JP6579956B2 - 神経変性疾患および他の疾患の治療のための併用治療薬および方法 - Google Patents

神経変性疾患および他の疾患の治療のための併用治療薬および方法 Download PDF

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JP6579956B2
JP6579956B2 JP2015545197A JP2015545197A JP6579956B2 JP 6579956 B2 JP6579956 B2 JP 6579956B2 JP 2015545197 A JP2015545197 A JP 2015545197A JP 2015545197 A JP2015545197 A JP 2015545197A JP 6579956 B2 JP6579956 B2 JP 6579956B2
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bryoid
bryostatin
disease
formulation according
retinoid
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JP2016501225A (ja
JP2016501225A5 (enExample
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カスター，トレバー・パーシバル
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アフィオス コーポレーション
アフィオス コーポレーション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Virology (AREA)
  • Neurosurgery (AREA)
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  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
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  • Botany (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015545197A 2012-11-28 2013-11-26 神経変性疾患および他の疾患の治療のための併用治療薬および方法 Expired - Fee Related JP6579956B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261730761P 2012-11-28 2012-11-28
US61/730,761 2012-11-28
PCT/US2013/072076 WO2014085494A1 (en) 2012-11-28 2013-11-26 Combination therapeutics and methods for the treatment of neurodegenerative and other diseases

Publications (3)

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JP2016501225A JP2016501225A (ja) 2016-01-18
JP2016501225A5 JP2016501225A5 (enExample) 2019-03-22
JP6579956B2 true JP6579956B2 (ja) 2019-09-25

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JP2015545197A Expired - Fee Related JP6579956B2 (ja) 2012-11-28 2013-11-26 神経変性疾患および他の疾患の治療のための併用治療薬および方法

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US (1) US10828276B2 (enExample)
EP (1) EP2925314B1 (enExample)
JP (1) JP6579956B2 (enExample)
CN (1) CN105228614A (enExample)
HK (1) HK1218882A1 (enExample)
WO (1) WO2014085494A1 (enExample)

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* Cited by examiner, † Cited by third party
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US9994585B2 (en) 2007-12-31 2018-06-12 Aphios Corporation Transplantation therapies
US9034347B2 (en) 2011-12-19 2015-05-19 Arphios Corporation Drug delivery system and method for the treatment of neuro-degenerative disease
JP6579956B2 (ja) 2012-11-28 2019-09-25 アフィオス コーポレーション 神経変性疾患および他の疾患の治療のための併用治療薬および方法
WO2026024784A1 (en) * 2024-07-22 2026-01-29 Mastery Biotech Co., Ltd. Composition and method for preventing or treating neurodegenerative diseases

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US6228843B1 (en) 1999-04-23 2001-05-08 University Technology Corporation Method of using PKC inhibiting compounds to treat vascular disease
CA2393026A1 (en) 1999-11-30 2001-06-07 Paul A. Wender Bryostatin analogues, synthetic methods and uses
WO2002028387A1 (en) * 2000-10-03 2002-04-11 Oncopharmaceutical, Inc. Inhibitors of angiogenesis and tumor growth for local and systemic administration
US20080004332A1 (en) 2002-03-07 2008-01-03 Alkon Daniel L Methods for alzheimer's disease treatment and cognitive enhancement
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WO2003086369A2 (en) * 2002-04-05 2003-10-23 Valorisation-Recherche, Societe En Commandite Stealthy polymeric biodegradable nanospheres and uses thereof
CA2490494A1 (en) * 2002-07-02 2004-01-15 Blanchette Rockefeller Neurosciences Institute Pkc activation as a means for enhancing sapp.alpha. secretion and improving cognition using bryostatin type compounds
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JP6579956B2 (ja) 2012-11-28 2019-09-25 アフィオス コーポレーション 神経変性疾患および他の疾患の治療のための併用治療薬および方法

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WO2014085494A1 (en) 2014-06-05
JP2016501225A (ja) 2016-01-18
WO2014085494A8 (en) 2015-04-23
EP2925314B1 (en) 2020-04-01
US10828276B2 (en) 2020-11-10
CN105228614A (zh) 2016-01-06
EP2925314A1 (en) 2015-10-07
US20150297555A1 (en) 2015-10-22
EP2925314A4 (en) 2016-06-01
HK1218882A1 (zh) 2017-03-17

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