JP6521967B2 - 疾患の治療のためのｋｄｍ１ａ阻害剤 - Google Patents

疾患の治療のためのｋｄｍ１ａ阻害剤 Download PDF

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JP6521967B2
JP6521967B2 JP2016533392A JP2016533392A JP6521967B2 JP 6521967 B2 JP6521967 B2 JP 6521967B2 JP 2016533392 A JP2016533392 A JP 2016533392A JP 2016533392 A JP2016533392 A JP 2016533392A JP 6521967 B2 JP6521967 B2 JP 6521967B2
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alkyl
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optionally substituted
amino
nitrogen
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JP2016531121A (ja
JP2016531121A5 (OSRAM
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ジョン エム． マッコール
ジョン エム． マッコール
ジュニア ヒュー ヤング ラインホフ
ジュニア ヒュー ヤング ラインホフ
マイケル クレア
マイケル クレア
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イマーゴ バイオサイエンシーズ インコーポレイテッド
イマーゴ バイオサイエンシーズ インコーポレイテッド
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • C07C2601/00—Systems containing only non-condensed rings
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2016533392A 2013-08-06 2014-08-06 疾患の治療のためのｋｄｍ１ａ阻害剤 Active JP6521967B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361862759P 2013-08-06 2013-08-06
US61/862,759 2013-08-06
US201461954276P 2014-03-17 2014-03-17
US61/954,276 2014-03-17
PCT/US2014/049906 WO2015021128A1 (en) 2013-08-06 2014-08-06 Kdm1a inhibitors for the treatment of disease

Publications (3)

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JP2016531121A JP2016531121A (ja) 2016-10-06
JP2016531121A5 JP2016531121A5 (OSRAM) 2017-09-14
JP6521967B2 true JP6521967B2 (ja) 2019-05-29

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US (4) US9790195B2 (OSRAM)
EP (1) EP3030323B1 (OSRAM)
JP (1) JP6521967B2 (OSRAM)
KR (1) KR102255778B1 (OSRAM)
CN (1) CN105592888A (OSRAM)
AU (1) AU2014306149B2 (OSRAM)
BR (1) BR112016002496B1 (OSRAM)
CA (1) CA2920257C (OSRAM)
DK (1) DK3030323T3 (OSRAM)
ES (1) ES2734209T3 (OSRAM)
IL (1) IL243976B (OSRAM)
MX (1) MX383590B (OSRAM)
WO (1) WO2015021128A1 (OSRAM)
ZA (1) ZA201600901B (OSRAM)

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MX383590B (es) 2013-08-06 2025-03-11 Imago Biosciences Inc Inhibidores de kdm1a para el tratamiento de enfermedades.
WO2016083458A1 (en) 2014-11-26 2016-06-02 Ieo - Istituto Europeo Di Oncologia S.R.L. Reprogramming-based models of neurodevelopmental disorders and uses thereof
RS66458B1 (sr) * 2015-02-12 2025-02-28 Imago Biosciences Inc Kdm1a inhibitor i njegova primena u terapiji
JP6855466B2 (ja) 2015-06-12 2021-04-07 オリゾン ジェノミックス ソシエダッド アノニマ Ｌｓｄ１阻害剤に関連するバイオマーカーおよびそれらの使用
WO2017013061A1 (en) 2015-07-17 2017-01-26 Oryzon Genomics, S.A. Biomarkers associated with lsd1 inhibitors and uses thereof
CN110402244B (zh) 2015-08-12 2023-02-03 因赛特公司 Lsd1抑制剂的盐
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WO2018035259A1 (en) * 2016-08-16 2018-02-22 Imago Biosciences, Inc. Methods and processes for the preparation of kdm1a inhibitors
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JP6738962B2 (ja) 2017-05-26 2020-08-12 大鵬薬品工業株式会社 新規なビフェニル化合物を用いた抗腫瘍効果増強剤
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