JP6611358B2 - 癌治療のためのｆａｓｎ阻害剤として有用なベンズアミド誘導体 - Google Patents

癌治療のためのｆａｓｎ阻害剤として有用なベンズアミド誘導体 Download PDF

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JP6611358B2
JP6611358B2 JP2016536232A JP2016536232A JP6611358B2 JP 6611358 B2 JP6611358 B2 JP 6611358B2 JP 2016536232 A JP2016536232 A JP 2016536232A JP 2016536232 A JP2016536232 A JP 2016536232A JP 6611358 B2 JP6611358 B2 JP 6611358B2
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methyl
phenyl
pyridin
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JP2016539146A (ja
JP2016539146A5 (enExample
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ジェイ． コノリー，ピーター
ル，ティアンバオ
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ヤンセン ファーマシューティカ エヌ．ベー．
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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JP2016536232A 2013-12-03 2014-11-21 癌治療のためのｆａｓｎ阻害剤として有用なベンズアミド誘導体 Expired - Fee Related JP6611358B2 (ja)

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US201361911016P 2013-12-03 2013-12-03
US61/911,016 2013-12-03
PCT/US2014/066743 WO2015084606A1 (en) 2013-12-03 2014-11-21 Benzamide derivative useful as fasn inhibitors for the treatment of cancer

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JP2016539146A JP2016539146A (ja) 2016-12-15
JP2016539146A5 JP2016539146A5 (enExample) 2019-03-07
JP6611358B2 true JP6611358B2 (ja) 2019-11-27

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US (1) US9562035B2 (enExample)
EP (1) EP3077387B1 (enExample)
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WO (1) WO2015084606A1 (enExample)

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US11202795B2 (en) 2014-11-20 2021-12-21 Vib Vzw Means and methods for treatment of early-onset Parkinson's disease
EP3310773B1 (en) 2015-06-18 2020-12-02 89Bio Ltd. Substituted 4-benzyl and 4-benzoyl piperidine derivatives
CN107847765B (zh) 2015-06-18 2021-05-04 89生物有限公司 1,4-取代的哌啶衍生物
CN105175284B (zh) * 2015-07-21 2017-06-16 中国药科大学 酰胺类化合物、制备方法及其医药用途
DK3458448T3 (da) * 2016-04-25 2021-08-23 Forma Therapeutics Inc Fasn-inhibitorer til anvendelse til behandling af non-alkoholisk steatohepatitis
CA3043308A1 (en) * 2016-11-11 2018-05-17 3-V Biosciences, Inc. Heterocyclic modulators of lipid synthesis
EP3636637A1 (en) * 2018-10-10 2020-04-15 Forma Therapeutics, Inc. Inhibiting fatty acid synthase (fasn)
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
CN109369634B (zh) * 2018-12-19 2021-07-27 陕西国际商贸学院 具有抗肿瘤活性的2-甲氧基烟酰胺衍生物制备方法及用途
CN111777593B (zh) * 2019-04-03 2024-07-23 南京天印健华医药科技有限公司 作为转染期间重排激酶抑制剂的新的化合物
EP4096661B1 (en) * 2020-01-29 2025-04-02 Kamari Pharma Ltd. Compounds and compositions for use in treating skin disorders
WO2022087422A1 (en) * 2020-10-22 2022-04-28 Chulalongkorn University Pyrrolidine-3-carboxamide derivatives and related uses
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008059214A1 (en) * 2006-11-13 2008-05-22 Astrazeneca Ab Bisamlde derivatives and use thereof as fatty acid synthase inhibitors
TW200833663A (en) * 2006-12-21 2008-08-16 Astrazeneca Ab Therapeutic agents
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