JP6720079B2 - 対象とするヒト標的に特異的に結合するリガンド - Google Patents
対象とするヒト標的に特異的に結合するリガンド Download PDFInfo
- Publication number
- JP6720079B2 JP6720079B2 JP2016541434A JP2016541434A JP6720079B2 JP 6720079 B2 JP6720079 B2 JP 6720079B2 JP 2016541434 A JP2016541434 A JP 2016541434A JP 2016541434 A JP2016541434 A JP 2016541434A JP 6720079 B2 JP6720079 B2 JP 6720079B2
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- human
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (67)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361916866P | 2013-12-17 | 2013-12-17 | |
US201361916862P | 2013-12-17 | 2013-12-17 | |
GB1322250.0A GB2521355A (en) | 2013-12-17 | 2013-12-17 | Human targets I |
GB1322250.0 | 2013-12-17 | ||
GB1322253.4 | 2013-12-17 | ||
US61/916,862 | 2013-12-17 | ||
US61/916,866 | 2013-12-17 | ||
GB1322253.4A GB2521356B (en) | 2013-12-17 | 2013-12-17 | Antibodies for use in treating conditions related to specific PCKS9 variants and associated diagnostic methods |
US14/138,446 US8883157B1 (en) | 2013-12-17 | 2013-12-23 | Targeting rare human PCSK9 variants for cholesterol treatment |
US14/138,446 | 2013-12-23 | ||
US14/228,760 US8951523B1 (en) | 2013-12-17 | 2014-03-28 | Targeting rare human PCSK9 variants for cholesterol treatment |
US14/228,760 | 2014-03-28 | ||
EP14172578.8 | 2014-06-16 | ||
EP14172578.8A EP2886557A1 (de) | 2013-12-17 | 2014-06-16 | Antikörper zur Anwendung bei der Behandlung von spezifischen PCSK9 Varianten bezüglich Erkrankungen bei spezifischen Patientengruppen |
EP14172579.6 | 2014-06-16 | ||
EP14172579.6A EP2886558A1 (de) | 2013-12-17 | 2014-06-16 | Antikörper zur Anwendung bei der Behandlung von spezifischen PCSK9 Varianten bezüglich Erkrankungen bei spezifischen Patientengruppen |
US14/331,665 US9023359B1 (en) | 2014-07-15 | 2014-07-15 | Targeting rare human PCSK9 variants for cholesterol treatment |
US14/331,730 US9914769B2 (en) | 2014-07-15 | 2014-07-15 | Precision medicine for cholesterol treatment |
US14/331,730 | 2014-07-15 | ||
US14/331,609 | 2014-07-15 | ||
US14/331,665 | 2014-07-15 | ||
US14/331,609 US9051378B1 (en) | 2014-07-15 | 2014-07-15 | Targeting rare human PCSK9 variants for cholesterol treatment |
US14/457,536 | 2014-08-12 | ||
US14/457,566 | 2014-08-12 | ||
US14/457,566 US8945560B1 (en) | 2014-07-15 | 2014-08-12 | Method of treating rheumatoid arthritis using antibody to IL6R |
US14/457,536 US9017678B1 (en) | 2014-07-15 | 2014-08-12 | Method of treating rheumatoid arthritis using antibody to IL6R |
US14/472,828 | 2014-08-29 | ||
US14/472,818 | 2014-08-29 | ||
US14/472,698 | 2014-08-29 | ||
US14/472,685 | 2014-08-29 | ||
US14/472,685 US8992927B1 (en) | 2014-07-15 | 2014-08-29 | Targeting human NAV1.7 variants for treatment of pain |
US14/472,698 US8986694B1 (en) | 2014-07-15 | 2014-08-29 | Targeting human nav1.7 variants for treatment of pain |
US14/472,818 US8980273B1 (en) | 2014-07-15 | 2014-08-29 | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
US14/472,828 US8986691B1 (en) | 2014-07-15 | 2014-08-29 | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
US14/490,160 US8999341B1 (en) | 2014-07-15 | 2014-09-18 | Targeting rare human PCSK9 variants for cholesterol treatment |
US14/490,091 | 2014-09-18 | ||
US14/490,091 US9068012B1 (en) | 2014-07-15 | 2014-09-18 | Targeting rare human PCSK9 variants for cholesterol treatment |
US14/490,112 | 2014-09-18 | ||
EP14185297.0 | 2014-09-18 | ||
US14/490,175 US9040052B1 (en) | 2013-12-17 | 2014-09-18 | Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment |
EP14185297.0A EP2975058A1 (de) | 2014-07-15 | 2014-09-18 | Antikörper zur Anwendung bei der Behandlung von spezifischen PCSK9 Varianten bezüglich Erkrankungen bei spezifischen Patientengruppen |
US14/490,160 | 2014-09-18 | ||
US14/490,175 | 2014-09-18 | ||
US14/490,112 US9034331B1 (en) | 2014-07-15 | 2014-09-18 | Targeting rare human PCSK9 variants for cholesterol treatment |
US14/500,397 US10618971B2 (en) | 2013-12-17 | 2014-09-29 | Targeting rare human PCSK9 variants for cholesterol treatment |
US14/500,233 | 2014-09-29 | ||
US14/500,233 US9045548B1 (en) | 2014-07-15 | 2014-09-29 | Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment |
US14/500,397 | 2014-09-29 | ||
US14/507,368 | 2014-10-06 | ||
US14/507,368 US9034332B1 (en) | 2014-07-15 | 2014-10-06 | Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment |
EP14190945 | 2014-10-29 | ||
EP14190945.7 | 2014-10-29 | ||
US14/536,049 US9045545B1 (en) | 2014-07-15 | 2014-11-07 | Precision medicine by targeting PD-L1 variants for treatment of cancer |
US14/536,129 | 2014-11-07 | ||
US14/536,129 US9062105B1 (en) | 2014-07-15 | 2014-11-07 | Precision Medicine by targeting VEGF-A variants for treatment of retinopathy |
US14/536,049 | 2014-11-07 | ||
US14/537,403 US9067998B1 (en) | 2014-07-15 | 2014-11-10 | Targeting PD-1 variants for treatment of cancer |
US14/537,403 | 2014-11-10 | ||
US14/552,816 | 2014-11-25 | ||
US14/552,816 US10611849B2 (en) | 2013-12-17 | 2014-11-25 | Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment |
EP14196641 | 2014-12-05 | ||
EP14196638 | 2014-12-05 | ||
EP14196641.6 | 2014-12-05 | ||
EP14196645 | 2014-12-05 | ||
EP14196645.7 | 2014-12-05 | ||
EP14196638.2 | 2014-12-05 | ||
PCT/GB2014/053729 WO2015092393A2 (en) | 2013-12-17 | 2014-12-17 | Human targets |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020104523A Division JP2020152729A (ja) | 2013-12-17 | 2020-06-17 | 対象とするヒト標的に特異的に結合するリガンド |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017502030A JP2017502030A (ja) | 2017-01-19 |
JP6720079B2 true JP6720079B2 (ja) | 2020-07-08 |
Family
ID=56800882
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016541434A Active JP6720079B2 (ja) | 2013-12-17 | 2014-12-17 | 対象とするヒト標的に特異的に結合するリガンド |
JP2020104523A Pending JP2020152729A (ja) | 2013-12-17 | 2020-06-17 | 対象とするヒト標的に特異的に結合するリガンド |
JP2021155708A Active JP7202431B2 (ja) | 2013-12-17 | 2021-09-24 | 対象とするヒト標的に特異的に結合するリガンド |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020104523A Pending JP2020152729A (ja) | 2013-12-17 | 2020-06-17 | 対象とするヒト標的に特異的に結合するリガンド |
JP2021155708A Active JP7202431B2 (ja) | 2013-12-17 | 2021-09-24 | 対象とするヒト標的に特異的に結合するリガンド |
Country Status (3)
Country | Link |
---|---|
JP (3) | JP6720079B2 (de) |
CN (1) | CN106062004A (de) |
DE (2) | DE112014005747T5 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160144025A1 (en) * | 2014-11-25 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and formulations for treating vascular eye diseases |
US11566073B2 (en) * | 2017-06-01 | 2023-01-31 | Bristol-Myers Squibb Company | Methods of treating a tumor using an anti-PD-1 antibody |
CN108034712A (zh) * | 2017-12-28 | 2018-05-15 | 上海市儿童医院 | 川崎病冠状动脉病变风险诊断与检测试剂盒 |
SG11202008848XA (en) * | 2018-03-26 | 2020-10-29 | Regeneron Pharma | Anti-pfrh5 antibodies and antigen-binding fragments thereof |
CN108315430B (zh) * | 2018-04-28 | 2021-07-23 | 上海交通大学医学院附属仁济医院 | Pdl1 snp基因型作为预测乳腺癌新辅助化疗疗效标记物的用途 |
WO2020151666A1 (zh) * | 2019-01-25 | 2020-07-30 | 四川大学华西医院 | 血管瘤治疗的生物标记物 |
CN112941164A (zh) * | 2021-01-27 | 2021-06-11 | 右江民族医学院附属医院 | 利用目标基因测序检测trpc6基因致病突变的方法 |
CN113502325A (zh) * | 2021-07-02 | 2021-10-15 | 厦门市妇幼保健院(厦门市计划生育服务中心) | 用于孕期铁营养缺乏风险评估检测试剂盒与应用方法 |
CN113945723B (zh) * | 2021-10-28 | 2024-03-12 | 复旦大学附属中山医院 | 预测免疫检查点抑制剂治疗相关肺炎发生风险的系统、储存介质及其应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
JOP20080381B1 (ar) * | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
EP2668212B1 (de) * | 2011-01-28 | 2018-03-21 | Sanofi Biotechnology | Menschliche antikörper gegen psck9 zur verwendung in verfahren zur behandlung bestimmter gruppen von personen |
JOP20200043A1 (ar) * | 2011-05-10 | 2017-06-16 | Amgen Inc | طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول |
CN111789944A (zh) * | 2011-09-16 | 2020-10-20 | 瑞泽恩制药公司 | 用前蛋白转化酶枯草溶菌素-9(PCSK9)抑制剂降低脂蛋白(a)水平的方法 |
CN106995822B (zh) * | 2011-09-19 | 2021-06-29 | 科马布有限公司 | 定制供人类使用的抗体、可变结构域和链 |
-
2014
- 2014-12-17 DE DE112014005747.9T patent/DE112014005747T5/de active Pending
- 2014-12-17 CN CN201480075772.XA patent/CN106062004A/zh active Pending
- 2014-12-17 JP JP2016541434A patent/JP6720079B2/ja active Active
- 2014-12-17 DE DE112014005975.7T patent/DE112014005975T5/de active Pending
-
2020
- 2020-06-17 JP JP2020104523A patent/JP2020152729A/ja active Pending
-
2021
- 2021-09-24 JP JP2021155708A patent/JP7202431B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
DE112014005747T5 (de) | 2016-10-06 |
JP2017502030A (ja) | 2017-01-19 |
CN106062004A (zh) | 2016-10-26 |
JP2022000457A (ja) | 2022-01-04 |
JP2020152729A (ja) | 2020-09-24 |
JP7202431B2 (ja) | 2023-01-11 |
DE112014005975T5 (de) | 2016-09-15 |
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