JP6502740B2 - Centrifuge rotor, centrifuge and method of using centrifuge - Google Patents

Description

  The present invention relates to a centrifuge rotor, a centrifuge, and a method of using the centrifuge, which are suitable for stirring, for example, a biological sample such as sputum and the like collected from a patient and a reagent.

Generally, a lidded tube container is known which is used to react or detect a target substance in a sample by stirring the sample and a reagent. The lidded tube container comprises a cylindrical tube body with a tapered bottom and a lid portion closing the upper opening of the tube body, and the lid portion can be opened and closed by a flexible hinge extending from the tube body It has an integral structure attached to the Reagents for performing reaction analysis or detection analysis at the time of contact with the sample are provided in advance in the lidded tube container, and the place to be provided includes the inside of the lid portion, the inner peripheral surface of the tube main body, or There is a type etc. which are provided at the bottom of the main body. (Refer to patent documents 1 and 2)
Both types are used by setting the lidded tube container to the centrifuge rotor of the stirring centrifuge for contacting the reagent with the sample. A wide variety of centrifuges are known, but in the case of centrifuges made especially for developing countries, it should be easy for anyone to operate and lower the cost of production. In order to curb, it has become a single-function, small-sized, compact product and has already been commercialized. An example is shown in FIG.

  In the conventional centrifuge 100 shown in FIG. 14, the centrifuge rotor 101R is rotatably disposed in the inner space of the centrifuge main body 101, and the upper part of the inner space can be opened and closed by the open / close lid 102. The rotating body 103 constituting the centrifuge rotor 101R is mounted on a rotating shaft 104 controlled to the rotation necessary for stirring. The rotary body 103 is formed in a rectangular plate shape, and both ends are bent short upward. The bent end edge portion 105 has a simple shape in which eight set through holes 106 for inserting and setting the lidded tube container 200 are provided.

  Therefore, when there is one lidded tube container 200, one set hole 106 is selected and used. Further, when multiple tube containers 200 are eight in number, all of the set holes 106 are used, and the bottom portion 200T of the tube container 200 is positioned in the set holes 106 from the inside on the rotary shaft 104 side, The lid 200H is attached by being fully inserted until it hits the set hole 106.

Patent No. 5057228 Patent No. 5209990

  The above-mentioned lidded tube container 200 may be a single container made alone or a multi-layered container made of eight, but in the case of a multiple-layered tube container, in particular, it will be supported at one place. At a location away from its support, it has a flexible connection structure that hangs down by its own weight, and does not form an integral rigid structure.

  For this purpose, even when multiple tube containers 200 inserted and set in the set hole 106 are removed from the set hole 106, the entire tube container 200 is set in the set hole 106 even if the lid portion is pulled and pulled in the drawing direction. There was a problem that it was not possible to take it off smoothly.

  It is considered that this problem is largely affected by the fact that the set hole 106 is a through hole and that the tube container 200 has a flexible and connected multi-connected shape. That is, when a portion of the lid portion 200H of the tube container 200 is held and pulled so as to remove the multiple tube containers 200 from the set hole 106, a drawing operation of receding rectilinearly along the insertion direction is exerted at that portion. However, it is considered that in the area away therefrom, it does not act as a drawing-out effect that recedes straight along the insertion direction but acts as a resistance action in the direction in which the tube body strongly contacts the set hole 106. This problem is not only in terms of workability that is difficult to remove, but also causes dispersion adhesion to the inner wall surface by the removal impact such as hitting the tube container 200 after completion of stirring and reaction against the edge of the hole, which adversely affects the analysis result. There was also a defect.

  In addition, a variation in agitation between the sample and the reagent may cause variation in inspection accuracy, which is also preferably improved.

  Therefore, in the present invention, as a matter of course, in the case of one tube made alone, it is easy to set and remove with one hand even with multiple tube containers, and the variation in inspection accuracy is suppressed. It is an object of the present invention to provide a centrifuge rotor, a centrifuge, and a method of using the centrifuge.

  In order to achieve the above object, a centrifuge rotor according to the present invention is a centrifuge rotor in which a tube container having a tube main body and a lid portion detachable from the tube main body is set, and the rotary shaft rotates at high speed. And a holding mechanism for holding the tube container formed integrally or separately from the horizontal member and formed in a single or multiple connection, the holding mechanism including the tube container It is characterized in that, when holding, the direction of the lid is a mechanism capable of holding the inner side and the outer side of the rotation.

  A centrifuge according to the present invention is characterized by including the centrifuge rotor according to any one of claims 1 to 3.

  A method of using a centrifuge according to the present invention is the method of using a centrifuge according to claim 4, wherein the tube container is set in the holding mechanism such that the lid faces the outside of rotation. And D. rotating the centrifuge rotor, and changing the direction of the tube container held by the holding mechanism so that the lid faces inward rotation, and rotating the centrifuge rotor. It features.

  According to the present invention, as a matter of course, even in the case of multiple tubes, it is easy to set and remove with one hand, and a centrifuge rotor with reduced variation in inspection accuracy. , Centrifuges, and methods of using the centrifuges.

It is a perspective view showing a centrifuge provided with a centrifuge rotor concerning a 1st embodiment. It is a perspective view which shows the example of a shape of multiple tube containers. It is a perspective view showing a centrifuge rotor concerning a 1st embodiment. It is a side view which shows the principal part of the centrifuge which concerns on 1st Embodiment. It is a side view which shows the principal part of the centrifuge which concerns on 1st Embodiment. It is a flowchart figure which shows an example of an operation | movement flow in 1st Embodiment. It is a perspective view showing a centrifuge rotor concerning a 2nd embodiment. It is side part principal part sectional drawing which shows the centrifuge rotor rotor which concerns on 2nd Embodiment. In 2nd Embodiment, it is a front view explaining setting the tube container so that the bottom part of a tube container may face the rotation inside of a centrifuge. It is a centrifuge which concerns on 2nd Embodiment, and is a front view explaining the process of orient | assigning the bottom part of a tube container to rotation outer side of a centrifuge. It is a centrifuge which concerns on 2nd Embodiment, and is a front view explaining the process of orient | assigning the bottom part of a tube container to rotation outer side of a centrifuge. It is a centrifuge which concerns on 2nd Embodiment, and is a front view explaining the process of orient | assigning the bottom part of a tube container to rotation outer side of a centrifuge. It is a centrifuge which concerns on 2nd Embodiment, and it is a front view explaining that the process of orient | assigning the bottom part of a tube container to rotation outer side of a centrifuge was complete | finished. It is a perspective view which shows an example of the conventional centrifuge.

  Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings. In the following description, the same or similar components as or to those described above are denoted by the same or similar reference numerals, and the detailed description thereof is appropriately omitted.

First Embodiment
First, the first embodiment will be described. As shown in FIG. 1, the centrifuge 1 has a centrifuge body 2 and a circular opening / closing lid 3. The centrifuge body 2 has a circular opening 2A at the top, and the centrifuge rotor 2R is rotatably disposed in the internal space of the opening 2A. The rotating body 10 constituting the centrifuge rotor 2R is mounted on the rotation shaft 4 of the centrifuge rotor 2R. The rotation shaft 4 is controlled to rotate by a motor (for example, a motor 8 shown in FIGS. 4 and 5) not shown in FIG. 1 so that high speed rotation necessary for stirring the sample and the sample can be performed. The rotating body 10 is provided with a holding mechanism 28 for holding a tube container described later at the time of rotation, and the holding mechanism 28 prevents the upward movement of the tube container at the time of rotation.

  As shown in FIG. 1, the operation panel 5 is disposed on the front side of the centrifuge main body 2 in an inclined manner, and the operation panel 5 is provided with a start button 5A and a stop button 5B. A switch 6 is provided on the top surface of the centrifuge body 2. The opening / closing lid 3 is provided with a protrusion 3 A at a position corresponding to the switch 6. Thereby, when the open / close lid 3 closes the opening 2A of the centrifuge main body 2, the projection 3A pushes the switch 6 to control the switch 6 not shown in FIG. 1 (for example, control shown in FIGS. 4 and 5) A signal is sent to the section 9), and it becomes possible to start when the start button 5A is pressed. Therefore, the projection 3A and the switch 6 constitute a safety device which can not start the operation of the centrifuge 1 unless the cover 3 is closed.

  Here, before describing an example of the structure of the centrifuge rotor 2R, an example of the shape of multiple tube containers 50 for containing a sample will be described with reference to FIG.

  As shown in FIG. 2, the tube container 50 is a tube container with a lid that is used to react or detect a target substance in a sample by stirring the sample and a reagent. The multiple tube containers 50 have a cylindrical tube main body 52 with a tapered bottom 51, an upper opening 53 of the tube main 52, and a lid that detachably closes the upper opening 53. 54 and a surface contact portion 59 protruding from the outer periphery of the upper release port 53 and in surface contact with the flange portion 54R of the lid 54.

  The surface contact portion 59 is continuously formed to extend from the hinge 55 and the connection portion 56. The lid 54 is attached by a flexible hinge 55 extending from the tube body 52 so that the upper opening 53 can be opened and closed. In the example shown in FIG. 2, for example, eight tube bodies 52 are connected in series by a connecting portion 56 continuous with the surface contact portion 59.

  In the tube container 50, reagents for performing reaction analysis or detection analysis at the time of contact with a sample are stored in advance.

  Next, with reference to FIGS. 3 to 5, structural examples of the above-described centrifuge rotor 2R will be sequentially described. The centrifuge rotor 2R is made of, for example, a metal plate, and is attached to the upper end portion of the rotating shaft 4 rotating at high speed. The motor 8 is driven by a control signal from the control unit 9 in which the program of the steps shown in FIG. 6 is incorporated. By driving the motor 8, the rotation shaft 4 can rotate at high speed, for example, around the rotation center axis CL, and can rotate clockwise and counterclockwise around the rotation center axis CL by a predetermined angle. It has become.

  The rotating body 10 includes a horizontal portion 11 and a first bending portion 12 (rotation outer portion) and a second bending portion 13 which are bent upward so as to be disposed on both side edges of the horizontal portion 11. And a rotating outer portion). The horizontal portion 11 is a rectangular flat portion, and the first bending portion 12 stands vertically (90 degrees with respect to the horizontal plate 11) from one end side of the horizontal portion 11, and the second bending portion 13 Is vertically rising from the other end side of the horizontal portion 11.

  A plurality of bottomed grooves 14 are formed on the end edge 12U (upper end) of the first bent portion 12 along the end edge 12U. The bottomed grooves 14 are formed at regular intervals along the edge 12U, and the upper side of each bottomed groove 14 is open. Moreover, as shown in FIG. 4, the bending guide portion 15 continuing on the upper side of the first bending portion 12 is inclined outward at an angle θ. That is, the forming direction S2 of the bending guide portion 15 is inclined at an angle θ with respect to the forming direction (vertical direction) S1 of the first bending portion 12. As described above, the bending guide portion 15 has a shape in which the insertion and release opening from the upper side is widened by the angle θ by being directed obliquely upward and outward.

  In addition, a plate-like opposing member 20 (rotation inner portion) disposed so as to face the first bent portion 12 (rotation outer portion) on the inner side of the rotation radius is fixed to the horizontal portion 11. The opposing member 20 is bent so as to be an L-shaped member, and includes a bent portion 22 parallel to the horizontal portion 11 and a vertical portion 24 continuous to the bent portion 22, The bent portion 22 is fixed to the horizontal portion 11.

  A bottomed groove 14 is formed in the vertical portion 24 at a position where the groove center and the bottomed groove 14 formed in the first bent portion 12 are the same. Then, at least from the bottom to the top of the bottomed groove 14, the opposing member 20 is in plane symmetry with the first bending portion 12, and the direction of inclination is opposite to the bending guide portion 15 of the first bending portion 12. The bending guide portion 16 extends from the vertical portion 24 such that the angle .theta.

  The gap S between the first bent portion 12 and the opposing member 20 is a predetermined distance d, and the flange portion 54R of the lid 54 and the surface contact portion 59 of the tube main body 52 enter the gap S. The container 50 is configured to be held between the first bent portion 12 and the opposing member 20.

  And in this configuration, when the tube container 50 is held, the lid 54 can be held either in the rotation inner side (rotational radius inward direction) or in the rotation outer side (rotational radius outward direction). There is. In the present embodiment, the first bending portion 12 and the opposing member 20 form a holding mechanism 28 for holding the tube container 50.

  The first bending portion 12 and the opposing member 20 may be integral with or separate from the horizontal portion 11. Further, the opposing member 21 disposed so as to face the second bending portion 13 on the inner side of the rotation is also fixed to the horizontal portion 11, but the configuration and arrangement are the same as the opposing member 20. The description is omitted. The holding mechanism 28 is also formed by the second bending portion 13 and the opposing member 21.

(Action, effect)
Next, an example of use of the above-described centrifuge 1 will be described with an example using multiple tube containers. FIG. 6 is an operation flow showing an operation example of the centrifuge 1 provided with the centrifuge rotor 2R of the present embodiment.

  First, at the preparation stage, the reagent is provided in advance inside the lid 54, and each tube container for each patient using a pipette or the like for the biological sample (patient's sputum in case of tuberculosis etc.) collected from the patient After putting in 50, the lid 54 is closed and the tube container 50 is sealed. In addition, it is also possible to use a test method in which the reagent is inserted when the biological sample is put, without the reagent being provided in advance in the tube container 50.

  Thereafter, as shown in FIG. 4, the multiple tube containers 50 are set in the bottomed groove 14 of the rotating body (rotor) 10. At that time, the surface contact portion 59 and the flange portion 54R are first bent so that the lid 54 of the tube container 50 faces the rotation outside (that is, the bottom 51 of the tube container 50 faces the rotation inside). The tube container 50 is pinched by the centrifuge rotor 2R by inserting into the gap S between the counter 12 and the opposing member 20, respectively. Similarly, multiple tube containers 50 are inserted into the gap S between the second bent portion 13 and the opposing member 21.

  As a result, the flange portion 54R of each tube container 50 makes surface contact with the first bent portion 12, and the surface contact portion 59 of each tube container 50 makes surface contact with the vertical portion 24 of the opposing member 20. The axial direction of the container 50 is in a state (horizontal state) along the horizontal axis HL. Moreover, in the state in which each tube container 50 is held in the gap S, the hinge 55 of the lid 54 is positioned on the upper side. Similarly, the multiple tube containers 50 inserted into the gap S between the second bent portion 13 and the opposing member 21 are also held horizontally along the horizontal axis HL, and the hinge 55 of the lid 54 is on the upper side. Located in

  Therefore, even if the centrifugal force F along the horizontal axis HL acts on the tube container 50 at high speed rotation, no upward action occurs in which the tube body 52 is detached from the bottomed groove 14, and the tube body 52 is reliable and stable. It is possible to secure the retention of

  Next, when the user presses the start button 5A (see FIG. 1), the operation based on the program of the control unit 9 (see FIG. 4) is started. In step S1 (see FIG. 6), the centrifuge rotor 2R rotates at a low speed (for example, about 500 rpm), for example, for 30 seconds. Thereby, the biological sample of the tube container 50 is sent to the reagent provided on the inside of the lid 54 to support the reaction generation.

  Subsequently, step S2 is performed. In this step 2, the centrifuge rotor 2R rotates for 9 seconds at an angle setting range of 90 degrees in the opposite direction to the clockwise direction, for example, at a speed corresponding to 2000 rpm. Thereby, the reagent in the tube container 50 and the biological sample are stirred and react with each other.

  In steps S1 and S2, the centrifugal force F acts on the tube container 50, but since the collar portion 54R is supported by the first bending portion 12 from the outside of the rotation, the lid portion 54 is prevented from coming off . In addition, since the tube container 50 is held horizontally, reaction contact between the reagent and the sample is ensured.

  After the step S2 is completed and the rotation of the centrifuge rotor 2R is stopped, the user changes the direction of the tube container 50 (step S3). In this step S3, the multiple tube containers 50 are taken out of the centrifuge rotor 2R with one hand, and the lid 54 is turned inward (that is, the bottom of the tube container 50 is turned outward). Set to 2R. At this time, the flange portion 54R of each tube container 50 is in surface contact with the vertical portion 24 of the opposing member 20, and the surface contact portion 59 of each tube container 50 is in surface contact with the first bent portion 12. The 50 axial directions are in a state (horizontal state) along the horizontal axis HL. Moreover, in the state in which each tube container 50 is held in the gap S, the hinge 55 of the lid 54 is positioned on the upper side. The same applies to the multiple tube containers 50 inserted into the gap S between the second bent portion 13 and the opposing member 21.

  After the end of step S3, step S4 is performed. In this step S4, for example, in the same way as step S2, for example, it rotates for 9 seconds at a speed corresponding to 2000 rpm in the opposite direction to the clockwise direction.

  Then, step S5 is continued. In this step S5, the centrifuge rotor 2R rotates at high speed, for example, clockwise for 6 seconds at a speed corresponding to 2000 rpm.

  When the specified time (6 seconds) elapses, a buzzer (not shown) sounds (step S6), and the user presses stop button 5B shown in FIG. 1 at step S7 to stop the buzzer from sounding. Then, the user takes out multiple tube containers 50 from the centrifuge 1.

  As described above, according to the present embodiment, when the centrifuge rotor 2R holds the tube container 50, it can be held regardless of whether the lid portion 54 is on the rotation inner side or the rotation outer side. It has become. Therefore, before the reagent and the biological sample are reacted by rotating the centrifuge rotor 2R forward, the reagent or the biological sample is moved to one side of the tube container in advance by rotating it in the opposite direction to this rotation. After that, the direction of the tube container 50 is reversed, and the reagent and the biological sample can be reacted by causing the centrifuge rotor 2R to rotate forward.

  Thereby, it is not necessary to shake the tube container 50 by hand to pre-stir the reagent and the biological sample. Therefore, even if it is shaken by hand, the reagent or the biological sample is not sufficiently moved in some of the multiple tube containers 50, the inspection accuracy is lowered due to the variation of the user's swing, and further, There is no possibility of causing a problem such as forgetting to shake the tube container 50 of the user by hand.

  Further, in the case of a single tube container 50 made by itself, it is needless to say that even multiple tube containers 50 can be easily set and removed with one hand. In addition, it is possible to significantly reduce the removal impact which is considered to adversely affect the analysis result, and a good analysis result can be obtained.

  Further, the gap S between the first bent portion 12 and the opposing member 20 is a predetermined distance d, and the flange portion 54R of the lid 54 and the surface contact portion 59 of the tube main body 52 enter the gap S. 50 are sandwiched between the first bent portion 12 and the opposing member 20. Therefore, the sealed state of the tube container 50 is maintained even if the centrifuge rotor 2R rotates at high speed, and the lid 54 is prevented from coming off even when the lid 54 is positioned on the rotation outside.

  In addition, the bending guide portion 15 of the first bending portion 12 is inclined outward at the angle θ, and the bending guide portion 16 of the opposing member 20 is inclined at the angle θ in the rotational direction. It has a shape that the insertion opening of. Thus, the operation of inserting the tube container 50 to the bottom of the bottomed groove 14 can be easily performed.

Second Embodiment
Next, a second embodiment will be described with reference to FIGS. 7 to 13. The centrifuge 70 of the present embodiment includes a centrifuge rotor 72R in place of the centrifuge rotor 2R of the first embodiment.

  The centrifuge rotor 72R has a horizontal plate 71 rotated by a motor (not shown), and holding mechanisms 78P and 78Q disposed on both sides of the horizontal plate 71, respectively.

  The holding mechanism 78P has a rotation outside portion 82 having a bottomed groove 74 (see FIG. 8 and FIG. 10, the same configuration as the bottomed groove 14 described in the first embodiment) at the top and a bottomed groove 74 at the top. It has a rotation inner side 92 facing the rotation outer side 82, a lower end of the outer rotation side 82 and a continuous portion 84 continuous with the lower end of the inner rotation portion 92, and is fixed to the continuous portion 84 at the top It has a rotation shaft 86 (see FIG. 8) pivotally supported at the lower part so as to be rotatable with respect to the horizontal plate 71, and a compression coil spring 88 through which the rotation shaft 86 is inserted. By this configuration, the turning positions of the holding mechanisms 78P and 78Q can be switched.

  Further, a bending guide portion 75 similar to the bending guide portion 15 is formed in the rotation outer portion 82, and a bending guide portion 76 similar to the bending guide portion 16 is formed in the rotation inner portion 92.

  The holding mechanism 78P is always urged upward by the compression coil spring 88. Then, the pivot shaft 86 is pushed downward to be in the pivotable state in which the height position is slightly lowered, and the pressure position is released, and the pivot in the height position is slightly raised from the pivotable state. It is configured to be disabled.

  Since the holding mechanism 78Q has the same configuration as the holding mechanism 78P, the detailed description of the holding mechanism 78Q will be omitted.

  In order to use the centrifuge 70 of the present embodiment, first, as in the first embodiment, the reagent and the biological sample are put in the tube container 50 and sealed.

  And as shown in FIG. 7, the bottom groove 74 of each holding mechanism 78P and 78Q of the multiple tube containers 50 is made so that the lid part 54 faces the rotation outside (that is, the bottom part 51 of the tube container 50 turns inside). The centrifugal separator 70 is set by inserting into. As a result, the surface contact portion 59 of the tube main body 52 and the flange portion 54R of the lid 54 are nipped by the gap S between the holding mechanisms 78P and 78Q (see FIGS. 7 and 8).

  Then, steps S1 and S2 are performed as in the first embodiment. Then, after the rotation of the centrifuge rotor 72R is stopped, the user presses the holding mechanism 78P downward, reverses (180 ° rotation) the holding mechanism 78P around the rotation shaft 86, and releases the pressing (FIG. 9 to FIG. 9). 11). Further, the user presses the holding mechanism 78Q downward and similarly reverses (rotates by 180 °) to release the pressing (see FIGS. 11 to 13).

  As a result, as shown in FIG. 13, in the holding mechanisms 78P and 78Q, a state in which the multiple tube containers 50 are held such that the lid 54 faces inward (that is, the bottom 51 of the tube container 50 faces outward). become.

  Then, as in the first embodiment, step S4 and the subsequent steps are performed, and then the user takes out multiple tube containers 50 from the centrifuge 70.

  Therefore, according to the present embodiment, when reversing the direction of the tube container 50, it is not necessary to withdraw the tube container 50 from the bottomed groove 74. Therefore, in addition to the effect exhibited in the first embodiment, the effect of good inspection workability and the time required for the inspection can be shortened.

  In the present embodiment, when the holding mechanisms 78P and 78Q are reversed, the user presses the holding mechanisms 78P and 78Q downward to turn the holding mechanisms 78P and 78Q. Has been described in the configuration example in which it is returned to its original position (upper position) and can not turn. However, when the holding mechanisms 78P and 78Q are reversed, the user pulls the holding mechanisms 78P and 78Q upward to turn In the possible state, by releasing the pulling force, the holding mechanisms 78P and 78Q may return to the original position (downward position) and be in a non-rotatable state.

  Further, in the present embodiment, an example is described in which the user directly touches and holds the holding mechanisms 78P and 78Q, but the lever for switching the rotational position of the holding mechanism 78P outside the housing of the centrifuge, and the holding mechanism A lever for switching the rotational position of 78Q may be protruded. As a result, the switching operation of the rotational positions of the holding mechanisms 78P and 78Q is simplified, and the inspection time can be further shortened.

  As mentioned above, although embodiment was described, these embodiments are the examples for embodying the technical idea of this invention, Comprising: The material of a component, a shape, a structure, arrangement, etc. are specified in the said embodiment. Rather, it can be implemented with various modifications without departing from the scope of the invention. For example, in the first embodiment and the second embodiment, an example in which eight tube containers are used is shown as an example, but a specification structure which can correspond to other than eight tubes may be adopted.

1 Centrifuge 2R Centrifuge rotor 11 horizontal part (horizontal member)
12 1st bend (rotation outer part)
13 2nd bend (rotation outer part)
14 Bottomed groove 20 Countering member (rotation inside)
21 Opposing member (rotation inner part)
28 holding mechanism 50 tube container 52 tube main body 54 lid 54R flange 59 surface contact portion 71 horizontal plate (horizontal member)
72R centrifuge rotor 78P holding mechanism 78Q holding mechanism 82 rotating outer part 84 continuous part 86 rotating shaft 92 rotating inner part S gap

Claims (4)

A centrifuge rotor in which a tube container having a tube body and a removable lid portion is set.
A horizontal member attached to the rotating shaft that rotates at high speed,
A holding mechanism provided integrally or separately with the horizontal member and holding the single or multiple tube container;
Equipped with
When holding the tube container, the holding mechanism is a mechanism that can hold the lid, regardless of whether it is on the rotational inner side or the rotational outer side .
The holding mechanism comprises a plate-like rotating outer portion and a rotating inner portion each having a bottomed groove released upward.
There is a predetermined gap between the rotating outer portion and the rotating inner portion, and when the tube container is sealed, the ridge portion of the lid portion and the surface contact portion of the tube main body in surface contact with the ridge portion A centrifuge rotor characterized in that the tube container is nipped between the outer side and the inner side by entering the gap . The holding mechanism
A continuous portion continuous with the outer side and the inner side;
A pivot shaft fixed at the upper portion to the continuous portion and pivotally supported at the lower portion relative to the horizontal member;
The centrifuge rotor according to claim 1 , wherein the rotational position of the holding mechanism is switchable by providing A centrifuge comprising the centrifuge rotor according to claim 1 or 2 . A method of using a centrifuge according to claim 3 , wherein
Setting the tube container on the holding mechanism so that the lid faces the outside of rotation, and rotating the centrifuge rotor;
Changing the direction of the tube container held by the holding mechanism so that the lid faces inward rotation, and rotating the centrifuge rotor;
A method of using a centrifuge, comprising:

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