JP6557654B2 - 新規の化合物及びその使用 - Google Patents

新規の化合物及びその使用 Download PDF

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Publication number
JP6557654B2
JP6557654B2 JP2016517041A JP2016517041A JP6557654B2 JP 6557654 B2 JP6557654 B2 JP 6557654B2 JP 2016517041 A JP2016517041 A JP 2016517041A JP 2016517041 A JP2016517041 A JP 2016517041A JP 6557654 B2 JP6557654 B2 JP 6557654B2
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Japan
Prior art keywords
alkyl
substituted
unsubstituted
certain embodiments
heterocyclyl
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JP2016517041A
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English (en)
Japanese (ja)
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JP2016520617A (ja
JP2016520617A5 (enExample
Inventor
ザパンタ オン、ウィンストン
ザパンタ オン、ウィンストン
ヴォイチェフ ノヴァク、パヴェル
ヴォイチェフ ノヴァク、パヴェル
シー アスキュー、ベン
シー アスキュー、ベン
グッド、アンドリュー
Original Assignee
カラ ファーマシューティカルズ インコーポレイテッド
カラ ファーマシューティカルズ インコーポレイテッド
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Publication of JP2016520617A publication Critical patent/JP2016520617A/ja
Publication of JP2016520617A5 publication Critical patent/JP2016520617A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2016517041A 2013-05-30 2014-05-30 新規の化合物及びその使用 Expired - Fee Related JP6557654B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361829117P 2013-05-30 2013-05-30
US61/829,117 2013-05-30
US201361898719P 2013-11-01 2013-11-01
US61/898,719 2013-11-01
PCT/US2014/040231 WO2014197313A2 (en) 2013-05-30 2014-05-30 Novel compounds and uses thereof

Publications (3)

Publication Number Publication Date
JP2016520617A JP2016520617A (ja) 2016-07-14
JP2016520617A5 JP2016520617A5 (enExample) 2017-07-20
JP6557654B2 true JP6557654B2 (ja) 2019-08-07

Family

ID=52008726

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016517041A Expired - Fee Related JP6557654B2 (ja) 2013-05-30 2014-05-30 新規の化合物及びその使用

Country Status (7)

Country Link
US (5) US9988386B2 (enExample)
EP (1) EP3003314B1 (enExample)
JP (1) JP6557654B2 (enExample)
AU (1) AU2014275198B2 (enExample)
CA (1) CA2913417A1 (enExample)
HK (1) HK1223307A1 (enExample)
WO (1) WO2014197313A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2913417A1 (en) * 2013-05-30 2014-12-11 Kala Pharmaceuticals, Inc. Substituted n-(5-(2-aminoimidaz0[1,2-b]pyridazin-6-yloxy) derivatives a nd pharmaceutical compositions thereof useful for the treatment of diseases associated with abnormal angiogenesis and/or aberrant signaling of a growth factor
KR102563675B1 (ko) * 2014-09-30 2023-08-04 트랜지션즈 옵티칼 인코포레이티드 자외선 광 흡수제
WO2016086026A1 (en) * 2014-11-26 2016-06-02 Kala Pharmaceuticals, Inc. Crystalline forms of a therapeutic compound and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1341771A2 (en) * 2000-11-29 2003-09-10 Glaxo Group Limited Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors
US7531553B2 (en) * 2003-03-21 2009-05-12 Amgen Inc. Heterocyclic compounds and methods of use
KR20090047509A (ko) 2006-08-04 2009-05-12 다케다 야쿠힌 고교 가부시키가이샤 융합 헤테로시클릭 유도체 및 이의 용도
JPWO2008016131A1 (ja) * 2006-08-04 2009-12-24 武田薬品工業株式会社 縮合複素環化合物
AR067326A1 (es) 2007-05-11 2009-10-07 Novartis Ag Imidazopiridinas y pirrolo -pirimidinas sustituidas como inhibidores de cinasa de lipido
EP2184285B1 (en) * 2007-08-29 2015-11-04 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
WO2009096435A1 (ja) * 2008-01-29 2009-08-06 Takeda Pharmaceutical Company Limited 縮合複素環誘導体およびその用途
WO2010032880A2 (en) 2008-09-19 2010-03-25 Takeda Pharmaceutical Company Limited Prophylactic/therapeutic agent for cancer
JP2010126530A (ja) * 2008-12-01 2010-06-10 Takeda Chem Ind Ltd 縮合複素環誘導体およびその用途
NZ741873A (en) 2012-05-03 2019-04-26 Kala Pharmaceuticals Inc Pharmaceutical nanoparticles showing improved mucosal transport
US9056057B2 (en) 2012-05-03 2015-06-16 Kala Pharmaceuticals, Inc. Nanocrystals, compositions, and methods that aid particle transport in mucus
CA2913417A1 (en) * 2013-05-30 2014-12-11 Kala Pharmaceuticals, Inc. Substituted n-(5-(2-aminoimidaz0[1,2-b]pyridazin-6-yloxy) derivatives a nd pharmaceutical compositions thereof useful for the treatment of diseases associated with abnormal angiogenesis and/or aberrant signaling of a growth factor

Also Published As

Publication number Publication date
HK1223307A1 (zh) 2017-07-28
US10544151B2 (en) 2020-01-28
EP3003314A4 (en) 2017-03-08
US20200157106A1 (en) 2020-05-21
US9988386B2 (en) 2018-06-05
EP3003314B1 (en) 2019-05-15
EP3003314A2 (en) 2016-04-13
AU2014275198B2 (en) 2017-04-13
US20210380588A1 (en) 2021-12-09
JP2016520617A (ja) 2016-07-14
CA2913417A1 (en) 2014-12-11
US10954244B2 (en) 2021-03-23
US10351570B2 (en) 2019-07-16
US20180251467A1 (en) 2018-09-06
WO2014197313A3 (en) 2015-04-16
US20190023710A1 (en) 2019-01-24
WO2014197313A2 (en) 2014-12-11
AU2014275198A1 (en) 2015-12-10
US20160137646A1 (en) 2016-05-19

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