JP6747080B2 - Air suction cap - Google Patents

Description

The present invention relates to an air suction cap that can be attached to a connector including a male member to introduce air into a flow path of the male member.

When administering a drug solution stored in a sealed vial bottle to a patient, it is necessary to transfer the drug solution in the vial bottle to a drug solution bag to prepare the drug solution. As a method of transferring a drug solution from a vial bottle to a drug solution bag, a method called “negative pressure adjusting method” using a syringe to which a metal needle having a sharp tip is attached is known. This method is roughly as follows.

First, the plunger of an empty syringe is pulled, and the same amount of air as the amount of the drug solution to be collected is sucked into the syringe. Then, the rubber stopper of the vial is punctured with the metal needle of the syringe. A drug solution is stored in the vial. Pull the plunger to draw the drug solution in the vial into the syringe. There will be a slight negative pressure in the vial. Lift the vial above the syringe and let go of the plunger. The negative pressure in the vial draws the plunger into the barrel of the syringe, and at the same time the air in the syringe moves to the vial. The inside of the vial returns to normal pressure. Thus, a part of the drug solution in the vial moves into the syringe, and instead, the air in the syringe moves into the vial. If necessary, this operation is repeated several times to move a predetermined amount (or the total amount) of the drug solution from the vial bottle to the syringe. Next, the metal needle of this syringe is pulled out from the rubber stopper of the vial bottle, and the rubber stopper of the port of the drug solution bag is punctured. Then, the plunger is pushed to transfer the drug solution in the syringe into the drug solution bag.

When it is necessary to transfer the drug solution in a plurality of vials to the drug solution bag, the same operation is performed for each vial using the above-mentioned syringe.

The drug solution in the vial may contain dangerous drugs designated as powerful drugs, such as some anticancer drugs. It is desired to avoid such a situation that the chemical liquid leaks out and adheres to the operator's finger or the operator sucks the vapor.

In the above negative pressure adjustment method, the drug solution may leak from the tip of the metal needle after the metal needle is pulled out from the rubber stopper of the vial bottle and before the metal needle is pierced into the rubber stopper of the drug solution bag. ..

Patent Document 1 describes a bottle needle with a cover in which a resin bottle needle (sometimes called a puncture needle) having a sharp tip is covered with a cover. The bottle needle can puncture the rubber stopper of the vial. A liquid flow path through which the drug solution flows is provided in the bottle needle, and the liquid flow path communicates with a lateral hole opened on the outer peripheral surface near the tip of the bottle needle. The cover can be elastically compressed and deformed in the longitudinal direction of the bottle needle. In the initial state, the head of the tip of the cover covers the tip of the bottle needle and closes the lateral hole of the bottle needle. When piercing the rubber stopper of the vial with the bottle needle, the bottle needle sequentially penetrates the head of the cover and the rubber stopper, and the lateral hole of the bottle needle is exposed in the vial. At this time, the cover is compressed and deformed. The drug solution in the vial is taken out through the liquid channel. After that, when the bottle needle is pulled out from the rubber stopper, the cover immediately returns to the initial state and closes the lateral hole of the bottle needle. Therefore, it is possible to prevent the liquid medicine from leaking out from the lateral hole of the bottle needle after the bottle needle is pulled out from the rubber stopper.

International publication 2013/141137 pamphlet International publication 2013/154050 pamphlet JP, 2013-165830, A JP, 11-197254, A JP, 2013-252165, A JP, 2014-079355, A JP, 2004-000483, A International Publication No. 2010/061742 Pamphlet International Publication No. 2010/061743 Pamphlet JP, 2013-226281, A

The bottle needle of Patent Document 1 is provided with a gas flow path in addition to the liquid flow path. The gas flow path allows the drug solution to flow out of the vial through the liquid flow path, and at the same time, allows air to flow into the vial through the gas flow path, resulting in a negative pressure inside the vial. It is provided to prevent the liquid medicine from being easily removed from the vial.

In the negative pressure adjusting method described above, the gas flow path is not necessary because air is allowed to flow into the vial via the same flow path as the flow path of the drug solution after the drug solution has flowed out from the vial bottle.

Therefore, instead of the metal needle, the bottle needle with the cover of Patent Document 1 in which the gas flow path is omitted is attached to the tip of the syringe used in the negative pressure adjustment method, thereby preventing the chemical solution from leaking to the outside. It is thought that you can do it.

However, when the above-mentioned bottle needle with a cover is attached to the syringe, there is a problem that the negative pressure adjusting method cannot be performed. The reason is as follows.

In the negative pressure adjusting method described above, a predetermined amount of air is sucked into the syringe before the needle of the syringe is pierced into the rubber stopper of the vial. This is because the air in the syringe is moved to the vial in exchange for moving the drug solution in the vial to the syringe as described above. If air is not sucked into the syringe in advance, the negative pressure generated in the vial will cause the plunger to be released even if the plunger can be pulled to draw the drug solution into the syringe. The drug solution is drawn into the outer cylinder and returns to the vial.

In the bottle needle with a cover described in Patent Document 1, the lateral hole of the bottle needle is closed by the cover in the initial state where the bottle needle does not puncture the rubber stopper. Therefore, it is not possible to pull the plunger to suck air into the syringe. Therefore, the negative pressure adjustment method cannot be performed. In particular, when transferring the drug solution in multiple vials to the drug solution bag using the same syringe, the plunger is moved to the deepest inside the barrel of the syringe when the drug solution in the first vial container is completely transferred to the drug solution bag. Since it is pushed in, the drug solution in the next vial cannot be moved into this syringe in this state. If the bottle needle is removed from the syringe, it is possible to pull the plunger and suck air into the syringe, but there is a possibility that the worker will be exposed to the drug during the operation of removing the bottle needle.

An object of the present invention is to allow the air of the outside world to flow into the flow path of the male member while reducing the possibility of exposure of the worker.

The air suction cap of the present invention is a first hole capable of connecting a housing having an inner cavity and a male member, and when the male member is connected to the first hole, the male member and the inner cavity are A first hole configured to communicate with each other, a second hole configured to allow communication between the lumen and the outside world, and the first hole passing from the outside world through the second hole and the lumen. A one-way valve provided on a path leading to the hole. The one-way valve is configured to allow fluid to flow from the outside world toward the first hole along the path and prevent fluid from flowing in the opposite direction. In the air suction cap, even if the pressure in the inner cavity is increased via the male member and the first hole in a state where the male member is connected to the first hole, the fluid in the inner cavity remains It is configured so that it does not leak to the outside world.

When the cap of the present invention is connected to the male member, the outside air can flow into the male member through the second hole and the inner cavity of the housing. The cap includes a one-way valve to prevent fluid from leaking from the male member through the cap to the outside world. For this reason, even if the male member is attached with the cap, the worker is less likely to be exposed to the fluid due to the leakage of the fluid.

FIG. 1A is a perspective view of an air suction cap according to an embodiment of the present invention as viewed from below. FIG. 1B is a cross-sectional perspective view seen from below the cap. FIG. 2A is a perspective view of the air suction cap according to the embodiment of the present invention seen from above. FIG. 2B is a cross-sectional perspective view seen from above the cap. FIG. 3 is a front view showing a state immediately before connecting the male connector mounted on the syringe to the first adapter mounted on the vial. FIG. 4A is an exploded perspective view showing the male connector and the tip portion of the syringe. FIG. 4B is a cross-sectional view of FIG. 4A. FIG. 5 is a perspective view showing the first adapter immediately before being attached to the vial. FIG. 6 is a front view showing the step of sucking the drug solution in the vial into the syringe. FIG. 7 is a perspective view of the drug solution bag to which the second adapter is attached. FIG. 8 is a front view showing a step of injecting the drug solution in the syringe into the drug solution bag. FIG. 9 is a front view showing a state immediately before the air suction cap according to the embodiment of the present invention is attached to the male connector attached to the syringe. FIG. 10 is a cross-sectional view of the air suction cap attached to the male connector according to the embodiment of the present invention. FIG. 11A is a perspective view of an air suction cap according to another embodiment of the present invention seen from below. FIG. 11B is a cross-sectional perspective view seen from below the cap.

In the air suction cap of the present invention described above, the male connector including the male member prevents fluid from leaking from the opening of the male member when the male member is not connected to the first hole. It may have a cover. The cover may be compressively deformable along the longitudinal direction of the male member such that the opening is exposed to the outside of the cover. In this case, when the male member is connected to the first hole, the opening of the male member may communicate with the inner cavity. This is advantageous for allowing the outside air to flow into the flow path of the closed system connector in which the opening is covered with a cover to prevent the fluid from flowing out of the flow path opening of the male member.

The cap may be configured such that a seal is formed between an edge of the first hole and the cover when the first hole and the male member are connected to each other. This is advantageous in reducing the possibility of exposure to the worker, because the fluid can be prevented from leaking to the outside through the space between the edge of the first hole and the cover.

The cap may further include an annular rib provided on the housing so as to surround the first hole. In this case, the cap may be configured such that a seal is formed between the tip of the rib and the cover when the first hole and the male member are connected to each other. This improves the liquid-tightness and air-tightness of the formed seal, which is advantageous in reducing the possibility of exposure to the operator.

The cap may further include an engagement structure capable of engaging a lock claw provided in the male connector including the male member. This can prevent the cap from being unintentionally detached from the male connector, which is advantageous in reducing the possibility of exposure of the worker.

The cap may further include a ventilation filter provided on the path. This is advantageous in preventing foreign matter (for example, solid matter such as dust or bacteria) contained in the air of the outside world from flowing into the flow path of the male member.

The first hole may be configured to be closed immediately after separating the male member from the first hole. This is advantageous in reducing the likelihood that hazardous fluid, which may be present in the lumen, will leak out of the cap through the first hole after separating the male member from the first hole.

The cap may further include a sealing material for closing the second hole. By sealing the second hole with the sealing material, it is possible to reduce the possibility that dangerous fluid that may be present in the lumen leaks out of the cap.

Hereinafter, the present invention will be described in detail with reference to preferred embodiments. However, it goes without saying that the present invention is not limited to the following embodiments. Each drawing referred to in the following description is a simplified view of main members constituting an embodiment of the present invention for convenience of description. Accordingly, the present invention may include any member not shown in the figures below. Further, within the scope of the present invention, each member shown in each of the following drawings may be changed or omitted. In the drawings shown below, the same members are designated by the same reference numerals, and duplicate description thereof will be omitted.

1. Configuration of Air Suction Cap FIG. 1A is a perspective view of an air suction cap (hereinafter, simply referred to as “cap”) 1 according to an embodiment of the present invention as seen from below, and FIG. 1B is seen from below as cap 1. It is a cross-sectional perspective view. 2A is a perspective view of the cap 1 seen from above, and FIG. 2B is a sectional perspective view of the cap 1 seen from above.

As best shown in FIGS. 1B and 2B, the cap 1 comprises a housing 10 having a generally hollow cylindrical shape. The housing 10 is provided with a first hole 21 and a second hole 22 that allow the inner cavity 10a, which is a space inside the housing 10, to communicate with the outside of the housing 10. The first hole 21 and the second hole 22 are arranged coaxially with the housing 10 at both ends of the housing 10 so as to sandwich the lumen 10a. For convenience of description of the cap 1, the side provided with the first hole 21 is referred to as the “lower” side, and the side provided with the second hole 22 is referred to as the “upper” side. The direction connecting the first hole 21 and the second hole 22 is referred to as the “vertical direction”, and the direction along the plane perpendicular to the vertical direction is referred to as the “horizontal direction”. These expressions are for describing the cap 1 and are not related to the actual orientation of the cap 1 in use.

As shown in FIG. 1B, the inner peripheral surface of the first hole 21 is a cylindrical surface. An annular rib 21a surrounding the first hole 21 along the edge of the first hole 21 protrudes outward (that is, downward). The shape of the inner peripheral surface of the first hole 21 is not limited to a cylindrical surface, and may be, for example, a tapered surface (so-called female tapered surface) whose inner diameter decreases as it approaches the inner cavity 10a.

A one-way valve 23 and a ventilation filter 24 are provided between the first hole 21 and the second hole 22 (that is, inside the lumen 10a).

The one-way valve 23 allows the fluid (air in the present embodiment) to flow from the outside of the housing 10 through the second hole 22 and the inner cavity 10a to the first hole 21. The fluid (the chemical solution and the gas in the present embodiment) is prevented from flowing from the one hole 21 to the outside of the housing 10 through the inner cavity 10a and the second hole 22. The valve that allows the fluid flow only in one direction and prevents the backflow is also called a check valve or a check valve. The structure of the one-way valve 23 is not limited as long as it has such a function. In the present embodiment, a duck bill type one-way valve is used as the one-way valve 23.

The ventilation filter 24 allows gas to pass therethrough, and captures foreign matter (for example, solid matter such as dust or bacteria) contained in the gas when the gas passes through. In this embodiment, the ventilation filter 24 is a circular sheet-shaped member having substantially the same diameter as the lumen 10a. The ventilation filter 24 is fixed on the circular bottom plate 12a having the second hole 22 so as to close the second hole 22. The ventilation filter 24 is arranged on the second hole 22 side with respect to the one-way valve 23.

The outer peripheral surface of the housing 10 is a substantially cylindrical surface. However, a large-diameter portion 15 having a relatively large outer diameter is provided on the side of the first hole 21. As a result, a step is formed between the large-diameter portion 15 and a portion above the large-diameter portion 15 (on the side of the second hole 22) due to the difference in outer diameter between the two.

As shown in FIGS. 2A and 2B, the cap 1 further includes a sealing material 25 that is a substantially columnar projection. The sealing material 25 is provided on a belt 26 extending from the outer peripheral edge on the upper side of the housing 10. Although illustration is omitted, the belt 26 can be bent and the sealing material 25 can be fitted into the second hole 22. The second hole 22 is hermetically sealed by the sealing material 25.

As shown in FIGS. 1B and 2B, in the present embodiment, the housing 10 includes the first component 11 having the first hole 21 and the second component 22 having the second hole 22 and the sealing material 25. It is composed of two parts, a part 12 and a part 12. The upper part of the first part 11 is fitted in the second part 12, and the first part 11 and the second part 12 are engaged with each other. The outer peripheral edge of the one-way valve 23 and the outer peripheral edge of the ventilation filter 24 are sandwiched between the upper end of the first component 11 and the bottom plate 12a of the second component 12. Thereby, the one-way valve 23 and the ventilation filter 24 are firmly fixed in the housing 10. Since the one-way valve 23 and the ventilation filter 24 are sandwiched and fixed between the first component 11 and the second component 12 in the vertical direction, the one-way valve 23 and the ventilation filter 24 flow into the lumen 10 a through the second hole 22. The one-way valve 23 and the ventilation filter 24 can be stably held at predetermined positions against the air flow and the positive pressure that may be applied from the first hole 21 side into the lumen 10a.

The method for fixing the one-way valve 23 and the ventilation filter 24 is not limited to the above. For example, a bonding method using an adhesive or a heat sealing method can be used instead of or in combination with the method of sandwiching and fixing the first component 11 and the second component 12.

The material of the housing 10 is not limited, but a hard material is preferable, such as polypropylene (PP), polyacetal (POM), polycarbonate (PC), acrylonitrile butadiene styrene copolymer (ABS), polyamide, hard polyvinyl chloride, Resin materials such as polyethylene, polyethylene terephthalate, and polybutylene terephthalate can be used. The housing 10 may be transparent so that the inside of the lumen 10a can be seen through the housing 10.

The materials of the first component 11 and the second component 12 may be the same or different. Considering that the second component 12 includes the bendable belt 26, a polyolefin resin such as polyethylene or polypropylene can be used. Each of the first and second parts 11 and 12 is preferably integrally manufactured as one part by injection molding the above resin material.

In the present embodiment, the first component 11 has a double pipe structure including an inner pipe that defines the inner cavity 10a and an outer pipe that is provided with the large diameter portion 15. The structure is not limited to this, and may be a simple single tube structure. The division position of the first component 11 and the second component 12 is not limited to this embodiment. The number of parts forming the housing 10 is not limited to two, and may be one or three or more. When the housing 10 is composed of a plurality of parts, the plurality of parts are liquid-tightly and airtightly connected so that the sealed lumen 10a is formed except for the first and second holes 21 and 22.

2. Method of Using Cap for Air Suction The cap 1 can be used for introducing air into the flow path of the male member. The method of using the cap 1 will be described below by taking the case where the drug solution in the vial is transferred to the drug solution bag by the negative pressure adjusting method as an example.

FIG. 3 is a front view showing a state immediately before connecting the male connector 830 mounted on the syringe 800 to the adapter (hereinafter referred to as “first adapter”) 910 mounted on the vial 900.

The syringe 800 includes an outer cylinder 801 having a hollow cylindrical shape and a plunger 805 that is removably inserted into the outer cylinder 801 similarly to a general syringe. A male connector 830 as a closed system device is attached to the tip of the outer cylinder 801.

4A is a perspective view of the male connector 830, and FIG. 4B is a sectional view thereof. 4A and 4B, the tip portion of the outer cylinder 801 of the syringe 800 to which the male connector 830 is attached is also shown.

As shown in FIG. 4B, the male connector 830 includes a connector body 840, a cover 860, and a fixing member 835.

The connector body 840 has substantially the same configuration as the male connector described in Patent Document 2, and includes a rod-shaped male luer 841 as a male member. A channel 842 is formed in the male luer 841 along the longitudinal direction thereof. A lateral hole 843 radially penetrates the male luer 841 near the tip of the male luer 841. The lateral hole 843 communicates with the flow path 842.

A circular base plate 849 projects outward from the base end portion of the male luer 841 in a flange shape. A hood 847 is provided on the outer peripheral edge of the substrate 949. The hood 847 has a hollow cylindrical shape coaxial with the male lure 841 and surrounds the male lure 841. The inner diameter of the inner peripheral surface (the surface facing the male lure 841) of the hood 847 is approximately the same as or slightly larger than the outer diameter of the large diameter portion 15 (see FIG. 1A) of the cap 1.

As shown in FIG. 4A, the hood 847 is provided with a cutout (opening) 848. The notch 848 is a hole that penetrates the hood 847 in the radial direction. A lock lever 850 is provided in the cutout 848. The lock lever 850 faces the male lure 841 and extends substantially parallel to the male lure 841. The lock lever 850 is cantilevered by the substrate 849. A lock claw 851 projects from the tip (free end) of the lock lever 850 toward the male luer 841 (see FIG. 4B). An operation arm 855 is provided on the surface of the lock lever 850 opposite to the male luer 841. The operation arm 855 extends upward (on the side of the cylindrical portion 845) beyond the substrate 849. The tip of the operation arm 855 is the operation unit 856. When the operation portion 856 is pushed inward in the radial direction, the lock lever 850 is elastically bent and deformed, and the lock claw 851 is displaced away from the male luer 841.

A tubular portion 845 is provided on the opposite side of the base plate 849 from the male luer 841. A spiral projection (male screw) 846 is provided on the outer peripheral surface of the cylindrical portion 845. As shown in FIG. 4B, the tubular portion 845 has a hollow, substantially cylindrical shape, and the inner peripheral surface 845 a thereof has a tapered surface (so-called inner diameter that increases toward the tip of the tubular portion 845). Female taper surface). The tubular portion 845 communicates with the flow path 842 of the male luer 841.

The cover 860 is substantially the same as the cover described in Patent Document 3, and as shown in FIG. 4B, an outer peripheral wall 861 having a substantially tubular shape, and a head 865 provided at one end of the outer peripheral wall 861. And a base portion 869 provided at the other end of the outer peripheral wall 861 so as to project outward. The cover 860 is integrally made of a material having flexibility (rubber elasticity) (for example, a rubber material such as isoprene rubber, silicone rubber, butyl rubber, or a thermoplastic elastomer). When a compressive force in the vertical direction (longitudinal direction of the male luer 841) is applied to the cover 860, the outer peripheral wall 861 elastically compressively deforms so that the vertical dimension thereof is shortened.

A cavity 866 communicating with the internal space of the outer peripheral wall 861 is formed in the head portion 865. The tip of the male luer 841 is inserted into the cavity 866. The inner peripheral surface of the cavity 866 is in close contact with the outer peripheral surface of the male luer 841 and liquid-tightly and airtightly seals the lateral hole 843 provided in the male luer 841. A slit 867 is formed at the deepest portion of the cavity 866 so as to vertically pass through the head portion 865. As shown in FIG. 4A, the slit 867 is a linear cut having a "-" (minus) shape in plan view. In the initial state in which the outer peripheral wall 861 is not compressed and deformed, the opposing edges forming the slit 867 are in contact with each other so that the slit 867 is liquid-tightly and airtightly sealed.

A dome-shaped protruding portion 868 is provided at the tip of the outer surface of the head portion 865. The slit 867 is provided so as to cross the most protruding portion (top portion) of the convex portion 868.

The fixing member 835 is a circular annular member. The fixing member 835 is used to fix the cover 860 to the connector body 840. That is, as shown in FIG. 4B, the cover 860 is inserted into the hood 847 of the connector body 840 so as to cover the male luer 841. Then, the fixing member 835 is inserted into the hood 847. The cover 860 is inserted into the fixing member 835. A plurality of protrusions (not shown) project toward the male luer 841 at a position on the inner peripheral surface of the hood 847 near the substrate 849. The fixing member 835 is engaged with this protrusion. The base portion 869 of the cover 860 is sandwiched between the fixing member 835 and the substrate 849.

As shown in FIGS. 4A and 4B, a hollow inner tube 811 and an outer tube 813 surrounding the inner tube 811 are coaxially provided at the tip of the outer cylinder 801 of the syringe 800. The outer peripheral surface 811a of the inner pipe 811 is a tapered surface (so-called male tapered surface) whose outer diameter decreases toward the tip. A channel 812 is formed in the inner pipe 811 so as to penetrate the male member 921 along the longitudinal direction thereof. The flow path 812 communicates with the inner cavity 802 of the outer cylinder 801 into which the plunger 805 is inserted and removed. A female screw 814 is formed on the inner peripheral surface of the outer pipe 813 facing the inner pipe 811.

The male connector 830 is attached to the distal end of the syringe 800 by inserting the inner tube 811 of the outer cylinder 801 into the cylindrical portion 845 of the connector body 840 and screwing the threaded protrusion 846 and the female screw 814 together. (See Figure 3). Since the inner peripheral surface 845a of the cylindrical portion 845 and the outer peripheral surface 811a of the inner pipe 811 are tapered surfaces having the same diameter and taper angle, they form a liquid-tight and air-tight seal and are in surface contact with each other. .. The screw-shaped protrusion 846 and the female screw 814 that are screwed with each other function as a lock mechanism for maintaining the connection state between the male connector 830 and the outer cylinder 801. The male connector 830 can be repeatedly attached to and detached from the syringe 800.

Returning to FIG. 3, the first adapter 910 is attached to the vial 900. The 900 vials and the first adapter 910 will be described.

FIG. 5 is a perspective view showing the first adapter 910 immediately before being attached to the vial 900.

The vial 900 includes a bottle body 901 and a rubber stopper 906. The bottle body 901 is made of a hard material such as glass that does not substantially deform. At the upper end of the bottle body 901, a mouth (not shown) that opens upward is provided. A rubber stopper 906 is fitted in the mouth of the bottle body 901. A drug solution (not shown) is contained in the bottle body 901. The rubber stopper 906 hermetically and liquid-tightly seals the mouth of the bottle body 901.

A flange having an enlarged diameter (not shown in FIG. 5 because it is covered with the cap 908) is provided at the upper end of the outer peripheral surface of the bottle body 901 so as to surround the mouth. A cap 908 covers the rubber stopper 906 and the flange in order to prevent the rubber stopper 906 from coming off the mouth of the bottle body 901. The cap 908 is made of a sheet of metal (for example, aluminum) or resin. The cap 908 extends to the upper surface of the rubber stopper 906. A central region of the upper surface of the rubber plug 906 is exposed to the outside through a circular opening 908a provided in the cap 908.

The portion of the vial 900 to which the cap 908 is attached constitutes the enlarged diameter portion 902 having a larger outer diameter than the portion (constricted portion) 904 immediately below it. A step is formed between the enlarged diameter portion 902 and the constricted portion 904 based on the difference in outer diameter between the two.

The vial 900 does not have to include the cap 908. In that case, the enlarged diameter portion 902 is constituted by an enlarged flange provided on the upper end of the bottle body 901.

The first adapter 910 includes a puncture needle 911 having a sharp tip at one end and a port 920 at the other end. An opening 912 is provided on the outer peripheral surface of the puncture needle 911. A channel (not shown) is provided in the puncture needle 911 along the longitudinal direction thereof. The opening 912 and the port 920 are in communication with each other via the flow path inside the puncture needle 911.

The port 920 is a female connector including a self-closing valve body 921. The valve body 921 is a circular thin plate made of a soft material having rubber elasticity (for example, a rubber material such as isoprene rubber, silicone rubber, butyl rubber, or a thermoplastic elastomer), and the valve body 921 is provided at the center thereof. A slit 922 is formed so as to pass through in the thickness direction. The valve body 921 is covered with a seal crown 923. A circular opening (through hole) 923a is provided at the center of the top plate of the seal crown 923, and the central region of the valve body 921 including the slit 922 is exposed to the outside through the opening 923a. When a cylindrical male luer having no sharp tip (for example, the male luer 841 of the male connector 830) is pushed toward the slit 922 of the valve body 921, the male lure can deform the valve body 921 and penetrate the slit 922. .. As a result, the port 920 and the male lure communicate with each other. Then, when the male luer is pulled out from the valve body 921, the valve body 921 immediately elastically returns to the initial state and the slit 922 is closed. When the male luer does not penetrate the slit 922, the slit 922 is liquid-tightly and airtightly closed. The male luer can be repeatedly inserted into and removed from the valve body 921. A female connector having such a resealability is also called a “septum” and is generally known (see, for example, Patent Documents 4 and 5).

Two arms 930 extend from a portion of the first adapter 910 between the puncture needle 911 and the port 920. The arm 930 extends along the radial direction (direction orthogonal to the central axis of the first adapter 910 passing through the puncture needle 911 and the port 920), and is then bent toward the puncture needle 911. A claw 931 protruding toward the puncture needle 911 is provided at the tip of the arm 930. The arm 930 is elastically deformable so that the claw 931 is separated from the puncture needle 911.

From the state of FIG. 5, the first adapter 910 is pushed toward the vial 900. The puncture needle 911 is punctured by the rubber stopper 906 exposed in the opening 908a of the cap 908 of the vial 900. The claw 931 engages with the enlarged diameter portion 902 of the vial 900. As shown in FIG. 3, the first adapter 910 is attached to the vial 900. The opening 912 (see FIG. 5) provided in the puncture needle 911 is located below the rubber stopper 906. Therefore, the vial 900 and the port 920 communicate with each other. As described above, since the slit 922 of the valve body 921 of the port 920 is closed, the drug solution in the vial 900 does not leak from the slit 922 to the outside.

First, the plunger 805 is pulled in a state where the male connector 830 is not attached to the syringe 800, and air of approximately the same amount as the drug solution to be collected from the vial 900 is sucked into the syringe 800. Next, the male connector 830 is attached to the tip of the syringe 800.

Next, as shown in FIG. 3, the male connector 830 attached to the syringe 800 is opposed to the first adapter 910 attached to the vial 900. The port 920 of the first adapter 910 is inserted into the hood 847 of the male connector 830, and the first adapter 910 is further pushed into the male connector 830. The male luer 841 of the male connector 830 penetrates the slit 867 provided in the head portion 865 of the cover 860 (see FIG. 4B), and further penetrates the slit 922 (see FIG. 5) of the valve body 921 of the first adapter 910. .. The cover 860 (see FIGS. 4A and 4B) provided on the male connector 830 is compressed and deformed in the longitudinal direction of the male luer 841. Thus, the vial 900, the first adapter 910, the male connector 830, and the syringe 800 are sequentially connected. The lock claw 851 (see FIG. 4B) of the male connector 830 engages with the lower end 928 (see FIG. 5) of the outer peripheral surface of the port 920.

Next, as shown in FIG. 6, the vial 900 is lifted upward with respect to the syringe 800. Then, the plunger 805 is pulled to suck the drug solution in the vial 900 into the syringe 800. Normally, the horizontal hole 843 (see FIG. 5) provided in the male luer 841 is located in the vicinity of the rubber stopper 906. Therefore, when the vial 900 is turned upside down as shown in FIG. 6, the liquid medicine is discharged from the horizontal hole 843. Easy to inhale. When the drug solution flows out from the vial 900, the inside of the vial 900 becomes slightly negative pressure. Then, the hand is released from the plunger 805. The negative pressure in the vial 900 causes the plunger 805 to be drawn into the outer cylinder 801 of the syringe 800, and at the same time, the air in the syringe 800 moves to the vial 900. The inside of the vial 900 returns to normal pressure. Thus, a part of the drug solution in the vial 900 moves into the syringe 800, and instead, the air in the syringe 800 moves into the vial 900. If necessary, this operation is repeated several times to move a predetermined amount (or total amount) of the drug solution from the vial 900 to the syringe 800.

Then, the male connector 830 is separated from the first adapter 910. That is, the operating portion 856 of the male connector 830 is pushed to bend and deform the lock lever 850 (see FIGS. 4A and 4B) to release the engagement between the lock claw 851 and the port 920. In this state, the male connector 830 and the first adapter 910 are pulled in directions away from each other. When the male connector 830 is separated from the first adapter 910, the cover 860 (see FIGS. 4A and 4B) of the male connector 830 immediately elastically returns to the initial state, and the slit 867 is closed. The cover 860 (particularly the head portion 865 thereof) liquid-tightly and airtightly seals the lateral hole 843 of the male luer 841. Therefore, even if an external force such as pushing the plunger 805 into the outer cylinder 801 is erroneously applied to the syringe 800, the drug solution in the syringe 800 or its vapor does not leak to the outside. Further, the slit 922 (see FIG. 5) of the valve body 921 of the first adapter 910 is also closed.

Next, the drug solution in the syringe 800 is transferred to the drug solution bag. FIG. 7 is a perspective view of the drug solution bag 950. The chemical solution bag 950 is a bag-shaped product formed by sticking together two flexible sheets at their outer peripheral edge portions. The drug solution bag 950 includes a port 951 for taking in and out a liquid such as a drug solution with respect to the drug solution bag 950. The opening of the port 951 is sealed with a rubber stopper (not visible in FIG. 7). A liquid (infusion) to be administered to a patient together with the liquid medicine may be stored in advance in the liquid medicine bag 950.

An adapter (hereinafter referred to as “second adapter”) 960 is attached to the port 951.

The second adapter 960 has substantially the same configuration as the adapter described in Patent Document 6, has a puncture needle (not visible in FIG. 7) having a sharp tip at one end, and has a port 970 at the other end. The puncture needle is punctured in the rubber stopper of the port 951. The second adapter 960 further comprises four generally “U” shaped arms 980 extending from the portion between the puncture needle and the port 970. Each arm is provided with a claw 981 protruding toward the puncture needle. The pawl 981 is engaged with the port 951. The second adapter 960 has substantially the same configuration as the first adapter 910 (see FIG. 5) except for the arm 980 and the claw 981. Like the port 920 of the first adapter 910, the port 970 is a female connector provided with a self-closing valve body 971. A slit penetrating the valve body 971 in the thickness direction is formed at the center of the valve body 971.

As shown in FIG. 8, the male connector 830 attached to the syringe 800 is connected to the second adapter 960 attached to the drug solution bag 950. The connection between the second adapter 960 and the male connector 830 can be performed in the same manner as the connection between the first adapter 910 and the male connector 830 (see FIG. 3). The drug solution bag 950, the second adapter 960, the male connector 830, and the syringe 800 are communicated in order. The locking pawl 851 (see FIG. 4B) of the male connector 830 engages the port 970. In this state, the plunger 805 is pushed into the outer cylinder 801 to inject the drug solution in the syringe 800 into the drug solution bag 950. In order to transfer all the drug solution in the syringe 800 into the drug solution bag 950, the plunger 805 is pushed into the outer cylinder 801 to the maximum depth.

Then, the male connector 830 is separated from the second adapter 960. The separation of the male connector 830 and the second adapter 960 is the same as the separation of the male connector 830 and the first adapter 910 (see FIG. 7). When the male connector 830 is separated from the second adapter 960, the cover 860 (see FIGS. 4A and 4B) of the male connector 830 immediately elastically returns to the initial state, and the slit 867 is closed. The lateral hole 843 of the male luer 841 is liquid-tightly and airtightly sealed by the cover 860 (in particular, the head portion 865 thereof).

Next, the cap 1 is attached to the male connector 830 attached to the syringe 800. That is, as shown in FIG. 9, the end surface of the cap 1 on the side of the first hole 21 (see FIG. 1A) faces the male connector 830. Then, the large diameter portion 15 of the cap 1 is inserted into the hood 847 of the male connector 830. The second hole 22 (see FIG. 2A) of the cap 1 is not closed by the sealing material 25 and is open. The plunger 805 of the syringe 800 is pushed deepest into the outer cylinder 801.

FIG. 10 is a cross-sectional view of the cap 1 attached to the male connector 830. The lock claw 851 of the male connector 830 engages with the large diameter portion 15 of the cap 1. The cap 1 cannot be separated from the male connector 830 even if a tensile force is applied to the cap 1 unless the lock claw 851 and the large-diameter portion 15 are disengaged.

When the rib 21a of the cap 1 abuts on the convex portion 868 at the tip of the cover 860, the cover 860 receives a compressive force in the vertical direction, and in particular, the outer peripheral wall 861 is deformed so that the vertical dimension is reduced. The male luer 841 penetrates the slit 867 (see FIG. 4A) provided in the head portion 865 of the cover 860 and is inserted into the first hole 21 of the cap 1. The lateral hole 843 provided in the male luer 841 is exposed in the inner cavity 10 a of the cap 1. Therefore, the flow path 842 of the male luer 841 and the inner cavity 10a of the cap 1 are communicated with each other.

The convex portion 868 of the cover 860 is pressed against the tip of the annular rib 21a of the cap 1 by the elastic force of the compressed cover 860 to return to the initial state, and the liquid-tightness and air-tightness are provided between the cover 860 and the rib 21a. A transparent seal is formed. As in this embodiment, bringing the cover 860 into contact with the tip of the rib 21a having a very narrow area is advantageous for improving the liquid-tightness and air-tightness of the seal formed between them.

In the state of FIG. 10, the plunger 805 of the syringe 800 is pulled. The air in the outside world sequentially passes through the second hole 22, the ventilation filter 24, the one-way valve 23, the inner cavity 10a, the lateral hole 843, the flow path 842, and the tubular portion 845, and then flows into the outer tube 801. Air, which is approximately the same amount as the amount of the drug solution to be collected in the syringe 800 from the next new vial, is sucked into the syringe 800.

When the outside air passes through the ventilation filter 24, the ventilation filter 24 captures foreign matter (for example, solid matter such as dust or bacteria) contained in the air. Therefore, the foreign matter flowing into the syringe 800 is reduced. Therefore, it is possible to reduce the possibility that foreign substances will be mixed in the drug solution collected into the syringe 800 from the next new vial.

A liquid-tight and air-tight seal is formed between the rib 21 a of the cap 1 and the convex portion 868 of the cover 860. A one-way valve 23 is provided between the first hole 21 (or the male luer 841) and the second hole 22. Therefore, even if an external force such as pushing the plunger 805 into the outer cylinder 801 is erroneously applied to the syringe 800 after sucking the air into the syringe 800, the air in the syringe 800 does not leak to the outside. .. A slight amount of the drug solution sucked from the vial 800 may remain in the syringe 800. If the air once sucked into such a syringe 800 leaks to the outside world, the drug solution or its vapor may leak to the outside world together with the air, and the worker may be exposed to the drug. Since the cap 1 reduces such a possibility, it is advantageous in improving safety.

Next, the cap 1 is separated from the male connector 830. The cap 1 can be separated by pushing the operating portion 856 of the male connector 830 toward the tubular portion 845 to release the engagement between the lock claw 851 and the large diameter portion 15.

When the cap 1 comes out of the hood 847, the outer peripheral wall 861 of the cover 860 immediately expands to the initial state (see FIG. 4B) due to its elastic recovery force. The male luer 841 is housed in the cover 860, and the lateral hole 843 of the male luer 841 is liquid-tightly sealed by the inner peripheral surface of the cavity 866 of the head portion 865. Therefore, even if an external force that pushes the plunger 805 into the outer cylinder 801 is erroneously applied to the syringe 800, the air in the syringe 800 does not leak to the outside. Therefore, the possibility that the chemical liquid or its vapor that may remain in the syringe 800 leaks to the outside and the worker is exposed to the chemical is reduced.

The used cap 1 is discarded. When the second hole 22 is discarded while being sealed with the sealing material 25, the possibility that the chemical liquid or its vapor that may be present in the inner cavity 10a leaks out of the cap 1 is reduced. Preferably, the second hole 22 is sealed with the sealing material 25 before the cap 1 is separated from the male connector 830.

Using a syringe 800 that has sucked a predetermined amount of air, the same negative pressure adjustment method as described above (see FIGS. 3 to 10) is performed on the next new vial, and the drug solution is transferred from the vial to the drug solution bag 950. can do. When it is necessary to transfer the drug solution in a plurality of vials to the drug solution bag 950, the same operation is performed for each vial using the same syringe 800.

3. Action As described above, when the drug solution contains a dangerous drug, a closed system device is often used in order to prevent the drug solution or its vapor from leaking to the outside. As a closed system device, like the male connector 830, the flow path of the male member in a state where it is not connected to its counterpart connector (the port 920 of the first adapter 910 and the port 970 of the second adapter 960 in the above embodiment). There is a closed system connector configured to seal the opening of the. In the state where such a closed system connector (male connector 830) is attached to the syringe 800, the operation of sucking the outside air into the syringe 800, which is essential in the negative pressure adjustment method, cannot be performed.

According to the present invention, air can be sucked into the syringe 800 simply by mounting the cap 1 on the male connector 830. Therefore, the same syringe 800 can be used to transfer the drug solution in the plurality of vials to the drug solution bag by the negative pressure adjusting method.

The conventional closed system device (male connector 830, first adapter 91, and second adapter 960) does not need to be changed in configuration, and only the cap 1 having a simple configuration is used. The drug solution in the vial bottle can be transferred to the drug solution bag by substantially the same procedure as the negative pressure adjusting method performed from.

Since the cap 1 includes the one-way valve 23, even if the plunger 805 is erroneously pushed in, the chemical liquid or its vapor does not leak to the outside through the second hole 22 of the cap 1. Therefore, the possibility that the worker will be exposed to the drug is not increased by mounting the cap 1 on the male connector 830.

The first hole 21 is an open hole that is always open so that it can be connected to the male luer 841. This simplifies the configuration of the cap 1 including the first hole 21, reduces the number of parts that configure the cap 1, and further facilitates the manufacturing of the cap 1. Further, the reliability of the connection between the first hole 21 and the male luer 841 is improved.

4. Various Modifications The above embodiments are merely examples. The present invention is not limited to the above embodiment and can be modified as appropriate.

The positions of the one-way valve 23 and the ventilation filter 24 are not limited to those in the above-described embodiment, and may be arranged at arbitrary positions on the path leading from the outside to the first hole 21 through the second hole 22 and the lumen 10a. You can For example, the one-way valve 23 and/or the ventilation filter 24 may be arranged at a position near the first hole 21 in the lumen 10a, may be arranged in the second hole 22, or may be arranged in the second hole 22. It may be arranged at the edge 22a (see FIG. 2B) exposed to the outside of the hole 22. The one-way valve 23 and/or the ventilation filter 24 may be arranged in the first hole 21 as long as they do not interfere with the male member connected to the first hole 21. The ventilation filter 24 may be arranged on the first hole 21 side with respect to the one-way valve 23.

In the present invention, the ventilation filter 24 may be omitted.

The configuration of the housing 10 is not limited to the above embodiment. For example, it is not essential that the inner diameters of the first hole 21 and the second hole 22 be smaller than the inner diameter of the lumen 10a. The inner diameter of the second hole 22 may be the same as or larger than the inner diameter of the lumen 10a. The first hole 21, the lumen 10a, and the second hole 22 may have the same inner diameter. The first hole 21, the lumen 10a, and the second hole 22 do not need to be coaxially arranged, and any of these may be eccentric with respect to the other. The path connecting the second hole 22 to the first hole 21 through the inner cavity 10a does not need to be along a straight line, and may be curved or bent.

The configuration of the sealing material 25 is not limited to the above embodiment. The sealing material 25 may be configured so as to be able to close the second hole 22. Therefore, it is not essential that the sealing material 25 be fitted into the second hole 22 as in the above embodiment. Particularly, depending on the positions of the one-way valve 23 and the ventilation filter 24 (for example, when the ventilation filter 24 is provided on the end edge 22a of the second hole 22 as described above), the configuration of the sealing material is also changed accordingly. May need to be done. For example, the sealing material can cover and fit the cylindrical member 22b (see FIG. 2B) that surrounds the second hole 22 and projects to the outside, or the end of the housing 10 on the second hole 22 side. It may be configured so that it covers the entire part and can be fitted therein. Alternatively, the sealing material may be configured to open and close the second hole 22 by sliding in a direction orthogonal to the central axis of the second hole 22. Alternatively, an adhesive layer may be provided on the surface of the seal material, and the seal material may be attached to the housing 10 via the adhesive layer so as to close the second hole 22. The sealing material and the housing 10 do not need to be connected by the belt 26. The sealing material may be a separate part separated from the housing 10.

The sealing material 25 may be configured to be able to repeatedly open and close the second hole 22, but once the sealing material closes the second hole 22, the second hole 22 cannot be opened again. In addition, the sealing material may be configured to irreversibly close the second hole 22. This is advantageous in reducing the possibility of accidentally reusing the used cap 1.

In the present invention, the sealing material 25 may be omitted.

The rib 21a protruding from the edge of the first hole 21 may be omitted. Even if the rib 21a is omitted, when the cap 1 is mounted on the male connector 830, the convex portion 868 of the cover 860 is brought into contact with the peripheral portion of the first hole 21 of the housing 10 to form a liquid-tight seal therebetween. It can be formed.

In the present invention, when the cap 1 is attached to the male connector 830, the first hole 21 and the male luer 841 are connected so that the inner cavity 10a of the housing 10 and the flow path 842 of the male luer 841 communicate with each other. At this time, preferably, a liquid-tight and air-tight seal is formed between the cap 1 and the male connector 830. The configuration for realizing this is not limited to the above embodiment, and various configurations are conceivable.

For example, when the male luer 841 is inserted into the first hole 21 (see FIG. 10 ), the outer peripheral surface of the male luer 841 and the inner peripheral surface of the first hole 21 are fitted to each other, whereby liquid tightness and An airtight seal may be formed.

Alternatively, the flow path 842 of the male lure 841 may penetrate the male lure 841 along the longitudinal direction of the male lure 841. That is, the lateral hole 843 may be omitted, and instead of this, the flow path 842 may be opened at the tip of the male luer 841. In this case, when the cap 1 is attached to the male connector 830, the male luer 841 is not inserted into the first hole 21, but the tip of the male luer 841 is abutted against the peripheral portion of the first hole 21. And an airtight seal may be formed.

When the seal is formed between the male luer 841 and the inner peripheral surface of the first hole 21 or the peripheral portion thereof as described above, the convex portion 868 of the cover 860 and the peripheral portion of the first hole 21 are connected to each other. The liquid-tight and air-tight seal as in the above-described embodiment may not be formed.

The configuration of the engagement structure with which the lock claw 851 of the male connector 830 can be engaged is not limited to the large diameter portion 15. For example, the engagement structure may be a recess (for example, an annular groove continuous in the circumferential direction) provided on the outer peripheral surface of the housing 10. In this case, the cap 1 is engaged with the lock claw 851 by fitting the lock claw 851 into the recess. In the present invention, the engagement structure with which the lock claw 851 can be engaged may be omitted.

In the above-described embodiment, the first hole 21 is an open hole that is always open, but in the present invention, the first hole 21 is configured to be automatically closed immediately when the male member is separated from the first hole. May be. FIG. 11A is a perspective view of the air suction cap 2 according to another embodiment of the present invention seen from below, and FIG. 11B is a sectional perspective view of the cap 2 seen from below. The cap 2 is provided at its lower end with a female connector 220 having a self-closing valve body 222 configured similarly to the port 920 (see FIG. 5) and the port 970 (see FIG. 7). The valve body 222 is a circular thin plate made of a soft material having rubber elasticity (for example, a rubber material such as isoprene rubber, silicone rubber, butyl rubber, or a thermoplastic elastomer). A slit 221 is formed in the center of the valve body 222 so as to penetrate the valve body 222 in the thickness direction. An opening of the substantially cylindrical first part 11 facing downward is closed by a valve body 222, and the valve body 222 is covered with a seal crown 223. The seal crown 223 includes a circular top plate 224 and a cylindrical peripheral wall 225 extending from an outer peripheral edge of the top plate 224. A circular opening (through hole) 223a is provided at the center of the top plate 224, and the central region of the valve body 222 including the slit 221 is exposed to the outside through the opening 223a. A hole 226 is formed in the peripheral wall 225 so as to penetrate the peripheral wall 225 in the radial direction. The seal crown 223 is fixed to the first component 11 by fitting the claw 216 protruding from the outer peripheral surface of the first component 11 into the hole 226. From the outer peripheral surface of the first component 11, an annular protrusion 215 continuous in the circumferential direction projects. The outer peripheral surface of the annular protrusion 215 and the peripheral wall 225 of the seal crown 223 continuously form a common cylindrical surface. The material of the seal crown 223 is not limited, but the hard resin material described above can be used as the material of the outer cylinder 10.

Similar to the case of the port 920 (see FIG. 5) and the port 970 (see FIG. 7), the female connector 220 can be attached to and detached from the male connector 830. The male luer 841 deforms the valve body 222 and penetrates the slit 221. As a result, the male luer 841 and the inner cavity 10a of the cap 2 communicate with each other. Then, when the male luer 841 is pulled out from the valve body 222, the valve body 222 immediately elastically returns to the initial state, and the slit 221 is closed. When the male luer 841 does not penetrate the slit 221, the slit 221 is liquid-tightly and airtightly closed. The male luer 841 can be repeatedly inserted into and removed from the valve body 222 as many times as desired. The female connector 220 is a closed device called a “septum” (see, for example, Patent Documents 4 and 5). The lock claw 851 of the male connector 830 engages with the annular protrusion 215.

The slit 221 of the valve body 222 functions as the first hole of the present invention. The first hole (slit) 221 of the cap 2 is configured such that, when the male luer 841 (male member) is inserted into the first hole 221, the flow path 842 of the male luer 841 and the lumen 10a communicate with each other. .. Therefore, as in the case where the cap 1 is attached to the male connector 830 (see FIG. 10 ), when the cap 2 is attached to the male connector 830, air can be sucked into the syringe 800 via the cap 2. Therefore, the same syringe 800 can be used to transfer the drug solution in the plurality of vials to the drug solution bag by the negative pressure adjusting method.

Unlike the first hole 21 of the cap 1, when the cap 2 is separated from the male connector 830, the first hole 221 is immediately liquid-tightly and airtightly sealed. Therefore, after separating the male connector 830, it is unlikely that the drug solution or its vapor that may be present in the inner cavity 10a leaks out of the cap 2 through the first hole 221. Compared to the cap 1, the cap 2 is used when sequentially transferring the drug solutions in a plurality of vials to the drug solution bags 950 by the negative pressure adjusting method using the same cap 2 or when discarding the used cap 2. This is advantageous in further reducing the possibility that the dangerous chemical liquid or its vapor that may remain in the inner cavity 10a leaks to the outside and the worker is exposed to the chemical.

Although illustration is omitted, when the cap 2 is attached to the male connector 830, the cover 860 of the male connector 830 is compressed and deformed in the longitudinal direction of the male luer 841. Due to the elastic restoring force of the compressed cover 860, the convex portion 868 (see FIG. 4A) at the tip of the cover 860 is pressed against the top plate 224 or the valve body 222 of the seal crown 223, and between the cover 860 and the female connector 220. A liquid-tight and airtight seal is formed. In addition to this, the edge of the slit 221 is in close contact with the outer peripheral surface of the male luer 841 inserted into the slit 221, and a liquid-tight and air-tight seal is formed between them. Therefore, after the air is sucked into the syringe 800, if an external force such as pushing the plunger 805 into the outer cylinder 801 is erroneously applied to the syringe 800, the air in the syringe 800 may leak to the outside. Can be reduced to a value equal to or less than that when the cap 1 is used. Therefore, the cap 2 is advantageous in reducing the possibility that the dangerous chemical liquid that may remain in the syringe 800 or its vapor will leak to the outside due to the above-mentioned erroneous operation and the worker will be exposed to the chemical.

In FIGS. 11A and 11B, the self-closing valve body is provided with the slit 221 that opens and closes in accordance with the insertion/removal of the male member (male lure 841), but the configuration of the self-closing valve body is not limited to this. The cap of the present invention may include any valve body configured to open and close the first hole in conjunction with connection/disconnection of the first hole and the male member. The slit 221 may not be formed in the valve body. For example, the opening edge of the first hole is not substantially deformed, and the valve body is moved in the first hole in conjunction with the insertion/extraction of the male member into/from the first hole so that the first hole is opened/closed. May be configured. Any closed female connector configuration configured to prevent fluid from leaking from the female connector when the male connector is not connected can be applied to the first hole of the cap of the present invention.

The cap 2 is the same as the cap 1 except for the above. The description about the cap 1 can be applied to the cap 2 as appropriate.

The connector to which the cap of the present invention is attached is not limited to the male connector 830 of the above embodiment.

For example, the connector may have two lock levers, each lock lever having a lock pawl that engages the cap of the present invention, as described in US Pat.

The male member connected to the first hole of the cap of the present invention may be a puncture needle (also called a bottle needle) having a sharp tip so that it can puncture the rubber stopper 906 of the vial 900.

Furthermore, the cap of the present invention can be used in situations other than the negative pressure adjusting method. For example, the cap of the present invention can be used for a connector connected between a vial bottle and a drug solution bag as described in Patent Documents 8 to 10. This connector includes a resin puncture needle having a sharp tip, which is punctured by a rubber stopper of a vial bottle. The puncture needle is provided with a liquid flow path through which a liquid flows and a gas flow path through which air flows independently of each other. A cover that covers the tip of the puncture needle may be provided in order to prevent the drug solution from leaking out from the opening of the liquid channel (see, for example, Patent Document 1). The cock provided on the connector is operated to switch the flow path inside the connector, and while changing the vertical position of the vial bottle and the drug solution bag, the liquid is transferred between the vial bottle and the drug solution bag to prepare the drug solution. do. If the operation is erroneous, the liquid may block the flow path and the chemical solution preparation work may not be continued. In such a case, by connecting the first hole of the cap of the present invention to the puncture needle and introducing the outside air into the flow path through the cap, it becomes possible to restart the drug solution preparation work.

INDUSTRIAL APPLICABILITY The present invention can be preferably used in the medical field, and further when preparing a drug solution (or infusion solution) to be administered to a patient by infusion therapy. In particular, it can be preferably used when preparing a drug solution containing a dangerous drug such as an anticancer drug which may cause an exposure accident. The cap of the present invention can be attached to a connector including a male member. Preferably, the connector is a closed system connector provided with a cover that closes the opening of the flow path of the male member.

1, 2 Air suction cap 10 Housing 10a Housing lumen 15 Large diameter part (engagement structure)
21 1st hole 21a Rib 22 2nd hole 23 One-way valve 24 Vent filter 25 Seal material 215 Annular protrusion (engagement structure)
221 slit (first hole)
830 Male connector 841 Male (male member)
843 lateral hole (opening of male member)
851 lock claw 860 cover

Claims (8)

A housing having a lumen,
A first hole capable of connecting a male member, wherein the male member and the inner hole are configured to communicate with each other when the male member is connected to the first hole,
A second hole configured so that the lumen and the outside world can communicate with each other;
A one-way valve provided on a path connecting from the outside world to the first hole through the second hole and the inner cavity,
The one-way valve is configured to allow a fluid to flow from the outside to the first hole along the path and prevent the fluid from flowing in the opposite direction ,
Even if the pressure inside the lumen is increased via the male member and the first hole while the male member is connected to the first hole, the fluid inside the lumen does not flow out to the outside. The air suction cap characterized by being . A male connector including the male member includes a cover that prevents fluid from leaking from the opening of the male member when the male member is not connected to the first hole,
The cover is compressively deformable along the longitudinal direction of the male member so that the opening is exposed to the outside of the cover,
The air suction cap according to claim 1, wherein when the male member is connected to the first hole, the opening of the male member communicates with the inner cavity. The air suction cap according to claim 2, wherein a seal is formed between an edge of the first hole and the cover when the first hole and the male member are connected to each other. Further comprising an annular rib provided on the housing so as to surround the first hole,
The air suction cap according to claim 2 or 3, wherein a seal is formed between the tip of the rib and the cover when the first hole and the male member are connected. The air suction cap according to any one of claims 1 to 4, further comprising an engagement structure capable of engaging a lock claw provided in the male connector including the male member. The air suction cap according to claim 1, further comprising a ventilation filter provided on the path. The air suction cap according to claim 1, wherein the first hole is configured to be closed immediately after separating the male member from the first hole. The air suction cap according to claim 1, further comprising a seal material for closing the second hole.

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