特許文献14)、図9に示されるテンプレートに対するその類似性を、相互相関によって評価する。
式中、fおよびgはそれぞれ、勾配配向ベクトル場およびテンプレートベクトル場を表し、f*は、fの複素共役である。中心位置推定Zt+1は、最大応答位置に相当する(図10を参照)。補正基準が利用可能な場合は常に、推定中心線地点は、カルマンフィルタフュージング
および補正基準Zt+1の出力である。この作業では、5回の反復ごとに補正基準を用いた。少なくとも、補正基準をより高頻度で計算することが可能であるが、これによって演算コストが増加するであろう。
式中、nは経路の最後のノード、g(n)は開始ノードからnまでの経路のコスト、h(n)は、nからゴールまでの最も安価な経路のコストを推定する発見的問題解決である。この作業では、nと標的ボクセルとの間のユークリッド距離をヒューリスティック関数として使用する。
式中、nは現在のノード、n+1は隣のノード、dn,n+1はそれらのノード間のユークリッド距離、C(n+1)は隣のノードの地形コストである。コストのボリュームは次式によって与えられる。
式中、F(n)は、範囲[0,1]に正規化されたボクセルnにおけるFrangiの血管性(非特許文献16)である。この公式は、発見的問題解決が許容可能であることを保証するために、脈管に属さないボクセル(F(n)=0)に対して比較的高いコストを、あるいは範囲[1,2]においてコストを付与する。
式中、*は畳み込み操作を表し、Vは局所ボリューム、Gはガウシアンであり、そのシグマによって、解析される局所構造のスケールが決定する。Frangiの方法は、各ボクセルに対して異なるスケールでHを計算するので、多重スケールである。
Claims (10)
- 対象の領域を通る軸スライスを表す複数のボクセルを備えた画像(115)を複数獲得するステップ(200)と、
高濃度画像と低濃度画像との境界を規定することによって、筋肉領域と皮下領域との間の筋膜層を規定するステップ(210)と、
血管の第1の目印および第2の目印を決定するステップと、
前記血管に沿って脈管方向を解析することを含む自動追跡手順により、前記血管の前記第1の目印と前記筋膜層との間の皮下経路を計算するステップ(215)と、
前記ボクセルを解析することにより前記筋膜層と前記第2の目印との間の筋肉内経路を計算し、前記ボクセルの血管性によって与えられる最小コスト経路を自動的に決定するステップ(220)とを含み、
前記第1の目印が前記筋膜層の一方の側にあり、前記第2の目印が前記筋膜層の他方の側にある、血管のセグメンテーションの方法。 - 獲得した前記複数の画像のグレースケールを二値画像に換算するステップを更に含む、請求項1に記載の方法。
- 前記複数の画像からアーチファクトを除去するステップ(510、560)を更に含む、請求項1または2に記載の方法。
- 前記画像中の前記アーチファクトが、皮膚に関連するピクセル、即ち連続特徴における空白、を含む、請求項3に記載の方法。
- 前記脈管方向の前記解析が局所勾配ベクトルの解析によって推定される、請求項1から4のいずれか一項に記載の方法。
- 前記血管の中心が、前記複数の獲得画像における前記ボクセルの濃度変化から決定される、請求項1から5のいずれか一項に記載の方法。
- 前記ボクセルの前記血管性がFrangiの方法によって決定される、請求項1から6のいずれか一項に記載の方法。
- コンピュータにより実施される、請求項1から7のいずれか一項に記載の方法。
- 対象領域の軸スライスの複数の画像(115)を格納するデータベース(110)と、
請求項1から7のいずれか一項に記載の方法を実施するソフトウェアを用いて、前記複数の画像を解析するように構成されたプロセッサ(130)と、
前記ソフトウェアからの結果を出力する表示デバイス(140)と
を備える、血管のセグメンテーションの装置。 - 非有形のコンピュータ可読媒体に格納され、プロセッサ(130)によって実行される際に、請求項1から7のいずれか一項に記載の方法を前記プロセッサ(130)に実施させる複数の命令を含む、コンピュータプログラム製品。
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PT10986417 | 2017-01-19 | ||
PT109864 | 2017-01-19 |
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JP2018134393A JP2018134393A (ja) | 2018-08-30 |
JP2018134393A5 JP2018134393A5 (ja) | 2020-03-12 |
JP6776283B2 true JP6776283B2 (ja) | 2020-10-28 |
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US (1) | US20180199997A1 (ja) |
EP (1) | EP3352135B1 (ja) |
JP (1) | JP6776283B2 (ja) |
CN (1) | CN108324300B (ja) |
ES (1) | ES2757629T3 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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US10068340B2 (en) * | 2014-11-03 | 2018-09-04 | Algotec Systems Ltd. | Method for segmentation of the head-neck arteries, brain and skull in medical images |
WO2020012884A1 (ja) * | 2018-07-13 | 2020-01-16 | 古野電気株式会社 | 超音波撮像装置、超音波撮像システム、超音波撮像方法および超音波撮像プログラム |
CN109903298B (zh) * | 2019-03-12 | 2021-03-02 | 数坤(北京)网络科技有限公司 | 血管分割图像断裂的修复方法、系统和计算机存储介质 |
CN110547869B (zh) * | 2019-09-17 | 2022-08-19 | 上海交通大学 | 一种基于虚拟现实的术前辅助规划装置 |
CN111311583B (zh) * | 2020-02-24 | 2021-03-12 | 广州柏视医疗科技有限公司 | 肺气管和血管的分段命名方法 |
CN111612743B (zh) * | 2020-04-24 | 2023-05-02 | 杭州电子科技大学 | 一种基于ct图像的冠状动脉中心线提取方法 |
CN112545567B (zh) * | 2021-02-22 | 2021-06-18 | 深圳华声医疗技术股份有限公司 | 超声图像处理方法、装置、超声诊断设备及存储介质 |
CN114202469B (zh) * | 2021-11-11 | 2022-08-19 | 北京医准智能科技有限公司 | Frangi滤子的超参数选取方法、装置、电子设备及存储介质 |
CN115375705B (zh) * | 2022-08-04 | 2023-03-31 | 北京医准智能科技有限公司 | 一种血管分割方法、装置、电子设备及存储介质 |
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