JP6488000B2 - ２−シアノ−３−シクロプロピル−３−ヒドロキシ−ｎ−アリール−チオアクリルアミド誘導体 - Google Patents
２−シアノ−３−シクロプロピル−３−ヒドロキシ−ｎ−アリール−チオアクリルアミド誘導体Info
- Publication number
- JP6488000B2 JP6488000B2 JP2017500146A JP2017500146A JP6488000B2 JP 6488000 B2 JP6488000 B2 JP 6488000B2 JP 2017500146 A JP2017500146 A JP 2017500146A JP 2017500146 A JP2017500146 A JP 2017500146A JP 6488000 B2 JP6488000 B2 JP 6488000B2
- Authority
- JP
- Japan
- Prior art keywords
- cyano
- cyclopropyl
- hydroxy
- thioacrylamide
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461954844P | 2014-03-18 | 2014-03-18 | |
| EP14000994 | 2014-03-18 | ||
| US61/954,844 | 2014-03-18 | ||
| EP14000994.5 | 2014-03-18 | ||
| PCT/EP2015/055379 WO2015140081A1 (en) | 2014-03-18 | 2015-03-15 | 2-cyano-3-cyclopropyl-3-hydroxy-n-aryl-thioacrylamide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017510632A JP2017510632A (ja) | 2017-04-13 |
| JP6488000B2 true JP6488000B2 (ja) | 2019-03-20 |
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| Country | Link |
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| US (1) | US10472324B2 (de) |
| EP (1) | EP3119744B1 (de) |
| JP (1) | JP6488000B2 (de) |
| CN (1) | CN106458878B (de) |
| AU (1) | AU2015233686B2 (de) |
| CA (1) | CA2941782C (de) |
| PL (1) | PL3119744T3 (de) |
| WO (1) | WO2015140081A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6957455B2 (ja) * | 2015-10-14 | 2021-11-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | ベータ細胞の複製及び／または生存の亢進 |
| EP3755314A1 (de) | 2018-02-22 | 2020-12-30 | Diamyd Medical AB | Gaba-a-rezeptoragonisten zur behandlung von erkrankungen, die durch dysfunktion von beta-zellen beeinflusst werden |
| EP4162933A1 (de) * | 2021-10-08 | 2023-04-12 | Algiax Pharmaceuticals GmbH | Verbindung zur behandlung von nicht-alkoholischer fettlebererkrankung und verwandten erkrankungen |
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| GB816019A (en) * | 1956-05-14 | 1959-07-08 | Us Rubber Co | Improvements in polymerization of alkyd resin systems |
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| GB9412719D0 (en) * | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| GB9504460D0 (en) | 1995-03-06 | 1995-04-26 | Bayer Ag | N-(3-Benzofuranyl)urea-derivatives |
| US5721277A (en) * | 1995-04-21 | 1998-02-24 | Sugen, Inc. | Compounds and methods for inhibiting hyper-proliferative cell growth |
| ES2164990T3 (es) * | 1996-04-30 | 2002-03-01 | Pfizer | Agonistas de receptores muscarinicos. |
| GB2350109A (en) | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active benzofuranyl sulfonates |
| JP2004532809A (ja) * | 2000-11-02 | 2004-10-28 | リサーチ ファウンデーション オブ シティ ユニバーシティ オブ ニューヨーク | ホスホジエステラーゼ４型を阻害することによって、神経系の再生および修復を刺激するための方法 |
| EP1500643A4 (de) | 2002-04-03 | 2007-03-28 | Dainippon Sumitomo Pharma Co | Benzamidinderivate |
| US20070265345A1 (en) | 2004-07-27 | 2007-11-15 | Smithkline Beecham Corporation | Novel Biphenyl Compounds And Their Use |
| CN104411699B (zh) * | 2012-06-26 | 2017-06-13 | 萨尼奥纳有限责任公司 | 苯基三唑衍生物及其用于调节gabaa 受体复合体的用途 |
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2015
- 2015-03-15 PL PL15713400T patent/PL3119744T3/pl unknown
- 2015-03-15 JP JP2017500146A patent/JP6488000B2/ja active Active
- 2015-03-15 EP EP15713400.8A patent/EP3119744B1/de active Active
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- 2015-03-15 WO PCT/EP2015/055379 patent/WO2015140081A1/en active Application Filing
- 2015-03-15 AU AU2015233686A patent/AU2015233686B2/en active Active
- 2015-03-15 US US15/126,378 patent/US10472324B2/en active Active
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|---|---|
| CA2941782A1 (en) | 2015-09-24 |
| JP2017510632A (ja) | 2017-04-13 |
| CN106458878A (zh) | 2017-02-22 |
| AU2015233686B2 (en) | 2019-07-11 |
| CA2941782C (en) | 2022-08-23 |
| CN106458878B (zh) | 2018-08-31 |
| US10472324B2 (en) | 2019-11-12 |
| PL3119744T3 (pl) | 2019-07-31 |
| EP3119744B1 (de) | 2019-03-06 |
| EP3119744A1 (de) | 2017-01-25 |
| US20170088513A1 (en) | 2017-03-30 |
| WO2015140081A1 (en) | 2015-09-24 |
| AU2015233686A1 (en) | 2016-09-22 |
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