JP6618892B2 - 細菌バイオフィルムの遺伝的リプログラミング - Google Patents

細菌バイオフィルムの遺伝的リプログラミング Download PDF

Info

Publication number
JP6618892B2
JP6618892B2 JP2016510750A JP2016510750A JP6618892B2 JP 6618892 B2 JP6618892 B2 JP 6618892B2 JP 2016510750 A JP2016510750 A JP 2016510750A JP 2016510750 A JP2016510750 A JP 2016510750A JP 6618892 B2 JP6618892 B2 JP 6618892B2
Authority
JP
Japan
Prior art keywords
csga
biofilm
curli
polypeptide
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016510750A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016526013A5 (cg-RX-API-DMAC7.html
JP2016526013A (ja
Inventor
ニール サティシュ ジョシ、
ニール サティシュ ジョシ、
ピーター クオック グエン、
ピーター クオック グエン、
ソフィア ボトヤンツキ、
ソフィア ボトヤンツキ、
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of JP2016526013A publication Critical patent/JP2016526013A/ja
Publication of JP2016526013A5 publication Critical patent/JP2016526013A5/ja
Application granted granted Critical
Publication of JP6618892B2 publication Critical patent/JP6618892B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Water Treatment By Sorption (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
JP2016510750A 2013-04-23 2014-04-23 細菌バイオフィルムの遺伝的リプログラミング Active JP6618892B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361814908P 2013-04-23 2013-04-23
US61/814,908 2013-04-23
PCT/US2014/035095 WO2014176311A1 (en) 2013-04-23 2014-04-23 Genetic reprogramming of bacterial biofilms

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018166085A Division JP2019022491A (ja) 2013-04-23 2018-09-05 細菌バイオフィルムの遺伝的リプログラミング

Publications (3)

Publication Number Publication Date
JP2016526013A JP2016526013A (ja) 2016-09-01
JP2016526013A5 JP2016526013A5 (cg-RX-API-DMAC7.html) 2017-06-15
JP6618892B2 true JP6618892B2 (ja) 2019-12-11

Family

ID=51792357

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016510750A Active JP6618892B2 (ja) 2013-04-23 2014-04-23 細菌バイオフィルムの遺伝的リプログラミング
JP2018166085A Pending JP2019022491A (ja) 2013-04-23 2018-09-05 細菌バイオフィルムの遺伝的リプログラミング

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018166085A Pending JP2019022491A (ja) 2013-04-23 2018-09-05 細菌バイオフィルムの遺伝的リプログラミング

Country Status (4)

Country Link
US (3) US9815871B2 (cg-RX-API-DMAC7.html)
EP (1) EP2989122B1 (cg-RX-API-DMAC7.html)
JP (2) JP6618892B2 (cg-RX-API-DMAC7.html)
WO (1) WO2014176311A1 (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9815871B2 (en) 2013-04-23 2017-11-14 President And Fellows Of Harvard College Genetic reprogramming of bacterial biofilms
US20160326220A1 (en) * 2013-12-24 2016-11-10 Vib Vzw Secretion and functional display of chimeric polypeptides
EP3280397A4 (en) * 2015-04-06 2018-08-22 President and Fellows of Harvard College Biosynthetic amyloid-based materials displaying functional protein sequences
US11365225B2 (en) 2015-11-19 2022-06-21 President And Fellows Of Harvard College Method of making recombinant silk and silk-amyloid hybrid proteins using bacteria
US11643443B2 (en) 2015-11-19 2023-05-09 President And Fellows Of Harvard College Electrically conductive protein nanofibers and biofilms
US12351805B2 (en) 2015-11-19 2025-07-08 Northeastern University Method of making recombinant silk and silk-amyloid hybrid proteins using bacteria
US10995114B2 (en) 2016-05-16 2021-05-04 President And Fellows Of Harvard College Scalable production of genetically engineered nanofibrous macroscopic materials via filtration
US11098133B2 (en) 2016-05-19 2021-08-24 President And Fellows Of Harvard College Methods of making gels and films using curli nanofibers
WO2018005493A2 (en) * 2016-06-27 2018-01-04 President And Fellows Of Harvard College Regeneratable curli nanofiber-based catalysts for multistep biotransformations
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
CN107446052A (zh) * 2017-06-09 2017-12-08 上海科技大学 多功能复合超分子纳米纤维自组装体系及其应用
JP2020534261A (ja) 2017-09-08 2020-11-26 ザ ユニバーシティ オブ ブリストル 膜へのタンパク質送達
GB201819850D0 (en) 2018-12-05 2019-01-23 Univ Oxford Innovation Ltd Polypeptide and its use in affinity purification
US20220127317A1 (en) 2019-03-06 2022-04-28 Cytoseek Ltd Antitumor cell comprising a charge modified globin
CN112646800B (zh) * 2019-10-11 2025-10-17 北京科技大学 制备固定化酶或固定化蛋白质的方法以及固定化酶或固定化蛋白质
CN112625991B (zh) * 2020-12-30 2023-05-05 江苏大学 一种具备石墨烯亲和能力的希瓦氏菌及其构建方法与应用
CN112934180B (zh) * 2021-01-26 2022-07-29 中南大学 甘氨酸衍生物-氧化石墨烯复合材料及其制备方法与应用
EP4525615A2 (en) 2022-05-14 2025-03-26 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
CN114934044B (zh) * 2022-05-27 2023-11-10 国网电力科学研究院武汉南瑞有限责任公司 一种重组大肠杆菌在养护铅酸蓄电池中的应用
KR102855274B1 (ko) * 2022-12-06 2025-09-08 충남대학교산학협력단 strep-tag 결합물질에 대한 결합능을 가지는 융합단백질을 암호화하는 유전자 구조물 및 이를 함유하는 발현벡터, 재조합 균주 및 항암 조성물

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5762620A (en) 1992-04-02 1998-06-09 Ndm Acquisition Corp. Wound dressing containing a partially dehydrated hydrogel
US6864365B1 (en) * 1999-04-05 2005-03-08 Innovation And Development Corporation, University Of Victoria Bacterial fimbrial system for presentation of heterologous peptide sequences
US6916789B2 (en) 2001-07-02 2005-07-12 Merrion Research I Limited Peyer's patch and/or M-cell targeting ligands
WO2003068934A2 (en) 2002-02-14 2003-08-21 Rutter William J Chimeric molecules for cleavage in a treated host
DE602004026570D1 (de) 2003-04-30 2010-05-27 Univ Drexel Thermogelierende polymermischungen für biomaterialanwendungen
WO2006096515A2 (en) 2005-03-04 2006-09-14 Biorexis Pharmaceutical Corporation Modified transferrin fusion proteins
CN101605900B (zh) 2007-01-12 2014-04-23 阿克图杰尼斯公司 乳球菌启动子和其用途
JP2009073766A (ja) 2007-09-21 2009-04-09 Otsuka Pharmaceut Co Ltd 医薬
WO2010111516A2 (en) * 2009-03-25 2010-09-30 Whitehead Institute For Biomedical Research Compositions and methods for inhibiting biofilms
US20110033389A1 (en) * 2009-04-29 2011-02-10 Zhifeng Chen Modified antibodies for passive immunotherapy
US20110108199A1 (en) 2009-11-10 2011-05-12 Tyco Healthcare Group Lp Hemostatic Tapes and Dispensers Therefor
JP2013519699A (ja) 2010-02-16 2013-05-30 ノヴォ ノルディスク アー／エス 因子ｖｉｉｉ融合タンパク質
US9526794B2 (en) 2010-03-31 2016-12-27 Wayne State University Injectable dendrimer hydrogel nanoparticles
KR20110111594A (ko) 2010-04-05 2011-10-12 서울대학교산학협력단 알파-시뉴클레인 유래 곱슬 아밀로이드 섬유의 제조방법, 이를 이용한 하이드로젤의 제조 방법 및 그 이용 방법
US8741417B2 (en) 2010-04-16 2014-06-03 Korea University Research And Business Foundation Films having switchable reflectivity
WO2012048289A1 (en) 2010-10-08 2012-04-12 Board Of Regents, The University Of Texas System Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications
US9265842B2 (en) 2010-10-15 2016-02-23 Cornell University Compositions and methods for treating endocrine, gastrointestinal or autoimmune disorders
KR20120060442A (ko) 2010-12-02 2012-06-12 가톨릭대학교 산학협력단 위암 진단용 마커로서 ｔｆｆ2의 용도
US9140698B2 (en) 2011-04-06 2015-09-22 The Board Of Regents Of The University Of Texas System Modulating bacterial MAM polypeptides in pathogenic disease
US9580480B2 (en) * 2011-05-31 2017-02-28 Massachusetts Institute Of Technology Cell-directed synthesis of multifunctional nanopatterns and nanomaterials
WO2013009545A1 (en) 2011-07-08 2013-01-17 Amylin Pharmaceuticals, Inc. Engineered polypeptides having enhanced duration of action with reduced immunogenicity
WO2013020074A2 (en) * 2011-08-03 2013-02-07 Children's Medical Center Corporation A broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin
US9814756B2 (en) 2012-06-15 2017-11-14 Temple University—Of the Commonwealth System of Higher Education Use of isolated bacterial amyloids for treatment of inflammatory disorders or diseases of the epithelium
CN104640561A (zh) 2012-07-23 2015-05-20 酵活有限公司 包含轻链和重链的选择性配对的免疫球蛋白构建体
WO2014078489A1 (en) * 2012-11-16 2014-05-22 President And Fellows Of Harvard College Methods and compositions relating to amyloidogenic polypeptides
HRP20191865T1 (hr) 2013-01-14 2020-01-10 Xencor, Inc. Novi heterodimerni proteini
JP2014156428A (ja) 2013-02-15 2014-08-28 Univ Of Tokyo 抗体結合タンパク質
WO2014139468A1 (en) 2013-03-15 2014-09-18 Admark Healthcare, Llc Fusion protein molecules and method of use
US9815871B2 (en) 2013-04-23 2017-11-14 President And Fellows Of Harvard College Genetic reprogramming of bacterial biofilms
CN105960411A (zh) 2013-11-30 2016-09-21 新加坡科技研究局 自组装肽、肽模拟物和肽缀合物作为构件用于生物制造和打印
US20160326220A1 (en) * 2013-12-24 2016-11-10 Vib Vzw Secretion and functional display of chimeric polypeptides
US20150342893A1 (en) 2014-05-29 2015-12-03 Sigmoid Pharma Limited Celecoxib formulations useful for treating colorectal cancer
EP3280397A4 (en) 2015-04-06 2018-08-22 President and Fellows of Harvard College Biosynthetic amyloid-based materials displaying functional protein sequences
US11098133B2 (en) 2016-05-19 2021-08-24 President And Fellows Of Harvard College Methods of making gels and films using curli nanofibers

Also Published As

Publication number Publication date
US9815871B2 (en) 2017-11-14
JP2016526013A (ja) 2016-09-01
US20200255480A1 (en) 2020-08-13
EP2989122A4 (en) 2016-10-26
JP2019022491A (ja) 2019-02-14
EP2989122A1 (en) 2016-03-02
EP2989122B1 (en) 2019-04-03
US11352397B2 (en) 2022-06-07
WO2014176311A1 (en) 2014-10-30
US20160185828A1 (en) 2016-06-30
US10550160B2 (en) 2020-02-04
US20180186840A1 (en) 2018-07-05

Similar Documents

Publication Publication Date Title
JP6618892B2 (ja) 細菌バイオフィルムの遺伝的リプログラミング
Pohlschroder et al. Archaeal type IV pili and their involvement in biofilm formation
Hall Sedlak et al. Engineered Escherichia coli silver-binding periplasmic protein that promotes silver tolerance
Nguyen et al. Programmable biofilm-based materials from engineered curli nanofibres
Jorgenson et al. The bacterial septal ring protein RlpA is a lytic transglycosylase that contributes to rod shape and daughter cell separation in P seudomonas aeruginosa
Dueholm et al. Expression of Fap amyloids in P seudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation
Esquivel et al. A conserved type IV pilin signal peptide H‐domain is critical for the post‐translational regulation of flagella‐dependent motility
JP7156726B2 (ja) 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料
Chen et al. Enterococcus faecalis PcfC, a spatially localized substrate receptor for type IV secretion of the pCF10 transfer intermediate
Cserti et al. Dynamics of the peptidoglycan biosynthetic machinery in the stalked budding bacterium Hyphomonas neptunium
Thoma et al. The Mth60 fimbriae of Methanothermobacter thermoautotrophicus are functional adhesins
Suh et al. Shiga toxin attacks bacterial ribosomes as effectively as eucaryotic ribosomes
EP3087186A1 (en) Secretion and functional display of chimeric polypeptides
Müller et al. Spore formation in Myxococcus xanthus is tied to cytoskeleton functions and polysaccharide spore coat deposition
JP2014207905A (ja) 膜に提示したタンパク質を特異的に認識するポリペプチドの調製方法
Biswas et al. The antimicrobial activity of the glycocin sublancin is dependent on an active phosphoenolpyruvate-sugar phosphotransferase system
Gambari et al. Control of pellicle biogenesis involves the diguanylate cyclases PdgA and PdgB, the c‐di‐GMP binding protein MxdA and the chemotaxis response regulator CheY3 in Shewanella oneidensis
Guo et al. Rombocin, a short stable natural nisin variant, displays selective antimicrobial activity against Listeria monocytogenes and employs a dual mode of action to kill target bacterial strains
Cengic et al. Surface display of small affinity proteins on Synechocystis sp. strain PCC 6803 mediated by fusion to the major type IV pilin PilA1
Srividhya et al. Sub classification and targeted characterization of prophage-encoded two-component cell lysis cassette
Matilla-Cuenca et al. Bacterial biofilm functionalization through Bap amyloid engineering
KR20230112606A (ko) 신규 박테리아 단백질 섬유
Biedendieck A Bacillus megaterium system for the production of recombinant proteins and protein complexes
Steiner et al. Recombinant glycans on an S‐layer self‐assembly protein: a new dimension for nanopatterned biomaterials
Guo et al. Molecular cloning, expression and adhesion analysis of silent slpB of Lactobacillus acidophilus NCFM

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170421

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170421

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180228

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180306

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180606

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180905

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190219

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190520

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20191023

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20191113

R150 Certificate of patent or registration of utility model

Ref document number: 6618892

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250