JP6598744B2 - Dentifrice composition - Google Patents

Description

  The present invention relates to a dentifrice composition.

  Oil-soluble medicinal ingredients and fragrances used in dentifrice compositions have low solubility in the composition and have a problem in stability. Further, when the blending amount of these oil-soluble components is increased, the feeling of use becomes greasy or the flavor is lowered. Therefore, many studies have been made to improve these.

  For example, Patent Document 1 discloses an oil-soluble medicinal component by adding a specific fragrance component such as origanum oil and thyme oil to a dentifrice composition containing glycyrrhetinic acid and a fragrance such as menthol, anethole, and cineole. It is disclosed that the stability of certain glycyrrhetinic acids is improved. Patent Document 2 describes the retention and storage stability of the antiplasmin agent in the oral cavity by blending a dentifrice composition containing an antiplasmin agent with a specific perfume component such as anetol and menthol together with a wax. Is disclosed to improve. Patent Document 3 shows excellent medicinal effects by blending a toothpaste composition containing a poorly water-soluble active ingredient such as tocopherol and glycyrrhetinic acid with an oil-soluble ingredient such as a surfactant and non-terpene cut peppermint oil. It is described that the storage stability and the feeling of use are improved. In Patent Document 4, calcium hydrogen phosphate is added to an oral composition containing a large amount of oily components containing a poorly water-soluble active ingredient such as glycyrrhetinic acid and an oily base such as hydrocarbon and higher alcohol. Thus, it is described that stickiness is suppressed and appearance stability is improved.

JP 62-155207 A JP 2002-20250 A JP 2007-45786 A JP 2011-144160 A

  However, the combination of the oil-soluble active ingredient and the specific fragrance disclosed in Patent Documents 1 to 3 is not sufficient for obtaining a flavor, although the formulation can be stabilized. Moreover, in patent document 4, although the stickiness of an oil-based component can be improved, there is no mention about the flavor standing by containing a large amount of an oil-based component, and it cannot be said that it is enough.

  Therefore, the present invention provides a dentifrice composition that exhibits a good flavor when used even when a large amount of oily ingredients such as oil-soluble medicinal ingredients are blended, and at the same time, can effectively enhance the cool feeling. About.

  As a result of examining the fragrance of a dentifrice containing a large amount of oily components such as oil-soluble medicinal ingredients, the present inventors have found that in a dentifrice composition that forms an α-gel structure containing a specific long-chain alcohol, It has been found that the perfume component effectively increases the amount of the oil-soluble active ingredient adsorbed to the gums and oral mucosa while imparting excellent flavor and feeling of use.

That is, the present invention includes the following components (A), (B), (C), (D) and (E):
(A) A fragrance composition comprising 30% by mass or more of a fragrance compound (a1) having a Hansen solubility parameter distance with cetanol of 4.1 to 10 in the fragrance composition,
(B) menthol,
(C) a higher alcohol having 12 to 22 carbon atoms, including at least cetanol (c1) and stearyl alcohol (c2),
(D) selected from at least a nonionic surfactant (d1) selected from sorbitan fatty acid ester and polyoxyethylene sorbitan fatty acid ester, and an anionic surfactant (d2) which is a fatty acid having 12 to 22 carbon atoms or a salt thereof. A surfactant containing one or more,
(E) It contains water, the content of component (A) is 0.05 to 2.5% by mass in the dentifrice, and the content of component (B) is 0.1% by mass in the dentifrice. 1 mass% or less, content of component (C) is 4 mass% or more and 30 mass% or less in dentifrice, and content of component (D) is 0.1 mass% or more and 10 mass% or less in dentifrice. And it is related with the dentifrice composition whose mass ratio ((A) / (B)) of a component (A) and a component (B) is 0.8 or more and 5 or less.

  According to the dentifrice composition of the present invention, while the oil-soluble active ingredient is stably embedded in the α-gel structure, the adsorbing performance is improved while giving an excellent flavor and feeling of use, and the gums and oral cavity are improved. The amount of adsorption to the inner mucous membrane can be effectively increased.

In the dentifrice composition of the present invention, as a component (A), a fragrance compound (a1) having a Hansen solubility parameter distance with cetanol of 4.1 or more and 10 or less is 30% by mass (hereinafter referred to as “%”) in the fragrance composition. And a perfume composition containing the above.
Here, the Hansen solubility parameter (hereinafter sometimes referred to as “HSP”) includes three types of energy terms (unit: MPa ^0.5 ), dispersion term (dD), and polarization term (dP) constituting the dispersed state of the substance. ), A value expressed as a point in the three-dimensional coordinate space using the hydrogen bond term (dH), and the HSP distance is expressed in two types when the HSP of each compound is expressed as a vector in the three-dimensional coordinate space. The HSP distance Ra can be obtained by the following equation.
(Ra) ² = 4 (δd2−δd1) ² + (δp2−δp1) ² + (δh2−δh1) ²
The shorter the HSP distance, the higher the compatibility of the compound. In addition, since the HSP distance between cetanol and stearyl alcohol is close, cetanol is used as a reference in the present invention.

Component (A) The content of (a1) in the fragrance composition is 30% or more in the fragrance composition, but it is preferably 40% or more, more preferably from the viewpoint of good flavor standing and a cool feeling. Is 45% or more. Moreover, from the point which obtains the freedom degree of flavor, Preferably it is 95% or less, More preferably, it is 80% or less, More preferably, it is 70% or less.
It is preferable that 30 to 95% of (a1) is contained in the component (A) fragrance composition.

  Examples of the fragrance compound (a1) include eugenol, acetyl eugenol, methyl eugenol, anethole, thymol, carvacrol, camphor, camphene, pulegone, β-cubeben, α-patuolene, p-cymene, α-pinene, β-pinene. , Sabinene, linalool, terpinen-4-ol, terpinen-1-ol, α-terpineol, cis-3-hexenol, phenylethyl alcohol, cinnamic aldehyde, cinnamic alcohol, anisaldehyde, anis alcohol, benzyl benzoate, etc. It is done. Table 1 shows the values of the HSP distance of these fragrance compounds (a1).

In the fragrance composition of component (A), as a fragrance component other than (a1), a fragrance compound (a2) having an HSP distance of less than 4.1 from cetanol from the viewpoint of strongly perceiving flavor and maintaining a cool feeling It is preferable to contain. Examples of the fragrance compound (a2) include cinnamyl acetate, linalyl acetate, α-terpinyl acetate, menthyl acetate, cis-3-hexenylhexanoate, 1,8-cineole, mentfuran, fenquil alcohol, guaiol, patchouli alcohol, menthone, isomenthone, alpha-ionone, beta-ionone, Mechiruheputano emissions, alpha - caryophyllene, beta-caryophyllene, n- caryophyllene oxide, alpha-farnesene, beta-elementary, beta-phellandrene, beta-bisabolene, limonene, .gamma.-terpinene, alpha-terpinolene, alpha-terpinene, myrcene, beta-ocimene, .delta. Guaien, Jingibere emissions, and the like.
Among these, the preferred perfume compound (a2) and the value of its HSP distance are shown together in Table 2.

The content of the component (a2) is preferably 4% or more and 70% or less in the fragrance composition.
Moreover, the mass ratio ((a1) / (a2)) of the component (a1) and the component (a2) in the fragrance composition is preferably 0.4 or more and 20 or less, from the viewpoint of strongly perceiving the flavor. Preferably they are 1.2 or more and 10 or less.

  Furthermore, the fragrance | flavor composition of a component (A) may contain the HSP distance with cetanol exceeding 10 as other fragrance | flavor compounds other than said (a1) and (a2). Examples of such a compound include vanillin and ethyl maltol. The content of other fragrance compounds in the fragrance composition is preferably 5% or less from the viewpoint of good flavor.

The content of the component (A) is 0.05% or more and 2.5% or less in the dentifrice, but is preferably 0.1% or more, more preferably 0.3%, from the viewpoint of strongly perceiving the flavor. More preferably, it is 0.7% or more. Moreover, it is preferably 2% or less, more preferably 1.8% or less, and still more preferably 1.3% or less, from the viewpoint of enhancing the cool feeling and improving the aftertaste.
In addition, various essential oils can also be used as a component (A) fragrance | flavor composition. When using essential oil, what is necessary is just to convert HSP of each fragrance | flavor compound contained in essential oil.

The dentifrice composition of the present invention contains menthol as a cooling sensation agent as component (B) in an amount of 0.1% to 1.5%. The content of menthol is preferably 0.3% or more, more preferably 0.5% or more, from the viewpoint of imparting a cool feeling and improving flavor standing, and also the flavor standing and stability of the formulation. From the viewpoint of balancing, it is preferably 1.1% or less, more preferably 0.8% or less. In the present invention, menthol is not included in the fragrance compound of component (A).
Moreover, although mass ratio ((A) / (B)) of a component (A) and a component (B) is 0.8 or more and 5 or less, From a viewpoint of making the outstanding flavor standing and a cool feeling compatible, Preferably It is 0.9 or more, and preferably 4.3 or less from the viewpoint of sustaining the cool feeling.

  The dentifrice composition of the present invention contains 4% or more and 30% or less of a higher alcohol having 12 to 22 carbon atoms including at least cetanol (c1) and stearyl alcohol (c2) as the component (C). That is, the component (C) contains cetanol and stearyl alcohol as essential components. By containing such component (C), together with component (D) and component (F) described later, an α-gel having a lamellar structure is formed, and the oily component is well embedded, while the gums and oral mucosa Adsorption performance can be effectively increased.

  The mass ratio ((c1) / (c2)) of the content of cetanol (c1) and the content of stearyl alcohol (c2) ((c1) / (c2)) is excellent in storage stability as a dentifrice composition while forming an α-gel. From the viewpoint of improving, preferably 0.5 or more, more preferably 0.7 or more. From the same viewpoint, it is preferably 5 or less, more preferably 3 or less, still more preferably 2 or less, and still more preferably 1.7 or less.

  From the viewpoint of maintaining an appropriate viscosity as a dentifrice composition while forming an α-gel well, the higher alcohol of component (C) is a total amount of cetanol content and stearyl alcohol content, The mass ratio (((c1) + (c2)) / (C)) to the content of (C) is preferably 0.85 or more, more preferably 0.9 or more, and further preferably 0. .92 or more and 1 or less.

  The component (C) other than cetanol and stearyl alcohol is preferably one or more selected from lauryl alcohol, myristyl alcohol, and behenyl alcohol, and more preferably selected from lauryl alcohol and myristyl alcohol. preferable. From the viewpoint of taste, lauryl alcohol and myristyl alcohol have a mass ratio of the total content of lauryl alcohol and myristyl alcohol to the content of component (C) ((lauryl alcohol + myristyl alcohol) / (C )) Is preferably 0.05 or less, more preferably 0.03 or less, and still more preferably 0.01 or less. On the other hand, behenyl alcohol has a mass ratio (behenyl alcohol / (C)) between the content of behenyl alcohol and the content of component (C), preferably 0.1 or less, from the viewpoint of suppressing the precipitation and separation of component (C). More preferably, it is 0.05 or less.

From the viewpoint of storage stability, the higher alcohol having 10 or less carbon atoms is a mass ratio of the content of higher alcohol having 10 or less carbon atoms and the content of component (C) (higher alcohol having 10 or less carbon atoms / (C). ) Is preferably 0.1 or less, more preferably 0.01 or less, even more preferably 0.005 or less, or the dentifrice composition of the present invention contains a higher alcohol having 10 or less carbon atoms. Even more preferably not.
Further, from the viewpoint of storage stability, the higher alcohol having 24 or more carbon atoms is a mass ratio of the content of higher alcohol having 24 or more carbon atoms and the content of component (C) (higher alcohol having 24 or more carbon atoms / ( C)) is preferably 0.1 or less, more preferably 0.01 or less, even more preferably 0.005 or less. Alternatively, the dentifrice composition of the present invention has a high carbon number of 24 or more. Even more preferably, no alcohol is contained.

  The content of the component (C) higher alcohol is 4% or more and 30% or less in the dentifrice of the present invention, and is preferably 4.5% or more from the viewpoint of favorably forming an α-gel. Further, from the viewpoint of obtaining an appropriate viscosity and ensuring the dispersibility of each component in the composition, it is preferably 25% or less, more preferably 20% or less, and even more preferably 18% or less. It is. The content of the component (C) is 4% to 30% in the dentifrice of the present invention, preferably 4% to 25%, more preferably 4% to 20%. More preferably 4.5% or more and 18% or less.

The dentifrice composition of the present invention is a nonionic surfactant (d1) selected from a sorbitan fatty acid ester and a polyoxyethylene sorbitan fatty acid ester as a component (D), and an anionic surfactant that is a fatty acid salt having 12 to 22 carbon atoms. The dentifrice contains 0.1% or more and 10% or less of at least one surfactant selected from the agent (d2).
Thus, by using one or more selected from (d1) nonionic surfactant and (d2) anionic surfactant, an α-gel is formed together with the above component (C) higher alcohol, which is good It can give a strong flavor and a cool feeling.

  Among (d1), the sorbitan fatty acid ester is preferably derived from a fatty acid having 10 or more carbon atoms, more preferably derived from a fatty acid having 12 or more carbon atoms, and preferably derived from a fatty acid having 20 or less carbon atoms. More preferably, one or two or more types selected from those derived from fatty acids having 18 or less carbon atoms can be mentioned. Specifically, for example, sorbitan monocaprate, sorbitan monoundecylate, sorbitan monolaurate, sorbitan monotridecylate, sorbitan monomyristate, sorbitan monopalmitate, sorbitan monooleate, sorbitan trioleate, sorbitan tetraoleate, sesquioxane Examples thereof include one or more selected from sorbitan oleate, sorbitan monostearate, sorbitan tristearate, and the like. Among these, one or more selected from sorbitan monopalmitate, sorbitan monooleate, sorbitan sesquioleate, and sorbitan monostearate are preferable.

  The polyoxyethylene sorbitan fatty acid ester is preferably derived from a fatty acid having 6 or more carbon atoms, more preferably derived from a fatty acid having 12 or more carbon atoms, and preferably derived from a fatty acid having 22 or less carbon atoms. Yes, more preferably one or two or more selected from those derived from fatty acids having 20 or less carbon atoms. Moreover, the average addition mole number of the ethyleneoxy group in polyoxyethylene sorbitan fatty acid ester is from the same viewpoint, Preferably it is 5-40 mol, More preferably, it is 10-25 mol, More preferably, it is 10-20 mol It is. Examples of such polyoxyethylene sorbitan fatty acid esters include polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monomyristic acid, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, and polyoxyethylene monooleate 1 type (s) or 2 or more types chosen from sorbitan etc. are mentioned. Among these, from the viewpoint of enhancing low-temperature stability while exhibiting excellent foamability, one or two selected from polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate and polyoxyethylene sorbitan monooleate More than species are preferred.

(D2) The anionic surfactant is a fatty acid having 12 to 22 carbon atoms or a salt thereof. (D2) is carbon number 12 or more from a viewpoint of ensuring a favorable flavor, Preferably it is carbon number 14 or more, More preferably, it is 16 or more, It is carbon number 22 or less, Preferably carbon The number is 20 or less, more preferably 18 or less. The fatty acid constituting (d2) is preferably a straight chain. Specific examples of such fatty acids include one or more selected from lauric acid, myristic acid, palmitic acid, stearic acid, coconut oil fatty acid, and salts thereof. Especially, 1 type (s) or 2 or more types chosen from myristic acid, palmitic acid, a stearic acid, and these salts are preferable, and it is still more preferable to contain a stearic acid or its salt.
Examples of the salt constituting (d2) include alkali metals selected from sodium and potassium; basic amino acids such as arginine; alkanol ammoniums such as monoethanolammonium, diethanolammonium and triethanolammonium; ammonium and the like. Especially, as a salt which comprises a component (d2), the alkali metal chosen from sodium and potassium is preferable from a stability viewpoint of a composition.

  The content of (d1) is preferably 0.1% or more, more preferably 0 in the dentifrice of the present invention from the viewpoint of forming an α-gel together with the component (C) and imparting a good flavor. .2% or more, more preferably 0.4% or more, and further preferably 0.5% or more. Moreover, from the viewpoint of ensuring the stability of the composition and from the viewpoint of balance with an appropriate viscosity and flavor, it is preferably 10% or less, more preferably 8% or less, and further preferably 6% or less. .

  The content of (d2) is an amount of fatty acid, preferably 0.05% or more, in the dentifrice of the present invention from the viewpoint of forming an α-gel together with the component (C) and imparting an appropriate viscosity. More preferably 0.08% or more, further preferably 0.1% or more, more preferably 0.2% or more, and preferably 1% by mass or more from the viewpoint of shape retention. is there. Further, from the viewpoint of reducing the stability of the composition, the appropriate viscosity, the balance with the flavor, and the harm to the mucous membrane in the oral cavity, the amount of the fatty acid equivalent in the dentifrice of the present invention is preferably 5% or less. More preferably 3% or less, still more preferably 2.5% or less, still more preferably 2% or less, and still more preferably 0.5% or less from the viewpoint of improving the flavor. More preferably, it is 0.2% or less.

  The content of (d1) and the total amount of fatty acid equivalents of (d2) form an α-gel together with the component (C), and preferably 0 in the dentifrice of the present invention from the viewpoint of good flavor. 0.1% or more, more preferably 0.2% or more, and further preferably 0.5% or more. Further, from the viewpoint of securing the stability of the composition and from the viewpoint of a balance with appropriate viscosity and flavor, it is preferably 10% or less, more preferably 8% or less, and even more preferably 6.5% or less. is there.

  The dentifrice composition of the present invention preferably contains at least the component (d1), and more preferably contains both (d1) and (d2).

  In addition to (d1) and (d2) above, component (D) is a nonionic surfactant (d3) selected from polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, and polyglycerin fatty acid ester, and sodium alkyl sulfate. And an anionic surfactant (d4) selected from acylmethyl taurine salts and acyl sarcosine salts.

Of (d3), the average number of moles of ethyleneoxy group added in the polyoxyethylene hydrogenated castor oil is preferably 20 to 100 moles, more preferably 40 to 80 moles from the viewpoint of ensuring the stability of the composition. It is.
Examples of the polyglycerin fatty acid ester include polyglycerin in which 2 to 20 glycerins are condensed and 1 to 4 fatty acids having 8 to 24 carbon atoms ester-bonded. In particular, those derived from fatty acids having 12 to 20 carbon atoms are preferred, those derived from fatty acids having 12 to 18 carbon atoms are more preferred, those derived from fatty acids having 12 to 14 carbon atoms are further preferred, It is preferable that it is a monoester comprised from the fatty acid part. Moreover, from the same viewpoint, the average degree of condensation of glycerin in the polyglycerin fatty acid ester is preferably 2 to 20, and more preferably 5 to 12. Among (d3), examples of sucrose fatty acid esters include sucrose fatty acid esters composed of fatty acid moieties derived from fatty acids having 6 to 20 carbon atoms. As a fatty-acid part, the thing derived from a C10-C18 fatty acid is preferable, and the thing derived from a C12-C14 fatty acid is more preferable.
When (d3) is contained in component (D), the content of (d3) is preferably 0.5% or less, more preferably 0.25% or less in the dentifrice composition of the present invention. Yes, more preferably 0.2% or less, even more preferably 0.1% or less, and even more preferably 0.05% or less.

(1) One or more anionic surfactants selected from alkyl sulfates, acylmethyl taurate salts, and acyl sarcosine salts of (d4) include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate; N-lauroyl Sodium or potassium salts of acyl sarcosine such as sarcosine, N-myristoyl sarcosine, N-palmitoyl sarcosine, N-stearoyl sarcosine, N-isostearoyl sarcosine, N-oleoyl sarcosine; caprylmethyl taurine, laurylmethyl taurine, myristylmethyl taurine , One or more selected from sodium or potassium salts of acylmethyltaurine such as palmitylmethyltaurine and stearylmethyltaurine. Among these, one or more selected from sodium lauryl sulfate, N-lauroyl sarcosine salt, N-myristoyl sarcosine salt, lauryl methyl taurine salt, and myristyl methyl taurine salt are preferable, and sodium lauryl sulfate is more preferable.
When the component (D) contains (d4), the content of (d4) is preferably 2 in the dentifrice composition of the present invention from the viewpoint of harmfulness to the gums and oral mucosa and flavor. % Or less, more preferably 1.5% or less, still more preferably 1% or less, and even more preferably 0.7% or less.

  Content of a component (D) is 0.1% or more in the dentifrice composition of this invention from a viewpoint which forms alpha gel with a component (C), and provides a favorable flavor standing and a cool feeling. Thus, it is preferably 0.2% or more, more preferably 0.3% or more, and further preferably 0.4% or more. Further, from the viewpoint of ensuring the stability of the composition and the balance with appropriate viscosity and flavor, the dentifrice of the present invention is 10% or less, preferably 9% or less, more preferably It is 8% or less, more preferably 7% or less.

The mass ratio ((C) / (d1)) between the content of the component (C) and the content of the component (d1) nonionic surfactant is preferably from the viewpoint of forming an α-gel. It is 1 or more, More preferably, it is 1.2 or more, More preferably, it is 1.4 or more. Moreover, from a viewpoint of maintenance of moderate viscosity and stability, Preferably it is 20 or less, More preferably, it is 17 or less, More preferably, it is 15 or less.
The mass ratio ((C) / (d2)) between the content of the component (C) and the content of the component (d2) anionic surfactant is preferably 3 or more from the viewpoint of satisfactorily forming an α-gel. More preferably, it is 5 or more, more preferably 7 or more, and still more preferably 10 or more. Further, from the viewpoint of ensuring stability while maintaining an appropriate viscosity and imparting a good feeling of use, it is preferably 200 or less, and more preferably 180 or less.

  In the dentifrice of the present invention, the mass ratio ((C) / ((d1) + (d2)) of the content of component (C) and the total amount of fatty acid equivalents of component (d1) and component (d2) ) Is preferably larger than 1, more preferably 1.2 or more, and even more preferably 1.5 or more, from the viewpoint of forming an α-gel well to enhance good flavor standing and cooling feeling. Further, from the viewpoint of ensuring the stability of the composition while maintaining an appropriate viscosity and imparting a clear cooling feeling, it is preferably 40 or less, more preferably 35 or less, and even more preferably 30 or less. is there.

  The dentifrice of this invention contains the water of a component (E). The water of component (E) in the present invention includes not only purified water directly blended into the dentifrice composition, but also water contained in other components blended into the dentifrice. For example, when the component to be blended contains moisture such as 70% sorbitol solution (aqueous solution) and 48% potassium hydroxide solution (aqueous solution), these moistures also mean moisture contained in the dentifrice. By containing the water of this component (E), while ensuring the moderate viscosity and good shape-retaining property as a dentifrice composition, each holding | maintaining the α-gel formed in a composition favorably The components can be well dispersed or dissolved. The content of component (E) in the dentifrice composition of the present invention is preferably 30% or more, more preferably 40% or more, still more preferably 50% or more, more preferably 55%. That's it. Moreover, it is preferably 95% or less, and more preferably 92% or less. The content of component (E) is preferably 50% or more and 95% or less in the dentifrice composition.

  The content of the component (E) of the dentifrice composition of the present invention, that is, the water content can be calculated from the blended water content and the water content in the blended component by calculation. For example, the Karl Fischer moisture meter Can be measured. As the Karl Fischer moisture meter, for example, a trace moisture measuring device (Hiranuma Sangyo) can be used. In this apparatus, 5 g of the dentifrice composition can be taken and suspended in 25 g of anhydrous methanol, and 0.02 g of this suspension can be collected to measure the amount of water.

  In addition, the dentifrice composition of the present invention preferably has a content of ethanol of 8% or less in the dentifrice composition from the viewpoint of suppressing the degradation of α-gel and maintaining an appropriate viscosity. 5% or less is more preferable, and 2% or less is more preferable.

  The dentifrice composition of the present invention can contain one or more oil-soluble medicinal ingredients selected from glycyrrhetinic acid, tocopherol, and tocopherol derivatives as the component (F). The combination of these medicinal ingredients can provide anti-inflammatory action, alveolar bone resorption suppression action, histamine release suppression action, blood circulation promotion action, etc., and can also provide prevention and improvement action for periodontitis, periodontal disease, etc. it can.

Examples of glycyrrhetinic acid include α-glycyrrhetinic acid, β-glycyrrhetinic acid, glycyrrhizic acid and the like. Of these, β-glycyrrhetinic acid is preferred. Examples of tocopherol and derivatives thereof include tocopherol acetate, tocopherol succinate, tocopherol nicotinate and the like. Of these, tocopherol acetate is preferable, and acetic acid-DL-α-tocopherol is more preferable.
The content of the component (F) is preferably 0.01% or more, more preferably 0.02% or more, more preferably 0.02% or more in the dentifrice composition from the viewpoint of effectively exerting a desired pharmacological action. It is 0.05% or more, More preferably, it is 0.08% or more. Further, from the viewpoint of ensuring a good flavor, it is preferably 2.5% or less, more preferably 2.3% or less, more preferably 1.5% or less, and even more preferably 1% or less. More preferably 0.5% or less, and still more preferably 0.3% or less.

Furthermore, the dentifrice composition of the present invention preferably contains a cationic bactericidal agent from the viewpoint of enhancing the adsorption performance of the component (F) to the gums and oral mucosa in the α-gel. Cationic fungicides include cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, stearyldimethylammonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, methylbenzethonium chloride, lauryltrimethylammonium chloride, and lauroylcoraminoformylmethyl chloride A quaternary ammonium compound selected from pyridinium is preferred.
The content of the cationic fungicide is preferably 0.005% or more in the dentifrice composition from the viewpoint of enhancing the adsorption performance of the component (F) to the gums and oral mucosa, and more preferably 0.005%. From the viewpoint of flavor and irritation, it is preferably 0.1% or less, more preferably 0.08% or less, and still more preferably 0.8% or more. It is 06% or less.

  Furthermore, in the dentifrice composition of the present invention, the content of the oil agent (G) other than the components (A), (B), (C) and (F) and the content of the component (C) higher alcohol The mass ratio ((G) / (C)) is preferably less than 1, more preferably 0.5 or less, and further preferably 0.3 or less. In the dentifrice composition of the present invention, by restricting the content of the oil (G) to the higher alcohol of the component (C) that forms the α-gel, the formation inhibition of the α-gel is sufficiently suppressed. This can improve the stability and improve the flavor. Examples of the component (G) include hydrocarbon oils such as liquid paraffin, petrolatum, mineral oil, light liquid paraffin, paraffin wax, ceresin, microcrystalline wax, carnauba wax, beeswax, squalane and squalene; isopropyl myristate, palmitic acid Ester oil such as isopropyl acid, propyl adipate, diethyl sebacate, glycerin fatty acid ester, etc. Triglyceride and vegetable oils including olive oil, rapeseed oil, shea fat, rice bran oil containing this; silicone oil; methyl paraoxybenzoate, ethyl paraoxybenzoate, etc. Antiseptics; oil-soluble disinfectants and the like. The content of component (G) is preferably 5% or less, more preferably 2% or less, still more preferably 1% or less, and even more preferably 0.5% in the dentifrice composition. It is as follows.

  Moreover, it is preferable that the dentifrice composition of this invention contains sugar alcohol from a viewpoint of flavor. As the sugar alcohol, one or more selected from sorbitol, xylitol, erythritol, reduced palatinose, and mannitol are preferable. From the viewpoint of high solubility in water and making the composition have a smooth feel, And one or two selected from xylitol are more preferable. The content of the sugar alcohol is preferably 30% or less, more preferably 20% or less, still more preferably 15% or less, preferably 1% or more, more preferably 2 from the viewpoint of flavor. % Or more, more preferably 5% or more.

  Moreover, it is preferable that the dentifrice composition of this invention sets content of the abrasive | polishing agent (abrasive powder) containing a polyvalent metal to 5% or less from a viewpoint which suppresses that alpha-gel disintegrates. Examples of the polyvalent metal include aluminum, calcium, zirconium, iron, copper, zinc, and manganese. Examples of the abrasive powder include water-insoluble calcium compounds such as calcium carbonate, calcium hydrogen phosphate, insoluble potassium metaphosphate, Examples include aluminum silicate, zirconium silicate, aluminum oxide, aluminum hydroxide, and zinc oxide.

  The dentifrice of the present invention is a binder, specifically, sodium alginate, carrageenan, xanthan gum, sodium polyacrylate, pectin, agar, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gela gum, tamarid gum , Psyllium seed gum, carboxyvinyl polymer, or the like. The content of the binder is preferably 0.5% or less. Among these, from the viewpoint of maintaining an appropriate viscosity and shape retention of the composition forming the α-gel, a cellulose-based binder, such as sodium carboxymethyl cellulose, hydroxyalkyl cellulose (for example, hydroxyethyl cellulose, hydroxypropyl cellulose) The content of such as is preferably 0.3% or less, and more preferably not contained.

  The dentifrice composition of the present invention preferably contains a thickener from the viewpoint of enhancing the viscoelasticity of the binder. As the thickener, one or two kinds selected from thickened silica having an oil absorption of 180 to 350 mL / 100 g and fatty acid dextrin are preferable, and the content of the thickener is preferably 3% or less.

  The dentifrice composition of the present invention can contain a polyhydric alcohol, a sweetener, a wetting agent, a preservative, a fluoride, an enzyme, a pigment, etc., in addition to the above components, as long as the effects of the present invention are not impaired. .

  The viscosity (20 ° C.) of the dentifrice composition of the present invention is preferably 5000 dPa · s or less, more preferably 4000 dPa · s or less, and still more preferably, from the viewpoint of ensuring good shape retention and usability. Is 3800 dPa · s or less, preferably 300 dPa · s or more, more preferably 400 dPa · s or more, still more preferably 500 dPa · s or more, and still more preferably 700 dPa · s or more. Such a viscosity is packed in a container for viscosity measurement and stored in a thermostat at 20 ° C. for 24 hours, and then the rotor T-C and the number of rotations of 2. using a helipath type viscometer (VISCOMETER TVB-10 Toki Sangyo). It can be measured at 5 rpm for 1 minute.

The dentifrice composition of the present invention is preferably produced, for example, by the following steps.
The component (C) and the component (D) surfactant are mixed at a temperature not lower than the melting point of the component (C) higher alcohol and not higher than 90 ° C., and the component (E) water is further added to obtain a mixed solution. After obtaining the mixed solution, components (A) and (B) are added and mixed to obtain a dentifrice composition.

  Hereinafter, the present invention will be specifically described based on examples. In addition, unless otherwise indicated in a table | surface, content of each component shows the mass%.

  As the fragrance composition of component (A), the blended fragrances (fragrances 1 to 8) shown in Table 3 were prepared.

Examples 1-6, Comparative Examples 1-2
Dentifrice compositions having the compositions shown in Table 4 were produced.
First, component (C), component (D), and other components were heated to 80 ° C. (80 to 82 ° C.), mixed, and stirred for about 10 minutes. Next, component (E) was added and mixed, and then mixed for 10 minutes to obtain an α-gel preparation. Component (A) fragrance composition and component (B) menthol were added to the resulting preparation to obtain a dentifrice composition.

  The obtained dentifrice composition was evaluated for flavor based on the following criteria. In addition, evaluation was made into the average value by three expert panelists. The results are shown in Table 4.

[Evaluation of flavor intensity during dentifrice]
5: The flavor when polishing is very strong.
4: The flavor when polishing is strongly felt.
3: The flavor when polishing is weak.
2: Some flavor is felt when polishing, but not clear.
1: The miscellaneous taste by a base is felt rather than the flavor when polishing.

[Evaluation of flavor immediately after brushing and after brushing]
5: A refreshing flavor is felt after rinsing, and there is no oiliness.
4: A refreshing flavor is felt after rinsing and almost no oiliness.
3: A refreshing flavor is felt after rinsing, but it is slightly oily.
2: Although it feels cool after rinsing, it feels oily.
1: There is no refreshing feeling after rinsing and a strong oily feeling is felt.

Claims (8)

The following components (A), (B), (C), (D) and (E):
(A) Eugenol, acetyleugenol, methyleugenol, anethole, thymol, carvacrol, camphor, camphene, pulegone, β-cubeben, α-patuolene, p-cymene, α-pinene, β-pinene, sabinene, linalool, terpinene One or more selected from 4-ol, terpinen-1-ol, α-terpineol, cis-3-hexenol, phenylethyl alcohol, cinnamic aldehyde, cinnamic alcohol, anisaldehyde, anis alcohol and benzyl benzoate A fragrance composition comprising a fragrance compound (a1) in a fragrance composition of 30% by mass or more and comprising a fragrance compound other than menthol ,
(B) menthol,
(C) a higher alcohol having 12 to 22 carbon atoms, including at least cetanol (c1) and stearyl alcohol (c2),
(D) selected from at least a nonionic surfactant (d1) selected from sorbitan fatty acid ester and polyoxyethylene sorbitan fatty acid ester, and an anionic surfactant (d2) which is a fatty acid having 12 to 22 carbon atoms or a salt thereof. A surfactant containing one or more,
(E) It contains water, the content of component (A) is 0.05 to 2.5% by mass in the dentifrice, and the content of component (B) is 0.1% by mass in the dentifrice. 1 mass% or less, content of component (C) is 4 mass% or more and 30 mass% or less in dentifrice, and content of component (D) is 0.1 mass% or more and 10 mass% or less in dentifrice. there are, the weight ratio of components (a) and (B) ((a) / (B)) is Ri der 0.8 to 5, dentifrice compositions having α- gel structure.   The dentifrice composition according to claim 1, wherein the component (A) fragrance composition contains 30% by mass to 95% by mass of (a1). In component (A), as (a2), cinnamyl acetate, linalyl acetate, α-terpinyl acetate, menthyl acetate, cis-3-hexenylhexanoate, 1,8-cineole, mentfuran, fenkyl alcohol , Guaioles, patchoulialcohol, menthone, isomenton, α-ionone, β-ionone, methylheptanone, α-caryophyllene, β-caryophyllene, n-caryophyllene oxide, α-farnesene, β-elemene, β-ferrandolene, β- Claims containing 4% by mass or more and 70% by mass of one or more fragrance compounds selected from bisabolen, limonene, γ-terpinene, α-terpinolene, α-terpinene, myrcene, β-osimene, δ-guayene and gingiveren. Item 3. A dentifrice composition according to Item 1 or 2 . The dentifrice composition according to claim 3 , wherein the mass ratio of the component (a1) to the component (a2) ((a1) / (a2)) is 0.43 or more and 20 or less. The mass ratio ((c1) + (c2)) / (C) of the total content of the component (c1) and the content of the component (c2) and the content of the component (C) is 0.85 or more. It is 1 or less, The dentifrice composition of any one of Claims 1-4 . The dentifrice composition according to any one of claims 1 to 5 , wherein the content of the component (E) is 50% by mass or more and 95% by mass or less. The mass ratio ((G) / (C)) of the content of the oil component (G) other than the components (A), (B) and (C) and the content of the component (C) is less than 1. Dentifrice composition according to any one of claims 1 to 6 . The method comprising adding and mixing the component (A) and the component (B) after mixing the component (C) to the component (E) at a temperature not lower than the melting point of the component (C) and not higher than 90 ° C. method for producing a dentifrice composition according to 7 or one of.