JP6732495B2 - Composition for suppressing sebum secretion - Google Patents

Description

The present invention relates to a composition for suppressing sebum secretion.

Sebum contains triglycerides, wax esters, squalene, free fatty acids and the like. Such sebum is secreted from the sebaceous glands, and has the effect of imparting flexibility and elasticity to the skin surface, keeping the skin moisturizing property, giving oil to the hair, and keeping the suppleness and beauty of the hair. In addition, sebum plays an important role in preventing damage to the skin surface due to ultraviolet rays and protecting the skin surface from foreign substances such as bacteria.

However, if excess sebum is present on the skin surface, it is generally referred to as oily skin and is in a state where gloss and makeup loss are likely to occur. In addition, excessive sebum secretion causes various skin troubles such as making the skin and hair lighter and facilitating the propagation of bacteria and the like. Well-known skin troubles include seborrheic dermatitis, which can cause increased dandruff on the scalp and hair loss. Therefore, it is important to suppress excessive sebum secretion.

On the other hand, butcher bloom is a known plant, and its extract is known to have a hyaluronic acid production promoting effect (Patent Document 1).

JP, 2007-262012, A

An object of the present invention is to provide a composition that can effectively suppress sebum secretion.

The inventors of the present invention have conducted extensive studies in view of the above problems and found that the use of the Butcher Bloom extract can suppress the secretion of sebum. The present invention has been completed as a result of further studies based on the findings, and is listed below.
Item 1. A composition for suppressing sebum secretion, comprising a butcher bloom extract.
Item 2. Item 2. The composition for suppressing sebum secretion according to Item 1, which contains the Butcher Bloom extract in an amount of 0.0001 to 20% by weight in terms of a dry matter of the extract.
Item 3. Item 3. The composition for suppressing sebum secretion according to Item 1 or 2, which is an external composition.

According to the present invention, secretion of sebum can be suppressed. Therefore, according to the present invention, skin symptoms associated with excessive secretion of sebum can be improved.

FIG. 1 shows the sebum secretion inhibitory effect of the butcher bloom extract. FIG. 2 shows the sebum secretion inhibitory effect of the butcher bloom extract. FIG. 3 shows the sebum secretion inhibitory effect of the butcher bloom extract.

The present invention provides a composition for suppressing sebum secretion, which comprises a butcher bloom extract.

The butcher bloom (Butcher's Broom), which is a raw material of the extract contained as an active ingredient in the composition of the present invention, includes genus Ruscus of the family Liliaceae, and specifically, Ruscus aculeatus L , Ruscus acleatus ver. Angustifolius Boss.), Ruscus hypoglossum L., Ruscus hypophyllum L., and the like. The use site is not particularly limited as long as it is a plant, but rhizome, leaf, flower, bud, fruit, branch, bark, seed, seed coat and the like are exemplified, and rhizome is more preferable. As the use site, one kind may be used alone, or two or more kinds may be used in combination.

In the extract, the production method (extraction method), extraction conditions, etc. are not particularly limited, and may be a conventionally known method. For example, an extract can be obtained by squeezing or solvent extraction after cutting, pulverizing, or drying, if necessary, the use part of the butcher bloom as it is. As a method of solvent extraction, a method known in the art may be adopted, and conventionally known extraction methods such as water (including hot water and hot water) extraction, alcohol extraction, supercritical extraction and the like can be used. ..

When solvent extraction is carried out, examples of the solvent include water; alcohols such as lower alcohols such as methanol and ethanol, polyhydric alcohols such as propylene glycol and 1,3-butylene glycol (whether anhydrous or water-containing); Examples include ketones such as acetone, diethyl ether, dioxane, acetonitrile, esters such as ethyl acetate, xylene, benzene, chloroform and the like. The solvent is preferably water, lower alcohol, 1,3-butylene glycol or the like, more preferably ethanol or 1,3-butylene glycol, and further preferably hydrous ethanol. These solvents may be used alone or in combination of two or more.

In the present invention, the extract thus obtained through the solvent extraction can be particularly referred to as a solvent extract. Further, although not limited to the present invention, as described above, for example, a water extract is used when water is used as a solvent, a lower alcohol extract is used when lower alcohols are used, and an ethanol extract is used when ethanol is used. It can be called a thing etc.

The obtained extract may be used as it is, or may be dried and used in a solid state such as powder or granules. If necessary, the obtained extract may be subjected to purification, concentration treatment, separation treatment of highly active fraction, and the like. Although not limited to the present invention, examples of the purification treatment include filtration, adsorption using an ion exchange resin and an activated carbon column, and decolorization. As the concentration treatment, a conventional method such as an evaporator can be used. As the separation treatment of the highly active fraction, known separation treatments such as gel filtration, adsorption treatment, silica gel column chromatography, HPLC (High performance liquid chromatography) can be used.

Further, for example, a method of subjecting the extract (or the dried product, the purified product, the concentrated product, the highly active fraction) obtained as described above to a freeze-drying process to form a powder, and if necessary, dextrin An extract to be used in the present invention may be obtained by adding an excipient such as corn starch, gum arabic or the like and pulverizing it by a conventionally known method such as a method of pulverizing by spray drying treatment. Further, the extract may be dissolved in pure water, ethanol or the like, if necessary.

The butcher bloom extract is preferably an extract obtained by drying, crushing and/or cutting the use site as a raw material, extracting using a suitable solvent, and filtering, and an extract thus obtained. The extract obtained by further drying is exemplified. As a preferred example, but not limited to the present invention, the Butcher Bloom extract has 100 g of the plant, more preferably 100 g of the dried product, crushed product and/or cut product of the plant, and the extraction solvent 1 to It can be obtained by immersing in 50 liters, performing extraction at any temperature (for example, 15 to 90° C.) for any time (for example, 10 minutes to 24 hours) with stirring, if necessary, and then filtering. it can.

The extract used in the present invention may be a commercially available product, or may be a commercially available product that has been appropriately subjected to a treatment such as drying.

The extract thus obtained may be used alone or in combination of two or more.

The content of butcher bloom extract in the composition of the present invention is not limited as long as the effect of the present invention can be obtained, but in the composition, preferably 0.0001 to 20% by weight in terms of dry matter of butcher bloom extract. Is exemplified, and more preferably 0.001 to 10% by weight. When two or more butcher bloom extracts are used, the total amount satisfies the value. The dried product of the extract is obtained by freeze-drying the butcher bloom extract. The freeze-drying treatment is carried out by vacuum concentration using a general evaporator and freeze-drying in a vacuum. The more detailed processing procedure follows the examples described later.

The composition of the present invention may further contain, in addition to the butcher bloom extract, any pharmaceutically or cosmetically acceptable component, if necessary, as long as the effects of the present invention are not impaired. Solvents (water, lower alcohols such as methanol and ethanol, alcohols such as propylene glycol and polyhydric alcohols such as 1,3-butylene glycol (whether anhydrous or water-containing), etc.) as optional components, shaping Agents, stabilizers, preservatives, thickeners, emulsifiers, surfactants, binders, lubricants, penetration enhancers, oils, antioxidants, anti-inflammatory agents, cooling agents, moisturizers, whitening agents, anti Allergic agents, wound healing agents, chelating agents, film forming agents, pH adjusters, solubilizing agents, gelling agents, ointment bases, fragrances, coloring agents, amino acids, vitamins, enzymes, various skin nutrition ingredients, ultraviolet absorbers, You may contain arbitrary components, such as a ultraviolet scattering agent and a skin protection agent. These may be used alone or in combination of two or more.

The application form of the composition of the present invention is not limited as long as it can suppress sebum secretion, but it is preferably applied to the skin (including the scalp) in an external form. The form is not limited to the present invention, but is in the form of liquid, paste, mousse, emulsion, suspension, cream, ointment, gel, solid (including powder, granules, etc.). , Sheet-like, aerosol-like, spray-like, bubble-like, patches, liniments, capsules and various other desired liquids, semi-solids, solids and the like.

In addition, the use of the composition of the present invention, which does not limit the present invention, lotion, beauty essence, emulsion, cream, lotion, pack, oil, massage cream, face wash cream, face wash gel, soap, makeup Cleansing, body wash, shampoo, rinse, treatment, cleansing agent, antiperspirant, hair restorer, hair restorer, hair tonic, makeup base, eye cream, foundation, sunscreen, tanning cosmetic, cheek, eye shadow, eyeliner, Examples include various cosmetics such as lipsticks, gloss, lip balms, bath agents and the like, quasi drugs, pharmaceuticals and the like.

The optional component may be appropriately selected according to the ordinary method in the art depending on the intended form and application. In addition, the composition for suppressing sebum secretion of the present invention can be produced by mixing the extract and, if necessary, any component according to a conventionally known method according to each form.

The composition for suppressing sebum secretion of the present invention is preferably used by applying it to the skin. The amount and the number of times the composition is applied are not particularly limited, and the type and concentration of the extract or any component to be blended, age of the user, sex, degree of symptom, application form, degree of expected effect, etc. Depending on the situation, a suitable amount may be applied once or several times a day, partially to the whole skin or desired skin.

According to the present invention, sebum secretion can be suppressed. More specifically, according to the present invention, sebum secretion from the sebaceous glands can be suppressed by applying the composition to the skin. In particular, as is clear from Examples described below, according to the present invention, it is possible to directly act on cells and suppress sebum secretion from the sebaceous glands. From this, according to the present invention, various skin symptoms associated with the increase in sebum secretion can be prevented or ameliorated.

Further, from this, the present invention provides a method for producing a composition for suppressing sebum secretion, which comprises using a butcher bloom extract, and a composition for suppressing sebum secretion, which comprises a step of solvent extraction of butcher bloom. It can be said to provide a method for manufacturing a product. Further, it can be said that the present invention provides a method for suppressing sebum secretion, which is characterized by using a butcher bloom extract.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited thereto.

1. Preparation of Extract A butcher bloom extract was prepared according to the following procedure. 100 g of commercially available Butcher Bloom extract (Butcher's Bloom extract, trade name, manufactured by Maruzen Pharmaceutical Co., Ltd.) was concentrated under reduced pressure for 30 minutes using an evaporator to remove ethanol, and then freeze-dried in a vacuum for 15 hours to obtain a powder. 1.4 g of solid was obtained. Then, the extract (powder solid) obtained as described above was dissolved in DMSO (Dimethyl sulfoxide) so as to have a concentration of 1, 10, 50, 100, and 200 mg/mL to obtain a butcher bloom extract.

2. Evaluation of sebum secretion activity
2-1. Cultivation of hamster sebaceous gland cells Normal hamster sebaceous gland cells (trade name: frozen Ha-SE (product number: KB-4009), purchased from Kurashiki Spinning Co., Ltd.) are thawed, and a culture vessel is prepared so that the number of cells is about 10,000 cells/cm ^2. The cells were inoculated into and cultured in an incubator (37° C., 5% CO ₂ ) until they became almost confluent. For cell culture, sebaceous gland cell proliferation supplemented with hEGF (human Epidermal Growth Factor) (10 ng/ml), fetal bovine serum (FBS) (8% V/V), human serum (HS) (2% V/V) The culture medium (product name: HuMedia-BG (product number: KB-2150S), purchased from Kurashiki Spinning Co., Ltd.) was used and cultured for 2 days.

Then, the proliferated hamster sebaceous gland cells were washed with a HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffer solution (purchased from Kurashiki Spinning Co., Ltd.), and then trypsin/EDTA solution (purchased from Kurashiki Spinning Co., Ltd.) was used. Peel off the culture dish, neutralize with trypsin neutralization solution (purchased from Kurashiki Spinning Co., Ltd.), and inoculate on a 24-well plate so that the cell number will be about 25,000 cells/cm ² , and for sebaceous gland cell growth every other day The medium was cultured for 5 days while exchanging 500 μL of medium (product name: HuMedia-BG (product number: KB-2150S)).

2-2. Addition of extract
-Test 1
Blank 1: 2 μL of DMSO (0.1% V/V) to which fetal bovine serum (FBS) (8% V/V) and human serum (HS) (2% V/V) were added to induce sebocyte differentiation (Product name: HuMedia-BD (product number: KB-2250S), purchased from Kurashiki Spinning Co., Ltd.) was added to 1998 μL to make a total of 2000 μL. 500 μL of the mixture thus obtained was added to the wells of the plate described above, and cultured at 37° C. for 17 days while changing the medium every other day.

Control 1: To enhance sebum secretion from cells, DMSO (0.1% V/V) was added with testosterone (purchased from Sigma) at 1×10 ⁻⁵ M to obtain a mixed solution. Then, 2 μL of the obtained mixed solution was added to 1998 μL of a medium for inducing sebaceous gland cell differentiation to which FBS and HS were added in the same manner as in blank 1 to make a total of 2000 μL. 500 μL of the mixture thus obtained was added to the wells of the above-mentioned plate and cultured in the same manner as in blank 1.

Test sample 1-1 (Example 1): Testosterone (purchased from Sigma) was added to DMSO (0.1% V/V) at 1×10 ⁻⁵ M to obtain a mixed solution, which was obtained. 2 μL of the obtained mixed liquid and 2 μL of Butcher Bloom extract (50 mg/mL) prepared as described above were added to 1996 μL of a medium for inducing sebaceous gland cell differentiation in the same manner as described above to make a total of 2000 μL. 500 μL of the mixture thus obtained was added to the wells of the above-mentioned plate and cultured in the same manner.

Test sample 1-2 (Example 2): Added and cultured in the same manner as in Test sample 1-1 except that 2 μL (100 mg/mL) of Butcher Bloom extract was used.

-Test 2
Blank 2: Culture was performed in the same manner as in the blank 1.

Control 2: 5α-dihydrotestosterone (purchased from Sigma) was added to DMSO (0.1% V/V) at 1×10 ⁻⁵ M to obtain a mixed solution, and the obtained mixed solution was 2 μL. Was added to the sebaceous gland cell differentiation induction medium 1998 μL to which FBS and HS were added in the same manner as in blank 1 to make a total of 2000 μL. 500 μL of the mixture thus obtained was added to the wells of the above-mentioned plate and cultured in the same manner.

Test sample 2-1 (Example 3): 5α-dihydrotestosterone (purchased from Sigma) was added to DMSO (0.1% V/V) at 1×10 ⁻⁵ M to obtain a mixed solution. Then, 2 μL of the obtained mixed liquid and 2 μL of Butcher Bloom extract (1 mg/mL) prepared as described above were added to 1996 μL of a medium for inducing sebaceous gland cell differentiation in the same manner as described above to make a total of 2000 μL. 500 μL of the mixture thus obtained was added to the wells of the above-mentioned plate and cultured in the same manner.

Test sample 2-2 (Example 4): The sample was added and cultured in the same manner as in Test sample 2-1 except that 2 μL (10 mg/mL) of Butcher Bloom extract was used.

Test sample 2-3 (Example 5): The sample was added and cultured in the same manner as in Test sample 2-1 except that 2 μL (50 mg/mL) of Butcher Bloom extract was used.

Test sample 2-4 (Example 6): Added and cultured in the same manner as in the test sample 2-1 except that 2 μL (100 mg/mL) of butcher bloom extract was used.

Test Sample 2-5 (Example 7): The test sample 2-5 was added and cultured in the same manner as in Test Sample 2-1 except that 2 μL (200 mg/mL) of Butcher Bloom extract was used.

-Test 3
Blank 3: Culture was performed in the same manner as in the blank 1.

Test sample 3-1 (Example 8): DMSO (0.1% V/V) and butcher bloom extract 2 μL (10 mg/mL) prepared as described above were used to induce sebaceous gland cell differentiation in the same manner as described above. The culture medium was added to 1996 μL to make a total of 2000 μL. 500 μL of the mixture thus obtained was added to the wells of the above-mentioned plate and cultured in the same manner.

Test sample 3-2 (Example 9): The same was added and cultured as in Test sample 3-1 except that 2 μL (50 mg/mL) of Butcher Bloom extract was used.

Test sample 3-3 (Example 10): The test sample 3-3 was added and cultured in the same manner as in the test sample 3-1 except that 2 μL (100 mg/mL) of Butcher Bloom extract was used.

Test Sample 3-4 (Example 11): Addition and culture were performed in the same manner as in Test Sample 3-1, except that 2 μL (200 mg/mL) of Butcher Bloom extract was used.

2-3. Measurement of cell number, measurement of lipid synthetic amount, and calculation of lipid synthetic amount After the culture, according to the instruction manual, cell number measuring solution (trade name: cell number measuring solution WST-8, purchased from Kurashiki Spinning Co., Ltd. ) Was added and incubated at 37° C. for 30 minutes. Next, 0.2 mL/well of the supernatant was transferred to a 96-well plate, and the absorbance was measured using an absorptiometer (model number GENios Spectra FLUOR plus, manufacturer name TEKAN, wavelength 450 nm) to measure the number of cells. Cell number can be determined by detecting the formazan product produced by the reduction of the tetrazolium salt.

For the amount of lipid synthesis, Oil Red O staining was performed according to the instruction manual using a lipid synthesis measurement kit (trade name: Lipid synthesis measurement kit SE-3001, purchased from Kurashiki Spinning Co., Ltd.). Specifically, the cells are washed twice with PBS(-) buffer, 10% formalin solution is added, and the cells are fixed by standing at room temperature for 10 minutes, and the cells are fixed with PBS(-) buffer. Washed twice. Next, 60% isopropanol as a solvent for the Oil Red O solution was added in advance, and the mixture was allowed to stand at room temperature for 1 minute, then the Oil Red O solution was added, and allowed to stand at room temperature for 30 minutes to stain the cells. Thereafter, the cells were washed twice with 60% isopropanol, 100% isopropanol was added, and the mixture was allowed to permeate at room temperature for 5 minutes, and 0.2 mL/well of the supernatant was transferred to a 96-well plate, and the absorbance was measured using an absorbance meter (wavelength: 520 nm). ) Was used to measure the amount of lipid synthesis.

The accumulated lipid synthesis amount per cell was calculated according to the following formula.
Lipid synthesis amount = absorbance 520 nm (lipid synthesis amount measurement value) / absorbance 450 nm (cell number measurement value)

3. Results Results are shown in FIGS. 1 to 3 show values obtained by dividing the amount of lipid by the number of cells, and show the amount of lipid per cell. Oil Red O stain is a hydrophobic dye, has a high affinity for lipids, and stains triglyceride, cholesterol, etc., which are the main components of sebum.

As is clear from FIGS. 1 to 3, sebum secretion was suppressed in the presence of the Butcher Bloom extract. As shown in FIGS. 1 and 2, although Control 1 and 2 to which testosterone and 5α-dihydrotestosterone were added were models in which sebum secretion was enhanced more than that of a normal sebaceous gland, butcher Bloom extract was added to each of them. In the test sample, effective suppression of sebum secretion was observed. Moreover, in FIG. 3, effective sebum secretion suppression was observed in sebaceous gland cells by using the Butcher Bloom extract, although testosterone and 5α-dihydrotestosterone were not added. The sebaceous gland cells used in this test are equipped with receptors involved in various substances such as steroids, growth hormones, insulin, linoleic acid, and neurotransmitters, and sebum secretion in a medium for inducing sebaceous gland cell differentiation is similar to that in vivo. Progresses. Even when compared with blanks 1 to 3 using such cells and medium, effective inhibition of sebum secretion was observed in each test sample to which the Butcher Bloom extract was added. In addition, sebum secretion was suppressed in a concentration-dependent manner in Butcher Bloom extract.

From this, it was confirmed that the butcher bloom extract effectively suppresses the secretion of sebum from the sebaceous glands, that is, has the sebum secretion inhibitory action.

Formulation Example A composition for suppressing sebum secretion containing a butcher bloom extract was produced according to the following formulation example and description. The composition for suppressing sebum secretion containing the extract can suppress sebum secretion. In each prescription example, a commercially available Butcher Bloom extract (trade name: Butchers Bloom extract, manufactured by Maruzen Pharmaceutical Co., Ltd., 100 g of the extract has a dry matter conversion value of 1.4 g) was used. The content of the liquid is shown.

Toner lotion According to the composition shown in Table 1 below, each component was mixed and heated to heat to 70° C. to obtain an A component that was uniformly dissolved and a B component that was uniformly mixed at room temperature. Next, while stirring the component A, the component B was added little by little at room temperature to obtain a lotion.

-Emulsion By mixing and heating each component according to the composition of the following Table 2, A component and B component heated at 75 degreeC or more were obtained. Next, the component A was added and emulsified while stirring and mixing the component B with a homomixer, and this was cooled to 50° C., then the component C was added and further stirred and mixed to obtain an emulsion.

-Cream By mixing and heating each component according to the composition of the following Table 3, the A component heated at 85 degreeC or more and the B component uniformly melt|dissolved at room temperature were obtained. Next, the components A and B were mixed with stirring, cooled to 50° C., then the component C was added and further mixed with stirring to obtain a gel cream.

-Body shampoo The components were mixed according to the composition shown in Table 4 below, and heated to 80°C to obtain components A and B uniformly dissolved. Next, the B component was added to the A component and cooled to room temperature while stirring and mixing. Component C was added to this to obtain a body shampoo.

-Soap The components were mixed according to the composition shown in Table 5 below and heated to 80°C to obtain A and B components that were uniformly dissolved. Then, the B component was added to the A component for saponification. This was cooled to 50° C. with stirring, and C component was added thereto. This was poured into a mold and cooled, and then dried at room temperature for several days, and a sufficiently dried product was taken out from the mold to obtain soap.

-Roll-on antiperspirant Each component was mixed according to the composition of the following Table 6, and heated at 75 degreeC, and the uniformly dissolved A component and B component were obtained. Then, the component A was gradually added to the component A while stirring, and the mixture was homogenized for several minutes. Further, the mixture was cooled with stirring, and the component C was added at 40° C. and stirred to obtain an antiperspirant.

-Sunscreen Each component was mixed according to the composition of the following Table 7, and heated at 80 degreeC, and the uniformly dissolved A component and B component were obtained. Next, the C component was gradually added while the B component was stirred with a disper, and the A component was further added. This was cooled while stirring with a paddle, component D was added at around 40°C and stirring was stopped at 35-30°C to obtain a sunscreen.

-Beauty liquid Mix each component according to the composition of the following Table 8, melt|dissolve each component A-D at room temperature, add component B gradually, stirring component A, and make viscous liquid, then C , D component were added and homogenized to obtain a beauty essence.

Foundation According to the composition shown in Table 9 below, the components A and B were melted at 80° C., and the component B was gradually added to the mixture while stirring with a homomixer to emulsify. Then, the mixture was cooled with stirring, and the component C was added at 70° C. to obtain a foundation.

Shampoo In accordance with the composition shown in Table 10 below, components A and B were heated and dissolved at 70° C., component B was added to component A, and the mixture was stirred and mixed. Then, the mixture was cooled with stirring, the C component was added at 50°C or lower, and the stirring was stopped at 40 to 35°C to obtain a shampoo.

-Rinse In accordance with the composition of the following Table 11, the components A and B were heated and dissolved at 80°C, and the component B was gradually added to the component while stirring to emulsify the component. Then, the mixture was cooled with stirring, the C component was added at 50°C or lower, and the stirring was stopped at 40 to 35°C to obtain a rinse.

Hair Treatment According to the composition shown in Table 12 below, the components A and B were heated and dissolved at 80° C., and the component A was gradually added to the component B with stirring to emulsify the component. Then, the mixture was cooled with stirring, the C component was added at 50°C or lower, and the stirring was stopped at 40 to 35°C to obtain a hair treatment.

Hair styling tonic According to the composition shown in Table 13 below, the component A was mixed at room temperature and uniformly dissolved. Next, the B component obtained by mixing was added to the A component with stirring to make the mixture uniform and a hair styling tonic was obtained.

-Body lotion According to the composition of the following Table 14, A component was heated to 80 degreeC and B component was heated to 75 degreeC, and it melt|dissolved. The component A was added to the component B, uniformly dispersed with a homomixer, and cooled with stirring. After the temperature reached 40° C., the component C was added and cooled to room temperature with uniform stirring to obtain a body lotion.

Facial cleansing foam According to the composition shown in Table 15 below, the components A and B are heated and melted at 80°C. Component C dissolves at room temperature. While component A is being stirred, component B is gradually added to dissolve uniformly, and then component C is added to homogenize. These were cooled with stirring and the stirring was stopped at 35 to 30° C. to obtain a face-wash foam.

-Bath milk According to the composition shown in Table 16 below, the components A and B are heated and dissolved at 70°C. The component A was emulsified by adding the component B while stirring the component A with a homomixer. Then, while stirring with a paddle, the mixture was cooled to 30°C to obtain bath milk.

Claims (3)

Composition for suppressing sebum secretion containing butcher bloom extract
(However, the topically applied composition containing the tripeptide consisting of glycyl-histidyl-lysine is excluded.) . The composition for suppressing sebum secretion according to claim 1, wherein the butcher bloom extract is contained in an amount of 0.0001 to 20% by weight in terms of a dry matter of the extract. The composition for suppressing sebum secretion according to claim 1 or 2, which is an external composition.