JP6595459B2 - 種々の細胞集団におけるナノ粒子媒介遺伝子送達、ゲノム編集およびリガンド標的化修飾 - Google Patents

種々の細胞集団におけるナノ粒子媒介遺伝子送達、ゲノム編集およびリガンド標的化修飾 Download PDF

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JP6595459B2
JP6595459B2 JP2016516540A JP2016516540A JP6595459B2 JP 6595459 B2 JP6595459 B2 JP 6595459B2 JP 2016516540 A JP2016516540 A JP 2016516540A JP 2016516540 A JP2016516540 A JP 2016516540A JP 6595459 B2 JP6595459 B2 JP 6595459B2
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nanoparticle
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nanoparticles
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JP2016533322A5 (cg-RX-API-DMAC7.html
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プラサド コータ，シヴァ
ロナルド ワトソン，アンドレ
エー． パンディト，ヴァイブハヴ
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レンセラール ポリテクニック インスティチュート
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
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    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/95—Protection of vectors from inactivation by agents such as antibodies or enzymes, e.g. using polymers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2016516540A 2013-09-23 2014-09-23 種々の細胞集団におけるナノ粒子媒介遺伝子送達、ゲノム編集およびリガンド標的化修飾 Expired - Fee Related JP6595459B2 (ja)

Applications Claiming Priority (3)

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US201361881072P 2013-09-23 2013-09-23
US61/881,072 2013-09-23
PCT/US2014/057000 WO2015042585A1 (en) 2013-09-23 2014-09-23 Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations

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JP2016533322A JP2016533322A (ja) 2016-10-27
JP2016533322A5 JP2016533322A5 (cg-RX-API-DMAC7.html) 2017-10-12
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EP (2) EP3049116B1 (cg-RX-API-DMAC7.html)
JP (1) JP6595459B2 (cg-RX-API-DMAC7.html)
KR (1) KR20160060133A (cg-RX-API-DMAC7.html)
CN (1) CN105579068A (cg-RX-API-DMAC7.html)
AU (1) AU2014321215B2 (cg-RX-API-DMAC7.html)
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