JP6669796B2 - 染色体異常判定装置 - Google Patents
染色体異常判定装置 Download PDFInfo
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- JP6669796B2 JP6669796B2 JP2018050623A JP2018050623A JP6669796B2 JP 6669796 B2 JP6669796 B2 JP 6669796B2 JP 2018050623 A JP2018050623 A JP 2018050623A JP 2018050623 A JP2018050623 A JP 2018050623A JP 6669796 B2 JP6669796 B2 JP 6669796B2
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- chromosome
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- 208000031404 Chromosome Aberrations Diseases 0.000 title claims description 63
- 206010067477 Cytogenetic abnormality Diseases 0.000 title claims description 56
- 210000000349 chromosome Anatomy 0.000 claims description 149
- 230000005856 abnormality Effects 0.000 claims description 102
- 238000012545 processing Methods 0.000 claims description 88
- 230000003595 spectral effect Effects 0.000 claims description 68
- 238000001228 spectrum Methods 0.000 claims description 54
- 238000000034 method Methods 0.000 claims description 34
- 230000002159 abnormal effect Effects 0.000 claims description 27
- 238000003062 neural network model Methods 0.000 claims description 26
- 230000008569 process Effects 0.000 claims description 21
- 238000010801 machine learning Methods 0.000 claims description 9
- 238000000411 transmission spectrum Methods 0.000 claims description 8
- 238000010276 construction Methods 0.000 claims description 3
- 238000000985 reflectance spectrum Methods 0.000 claims description 2
- 238000010191 image analysis Methods 0.000 description 25
- 238000010183 spectrum analysis Methods 0.000 description 24
- 238000002834 transmittance Methods 0.000 description 23
- 238000013500 data storage Methods 0.000 description 19
- 238000010586 diagram Methods 0.000 description 14
- 230000008859 change Effects 0.000 description 11
- 238000005259 measurement Methods 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 238000003384 imaging method Methods 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 6
- 238000007447 staining method Methods 0.000 description 6
- 239000012192 staining solution Substances 0.000 description 6
- 230000005540 biological transmission Effects 0.000 description 5
- 206010008805 Chromosomal abnormalities Diseases 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 238000013528 artificial neural network Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000000877 morphologic effect Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 210000003793 centrosome Anatomy 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000031864 metaphase Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 210000003765 sex chromosome Anatomy 0.000 description 2
- 238000012706 support-vector machine Methods 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 239000012620 biological material Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 230000024321 chromosome segregation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
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- 238000000879 optical micrograph Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
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- 230000005945 translocation Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017064975 | 2017-03-29 | ||
| JP2017064975 | 2017-03-29 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018169390A JP2018169390A (ja) | 2018-11-01 |
| JP2018169390A5 JP2018169390A5 (https=) | 2019-04-11 |
| JP6669796B2 true JP6669796B2 (ja) | 2020-03-18 |
Family
ID=64020100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018050623A Active JP6669796B2 (ja) | 2017-03-29 | 2018-03-19 | 染色体異常判定装置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6669796B2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3591572B1 (en) * | 2018-07-06 | 2021-09-01 | Tata Consultancy Services Limited | Method and system for automatic chromosome classification |
| JP6637132B1 (ja) * | 2018-09-12 | 2020-01-29 | Ｊｆｅテクノリサーチ株式会社 | 染色体異常判定システム、測定装置及び解析装置 |
| WO2020168511A1 (zh) * | 2019-02-21 | 2020-08-27 | 中国医药大学附设医院 | 染色体异常检测模型、其检测系统及染色体异常检测方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03123860A (ja) * | 1989-10-06 | 1991-05-27 | Sumitomo Metal Ind Ltd | 染色体検査装置 |
| US5784162A (en) * | 1993-08-18 | 1998-07-21 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for biological research, medical diagnostics and therapy |
| DE102008011283B4 (de) * | 2008-02-27 | 2012-03-29 | Hochschule Reutlingen | Markerfreies Chromosomenscreening |
| CA2938896A1 (en) * | 2013-02-06 | 2014-08-14 | Alentic Microscience Inc. | Detecting and using light representative of a sample |
| JP2016070698A (ja) * | 2014-09-26 | 2016-05-09 | 富士フイルム株式会社 | 有核赤血球の選別方法 |
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2018
- 2018-03-19 JP JP2018050623A patent/JP6669796B2/ja active Active
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| Publication number | Publication date |
|---|---|
| JP2018169390A (ja) | 2018-11-01 |
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