JP6626446B2 - 薬学的に適切な芳香族カチオン性ペプチド - Google Patents

薬学的に適切な芳香族カチオン性ペプチド Download PDF

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Publication number
JP6626446B2
JP6626446B2 JP2016542948A JP2016542948A JP6626446B2 JP 6626446 B2 JP6626446 B2 JP 6626446B2 JP 2016542948 A JP2016542948 A JP 2016542948A JP 2016542948 A JP2016542948 A JP 2016542948A JP 6626446 B2 JP6626446 B2 JP 6626446B2
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acid
hexafluorophosphate
compound
hydrogen
formula
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JP2017502956A (ja
JP2017502956A5 (enExample
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ディー トラヴィス ウィルソン
ディー トラヴィス ウィルソン
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ステルス バイオセラピューティックス コープ
ステルス バイオセラピューティックス コープ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2016542948A 2013-12-27 2014-12-23 薬学的に適切な芳香族カチオン性ペプチド Active JP6626446B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361921376P 2013-12-27 2013-12-27
US61/921,376 2013-12-27
US201461947261P 2014-03-03 2014-03-03
US61/947,261 2014-03-03
PCT/US2014/072264 WO2015100376A1 (en) 2013-12-27 2014-12-23 Pharmaceutically relevant aromatic-cationic peptides

Publications (3)

Publication Number Publication Date
JP2017502956A JP2017502956A (ja) 2017-01-26
JP2017502956A5 JP2017502956A5 (enExample) 2018-02-08
JP6626446B2 true JP6626446B2 (ja) 2019-12-25

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JP2016542948A Active JP6626446B2 (ja) 2013-12-27 2014-12-23 薬学的に適切な芳香族カチオン性ペプチド

Country Status (6)

Country Link
US (2) US10221213B2 (enExample)
EP (1) EP3087093B1 (enExample)
JP (1) JP6626446B2 (enExample)
CN (2) CN106132984B (enExample)
CA (1) CA2935207C (enExample)
WO (1) WO2015100376A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015100376A1 (en) * 2013-12-27 2015-07-02 Stealth Peptides International, Inc. Pharmaceutically relevant aromatic-cationic peptides
HUE054626T2 (hu) * 2014-06-25 2021-09-28 Flamma Spa Eljárás D-arginil-2,6-dimetil-L-tirozil-L-lizil-L-fenilalaninamid elõállítására
US10112976B2 (en) 2014-06-30 2018-10-30 Flamma S.P.A. Process for the production of D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
EP3800192A1 (en) * 2015-03-06 2021-04-07 Stealth Biotherapeutics Corp Processes for preparing pharmaceutically relevant peptides
AU2017249218B2 (en) 2016-04-11 2020-08-27 Arcuate Therapeutics, Inc. Chiral peptides
US10961273B2 (en) 2016-08-16 2021-03-30 Stealth Biotherapeutics Corp. N-carboxyanhydride-based-scale synthesis of elamipretide
WO2018187400A1 (en) 2017-04-05 2018-10-11 Stealth Biotherapeutics Corp. Crystalline salt forms of boc-d-arg-dmt-lys-(boc)-phe-nh2
US20200361987A1 (en) * 2017-11-15 2020-11-19 Stealth Biotherapeutics Corp. Deuterated tetrapeptides that target mitochondria
US10676506B2 (en) 2018-01-26 2020-06-09 Stealth Biotherapeutics Corp. Crystalline bis- and tris-hydrochloride salt of elamipretide
CN108929371A (zh) * 2018-08-02 2018-12-04 哈尔滨师范大学 一种Phakellistatin13直链衍生物、其制备办法及用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2067000C1 (ru) 1994-06-29 1996-09-27 Владислав Исакович Дейгин Пептид и способ его получения
US6248716B1 (en) * 1995-06-27 2001-06-19 Immunotech Developments Inc. Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
US20030069231A1 (en) * 1999-10-12 2003-04-10 Klaus Rudolf Modified aminoacids, pharmaceuticals containing these compounds and method for their production
WO2002000263A2 (en) 2000-06-14 2002-01-03 Medarex, Inc. Tripeptide prodrug compounds
JP5374162B2 (ja) 2006-02-22 2013-12-25 エジソン ファーマシューティカルズ， インコーポレイテッド ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節
US20070213505A1 (en) * 2006-03-08 2007-09-13 David Epstein Solution Synthesis of Peptide Cell Growth Stimulators
WO2011116007A1 (en) * 2010-03-15 2011-09-22 Stealth Peptides International, Inc. Combination therapies using cyclosporine and aromatic cationic peptides
CN105126071A (zh) * 2011-06-14 2015-12-09 康肽德生物医药技术有限公司 芳香族阳离子肽及其用途
HK1204988A1 (en) 2012-02-22 2015-12-11 Stealth Peptides International, Inc. Methods and compositions for preventing or treating ophthalmic conditions
EP3459598A1 (en) 2012-12-06 2019-03-27 Stealth Peptides International, Inc. Combinations of peptide therapeutics and methods for using same
WO2015060462A1 (en) 2013-10-23 2015-04-30 Kaneka Corporation Tetrapeptide compound and method for producing same
WO2015100376A1 (en) * 2013-12-27 2015-07-02 Stealth Peptides International, Inc. Pharmaceutically relevant aromatic-cationic peptides
WO2015134096A1 (en) 2014-03-03 2015-09-11 Stealth Peptides International, Inc. Pharmaceutically relevant aromatic-cationic peptides

Also Published As

Publication number Publication date
CA2935207A1 (en) 2015-07-02
CN112457368A (zh) 2021-03-09
US20200024308A1 (en) 2020-01-23
EP3087093A4 (en) 2017-09-27
EP3087093A1 (en) 2016-11-02
JP2017502956A (ja) 2017-01-26
CA2935207C (en) 2022-06-21
CN106132984A (zh) 2016-11-16
EP3087093B1 (en) 2021-11-10
US10221213B2 (en) 2019-03-05
US20160340389A1 (en) 2016-11-24
CN106132984B (zh) 2020-12-08
US10696716B2 (en) 2020-06-30
WO2015100376A1 (en) 2015-07-02

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