JP6674038B2 - 心血管診断用統合型カテーテル装置及びそれを用いた画像処理システム - Google Patents
心血管診断用統合型カテーテル装置及びそれを用いた画像処理システム Download PDFInfo
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Description
血管内超音波は、カテーテル形態の機器が血管に挿入されて血管の断層画像を取得する技術であって、未だに病院で最も多用されている血管内画像化技術である。超音波技術を利用するため、解像度が100μmのレベルと低く、コントラストも低く、画像取得速度が約30秒程度と遅い。
Claims (7)
- 近赤外線光を用いてステントと血管との密着画像、薄い線維膜の厚さ測定及び血管内の光断層微細構造画像を取得するOCT画像部を含み、超音波を用いて血管の内径の測定が可能な血管内の構造画像を取得し、光音響用光を用いて血管内の血液の濃度及び脂質コアの面積を測定するための画像を取得する超音波及び光音響画像部を含む画像装置;
前記画像装置で生成された、OCT用の多数の所定波長の近赤外線光、光音響用光及び超音波をサンプルに伝達するカテーテル装置;並びに
前記カテーテル装置に提供される、OCT用の多数の所定波長の近赤外線光及び光音響用光を集中して前記カテーテル装置へ伝達し、前記サンプルから戻ってくる所定波長の近赤外線光、音波及び超音波を前記画像装置へ分離させて伝達する光処理装置を含み、
前記OCT画像部は、
多数の所定波長の光を発生する近赤外線光発生器;
前記光を第1経路を介して基準段へガイドする第1SMFカプラ(Single−mode fiber coupler);
前記第1SMFカプラの第2経路を介して光を受信した後、前記光処理装置へ伝達するダブルクラッド光ファイバカプラ;及び
OCT画像を取得するために、サンプルから反射された光をガイドする前記ダブルクラッド光ファイバカプラで受信した光と前記基準段から反射される光とを結合して検出器へ伝達する第2SMFカプラを含み、
前記超音波及び光音響画像部は、
前記ダブルクラッド光ファイバカプラを介して前記光処理装置を経由して前記カテーテル装置へ伝達し、サンプルに照射されるパルスレーザーの光音響用光を発生させるパルスレーザー発生器を含み、
前記ダブルクラッド光ファイバカプラは、単一モードで動作してOCT用の近赤外線光をガイドして前記光処理装置へ伝達するコア部分と、マルチモードで動作して光音響用光をガイドして前記光処理装置へ伝達するクラッド部分とを有することを特徴とする、心血管診断用統合型カテーテルを用いた画像処理システム。 - 前記超音波及び光音響画像部は、
前記サンプルから照射された光によって生成した熱エネルギーにより発生した音波を前記カテーテル装置を介して受信し、前記光音響用光を遅延させて基準信号として受信する受信段;及び
前記受信段の基準信号及び音波信号を加工処理してIVPA画像を取得する加工部を含むことを特徴とする、請求項1に記載の心血管診断用統合型カテーテルを用いた画像処理システム。 - 前記超音波及び光音響画像部は、
サンプルへ伝達するための予め定められた周波数の超音波を生成する超音波生成器をさらに含み、
サンプルから反射された超音波を前記受信段で受信して加工部へ伝達するように備えられることを特徴とする、請求項2に記載の心血管診断用統合型カテーテルを用いた画像処理システム。 - 前記カテーテル装置は、
前記光処理装置から提供されたOCT用の多数の所定波長の近赤外線光および光音響用光をサンプルへガイドするDCF(Double Cladding Fiber);
前記DCFを通過した光を通過させるレンズ;及び
前記レンズを通過した光を屈折させ、予め定められた目標位置のサンプルに照射するプリズムを含み、
前記DCF、レンズ及びプリズムを一つにモジュール化して前記OCT用の多数の所定波長の近赤外線光および光音響用光をサンプルへ走査するための光源開口を有する一つのハウジング内に設けるように備えられることを特徴とする、請求項1に記載の心血管診断用統合型カテーテルを用いた画像処理システム。 - 前記ハウジングは、
液体の流入を防止するための石英キャピラリーとして備えられることを特徴とする、請求項4に記載の心血管診断用統合型カテーテルを用いた画像処理システム。 - 前記カテーテル装置は、
所定波長の光音響用光に対してサンプルから反射された音波を受信して前記超音波及び光音響画像部の受信段へ伝達する超音波トランスデューサをさらに含むことを特徴とする、請求項5に記載の心血管診断用統合型カテーテルを用いた画像処理システム。 - 前記DCFは、
前記OCT画像部の予め定められた所定波長の光をサンプルへガイドし、サンプルから反射された光を前記OCT画像部へ伝達するコア部分と、前記超音波及び光音響画像部の光音響用光をサンプルへガイドするクラッド部分とを含む2つのチャネルを含むことを特徴とする、請求項4に記載の心血管診断用統合型カテーテルを用いた画像処理システム。
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KR10-2016-0031648 | 2016-03-16 | ||
KR1020160031648A KR101736113B1 (ko) | 2016-03-16 | 2016-03-16 | 심혈관 진단용 통합형 카테터 장치 및 이를 이용한 영상 처리 시스템 |
PCT/KR2016/012681 WO2017159951A1 (ko) | 2016-03-16 | 2016-11-04 | 심혈관 진단용 통합형 카테터 장치 및 이를 이용한 영상 처리 시스템 |
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US11045169B2 (en) * | 2016-06-24 | 2021-06-29 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems for multimodal real-time imaging for biopsies and related methods |
CN107411708A (zh) * | 2017-05-22 | 2017-12-01 | 上海交通大学 | 一种光学相干层析与光声成像双模态内窥镜 |
WO2020113570A1 (zh) * | 2018-12-07 | 2020-06-11 | 深圳先进技术研究院 | 多模态胰胆管成像系统 |
CN109349983B (zh) * | 2018-12-07 | 2023-10-17 | 深圳皓影医疗科技有限公司 | 一种胰胆管的多模态成像系统及其内窥导管装置 |
JP7221787B2 (ja) * | 2019-05-10 | 2023-02-14 | i-PRO株式会社 | 血管径測定システム |
JP7221786B2 (ja) * | 2019-05-10 | 2023-02-14 | i-PRO株式会社 | 血管径測定システム |
WO2020230389A1 (ja) * | 2019-05-10 | 2020-11-19 | パナソニックi-PROセンシングソリューションズ株式会社 | 血管径測定システムおよび血管径測定方法 |
KR102326307B1 (ko) | 2019-11-20 | 2021-11-15 | 전남대학교산학협력단 | 광음향 영상 기반의 복강경 장치 및 광음향 영상 기반의 혈관 내 카테터 위치 확인 장치 |
KR20220136937A (ko) * | 2021-04-01 | 2022-10-11 | 주식회사 뷰웍스 | 입자 빔 조사 장치 및 방법 |
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WO2008137710A1 (en) * | 2007-05-03 | 2008-11-13 | University Of Washington | High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor |
US8792757B2 (en) * | 2011-01-24 | 2014-07-29 | Polyvalor, Limited Partnership | Double clad fiber coupler and device |
JP5626903B2 (ja) * | 2011-07-27 | 2014-11-19 | 富士フイルム株式会社 | カテーテル型の光音響プローブおよびそれを備えた光音響撮像装置 |
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KR101736113B1 (ko) | 2017-05-17 |
US20190021598A1 (en) | 2019-01-24 |
JP2019506981A (ja) | 2019-03-14 |
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