JP6447508B2 - ３−（イミダゾ［１，２−ｂ］ピリダジン−３−イルエチニル）−４−メチル−Ｎ−｛４−［（４−メチルピペラジン−１−イル）メチル］−３−（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 - Google Patents

３−（イミダゾ［１，２−ｂ］ピリダジン−３−イルエチニル）−４−メチル−Ｎ−｛４−［（４−メチルピペラジン−１−イル）メチル］−３−（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 Download PDF

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JP6447508B2
JP6447508B2 JP2015547524A JP2015547524A JP6447508B2 JP 6447508 B2 JP6447508 B2 JP 6447508B2 JP 2015547524 A JP2015547524 A JP 2015547524A JP 2015547524 A JP2015547524 A JP 2015547524A JP 6447508 B2 JP6447508 B2 JP 6447508B2
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ponatinib
methyl
xrpd
crystalline form
peaks
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JP2016503010A5 (Direct
JP2016503010A (ja
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マリー、クリストファー・ケイ
ロザマス、レナード・ダブリュー
チェイバー、ジョン・ジェイ
シャーマ、プラディープ
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アリアド・ファーマシューティカルズ・インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015547524A 2012-12-12 2013-12-12 ３−（イミダゾ［１，２−ｂ］ピリダジン−３−イルエチニル）−４−メチル−Ｎ−｛４−［（４−メチルピペラジン−１−イル）メチル］−３−（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 Active JP6447508B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261736543P 2012-12-12 2012-12-12
US61/736,543 2012-12-12
US201261737007P 2012-12-13 2012-12-13
US61/737,007 2012-12-13
US201361788208P 2013-03-15 2013-03-15
US61/788,208 2013-03-15
PCT/US2013/074571 WO2014093579A2 (en) 2012-12-12 2013-12-12 Crystalline forms of 3-(imidazo[1,2-b] pyridazin-3-ylethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl)benzamide and its mono hydrochloride salt

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JP2018129624A Division JP7042175B2 (ja) 2012-12-12 2018-07-09 ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形

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JP2016503010A JP2016503010A (ja) 2016-02-01
JP2016503010A5 JP2016503010A5 (Direct) 2017-01-26
JP6447508B2 true JP6447508B2 (ja) 2019-01-09

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JP2018129624A Active JP7042175B2 (ja) 2012-12-12 2018-07-09 ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形
JP2021203538A Active JP7352841B2 (ja) 2012-12-12 2021-12-15 ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形
JP2023150905A Pending JP2023179498A (ja) 2012-12-12 2023-09-19 ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形

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JP2018129624A Active JP7042175B2 (ja) 2012-12-12 2018-07-09 ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形
JP2021203538A Active JP7352841B2 (ja) 2012-12-12 2021-12-15 ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形
JP2023150905A Pending JP2023179498A (ja) 2012-12-12 2023-09-19 ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形

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US (9) US9493470B2 (Direct)
JP (4) JP6447508B2 (Direct)
CN (2) CN115043843A (Direct)
CA (3) CA3022250A1 (Direct)
CL (1) CL2015001643A1 (Direct)
HK (1) HK1218878A1 (Direct)
MX (11) MX359147B (Direct)
NZ (1) NZ709648A (Direct)
WO (2) WO2014093579A2 (Direct)

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US20210277012A1 (en) 2021-09-09
MX2021002259A (es) 2021-05-27
MX2021002264A (es) 2021-05-27
JP7042175B2 (ja) 2022-03-25
NZ709648A (en) 2020-05-29
US10662197B2 (en) 2020-05-26
US10125136B2 (en) 2018-11-13
US11192897B2 (en) 2021-12-07
US20240083902A1 (en) 2024-03-14
US11279705B2 (en) 2022-03-22
US20150315194A1 (en) 2015-11-05
MX2015007578A (es) 2016-03-21
CN115043843A (zh) 2022-09-13
CA2815506A1 (en) 2014-06-12
MX2021002255A (es) 2021-05-27
MX391445B (es) 2025-03-21
US20190169196A1 (en) 2019-06-06
CA3167093A1 (en) 2014-06-12
MX2021002257A (es) 2021-05-27
US20210277011A1 (en) 2021-09-09
CL2015001643A1 (es) 2015-10-02
US20210024527A1 (en) 2021-01-28
CA3022250A1 (en) 2014-06-12
WO2014093579A2 (en) 2014-06-19
US11192896B2 (en) 2021-12-07
MX2021002256A (es) 2021-05-27
JP2018168191A (ja) 2018-11-01
HK1218878A1 (zh) 2017-03-17
US11192895B2 (en) 2021-12-07
WO2014093579A3 (en) 2014-07-10
MX2021002261A (es) 2021-05-27
JP7352841B2 (ja) 2023-09-29
US20210340149A1 (en) 2021-11-04
WO2014093583A2 (en) 2014-06-19
MX2021002258A (es) 2021-05-27
CA2815506C (en) 2018-12-11
JP2022037122A (ja) 2022-03-08
US20210277010A1 (en) 2021-09-09
US11384086B2 (en) 2022-07-12
US20170190707A1 (en) 2017-07-06
JP2023179498A (ja) 2023-12-19
MX359147B (es) 2018-09-17
US9493470B2 (en) 2016-11-15
MX2021002253A (es) 2021-05-27
JP2016503010A (ja) 2016-02-01
MX2021002254A (es) 2021-05-27
WO2014093583A3 (en) 2014-08-07
CN105188701A (zh) 2015-12-23

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