WO2017217105A1

WO2017217105A1 - Cap for sucking in air

Info

Publication number: WO2017217105A1
Application number: PCT/JP2017/015559
Authority: WO
Inventors: 野口裕祐
Original assignee: 株式会社ジェイ・エム・エス
Priority date: 2016-06-15
Filing date: 2017-04-18
Publication date: 2017-12-21
Also published as: JP6747080B2; JP2017221440A

Abstract

A cap (1) is provided with: a housing (10) having an inner cavity (10a); a first hole (21) to which a male member (841) can be connected, the first hole (21) being configured so that the male member (841) and the inner cavity (10a) will be in communication with each other when the male member (841) is connected to the first hole (21); a second hole (22) configured so as to be capable of bringing the inner cavity (10a) and the outside into communication with each other; and a one-way valve (23) provided in a path leading from the outside to the first hole (21) through both the second hole (22) and the inner cavity (10a). The one-way valve (23) is configured so as to permit fluid to flow along the path from the outside toward the first hole (21) and so as to prevent the fluid from flowing in the opposite direction.

Description

Air suction cap

The present invention relates to an air suction cap that is attached to a connector including a male member and allows air to be introduced into the flow path of the male member.

場合 When administering a drug solution stored in a sealed vial to a patient, it is necessary to prepare the drug solution by transferring the drug solution in the vial to a drug solution bag. As a method for transferring a chemical solution from a vial to a chemical solution bag, a method called “negative pressure adjustment method” using a syringe to which a metal needle having a sharp tip is attached is known. This method is roughly as follows.

First, pull the plunger of the empty syringe and suck the air of approximately the same amount as the amount of the chemical to be collected into the syringe. Next, the rubber needle of the vial is punctured with a metal needle of a syringe. A drug solution is stored in the vial. Pull the plunger to draw the drug solution in the vial into the syringe. There is a slight negative pressure inside the vial. Lift the vial above the syringe and release the plunger. The negative pressure in the vial pulls the plunger into the outer cylinder of the syringe, and at the same time, the air in the syringe moves to the vial. The inside of the vial returns to normal pressure. Thus, a part of the drug solution in the vial moves into the syringe, and instead, the air in the syringe moves into the vial. This operation is repeated several times as necessary to move a predetermined amount (or total amount) of the drug solution from the vial to the syringe. Next, the metal needle of this syringe is pulled out from the rubber stopper of the vial bottle and punctured into the rubber stopper of the port of the drug solution bag. And a plunger is pushed in and the chemical | medical solution in a syringe is transferred in a chemical | medical solution bag.

When it is necessary to transfer the chemicals in a plurality of vials to the chemical solution bag, the same operation is performed on each vial using the above syringe.

薬 The drug solution in the vial may contain dangerous drugs designated as powerful drugs, such as some anticancer drugs. It is desired to avoid such a situation that such a chemical solution leaks and adheres to the operator's finger or the operator sucks the vapor.

In the negative pressure adjustment method described above, the drug solution may leak from the tip of the metal needle after the metal needle is pulled out from the rubber stopper of the vial bottle and before the metal needle is punctured into the rubber stopper of the drug solution bag. .

Patent Document 1 describes a bottle needle with a cover in which a resin bottle needle (sometimes called a puncture needle) having a sharp tip is covered with a cover. The bottle needle can puncture the rubber stopper of the vial. A liquid flow path through which the chemical solution flows is provided in the bottle needle, and the liquid flow path communicates with a lateral hole opened on the outer peripheral surface near the tip of the bottle needle. The cover is elastically compressible and deformable in the longitudinal direction of the bottle needle. In the initial state, the head at the tip of the cover covers the tip of the bottle needle and closes the side hole of the bottle needle. When the bottle needle is punctured into the rubber stopper of the vial, the bottle needle penetrates the head of the cover and the rubber stopper in order, and the lateral hole of the bottle needle is exposed in the vial. At this time, the cover is compressed and deformed. The chemical solution in the vial is taken out via the liquid channel. Thereafter, when the bottle needle is pulled out from the rubber stopper, the cover immediately returns to the initial state and closes the lateral hole of the bottle needle. For this reason, after the bottle needle is pulled out from the rubber stopper, the chemical liquid is prevented from leaking from the side hole of the bottle needle.

International Publication No. 2013/141137 Pamphlet International Publication No. 2013/154050 JP 2013-165830 A JP-A-11-197254 JP 2013-252165 A JP 2014-079355 A1 JP 2004-000483 A International Publication No. 2010/061742 Pamphlet International Publication No. 2010/061743 Pamphlet JP 2013-226281 A

The bottle needle of Patent Document 1 is provided with a gas flow path separately from the liquid flow path. The gas flow path allows air to flow into the vial through the gas flow path and the negative pressure in the vial at the same time as the drug solution flows out of the vial through the liquid flow path. Is provided to facilitate the removal of the drug solution from the vial.

In the negative pressure adjustment method described above, since the chemical liquid flows out from the vial and then the air flows into the vial through the same flow path as the flow of the chemical liquid, a gas flow path is unnecessary.

Therefore, instead of a metal needle, the bottle needle with a cover of Patent Document 1 in which the gas flow path is omitted is attached to the tip of a syringe used in the negative pressure adjustment method, thereby preventing the chemical solution from leaking to the outside. It is thought that you can.

However, there is a problem that the negative pressure adjustment method cannot be performed when the bottle needle with the cover is attached to the syringe. The reason is as follows.

In the negative pressure adjustment method described above, a predetermined amount of air is sucked into the syringe before the syringe needle is punctured into the rubber stopper of the vial. This is for moving the air in the syringe to the vial in exchange for moving the drug solution in the vial to the syringe as described above. If air is not sucked into the syringe in advance, even if the plunger can be pulled and the drug solution can be sucked into the syringe, the plunger will be released when the hand is released from the plunger due to the negative pressure generated in the vial. The drug solution is drawn back into the vial and returned to the vial.

In the bottle needle with a cover described in Patent Document 1, in the initial state where the bottle needle does not puncture the rubber stopper, the lateral hole of the bottle needle is closed with the cover. For this reason, the plunger cannot be pulled to suck air into the syringe. Therefore, the negative pressure adjustment method cannot be performed. In particular, when transferring the drug solution in multiple vials to the drug solution bag using the same syringe, the plunger reaches the deepest position in the outer cylinder of the syringe when the drug solution in the first vial is transferred to the drug solution bag. Since it is pushed in, the drug solution in the next vial cannot be moved into this syringe in this state. If the bottle needle is removed from the syringe, it is possible to draw air into the syringe by pulling the plunger, but there is a possibility that the operator may be exposed to the drug during the operation of removing the bottle needle.

An object of the present invention is to make it possible to allow external air to flow into the flow path of the male member while reducing the possibility of exposure to the operator.

The air suction cap of the present invention is a housing having a lumen and a first hole to which a male member can be connected, and the male member and the lumen are connected when the male member is connected to the first hole. A first hole configured to communicate, a second hole configured to allow communication between the lumen and the outside, and the first hole from the outside through the second hole and the lumen. And a one-way valve provided on a path leading to the hole. The one-way valve is configured to allow the fluid to flow from the outside toward the first hole along the path, and to prevent the fluid from flowing in the opposite direction.

When the cap of the present invention is connected to the male member, external air can flow into the male member through the second hole and the lumen of the housing. Since the cap includes a one-way valve, fluid is prevented from leaking from the male member through the cap to the outside. For this reason, even if it attaches a cap to a male member, possibility that an operator will be exposed by fluid leaking is low.

FIG. 1A is a perspective view of an air suction cap according to an embodiment of the present invention as seen from below. FIG. 1B is a cross-sectional perspective view seen from below the cap. FIG. 2A is a perspective view of the air suction cap according to the embodiment of the present invention as seen from above. FIG. 2B is a cross-sectional perspective view of the cap as viewed from above. FIG. 3 is a front view showing a state immediately before the male connector attached to the syringe is connected to the first adapter attached to the vial. FIG. 4A is an exploded perspective view showing a male connector and a tip portion of a syringe. 4B is a cross-sectional view of FIG. 4A. FIG. 5 is a perspective view showing the first adapter immediately before being attached to the vial. FIG. 6 is a front view showing a step of sucking the drug solution in the vial into the syringe. FIG. 7 is a perspective view of the chemical bag with the second adapter attached thereto. FIG. 8 is a front view showing a process of injecting the chemical solution in the syringe into the chemical solution bag. FIG. 9 is a front view showing a state immediately before the air suction cap according to the embodiment of the present invention is attached to the male connector attached to the syringe. FIG. 10 is a cross-sectional view of an air suction cap according to an embodiment of the present invention, which is attached to a male connector. FIG. 11A is a perspective view seen from below of an air suction cap according to another embodiment of the present invention. FIG. 11B is a cross-sectional perspective view seen from below the cap.

In the air suction cap of the present invention, the male connector provided with the male member prevents fluid from leaking from the opening of the male member when the male member is not connected to the first hole. A cover may be provided. The cover may be compressible and deformable along a longitudinal direction of the male member such that the opening is exposed outside the cover. In this case, when the male member is connected to the first hole, the opening of the male member and the lumen may be communicated with each other. This is advantageous in letting outside air flow into the flow path of the closed connector in which the opening is covered with a cover in order to prevent the fluid from flowing out from the opening of the flow path of the male member.

The cap may be configured such that a seal is formed between an edge of the first hole and the cover when the first hole and the male member are connected. This is advantageous in reducing the possibility of exposure to the operator because the fluid can be prevented from leaking to the outside through between the edge of the first hole and the cover.

The cap may further include an annular rib provided in the housing so as to surround the first hole. In this case, the cap may be configured such that a seal is formed between the tip of the rib and the cover when the first hole and the male member are connected. This improves the liquid tightness and air tightness of the formed seal, which is advantageous in reducing the possibility of exposure to the operator.

The cap may further include an engagement structure with which a lock claw provided on a male connector provided with the male member can be engaged. This is advantageous in reducing the possibility that the operator will be exposed because the cap can be prevented from unintentionally falling off the male connector.

The cap may further include a ventilation filter provided on the path. This is advantageous in preventing foreign matters (for example, solid matter such as dust and bacteria) contained in the outside air from flowing into the flow path of the male member.

The first hole may be configured to be immediately closed when the male member is separated from the first hole. This is advantageous in reducing the likelihood that dangerous fluid that may be present in the lumen will leak out of the cap through the first hole after separating the male member from the first hole.

The cap may further include a sealing material for closing the second hole. By sealing the second hole with a sealing material, it is possible to reduce the possibility that dangerous fluid that may exist in the lumen leaks out of the cap.

Hereinafter, the present invention will be described in detail while showing preferred embodiments. However, it goes without saying that the present invention is not limited to the following embodiments. Each drawing referred to in the following description shows simplified main members constituting an embodiment of the present invention for convenience of description. Therefore, the present invention can include any member not shown in the following drawings. Further, within the scope of the present invention, each member shown in the following drawings can be changed or omitted. In the figure shown below, the same code | symbol is attached to the same member, and the overlapping description about them is abbreviate | omitted.

1. Configuration of Air Suction Cap FIG. 1A is a perspective view of an air suction cap (hereinafter simply referred to as “cap”) 1 according to an embodiment of the present invention, and FIG. 1B is a view of the cap 1 from below. It is a cross-sectional perspective view. 2A is a perspective view of the cap 1 as viewed from above, and FIG. 2B is a cross-sectional perspective view of the cap 1 as viewed from above.

1B and 2B, the cap 1 includes a housing 10 having a hollow cylindrical shape as a whole. The housing 10 is provided with a first hole 21 and a second hole 22 that allow a lumen 10 a that is a space in the housing 10 and the outside of the housing 10 to communicate with each other. The first hole 21 and the second hole 22 are disposed on both ends of the housing 10 so as to face the housing 10 so as to sandwich the inner cavity 10a. For convenience in describing the cap 1, the side on which the first hole 21 is provided is referred to as the “lower” side, and the side on which the second hole 22 is provided is referred to as the “upper” side. The direction connecting the first hole 21 and the second hole 22 is referred to as “vertical direction”, and the direction along a plane perpendicular to the vertical direction is referred to as “horizontal direction”. These expressions are for explaining the cap 1 and are not related to the orientation of the cap 1 in actual use.

As shown in FIG. 1B, the inner peripheral surface of the first hole 21 is a cylindrical surface. An annular rib 21a that surrounds the first hole 21 along the edge of the first hole 21 protrudes outward (that is, downward). In addition, the shape of the inner peripheral surface of the first hole 21 is not limited to a cylindrical surface, and may be, for example, a tapered surface (so-called female tapered surface) whose inner diameter decreases as it approaches the lumen 10a.

A one-way valve 23 and a ventilation filter 24 are provided between the first hole 21 and the second hole 22 (that is, in the lumen 10a).

The one-way valve 23 allows fluid (air in the present embodiment) to flow from the outside of the housing 10 to the first hole 21 through the second hole 22 and the lumen 10a. The fluid (the chemical solution and the gas in this embodiment) is prevented from flowing from the first hole 21 through the lumen 10 a and the second hole 22 to the outside of the housing 10. Such a valve that allows fluid flow only in one direction and prevents backflow is also called a check valve or a check valve. The configuration of the one-way valve 23 is not limited as long as it has such a function. In this embodiment, a duckbill type one-way valve is used as the one-way valve 23.

The ventilation filter 24 allows gas to pass through and captures foreign matters (for example, solid matter such as dust and bacteria) contained in the gas when the gas passes. In the present embodiment, the ventilation filter 24 is a circular sheet-like member having substantially the same diameter as the lumen 10a. The ventilation filter 24 is fixed on the circular bottom plate 12 a provided with the second hole 22 so as to close the second hole 22. The ventilation filter 24 is disposed on the second hole 22 side with respect to the one-way valve 23.

The outer peripheral surface of the housing 10 is a substantially cylindrical surface. However, a large-diameter portion 15 having a relatively large outer diameter is provided on the first hole 21 side. As a result, a step due to the difference between the outer diameters is formed between the large-diameter portion 15 and the portion above the large-diameter portion 15 (on the second hole 22 side).

2A and 2B, the cap 1 further includes a seal member 25 that is a substantially cylindrical protrusion. The sealing material 25 is provided on a belt 26 extending from the outer peripheral edge on the upper side of the housing 10. Although not shown, the belt 26 can be bent and the sealing material 25 can be fitted into the second hole 22. The second hole 22 is hermetically sealed by the sealing material 25.

As shown in FIGS. 1B and 2B, in this embodiment, the housing 10 includes a first part 11 provided with the first hole 21, and a second part provided with the second hole 22 and the sealing material 25. It consists of two parts, the part 12. The upper part of the first part 11 is fitted into the second part 12, and the first part 11 and the second part 12 are engaged. The outer peripheral edge of the one-way valve 23 and the outer peripheral edge of the ventilation filter 24 are sandwiched between the upper end of the first component 11 and the bottom plate 12 a of the second component 12. As a result, the one-way valve 23 and the ventilation filter 24 are firmly fixed in the housing 10. Since the one-way valve 23 and the ventilation filter 24 are sandwiched and fixed between the first component 11 and the second component 12 in the vertical direction, they flow through the second hole 22 to the lumen 10a. The one-way valve 23 and the ventilation filter 24 can be stably held at predetermined positions against an air flow and a positive pressure that may be applied to the inner cavity 10a from the first hole 21 side.

The fixing method of the one-way valve 23 and the ventilation filter 24 is not limited to the above. For example, an adhesive method using an adhesive or a heat seal method can be used in place of or in combination with the method of sandwiching and fixing the first component 11 and the second component 12 together.

The material of the housing 10 is not limited, but is preferably a hard material. For example, polypropylene (PP), polyacetal (POM), polycarbonate (PC), acrylonitrile butadiene styrene copolymer (ABS), polyamide, hard polyvinyl chloride, Resin materials such as polyethylene, polyethylene terephthalate, and polybutylene terephthalate can be used. The housing 10 may have transparency so that the inside of the lumen 10a can be seen through the housing 10.

The material of the first part 11 and the second part 12 may be the same or different. Considering that the second component 12 includes a bendable belt 26, a polyolefin-based resin such as polyethylene or polypropylene can be used. Each of the first and

second parts

11 and 12 is preferably manufactured integrally as one part by injection molding the above resin material.

In the present embodiment, the first component 11 has a double tube structure including an inner tube defining the lumen 10a and an outer tube provided with a large diameter portion 15, but the present invention is not limited to this. However, it may be a simple single tube structure. The division position of the first component 11 and the second component 12 is not limited to this embodiment. The number of parts constituting the housing 10 is not limited to two, and may be one or three or more. When the housing 10 is composed of a plurality of components, the plurality of components are connected in a liquid-tight and air-tight manner so that a sealed lumen 10 a is formed except for the first and

second holes

21 and 22.

2. How to Use Air Suction Cap The cap 1 can be used to allow air to flow into the flow path of the male member. Below, the usage method of the cap 1 is demonstrated to the case where the chemical | medical solution in a vial bottle is transferred to a chemical | medical solution bag by a negative pressure adjustment method.

FIG. 3 is a front view showing a state immediately before the male connector 830 attached to the syringe 800 is connected to an adapter 910 attached to the vial 900 (hereinafter referred to as “first adapter”).

The syringe 800 is provided with an outer cylinder 801 having a hollow cylindrical shape and a plunger 805 inserted into the outer cylinder 801 so as to be insertable / removable, like a general syringe. A male connector 830 as a closed system device is attached to the tip of the outer cylinder 801.

4A is a perspective view of the male connector 830, and FIG. 4B is a cross-sectional view thereof. 4A and 4B also show the distal end portion of the outer cylinder 801 of the syringe 800 to which the male connector 830 is attached.

4B, the male connector 830 includes a connector main body 840, a cover 860, and a fixing member 835.

The connector body 840 has substantially the same configuration as the male connector described in Patent Document 2, and includes a rod-shaped male luer 841 as a male member. A flow path 842 is formed in the male luer 841 along the longitudinal direction thereof. In the vicinity of the tip of the male luer 841, the horizontal hole 843 penetrates the male luer 841 in the radial direction. The lateral hole 843 communicates with the flow path 842.

A circular substrate 849 protrudes outward from the base end of the male luer 841 in a flange shape. A hood 847 is provided on the outer peripheral edge of the substrate 949. The hood 847 has a hollow cylindrical shape that is coaxial with the male luer 841 and surrounds the male luer 841. The inner diameter of the inner peripheral surface of the hood 847 (the surface facing the male luer 841) is substantially the same as or slightly larger than the outer diameter of the large diameter portion 15 (see FIG. 1A) of the cap 1.

As shown in FIG. 4A, the hood 847 is provided with a notch (opening) 848. The notch 848 is a hole that penetrates the hood 847 in the radial direction. A lock lever 850 is provided in the notch 848. The lock lever 850 faces the male luer 841 and extends substantially parallel to the male luer 841. The lock lever 850 is cantilevered by the substrate 849. A lock claw 851 protrudes from the tip (free end) of the lock lever 850 toward the male luer 841 (see FIG. 4B). An operation arm 855 is provided on the surface of the lock lever 850 opposite to the male luer 841. The operation arm 855 extends upward (on the cylindrical portion 845 side) beyond the substrate 849. The distal end of the operation arm 855 is an operation unit 856. When the operation unit 856 is pushed inward in the radial direction, the lock lever 850 is elastically bent and deformed so that the lock claw 851 is separated from the male luer 841.

A cylindrical portion 845 is provided on the opposite side of the substrate 849 from the male luer 841. A screw-shaped protrusion (male screw) 846 is provided on the outer peripheral surface of the cylindrical portion 845. As shown in FIG. 4B, the cylindrical portion 845 has a hollow, generally cylindrical shape, and an inner peripheral surface 845a thereof is a tapered surface (so-called “so-called”) whose inner diameter increases toward the tip of the cylindrical portion 845. Female taper surface). The tubular portion 845 communicates with the flow path 842 of the male luer 841.

The cover 860 is substantially the same as the cover described in Patent Document 3, and as shown in FIG. 4B, an outer peripheral wall 861 having a substantially cylindrical shape, and a head 865 provided at one end of the outer peripheral wall 861. And a base 869 provided at the other end of the outer peripheral wall 861 so as to protrude outward. The cover 860 is integrally formed of a material having flexibility (rubber elasticity) (for example, a rubber material such as isoprene rubber, silicone rubber, butyl rubber, or a thermoplastic elastomer). When a compressive force in the vertical direction (longitudinal direction of the male luer 841) is applied to the cover 860, the outer peripheral wall 861 is elastically compressed and deformed so that its vertical dimension is shortened.

A cavity 866 that communicates with the internal space of the outer peripheral wall 861 is formed in the head 865. The front end of the male luer 841 is inserted into the cavity 866. The inner peripheral surface of the cavity 866 is in close contact with the outer peripheral surface of the male luer 841, and the lateral hole 843 provided in the male luer 841 is sealed in a liquid-tight and air-tight manner. A slit 867 that penetrates the head 865 in the vertical direction is formed at the deepest portion of the cavity 866. As shown in FIG. 4A, the slit 867 is a straight cut having a “−” (minus) shape in plan view. In an initial state in which the outer peripheral wall 861 is not compressed and deformed, opposing edges that form the slit 867 are in contact so that the slit 867 is sealed in a liquid-tight and air-tight manner.

A convex portion 868 protruding in a dome shape is provided at the tip of the outer surface of the head 865. The slit 867 is provided so as to cross the most protruding portion (top) of the convex portion 868.

The fixing member 835 is a circular annular member. The fixing member 835 is used for fixing the cover 860 to the connector main body 840. That is, as shown in FIG. 4B, the cover 860 is inserted into the hood 847 of the connector main body 840 so as to cover the male luer 841. Next, the fixing member 835 is inserted into the hood 847. The cover 860 is inserted into the fixing member 835. A plurality of protrusions (not shown) protrude toward the male luer 841 at a position near the substrate 849 on the inner peripheral surface of the hood 847. The fixing member 835 is engaged with this protrusion. The base 869 of the cover 860 is sandwiched between the fixing member 835 and the substrate 849.

As shown in FIGS. 4A and 4B, a hollow inner tube 811 and an outer tube 813 surrounding the inner tube 811 are provided coaxially at the distal end of the outer cylinder 801 of the syringe 800. The outer peripheral surface 811a of the inner tube 811 is a tapered surface (so-called male tapered surface) whose outer diameter decreases as it approaches the tip. A flow path 812 that penetrates the male member 921 along the longitudinal direction is formed in the inner tube 811. The channel 812 communicates with the inner cavity 802 of the outer cylinder 801 into which the plunger 805 is inserted and removed. A female screw 814 is formed on the inner peripheral surface of the outer tube 813 facing the inner tube 811.

The male connector 830 is attached to the tip of the syringe 800 by inserting the inner tube 811 of the outer cylinder 801 into the cylindrical portion 845 of the connector main body 840 and screwing the screw-shaped protrusion 846 and the female screw 814. (See FIG. 3). Since the inner peripheral surface 845a of the cylindrical portion 845 and the outer peripheral surface 811a of the inner tube 811 are tapered surfaces having the same diameter and taper angle, they form a liquid-tight and air-tight seal and are in surface contact. . The screw-shaped protrusion 846 and the female screw 814 that are screwed together function as a lock mechanism for maintaining the connection state between the male connector 830 and the outer cylinder 801. The male connector 830 can be attached to and detached from the syringe 800 repeatedly.

3, the first adapter 910 is attached to the vial bottle 900. The 900 vials and the first adapter 910 will be described.

FIG. 5 is a perspective view showing the first adapter 910 immediately before being attached to the vial 900.

The vial bottle 900 includes a bottle body 901 and a rubber stopper 906. The bottle body 901 is made of a hard material that does not substantially deform such as glass. The upper end of the bottle body 901 is provided with a mouth (not shown) that opens upward. A rubber stopper 906 is inserted into the mouth of the bottle body 901. A chemical (not shown) is accommodated in the bottle body 901. The rubber stopper 906 seals the mouth of the bottle body 901 in an airtight and liquid tight manner.

A flange with an enlarged diameter (not visible because it is covered with a cap 908 in FIG. 5) is provided at the upper end of the outer peripheral surface of the bottle body 901 so as to surround the mouth. In order to prevent the rubber stopper 906 from dropping from the mouth of the bottle body 901, a cap 908 covers the rubber stopper 906 and the flange. The cap 908 is made of a sheet of metal (for example, aluminum) or resin. The cap 908 extends to the upper surface of the rubber plug 906. A central region of the upper surface of the rubber plug 906 is exposed to the outside through a circular opening 908 a provided in the cap 908.

The portion of the vial 900 to which the cap 908 is attached constitutes an enlarged diameter portion 902 having a larger outer diameter than the portion (constriction portion) 904 immediately below it. A step is formed between the enlarged diameter portion 902 and the constricted portion 904 based on the difference in outer diameter between the two.

Note that the vial 900 may not include the cap 908. In that case, the enlarged diameter portion 902 is configured by an enlarged flange provided at the upper end of the bottle body 901.

The first adapter 910 includes a puncture needle 911 having a sharp tip at one end and a port 920 at the other end. An opening 912 is provided on the outer peripheral surface of the puncture needle 911. In the puncture needle 911, a flow path (not shown) is provided along the longitudinal direction thereof. The opening 912 and the port 920 communicate with each other through a flow path in the puncture needle 911.

The port 920 is a female connector provided with a self-closing valve body 921. The valve body 921 is a circular thin plate made of a soft material having rubber elasticity (for example, a rubber material such as isoprene rubber, silicone rubber, butyl rubber, or a thermoplastic elastomer). A slit 922 is formed through the substrate in the thickness direction. The valve body 921 is covered with a seal crown 923. A circular opening (through hole) 923a is provided at the center of the top plate of the seal crown 923, and a central region of the valve body 921 including the slit 922 is exposed to the outside through the opening 923a. When a cylindrical male luer that does not have a sharp tip (for example, male luer 841 of the male connector 830) is pushed into the slit 922 of the valve body 921, the male luer can deform the valve body 921 and penetrate the slit 922. . Thereby, the port 920 communicates with the male lure. Thereafter, when the male luer is pulled out from the valve body 921, the valve body 921 immediately returns to its initial state and the slit 922 is closed. When the male luer does not penetrate the slit 922, the slit 922 is closed in a liquid-tight and air-tight manner. The male lure can be inserted into and removed from the valve body 921 repeatedly. Such a female connector having resealability is also called a “septum” and is generally known (see, for example, Patent Documents 4 and 5).

Two arms 930 extend from a portion of the first adapter 910 between the puncture needle 911 and the port 920. The arm 930 extends along a radial direction (a direction orthogonal to the central axis of the first adapter 910 that passes through the puncture needle 911 and the port 920), and is subsequently bent toward the puncture needle 911. A claw 931 protruding toward the puncture needle 911 is provided at the tip of the arm 930. The arm 930 can be elastically deformed so that the claw 931 is separated from the puncture needle 911.

From the state of FIG. 5, the first adapter 910 is pushed toward the vial 900. The puncture needle 911 is pierced into the rubber stopper 906 exposed in the opening 908a of the cap 908 of the vial 900. The claw 931 engages with the enlarged diameter portion 902 of the vial 900. As shown in FIG. 3, the first adapter 910 is attached to the vial 900. An opening 912 (see FIG. 5) provided in the puncture needle 911 is located below the rubber stopper 906. Accordingly, the vial 900 and the port 920 communicate with each other. As described above, since the slit 922 of the valve body 921 of the port 920 is closed, the chemical solution in the vial 900 does not leak from the slit 922 to the outside.

First, the plunger 805 is pulled in a state where the male connector 830 is not attached to the syringe 800, and air of approximately the same amount as the amount of the chemical solution to be collected from the vial 900 is sucked into the syringe 800. Next, the male connector 830 is attached to the tip of the syringe 800.

Next, as shown in FIG. 3, the male connector 830 attached to the syringe 800 is opposed to the first adapter 910 attached to the vial 900. The port 920 of the first adapter 910 is inserted into the hood 847 of the male connector 830, and the first adapter 910 is further pushed into the male connector 830. The male luer 841 of the male connector 830 passes through the slit 867 provided in the head 865 of the cover 860 (see FIG. 4B), and further passes through the slit 922 of the valve body 921 of the first adapter 910 (see FIG. 5). . A cover 860 (see FIGS. 4A and 4B) provided on the male connector 830 is compressed and deformed in the longitudinal direction of the male luer 841. Thus, the vial 900, the first adapter 910, the male connector 830, and the syringe 800 are communicated in order. The lock claw 851 (see FIG. 4B) of the male connector 830 engages with the lower end 928 (see FIG. 5) of the outer peripheral surface of the port 920.

Next, as shown in FIG. 6, the vial 900 is lifted upward with respect to the syringe 800. Then, the plunger 805 is pulled to suck the drug solution in the vial 900 into the syringe 800. Usually, the horizontal hole 843 (see FIG. 5) provided in the male luer 841 is located in the vicinity of the rubber stopper 906. Therefore, when the vial 900 is turned upside down as shown in FIG. Easy to suck. When the chemical solution flows out of the vial 900, the inside of the vial 900 is slightly negative pressure. Thereafter, the plunger 805 is released. The plunger 805 is drawn into the outer cylinder 801 of the syringe 800 by the negative pressure in the vial 900, and at the same time, the air in the syringe 800 moves to the vial 900. The inside of the vial 900 returns to normal pressure. Thus, a part of the chemical solution in the vial 900 moves into the syringe 800, and instead, the air in the syringe 800 moves into the vial 900. This operation is repeated several times as necessary to move a predetermined amount (or total amount) of the chemical solution from the vial 900 to the syringe 800.

Thereafter, the male connector 830 is separated from the first adapter 910. That is, the operating portion 856 of the male connector 830 is pushed to cause the lock lever 850 (see FIGS. 4A and 4B) to bend and deform to release the engagement between the lock claw 851 and the port 920. In this state, the male connector 830 and the first adapter 910 are pulled away from each other. When the male connector 830 is separated from the first adapter 910, the cover 860 (see FIGS. 4A and 4B) of the male connector 830 immediately returns to its initial state, and the slit 867 is closed. The cover 860 (particularly its head 865) seals the lateral hole 843 of the male luer 841 in a liquid-tight and air-tight manner. For this reason, even if an external force that pushes the plunger 805 into the outer cylinder 801 is accidentally applied to the syringe 800, the chemical solution and the vapor in the syringe 800 do not leak to the outside. Further, the slit 922 (see FIG. 5) of the valve body 921 of the first adapter 910 is also closed.

Next, the chemical solution in the syringe 800 is transferred to the chemical solution bag. FIG. 7 is a perspective view of the chemical solution bag 950. The chemical solution bag 950 is a bag-like product formed by bonding two flexible sheets at the outer peripheral edge portion. The chemical solution bag 950 includes a port 951 for taking in and out a liquid such as a chemical solution with respect to the chemical solution bag 950. The opening of the port 951 is sealed with a rubber stopper (not visible in FIG. 7). In the drug solution bag 950, a liquid (infusion solution) to be administered to the patient together with the drug solution may be stored in advance.

An adapter (hereinafter referred to as “second adapter”) 960 is attached to the port 951.

The second adapter 960 has substantially the same configuration as the adapter described in Patent Document 6, includes a puncture needle (not visible in FIG. 7) having a sharp tip at one end, and a port 970 at the other end. The puncture needle is punctured by a rubber stopper of the port 951. The second adapter 960 further includes four arms 980 having a substantially “U” shape extending from a portion between the puncture needle and the port 970. Each arm is provided with a claw 981 protruding toward the puncture needle. The claw 981 is engaged with the port 951. The second adapter 960 has substantially the same configuration as the first adapter 910 (see FIG. 5) except for the arm 980 and the claw 981. The port 970 is a female connector including a self-closing valve body 971, similar to the port 920 of the first adapter 910. In the center of the valve body 971, a slit that penetrates the valve body 971 in the thickness direction is formed.

As shown in FIG. 8, the male connector 830 attached to the syringe 800 is connected to the second adapter 960 attached to the chemical solution bag 950. The connection between the second adapter 960 and the male connector 830 can be performed in the same manner as the connection between the first adapter 910 and the male connector 830 (see FIG. 3). The chemical solution bag 950, the second adapter 960, the male connector 830, and the syringe 800 are communicated in this order. The lock claw 851 (see FIG. 4B) of the male connector 830 engages with the port 970. In this state, the plunger 805 is pushed into the outer cylinder 801 and the chemical solution in the syringe 800 is injected into the chemical solution bag 950. In order to transfer all the chemical solution in the syringe 800 into the chemical solution bag 950, the plunger 805 is pushed into the outer cylinder 801 to the deepest.

Thereafter, the male connector 830 is separated from the second adapter 960. The separation between the male connector 830 and the second adapter 960 is the same as the separation between the male connector 830 and the first adapter 910 (see FIG. 6). When the male connector 830 is separated from the second adapter 960, the cover 860 of the male connector 830 (see FIGS. 4A and 4B) immediately returns to its initial state, and the slit 867 is closed. The lateral hole 843 of the male luer 841 is sealed in a liquid-tight and air-tight manner by a cover 860 (particularly, its head 865).

Next, the cap 1 is attached to the male connector 830 attached to the syringe 800. That is, as shown in FIG. 9, the end surface of the cap 1 on the first hole 21 (see FIG. 1A) side is opposed to the male connector 830. Then, the large diameter portion 15 of the cap 1 is inserted into the hood 847 of the male connector 830. The second hole 22 (see FIG. 2A) of the cap 1 is not closed by the sealing material 25 and is open. The plunger 805 of the syringe 800 is pushed deepest into the outer cylinder 801.

FIG. 10 is a cross-sectional view of the cap 1 attached to the male connector 830. The lock claw 851 of the male connector 830 is engaged with the large diameter portion 15 of the cap 1. Unless the engagement between the lock claw 851 and the large diameter portion 15 is released, the cap 1 cannot be separated from the male connector 830 even if a tensile force is applied to the cap 1.

When the rib 21a of the cap 1 comes into contact with the convex portion 868 at the tip of the cover 860, the cover 860 receives a compressive force in the vertical direction, and in particular, the outer peripheral wall 861 is deformed to reduce the vertical dimension. The male luer 841 passes through a slit 867 (see FIG. 4A) provided in the head 865 of the cover 860 and is inserted into the first hole 21 of the cap 1. A lateral hole 843 provided in the male luer 841 is exposed in the lumen 10 a of the cap 1. For this reason, the flow path 842 of the male luer 841 communicates with the lumen 10a of the cap 1.

The convex portion 868 of the cover 860 is pressed against the tip of the annular rib 21a of the cap 1 by the elastic force that the compressed cover 860 tries to return to the initial state, and liquid-tight and air-tight between the cover 860 and the rib 21a. A good seal is formed. As in the present embodiment, bringing the cover 860 into contact with the tip of the rib 21a having a very narrow area is advantageous in improving the liquid tightness and air tightness of the seal formed therebetween.

In the state shown in FIG. 10, the plunger 805 of the syringe 800 is pulled. The outside air passes through the second hole 22, the ventilation filter 24, the one-way valve 23, the lumen 10 a, the lateral hole 843, the flow path 842, and the cylindrical portion 845 in order and flows into the outer cylinder 801. Air of approximately the same amount as the amount of the chemical solution to be collected in the syringe 800 from the next new vial is sucked into the syringe 800.

When the outside air passes through the ventilation filter 24, the ventilation filter 24 captures foreign matters (for example, solid matter such as dust and bacteria) contained in the air. For this reason, the foreign material which flows in into the syringe 800 is reduced. Therefore, after that, the possibility that foreign substances are mixed into the chemical solution collected in the syringe 800 from the next new vial is reduced.

A liquid-tight and air-tight seal is formed between the rib 21a of the cap 1 and the convex portion 868 of the cover 860. A one-way valve 23 is provided between the first hole 21 (or male luer 841) and the second hole 22. For this reason, even if an external force that pushes the plunger 805 into the outer cylinder 801 is accidentally applied to the syringe 800 after the air is sucked into the syringe 800, the air in the syringe 800 does not leak to the outside. . In the syringe 800, there may be a slight remaining of the chemical liquid sucked from the vial 800. When the air once sucked into the syringe 800 leaks to the outside, the chemical liquid and the vapor thereof leak to the outside together with the air, and the worker may be exposed to the medicine. The cap 1 is advantageous in improving safety because it reduces such a possibility.

Next, the cap 1 is separated from the male connector 830. The cap 1 can be separated by pushing the operating portion 856 of the male connector 830 toward the cylindrical portion 845 to release the engagement between the lock claw 851 and the large diameter portion 15.

When the cap 1 comes out of the hood 847, the outer peripheral wall 861 of the cover 860 immediately expands to the initial state (see FIG. 4B) due to its elastic recovery force. The male luer 841 is housed in the cover 860, and the lateral hole 843 of the male luer 841 is liquid-tightly sealed on the inner peripheral surface of the cavity 866 of the head 865. For this reason, even if an external force that pushes the plunger 805 into the outer cylinder 801 is accidentally applied to the syringe 800, the air in the syringe 800 does not leak to the outside. Therefore, the possibility that the chemical liquid that may remain in the syringe 800 and its vapor leak to the outside world and the operator is exposed to the chemical is reduced.

使用 Used cap 1 is discarded. If the second hole 22 is discarded in a state where it is sealed with the sealing material 25, the possibility that a chemical solution or its vapor that may exist in the lumen 10a leaks out of the cap 1 is reduced. Preferably, the second hole 22 is sealed with a sealing material 25 before the cap 1 is separated from the male connector 830.

Using the syringe 800 that has sucked in a predetermined amount of air, the negative pressure adjustment method (see FIGS. 3 to 10) is performed on the next new vial as described above, and the drug solution is transferred from the vial to the drug solution bag 950. can do. When it is necessary to transfer the chemicals in the plurality of vials to the chemical solution bag 950, the same operation is performed on each vial using the same syringe 800.

3. Operation As described above, when a chemical solution contains a dangerous drug, a closed system device is often used to prevent the chemical solution and its vapor from leaking to the outside. As a closed system device, like the male connector 830, the flow path of the male member is not connected to the mating connector (the port 920 of the first adapter 910 and the port 970 of the second adapter 960 in the above embodiment). There is a closed system connector configured to seal the opening. In a state where such a closed system connector (male connector 830) is attached to the syringe 800, an operation of sucking outside air into the syringe 800, which is essential in the negative pressure adjustment method, cannot be performed.

According to the present invention, air can be sucked into the syringe 800 simply by attaching the cap 1 to the male connector 830. For this reason, the chemical | medical solution in a several vial bottle can be transferred to a chemical | medical solution bag by the negative pressure adjustment method using the same syringe 800. FIG.

Only by using the cap 1 having a simple configuration without changing the configuration of the closed system devices (the male connector 830, the first adapter 91, and the second adapter 960) that are generally used conventionally. The drug solution in the vial can be transferred to the drug solution bag in substantially the same procedure as the negative pressure adjustment method performed from the above.

Since the cap 1 includes the one-way valve 23, even if the plunger 805 is accidentally pushed, the chemical liquid and the vapor thereof do not leak to the outside through the second hole 22 of the cap 1. Therefore, the possibility that the operator will be exposed to the drug is not increased by attaching the cap 1 to the male connector 830.

The first hole 21 is an open hole that is always open so that it can be connected to the male luer 841. Thereby, the structure of the cap 1 provided with the 1st hole 21 becomes easy, the number of parts which comprise the cap 1 can be decreased, and also manufacture of the cap 1 becomes easy. Further, the reliability of connection between the first hole 21 and the male luer 841 is improved.

4). Various modifications The above embodiment is merely an example. The present invention is not limited to the above embodiment, and can be modified as appropriate.

The positions of the one-way valve 23 and the ventilation filter 24 are not limited to the above-described embodiment, and the one-way valve 23 and the ventilation filter 24 are arranged at arbitrary positions on the path leading from the outside to the first hole 21 through the second hole 22 and the lumen 10a. Can do. For example, the one-way valve 23 and / or the ventilation filter 24 may be disposed at a position near the first hole 21 in the lumen 10a, may be disposed in the second hole 22, or may be second. You may arrange | position to the edge 22a (refer FIG. 2B) exposed to the external field of the hole 22. FIG. The one-way valve 23 and / or the ventilation filter 24 may be disposed in the first hole 21 as long as the male member connected to the first hole 21 is not buffered. The ventilation filter 24 may be disposed on the first hole 21 side with respect to the one-way valve 23.

In the present invention, the ventilation filter 24 may be omitted.

The configuration of the housing 10 is not limited to the above embodiment. For example, it is not essential that the inner diameters of the first hole 21 and the second hole 22 are smaller than the inner diameter of the lumen 10a. The inner diameter of the second hole 22 may be the same as or larger than the inner diameter of the lumen 10a. The first hole 21, the lumen 10a, and the second hole 22 may have the same inner diameter. The first hole 21, the lumen 10a, and the second hole 22 do not need to be arranged coaxially, and any of these may be eccentric with respect to the other. The path leading from the second hole 22 through the lumen 10a to the first hole 21 does not have to be along a straight line, and may be curved or bent.

The configuration of the sealing material 25 is not limited to the above embodiment. The sealing material 25 should just be comprised so that the 2nd hole 22 can be plugged up. Therefore, it is not essential that the sealing material 25 is fitted into the second hole 22 as in the above embodiment. In particular, depending on the positions of the one-way valve 23 and the ventilation filter 24 (for example, when the ventilation filter 24 is provided on the edge 22a of the second hole 22 as described above), the configuration of the sealing material is changed accordingly. May need to be done. For example, the sealing material can cover and fit the cylindrical member 22b (see FIG. 2B) surrounding the second hole 22 and projecting to the outside, or the end of the housing 10 on the second hole 22 side. You may be comprised so that the whole part may be covered and can be fitted to this. Alternatively, the sealing material may be configured to open and close the second hole 22 by sliding in a direction orthogonal to the central axis of the second hole 22. Alternatively, a pressure-sensitive adhesive layer may be provided on the surface of the sealing material, and the sealing material may be attached to the housing 10 via the pressure-sensitive adhesive layer so as to close the second hole 22. The sealing material and the housing 10 need not be connected by the belt 26. The sealing material may be a separate part separated from the housing 10.

The sealing material 25 may be configured to repeatedly open and close the second hole 22, but once the second hole 22 is closed with the sealing material, the second hole 22 cannot be opened again. Moreover, the sealing material may be configured to irreversibly block the second hole 22. This is advantageous in reducing the possibility of accidentally reusing the used cap 1.

In the present invention, the sealing material 25 may be omitted.

The rib 21a protruding from the edge of the first hole 21 may be omitted. Even when the rib 21a is omitted, when the cap 1 is attached to the male connector 830, the convex portion 868 of the cover 860 is brought into contact with the peripheral portion of the first hole 21 of the housing 10 to provide a liquid-tight seal therebetween. It is possible to form.

In the present invention, when the cap 1 is attached to the male connector 830, the first hole 21 and the male luer 841 are connected such that the lumen 10a of the housing 10 and the flow path 842 of the male luer 841 are communicated. At this time, a liquid-tight and air-tight seal is preferably formed between the cap 1 and the male connector 830. The configuration for realizing this is not limited to the above embodiment, and various configurations are conceivable.

For example, when the male luer 841 is inserted into the first hole 21 (see FIG. 10), the outer peripheral surface of the male luer 841 and the inner peripheral surface of the first hole 21 are fitted to each other. An airtight seal may be formed.

Alternatively, the flow channel 842 of the male luer 841 may penetrate the male luer 841 along the longitudinal direction of the male luer 841. That is, the horizontal hole 843 may be omitted, and the flow path 842 may be opened at the tip of the male luer 841 instead. In this case, when the cap 1 is attached to the male connector 830, the male luer 841 is not inserted into the first hole 21, and the tip of the male luer 841 is abutted against the peripheral portion of the first hole 21. And an airtight seal may be formed.

As described above, when a seal is formed between the male luer 841 and the inner peripheral surface of the first hole 21 or the peripheral portion thereof, between the convex portion 868 of the cover 860 and the peripheral portion of the first hole 21. The liquid-tight and air-tight seals as in the above embodiment may not be formed.

The configuration of the engagement structure with which the lock claw 851 of the male connector 830 can be engaged is not limited to the large diameter portion 15. For example, the engagement structure may be a recess (for example, an annular groove continuous in the circumferential direction) provided on the outer peripheral surface of the housing 10. In this case, the cap 1 is engaged with the lock claw 851 by fitting the lock claw 851 into the recess. In the present invention, the engagement structure with which the lock claw 851 can be engaged may be omitted.

In the above embodiment, the first hole 21 is an open hole that is always open. However, in the present invention, the first hole is configured to be automatically and immediately closed when the male member is separated from the first hole. It may be. FIG. 11A is a perspective view of the air suction cap 2 according to another embodiment of the present invention configured as described above, as viewed from below, and FIG. 11B is a cross-sectional perspective view of the cap 2 as viewed from below. The cap 2 includes a female connector 220 having a self-closing valve body 222 configured at the lower end thereof in the same manner as the port 920 (see FIG. 5) and the port 970 (see FIG. 7). The valve body 222 is a circular thin plate made of a soft material having rubber elasticity (for example, a rubber material such as isoprene rubber, silicone rubber, butyl rubber, or a thermoplastic elastomer). A slit 221 that penetrates the valve body 222 in the thickness direction is formed at the center of the valve body 222. An opening of the substantially cylindrical first part 11 facing downward is closed by a valve body 222, and a seal crown 223 is covered on the valve body 222. The seal crown 223 includes a circular top plate 224 and a cylindrical peripheral wall 225 extending from the outer peripheral edge of the top plate 224. A circular opening (through hole) 223a is provided at the center of the top plate 224, and a central region of the valve body 222 including the slit 221 is exposed to the outside through the opening 223a. A hole 226 that penetrates the peripheral wall 225 in the radial direction is formed in the peripheral wall 225. The seal crown 223 is fixed to the first component 11 by fitting the claw 216 protruding from the outer peripheral surface of the first component 11 into the hole 226. An annular protrusion 215 that is continuous in the circumferential direction protrudes from the outer peripheral surface of the first component 11. The outer peripheral surface of the annular protrusion 215 and the peripheral wall 225 of the seal crown 223 continuously form a common cylindrical surface. The material of the seal crown 223 is not limited, but the hard resin material described above can be used as the material of the outer cylinder 10.

As in the case of the port 920 (see FIG. 5) and the port 970 (see FIG. 7), the female connector 220 can be attached to and detached from the male connector 830. The male luer 841 deforms the valve body 222 and penetrates the slit 221. Thereby, the male luer 841 and the lumen 10a of the cap 2 communicate with each other. Thereafter, when the male luer 841 is pulled out from the valve body 222, the valve body 222 immediately returns to its initial state and the slit 221 is closed. When the male luer 841 does not penetrate the slit 221, the slit 221 is closed in a liquid-tight and air-tight manner. The male luer 841 can be inserted into and removed from the valve body 222 repeatedly. The female connector 220 is a closed system device called a “septum” (see, for example, Patent Documents 4 and 5). The lock claw 851 of the male connector 830 engages with the annular protrusion 215.

The slit 221 of the valve body 222 functions as the first hole of the present invention. The first hole (slit) 221 of the cap 2 is configured such that when the male luer 841 (male member) is inserted into the first hole 221, the flow path 842 of the male luer 841 and the lumen 10a communicate with each other. . For this reason, similarly to the case where the cap 1 is attached to the male connector 830 (see FIG. 10), when the cap 2 is attached to the male connector 830, air can be sucked into the syringe 800 via the cap 2. Therefore, using the same syringe 800, the chemical solution in the plurality of vials can be transferred to the chemical solution bag by the negative pressure adjustment method.

Unlike the first hole 21 of the cap 1, when the cap 2 is separated from the male connector 830, the first hole 221 is immediately sealed in a liquid-tight and air-tight manner. For this reason, after the male connector 830 is separated, there is a low possibility that a chemical solution or its vapor that may exist in the lumen 10 a leaks out of the cap 2 through the first hole 221. Cap 2 is the same as Cap 1 when the same cap 2 is used to sequentially transfer the chemicals in a plurality of vials to the chemical solution bag 950 by the negative pressure adjustment method, or when the used cap 2 is discarded. This is advantageous in further reducing the possibility that dangerous chemicals and vapors that may remain in the lumen 10a leak to the outside and the worker is exposed to the chemicals.

Although not shown, when the cap 2 is attached to the male connector 830, the cover 860 of the male connector 830 is compressed and deformed in the longitudinal direction of the male luer 841. Due to the elastic restoring force of the compressed cover 860, the convex portion 868 (see FIG. 4A) at the tip of the cover 860 is pressed against the top plate 224 or the valve body 222 of the seal crown 223, and between the cover 860 and the female connector 220. A liquid tight and air tight seal is formed. In addition, the edge of the slit 221 is in close contact with the outer peripheral surface of the male luer 841 inserted in the slit 221, and a liquid-tight and air-tight seal is formed between them. For this reason, after the air is sucked into the syringe 800, if an external force that pushes the plunger 805 into the outer cylinder 801 is accidentally applied to the syringe 800, the air in the syringe 800 may leak to the outside. The cap 2 can be reduced to be equal to or less than that when the cap 1 is used. Therefore, the cap 2 is advantageous in reducing the possibility that a dangerous chemical solution or its vapor that may remain in the syringe 800 leaks to the outside due to the above-described erroneous operation and the worker is exposed to the drug.

11A and 11B, the self-closing valve body includes the slit 221 that opens and closes in response to insertion and removal of the male member (male luer 841), but the configuration of the self-closing valve body is not limited thereto. The cap of the present invention may include an arbitrary valve body configured such that the first hole opens and closes in conjunction with connection / separation between the first hole and the male member. The slit 221 may not be formed in the valve body. For example, the opening edge of the first hole is not substantially deformed, and the first hole opens and closes by moving the valve body in the first hole in conjunction with the insertion and removal of the male member with respect to the first hole. It may be configured. Any closed female connector configuration configured to prevent fluid leakage from the female connector when the male connector is not connected can be applied to the first hole of the cap of the present invention.

The cap 2 is the same as the cap 1 except for the above. The description regarding the cap 1 can be applied to the cap 2 as appropriate.

The connector to which the cap of the present invention is attached is not limited to the male connector 830 of the above embodiment.

For example, as described in Patent Documents 7 to 9, the connector may have two lock levers, and each lock lever may have a lock claw that engages with the cap of the present invention.

The male member connected to the first hole of the cap of the present invention may be a puncture needle (also called a bottle needle) having a sharp tip so that the rubber stopper 906 of the vial 900 can be punctured.

Furthermore, the cap of the present invention can be used in scenes other than the negative pressure adjustment method. For example, the cap of the present invention can be used for a connector connected between a vial and a drug solution bag as described in Patent Documents 8 to 10. This connector includes a resin puncture needle having a sharp tip, which is punctured into a rubber stopper of a vial. The puncture needle is provided with a liquid flow path through which liquid flows and a gas flow path through which air flows. In order to prevent the drug solution from leaking from the opening of the liquid channel, a cover that covers the tip of the puncture needle may be provided (see, for example, Patent Document 1). Operate the cock provided in the connector to switch the flow path in the connector and change the vertical position of the vial and the chemical solution bag while transferring the liquid between the vial and the chemical solution bag to prepare the chemical solution do. If the operation is wrong, the liquid may block the flow path and the chemical preparation process may not be continued. In such a case, the liquid preparation operation can be resumed by connecting the first hole of the cap of the present invention to the puncture needle and introducing external air into the flow path through the cap.

The present invention can be preferably used in the medical field, and further in the case of preparing a drug solution (or infusion) to be administered to a patient by infusion therapy. In particular, it can be preferably used when preparing a drug solution containing a dangerous drug such as an anticancer drug that may cause an exposure accident. The cap of the present invention can be attached to a connector having a male member. Preferably, the connector is a closed system connector provided with a cover for closing the opening of the flow path of the male member.

1, 2 Air suction cap 10 Housing 10a Housing bore 15 Large diameter portion (engagement structure)
21 1st hole 21a Rib 22 2nd hole 23 One way valve 24 Ventilation filter 25 Seal material 215 Annular projection (engagement structure)
221 Slit (first hole)
830 Male connector 841 Male luer (male member)
843 Horizontal hole (opening of male member)
851 Lock claw 860 Cover

Claims

A housing having a lumen;
A first hole connectable with a male member, the first hole configured to communicate with the male member when the male member is connected to the first hole;
A second hole configured to allow the lumen and the outside to communicate with each other;
A one-way valve provided on a path leading from the outside to the first hole through the second hole and the lumen;
The one-way valve is configured to allow fluid to flow from the outside toward the first hole along the path, and to prevent fluid from flowing in the opposite direction. Cap for air suction.
The male connector including the male member includes a cover that prevents fluid from leaking from the opening of the male member when the male member is not connected to the first hole.
The cover is compressible and deformable along the longitudinal direction of the male member such that the opening is exposed outside the cover.
The air suction cap according to claim 1, wherein when the male member is connected to the first hole, the opening of the male member communicates with the lumen.
The air suction cap according to claim 2, wherein a seal is formed between an edge of the first hole and the cover when the first hole and the male member are connected.
An annular rib provided on the housing so as to surround the first hole;
The air suction cap according to claim 2 or 3, wherein a seal is formed between a tip of the rib and the cover when the first hole and the male member are connected.
The air suction cap according to any one of claims 1 to 4, further comprising an engagement structure capable of engaging a lock claw provided on the male connector including the male member.
The air suction cap according to any one of claims 1 to 5, further comprising a ventilation filter provided on the path.
The air suction cap according to any one of claims 1 to 6, wherein the first hole is configured to be immediately closed when the male member is separated from the first hole.
The air suction cap according to any one of claims 1 to 7, further comprising a sealing material for closing the second hole.