JP6651155B1 - Syringe and kit suitable for hydrogen peroxide solution - Google Patents

Abstract

A syringe for suppressing decomposition of hydrogen peroxide is provided. Kind Code: A1 A syringe for a hydrogen peroxide solution in which a hydrogen peroxide solution is prefilled, wherein a syringe material of a portion where the syringe and the hydrogen peroxide solution are in direct contact is a cycloolefin polymer (COP) or a cycloolefin. A copolymer (COC), wherein the hydrogen peroxide solution is a solution obtained by dissolving hydrogen peroxide in water, and may be a solution that can contain an additive, if necessary. A syringe provided with an administration nozzle in the needle mounting section 30 of the syringe. [Selection diagram] Fig. 1

Description

  The present invention relates to syringes, and in particular, to syringes having a lower resolution of hydrogen peroxide solution than glass.

  Hydrogen peroxide solution is used industrially as a bleaching agent, and is used as a bactericide in the food field. Oxitol containing 2.5 to 3.5 w / v% of hydrogen peroxide is used for medical purposes as a disinfectant.

  The hydrogen peroxide solution can be used as a radiation sensitizer by combining it with hyaluronic acid (Patent Document 1).

WO2008 / 041514

  When a hydrogen peroxide solution is used as a radiosensitizer as in Patent Literature 1, it is necessary to weigh the hydrogen peroxide solution from a container at the time of use due to the characteristics of the hydrogen peroxide solution that is easily decomposed.

  Also, if the hydrogen peroxide solution is prefilled using a conventional glass (made of borosilicate glass or the like) syringe, problems such as expansion during storage and pushing back of the gasket occur, making long-term storage impossible. there were. In order to solve this problem, the present invention provides a prefilled syringe for a hydrogen peroxide solution that can be stored for a long time.

The purpose of the present invention is
Hydrogen peroxide solution prefilled hydrogen peroxide solution syringe,
The syringe material of the portion where the syringe and the hydrogen peroxide solution come into direct contact is a cycloolefin polymer (COP) or a cycloolefin copolymer (COC),
The hydrogen peroxide solution is a solution obtained by dissolving hydrogen peroxide in water, and if necessary, a solution that can contain additives.
The syringe includes an administration nozzle at a needle mounting portion of the syringe,
Is to provide a syringe.

  By using this syringe, it is possible to suppress the decomposition of hydrogen peroxide in the hydrogen peroxide solution. For example, it is thought that long-term storage is possible even with a syringe prefilled with a hydrogen peroxide solution. Can be Furthermore, this syringe is equipped with a dosing nozzle, so that quick dosing is possible.

The administration nozzle may include an adapter unit connected to a needle mounting unit of the syringe and a nozzle unit.
The nozzle section may be a dosing needle or a spray nozzle.

  The dosing needle may have an echogenic pattern groove formed on an outer surface thereof.

  The nozzle portion may be covered with a protector.

The protector may include a support member, a nozzle protection unit connected to one end of the support member, and an engagement unit connected to the other end of the support member.
The engagement section may be movably connected to the other end of the support member via a movable section.
The nozzle protection section may include a space capable of accommodating the nozzle section.

  The engagement section may be movably connected to the other end of the support member via a movable section.

  The space may be provided on a side wall of the nozzle protection unit.

The support member may include a first arm, a second arm, a first movable section, a second movable section, and a third movable section.
One end of the first arm is movably connected to the nozzle protection portion via the first movable portion, and the other end of the first arm is connected to the one end of the second arm via the second movable portion. And the one end of the second arm may be movably connected to the engaging portion via the third movable portion.

The movable section may include a rail section connected to the nozzle protection section, and a rail holding section connected to the engagement section.
The rail holding section may slidably hold the rail section.

The space may be provided inside the nozzle protection unit.
The nozzle protection section may have a hollow structure.

  The syringe may further include a syringe pump.

  The concentration of the hydrogen peroxide in the hydrogen peroxide solution may be from 0.01 to 40% (w / v).

Another object of the invention is
A hydrogen peroxide solution syringe pre-filled with a hydrogen peroxide solution,
A dosing nozzle,
With
The syringe material of the portion where the syringe and the hydrogen peroxide solution come into direct contact is a cycloolefin polymer (COP) or a cycloolefin copolymer (COC),
It is an object of the present invention to provide a kit, wherein the hydrogen peroxide solution is a solution in which hydrogen peroxide is dissolved in water, and is a solution that can contain an additive as needed.

  By using this kit, it is not necessary to consider an administration nozzle for the syringe, and rapid administration becomes possible.

  The kit may further include a protector for covering the nozzle unit.

  According to the present invention, a prefilled syringe for a radiosensitizer capable of storing a hydrogen peroxide solution for a long period of time can be provided, and rapid administration becomes possible. In addition, by providing the administration nozzle with the protector, a safe administration operation can be performed. By using an administration needle as the administration nozzle, the hydrogen peroxide solution can be administered with good operability. Further, by using a spray nozzle as the administration nozzle, the hydrogen peroxide solution can be sprayed with good operability. By using the syringe pump, the prefilled syringe can be operated stably and quantitatively.

FIG. 1 shows a schematic view of a pre-filled syringe filled with a hydrogen peroxide solution according to the present embodiment. FIG. 2 shows a pre-filled syringe with a dosing needle according to this embodiment. FIG. 3 shows a prefilled syringe with a spray nozzle according to the present embodiment. FIG. 4 is a partially enlarged cross-sectional view of the spray nozzle according to the present embodiment. FIG. 5 shows a pre-filled syringe with a protector according to the present embodiment. FIG. 6 shows a prefilled syringe with a movable protector in a protected mode according to the present embodiment. FIG. 7 shows a pre-filled syringe with a movable protector under a dosing mode according to this embodiment. FIG. 8 shows a prefilled syringe with a liftable protector in a protected mode according to the present embodiment. FIG. 9 shows a pre-filled syringe with a liftable protector under administration mode, according to this embodiment. FIG. 10 shows a pre-filled syringe with a syringe pump according to the present embodiment. FIG. 11 is a schematic diagram illustrating the operation of the syringe pump according to the present embodiment. FIG. 12 shows a graph of the residual ratio of hydrogen peroxide of each syringe material in the example.

Definitions For convenience, certain terms used in the present application are collected here. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Unless otherwise stated in context, the singular forms “a”, “an”, and “the” include plural references.

  The numerical ranges and parameters given in the present invention are approximations, but the numerical values given in specific examples are described as accurately as possible. However, any numerical value inherently contains certain errors necessarily resulting from the standard deviation found in each test measurement. Also, as used herein, the term "about" generally means within 10%, 5%, 1% or 0.5% of a given value or range. Alternatively, the term "about" means within an acceptable standard error, as considered by one skilled in the art.

  As used herein, the “protection mode” means a state where the skin cannot access the tip of the nozzle unit by the protector, that is, a state where administration is not possible. The “administration mode” as used herein means a state in which the tip of the nozzle is exposed from the protector, that is, a state in which administration is possible.

  Hereinafter, embodiments of the present invention will be described. The following embodiments are exemplifications, and the scope of the present invention is not limited to those shown in the following embodiments. In addition, in order to avoid repetitive complications about the same content, the description is omitted.

Syringe The syringe according to the present embodiment is:
Hydrogen peroxide solution prefilled hydrogen peroxide solution syringe,
The syringe material of the portion where the syringe and the hydrogen peroxide solution come into direct contact is a cycloolefin polymer (COP) or a cycloolefin copolymer (COC),
The hydrogen peroxide solution is a solution obtained by dissolving hydrogen peroxide in water, and if necessary, a solution that can contain additives.
The syringe includes an administration nozzle at a needle mounting portion of the syringe,
It is a syringe.

  FIG. 1 shows a schematic diagram of a prefilled syringe 1 filled with a hydrogen peroxide solution 50 according to the present embodiment. In the present embodiment, the shape of the syringe 10, particularly the barrel 20, is generally cylindrical, and one end of the syringe 10 is provided with a needle mounting portion 30 through which the hydrogen peroxide solution 50 is discharged. Is provided with a rod insertion portion 80 for inserting the plunger rod 70, and a flange 90 is provided around the rod insertion portion 80. The prefilled syringe 1 shown in FIG. 1 has a cap 40 in the needle mounting section 30 to seal the filled hydrogen peroxide solution 50, and a plunger rod 70 having a gasket 60 is inserted from a rod insertion section 80. ing.

  In the present embodiment, the hydrogen peroxide solution syringe means a syringe having a low resolution of hydrogen peroxide in the hydrogen peroxide solution. In the present embodiment, the hydrogen peroxide solution refers to a solution in which hydrogen peroxide is dissolved in a solvent (for example, water), and may contain additives (for example, phosphoric acid and phenacetin) as necessary. Good. In the present embodiment, the syringe may be manufactured from a single material, or may be formed from a plurality of materials (including a multilayer structure such as a coating). In the case of a syringe manufactured from a single material, the entire syringe is made of the above resin. In the case of a syringe composed of a plurality of materials, a portion where the syringe and the hydrogen peroxide solution directly contact each other is made of the above resin, and the other portion is made of a material having a high resolution of hydrogen peroxide such as glass. You may. It is not necessary that all parts that come into contact with the hydrogen peroxide solution be made of the above resin, and it is sufficient that the main part including the inner surface of the barrel of the syringe body be made of the above resin. That is, plunger rods, luer locks, caps, gaskets, etc., which may also come into contact with the hydrogen peroxide solution, need not be made of the above resin. Also, a lubricant such as silicone oil that may be applied to the inner surface of the barrel of the syringe body does not need to be made of the above resin.

  The resolution of hydrogen peroxide is the ratio of the concentration of hydrogen peroxide in the hydrogen peroxide solution after a specific storage period under a specific temperature condition to the concentration of hydrogen peroxide in the hydrogen peroxide solution before the start of storage ( (Percentage of remaining hydrogen peroxide). Storage is performed in a sealed state. The temperature conditions are not limited, but may be 35 ° C, 37 ° C, 40 ° C, or 60 ° C. The storage period is not limited, but may be one week, two weeks, three weeks, or four weeks, or may be four weeks or longer. The concentration of hydrogen peroxide in the hydrogen peroxide solution before the start of storage may be tested, for example, at any concentration in the range of 0.01 to 40% (w / v). In the embodiment, the resolution of hydrogen peroxide of the resin may be lower than that of glass. The residual ratio of hydrogen peroxide of the above resin is 70% or more, preferably 75% or more, more preferably 78% or less under the condition that a solution containing 2.5 to 3.5 w / v% of hydrogen peroxide is sealed and stored at 60 ° C. for 4 weeks. %, More preferably 80% or more. The amount of hydrogen peroxide in the hydrogen peroxide solution can be determined by titration with a potassium permanganate solution according to the oxidol determination method of the Japanese Pharmacopoeia.

  In the present embodiment, the resin may be exemplified by cycloolefin polymer (COP), cycloolefin copolymer (COC) and polypropylene, provided that the resin has a lower hydrogen peroxide resolution than glass. However, the present invention is not limited to these.

Dosing Nozzle FIG. 2 shows a prefilled syringe 1 with a dosing nozzle 100. The administration nozzle 100 is mounted on the needle mounting section 30 of the prefilled syringe 1. The administration nozzle 100 may be mounted in advance on the needle mounting section 30 of the prefilled syringe 1, or may be included in a kit including the prefilled syringe 1. When the dosing nozzle 100 is pre-mounted on the needle mounting portion 30 of the pre-filled syringe 1, the dosing nozzle 100 (or the pre-filled syringe 1) has a shut-off mechanism that prevents the hydrogen peroxide solution 50 from leaking until the pre-filled syringe 1 is used. Preferably, it is provided.

  The administration nozzle 100 includes a nozzle unit 110 and an adapter unit 120 connected to the nozzle unit 110. The adapter unit 120 is connected to the needle mounting unit 30 of the prefilled syringe 1. The interior of the nozzle 110 is in fluid communication with the interior of the adapter 120.

  The prefilled syringe 1 shown in FIG. 2 includes an administration needle 111 as the nozzle unit 110. As another embodiment, the prefilled syringe 1 includes a spray nozzle 112 as the nozzle unit 110 (FIG. 3). The spray nozzle 112 shown in FIG. 3 is integrally molded in the adapter section 120. In another embodiment, the spray nozzle 112 is detachably attached to the adapter unit 120.

  FIG. 4 is a partially enlarged sectional view of the spray nozzle 112 shown in FIG. The cross-sectional view of FIG. 4 shows a cross section passing through the central axis AA of the prefilled syringe 1 shown in FIG. The spray nozzle 112 includes an outlet 112A, an orifice 112B, and an inlet 112C. The inner diameter of the outlet 112A according to the present embodiment decreases from the outside of the spray nozzle 112 toward the orifice 112B. The inner diameter of the inlet 112C according to the present embodiment decreases from the inside of the spray nozzle 112 toward the orifice 112B. Depending on the desired particle size of the hydrogen peroxide solution 50, the inner diameter of the orifice 112B can vary. The inner diameter of the outlet 112A may be the same as the inner diameter of the orifice 112B, and the inner diameter of the inlet 112C may be the same as the inner diameter of the orifice 112B. The inner diameter of the spray nozzle 112 may be constant.

  The dosing needle 111 may have an echogenic pattern groove formed on the outer surface thereof. The echogenic pattern is not particularly limited as long as the groove pattern improves the visibility of the administration needle 111 even under an ultrasonic image.

Protector FIG. 5 shows a prefilled syringe 1 equipped with a protector 200. The protector 200 can cover the dispensing nozzle 100. The protector 200 may be detachably connected to the adapter section 120 (or the prefilled syringe 1) of the administration nozzle 100 by fitting or screwing. The protector 200 may include a blocking mechanism for preventing the leakage of the hydrogen peroxide solution 50 of the prefilled syringe 1. The blocking mechanism can prevent leakage of the hydrogen peroxide solution 50 of the prefilled syringe 1 by, for example, contacting the inside of the tip of the protector 200 with the tip of the administration nozzle 100.

Movable Protector FIGS. 6 and 7 show a prefilled syringe 1 having a movable protector 300. The movable protector 300 of FIG. 6 protects the nozzle unit 110. The movable protector 300 in FIG. 7 is positioned so as to expose the nozzle portion 110.

  The movable protector 300 includes a support member 320, a nozzle protection portion 310 connected to one end 321 of the support member 320, and an engagement portion 330 connected to the other end 322 of the support member 320. Are connected to the other end 322 of the support member 320 via the movable portion 340. The engagement section 330 is detachably connected to the adapter section 120.

  The nozzle protector 310 of the movable protector 300 has a space in which the nozzle unit 110 of the administration nozzle 100 can be accommodated in the nozzle protector 310. In the present embodiment, the space is the groove 311. The groove 311 is formed in the side wall 314 of the nozzle protection unit 310, the front end 312 of the nozzle protection unit 310 is closed, and the rear end 313 of the nozzle protection unit 310 is open.

  By moving the movable protector 300 in the circumferential direction about the movable portion 340, the movable protector 300 does not physically separate the movable protector 300 from the adapter portion 120, and the nozzle portion 110 of the administration nozzle 100 is connected to the nozzle protection portion 310. Can be exposed from the groove 311 and vice versa.

  The movable protector 300 may include a plurality of support members 320. When the movable protector 300 includes a plurality of support members 320, the support members 320 may be connected to each other via a movable part. The engaging section 330 may be engaged with the adapter section 120 of the administration nozzle 100, or may be engaged with the prefilled syringe 1. In the present embodiment, the movable section 340 is a pivoting section having a shaft, but is not limited to this. The movable section 340 may be a bendable section. When the movable portion 340 is a bent portion, the support member 320 and the engagement portion 330 may be integrally formed.

Elevating Protector FIGS. 8 and 9 show a prefilled syringe 1 having an elevating protector 400. The up-and-down protector 400 shown in FIG. The up-and-down protector 400 in FIG. 9 is positioned so as to expose the nozzle unit 110.

  The liftable protector 400 includes a support member 420, a nozzle protection part 410 connected to one end of the support member 420, and an engagement part 430 connected to the other end of the support member 420. The engagement section 430 is detachably connected to the adapter section 120. The support member 420 includes a first arm 421, a second arm 422, a first movable part 441, a second movable part 442, and a third movable part 443. In the present embodiment, the nozzle protection unit 410 has a hollow structure, and has a space that can accommodate the front end of the nozzle unit 110 from the rear end 413 of the nozzle protection unit 410. When the up / down protector 400 is in the protection mode, the tip of the nozzle unit 110 is housed inside the nozzle protection unit 410. When the up / down protector 400 is in the administration mode, the tip of the nozzle unit 110 projects from the opening 411 of the nozzle protection unit 410. In the present embodiment, the opening 411 has a cross shape, but may have another shape.

  One end 421A of the first arm 421 is movably connected to the nozzle protection section 410 via the first movable section 441. The other end 421B of the first arm 421 is movably connected to one end 422A of the second arm 422 via the second movable portion 442. One end 422B of the second arm 422 is movably connected to the engaging portion 430 via the third movable portion 443.

  By moving each arm in the circumferential direction with respect to the center axis of each movable part so that the second movable part 442 is separated from the administration nozzle 100, the nozzle protection part 410 can be moved in the direction of the adapter part 120. This allows the nozzle section 110 of the administration nozzle 100 to be exposed from the opening section 411 of the nozzle protection section 410 without physically separating the liftable protector 400 from the adapter section 120, and vice versa. is there.

  The number of arms and the number of movable parts can be changed as needed. The length of the arm can be changed according to the length of the nozzle unit 110.

Another Embodiment In another embodiment, the liftable protector 400 includes a rail portion, a nozzle protection portion 410 connected to one end of the rail portion, and a rail holding portion connected to the other end of the rail. The rail holding unit slidably holds the rail unit. The rail holding unit is detachably connected to the adapter unit 120. The opening 411 is provided at the tip of the nozzle protection unit 410. By sliding the nozzle protection section 410 in the longitudinal direction of the prefilled syringe 1, the nozzle section 110 can be housed in or exposed from the opening section 411.

Syringe Pump FIG. 10 shows a prefilled syringe 1 equipped with a syringe pump 500. The syringe pump 500 according to the present embodiment includes a slit 510 into which one end of the flange 90 of the prefilled syringe 1 is inserted, a restraint 520 for fixing the prefilled syringe 1, a movable wall 530 that presses the plunger rod 70 of the prefilled syringe 1, and a monitor. 540, a switch group 550, a processor 560, a memory 561, a pressure sensor 562, a battery 563, and an electric motor 564.

  The monitor 540 and the switch group 550 are provided on a first surface 501A of the syringe pump 500, and the movable wall 530 is provided on a second surface 501B of the syringe pump 500. The second surface 501B of the syringe pump 500 is provided at a position lower than the first surface 501A of the syringe pump 500. First surface 501A of syringe pump 500 is connected to second surface 501B of syringe pump 500 via first wall surface 502A of syringe pump 500. The slit 510 is formed so as to pass through the first surface 501A of the syringe pump 500 and the first wall surface 502A of the syringe pump 500.

  The movable wall 530 is connected to two screw rods 570A and 570B provided on the second surface 501B. As the screw rods 570A, 570B are rotated, for example, by the electric motor 564, the movable wall 530 can move in the direction of pushing the plunger rod 70 of the prefilled syringe 1 (or the opposite direction). The movable wall 530 of the syringe pump 500 is driven electrically, but may be driven mechanically.

  When using the syringe pump 500, one end of the flange 90 of the prefilled syringe 1 is inserted into one of the slits 510. By inserting one end of the flange 90 of the prefilled syringe 1 into the slit 510, the prefilled syringe 1 is prevented from moving in the moving direction of the movable wall 530. An arbitrary slit 510 can be selected according to the length of the prefilled syringe 1.

  The prefilled syringe 1 is further fixed by the restraining device 520. Restrictor 520 is configured to press prefilled syringe 1 against first wall surface 502A and second surface 501B. By fixing the pre-filled syringe 1 using the restraint device 520, the pre-filled syringe 1 is prevented from dropping out of the syringe pump 500.

  The operation of the syringe pump 500 will be described based on FIG. The syringe pump 500 is operated by the electric power of the battery 563. By operating the switch group 550, the operation of the syringe pump 500 can be set. The request from the switch group 550 is processed by the processor 560. The processor 560 can read necessary information (such as a program) from the memory 561 and store the necessary information in the memory 561 on request. The processor 560 can display the processing result on the monitor 540. When operating the syringe pump 500, the processor 560 rotates the electric motor 564 on request. With the information of the pressure sensor 562 connected to the movable wall 530, the processor 560 can stop the electric motor 564.

  The syringe pump 500 can set the flow rate, the administration time, the inner diameter of the syringe, the pressure threshold, and the like, thereby enabling stable administration.

Kit In yet another embodiment,
A hydrogen peroxide solution syringe pre-filled with a hydrogen peroxide solution,
A dosing nozzle,
With
The syringe material of the portion where the syringe and the hydrogen peroxide solution come into direct contact is a cycloolefin polymer (COP) or a cycloolefin copolymer (COC),
A kit is provided, wherein the hydrogen peroxide solution is a solution in which hydrogen peroxide is dissolved in water, and is a solution that can contain an additive as needed.

  The kit includes a prefilled syringe 1 and an administration nozzle 100. The kit may include a plurality of prefilled syringes 1 and a dispensing nozzle 100. The kit may include a protector 200, 300 or 400 covering the administration nozzle 100. The kit may include additional components (eg, instructions or dosing schedules) for treating tumors with radiation or anti-cancer.

  In the present embodiment, the concentration of hydrogen peroxide in the hydrogen peroxide solution in the prefilled syringe is, for example, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.5, 1, 5 , 10, 15, 20, 25, 30, 35 or 40%, and may be in the range between any two of the numerical values exemplified herein, for example, 0.01 to 40% (w / v), Preferably, it is 0.05 to 30% (w / v).

Material The material of the nozzle part 110 can be changed according to the purpose of use and the situation of the present embodiment. When the nozzle 110 is the administration needle 111, the material of the nozzle 110 (that is, the administration needle 111) may be a metal such as stainless steel. The material of the adapter section 120 may be a resin (for example, cycloolefin polymer (COP), cycloolefin copolymer (COC), polypropylene and polycarbonate), metal, rubber or glass. When the nozzle unit 110 is the spray nozzle 112, the material of the nozzle unit 110 (that is, the spray nozzle 112) is resin (for example, cycloolefin polymer (COP), cycloolefin copolymer (COC), polypropylene and polycarbonate), metal, rubber Or it may be glass. When the spray nozzle 112 is formed integrally with the adapter unit 120, the spray nozzle 112 is made of the same material as the adapter unit 120.

  The material of the protector 200 includes, but is not limited to, a resin (for example, cycloolefin polymer (COP), cycloolefin copolymer (COC), polypropylene and polycarbonate), metal, rubber, and glass. The material of the movable protector 300 and the lifting / lowering protector 400 may be the same as the material of the protector 200. The material of the movable parts (the movable part 340, the first movable part 441, the second movable part 442, and the third movable part 443) of the movable protector 300 and the liftable protector 400 depends on the purpose of use and the situation of the present embodiment. The material of the other parts of the movable protector 300 and the liftable protector 400 may be different.

  The housing of the syringe pump 500 may be made of metal or resin (for example, polycarbonate). The material of the movable wall 530 may be the same as or different from the material of the housing of the syringe pump 500. Restraint 520 may be made of metal, rubber, or resin. The screw rods 570A and 570B are preferably made of metal, but may be made of resin.

Stability test of hydrogen peroxide solution The stability test of the hydrogen peroxide solution was performed using a glass syringe, a COP syringe, and a COC syringe. 1 mL of a hydrogen peroxide solution was added to each syringe, sealed, and stored at 60 ° C for 4 weeks. The residual ratio of hydrogen peroxide in the hydrogen peroxide solution after storage was measured. The hydrogen peroxide solution used was oxidol “KENAE” manufactured by Kenei Pharmaceutical Co., Ltd. (containing 2.5 to 3.5 w / v% of hydrogen peroxide, containing phosphoric acid and phenacetin). The amount of hydrogen peroxide in the hydrogen peroxide solution was detected by titration with a potassium permanganate solution according to the oxidol determination method of the Japanese Pharmacopoeia.

  The result is shown in FIG. In the case of glass, the residual ratio of hydrogen peroxide was less than 70%, while the COP and COC were 70% or more. As a result, the COP and COC syringes could suppress the decomposition of hydrogen peroxide more than the glass syringe.

1 Prefilled syringe
10 syringe
20 barrels
30 Needle mount
40 cap
50 Hydrogen peroxide solution
60 gasket
70 plunger rod
80 Rod insertion part
90 flange
100 dosing nozzle
110 Nozzle
111 Dosing needle
112 spray nozzle
112A outlet
112B orifice
112C inlet
120 Adapter
200 protector
300 Movable protector
310 Nozzle protection section
311 groove
312 Tip of nozzle protection section
313 Nozzle protection section rear end
314 Side wall of nozzle protection part
320 support members
321 One end of support member
322 The other end of the support member
330 engaging part
340 Moving parts
400 lifting protector
410 Nozzle protection section
411 opening
412 Tip of nozzle protection part
413 Nozzle protection section rear end
420 support members
421 First arm
421A One end of the first arm
421B The other end of the first arm
422 Second arm
422A One end of the second arm
422B The other end of the second arm
430 engaging part
441 First movable part
442 Second movable part
443 Third movable part
500 syringe pump
First surface of 501A syringe pump
Second surface of 501B syringe pump
502A First wall of syringe pump
510 slit
520 restraint
530 movable wall
540 monitor
550 switch group
560 processor
561 memory
562 pressure sensor
563 battery
564 electric motor
570A, 570B screw rod

Claims (7)

Hydrogen peroxide solution prefilled hydrogen peroxide solution syringe,
The syringe material of the portion where the syringe and the hydrogen peroxide solution come into direct contact is a cycloolefin polymer (COP) or a cycloolefin copolymer (COC),
The hydrogen peroxide solution is a solution obtained by dissolving hydrogen peroxide in water, and if necessary, a solution that can contain additives,
The syringe includes an administration nozzle at a needle mounting portion of the syringe,
The administration nozzle includes an adapter unit and a nozzle unit connected to a needle mounting unit of the syringe,
The nozzle portion is covered with a protector,
The protector includes a support member, a nozzle protection unit connected to one end of the support member, and an engagement unit connected to the other end of the support member,
The engagement portion is movably connected to the other end of the support member via a movable portion,
The movable section includes a rail section connected to the nozzle protection section, and a rail holding section connected to the engagement section.
The rail holding section slidably holds the rail section,
The syringe, wherein the nozzle protection unit includes a space capable of accommodating the nozzle unit.   The syringe according to claim 1, wherein the nozzle unit is a dosing needle or a spray nozzle.   The syringe according to claim 2, wherein the administration needle has an echogenic pattern groove formed on an outer surface thereof. The space is provided inside the nozzle protection unit,
The nozzle protection unit has a hollow structure,
The syringe according to claim 1 . Further comprising a syringe pump, the syringe according to any one of claims 1 to 4. The syringe according to any one of claims 1 to 5 , wherein the concentration of the hydrogen peroxide in the hydrogen peroxide solution is 0.01 to 40% (w / v). A hydrogen peroxide solution syringe pre-filled with a hydrogen peroxide solution,
A dosing nozzle,
A protector for covering the nozzle portion,
With
The syringe material of the portion where the syringe and the hydrogen peroxide solution come into direct contact is a cycloolefin polymer (COP) or a cycloolefin copolymer (COC),
The hydrogen peroxide solution is a solution obtained by dissolving hydrogen peroxide in water, and, if necessary, is a solution that can contain an additive.The protector includes a support member and one end of the support member. A connected nozzle protection portion, and an engagement portion connected to the other end of the support member,
The engagement portion is movably connected to the other end of the support member via a movable portion,
The movable section includes a rail section connected to the nozzle protection section, and a rail holding section connected to the engagement section.
The rail holding section slidably holds the rail section,
The kit, wherein the nozzle protection unit includes a space capable of accommodating the nozzle unit.