JP6441818B2 - 心不全の治療法 - Google Patents

心不全の治療法 Download PDF

Info

Publication number
JP6441818B2
JP6441818B2 JP2015557120A JP2015557120A JP6441818B2 JP 6441818 B2 JP6441818 B2 JP 6441818B2 JP 2015557120 A JP2015557120 A JP 2015557120A JP 2015557120 A JP2015557120 A JP 2015557120A JP 6441818 B2 JP6441818 B2 JP 6441818B2
Authority
JP
Japan
Prior art keywords
nitrate
pharmaceutical composition
heart failure
subject
inorganic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015557120A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016507570A (ja
JP2016507570A5 (enExample
Inventor
エー．チリノス ジュリオ
エー．チリノス ジュリオ
Original Assignee
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア, ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア filed Critical ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
Publication of JP2016507570A publication Critical patent/JP2016507570A/ja
Publication of JP2016507570A5 publication Critical patent/JP2016507570A5/ja
Application granted granted Critical
Publication of JP6441818B2 publication Critical patent/JP6441818B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
JP2015557120A 2013-02-07 2014-02-07 心不全の治療法 Active JP6441818B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361761863P 2013-02-07 2013-02-07
US61/761,863 2013-02-07
PCT/US2014/015300 WO2014124256A1 (en) 2013-02-07 2014-02-07 Methods of treating heart failure

Publications (3)

Publication Number Publication Date
JP2016507570A JP2016507570A (ja) 2016-03-10
JP2016507570A5 JP2016507570A5 (enExample) 2017-03-16
JP6441818B2 true JP6441818B2 (ja) 2018-12-19

Family

ID=51300154

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015557120A Active JP6441818B2 (ja) 2013-02-07 2014-02-07 心不全の治療法

Country Status (6)

Country Link
US (1) US20150366901A1 (enExample)
EP (1) EP2953631A4 (enExample)
JP (1) JP6441818B2 (enExample)
CN (1) CN105101977A (enExample)
CA (1) CA2900526C (enExample)
WO (1) WO2014124256A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014134585A1 (en) 2013-02-28 2014-09-04 Aires Pharmaceuticals, Inc. Inorganic nitrite to improve cardiopulmonary hemodynamics
CN110461171A (zh) 2017-03-23 2019-11-15 美生盐有限公司 含甜菜根的组合物
WO2018195537A1 (en) * 2017-04-21 2018-10-25 Northeast Ohio Medical University Vasodilators for treatment of heart failure
WO2019055704A1 (en) * 2017-09-13 2019-03-21 Thermolife International, Llc ENRICHED ROOT POWDER PRODUCTS AND METHODS OF MAKING SAME
FI128489B (en) 2018-10-01 2020-06-15 Precordior Oy Equipment for generating information indicating cardiac abnormality

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005004884A2 (en) * 2003-07-09 2005-01-20 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
CA3187624A1 (en) * 2007-02-26 2008-09-04 Heartbeet Ltd. New use of nitrites and nitrates and compositions containing these
US20120214818A1 (en) * 2009-09-11 2012-08-23 The Board Of Trustees Of The University Of Illinois Methods of treating diastolic dysfunction and related conditions
US20120208762A1 (en) * 2009-10-27 2012-08-16 The Board Of Trustees Of The University Of Illinois Methods of Diagnosing Diastolic Dysfunction
GB201020811D0 (en) * 2010-12-08 2011-01-19 Solvotrin Innovations Ltd Compounds
US20140112983A1 (en) * 2011-04-14 2014-04-24 Theravasc Inc. Nitrite compositions and uses thereof
WO2014134585A1 (en) * 2013-02-28 2014-09-04 Aires Pharmaceuticals, Inc. Inorganic nitrite to improve cardiopulmonary hemodynamics

Also Published As

Publication number Publication date
CN105101977A (zh) 2015-11-25
CA2900526C (en) 2021-05-04
US20150366901A1 (en) 2015-12-24
JP2016507570A (ja) 2016-03-10
EP2953631A4 (en) 2017-03-01
EP2953631A1 (en) 2015-12-16
CA2900526A1 (en) 2014-08-14
WO2014124256A1 (en) 2014-08-14

Similar Documents

Publication Publication Date Title
O’Hara et al. Applications of SGLT2 inhibitors beyond glycaemic control
Papadia et al. Citrulline in health and disease. Review on human studies
Kawano et al. Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery
Eggebeen et al. One week of daily dosing with beetroot juice improves submaximal endurance and blood pressure in older patients with heart failure and preserved ejection fraction
Kim et al. Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure
Berg-Hansen et al. Beneficial effects of ketone ester in patients with cardiogenic shock: a randomized, controlled, double-blind trial
van Wijck et al. Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: strategies for evaluation and prevention
Viethen et al. Ferric carboxymaltose improves exercise capacity and quality of life in patients with pulmonary arterial hypertension and iron deficiency: a pilot study
Kenjale et al. Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease
JP6441818B2 (ja) 心不全の治療法
Khanna et al. The management of hyperkalemia in patients with cardiovascular disease
KR20200102982A (ko) 보존된 박출률을 갖는 심부전의 치료 방법
Stevens et al. Exercise improves cardiac function and attenuates insulin resistance in Dahl salt-sensitive rats
AU2017217466A1 (en) Chromium containing compositions for improving health and fitness
Xiang et al. Impaired blood pressure compensation following hemorrhage in conscious obese Zucker rats
JP2022550734A (ja) ウデナフィル組成物を用いた単心室心疾患における運動能力、単心室性能、および心筋性能指数（ｍｐｉ）を改善する方法
CN114222566A (zh) 用于改善癌症患者的结果的方法和组合物
ES2970283T3 (es) Composiciones que comprenden HMB y ATP así como su uso
US20160184248A1 (en) Compositions and methods of use of -hydroxy-methylbutyrate (hmb) resulting in an acute endocrine response
EP2986301A1 (en) Phosphodiesterase 5a inhibitors for the treatment of muscular dystrophy
Boldt et al. A high-whey-protein diet does not enhance mechanical and structural remodeling of cardiac muscle in response to aerobic exercise in rats
US10888576B2 (en) Composition of HMB and ATP and methods of use
Hillegass et al. Cardiac muscle dysfunction and failure
Holloway The effects of exercise training on cardiac and peripheral function in men and women
Thomas Evaluation of Modified Borg Dyspnoea Score and 6-Minute Walk Test in Pulmonaryarterial Hypertensionpatients Recievingphosphodiesterase Inhibitors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170206

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170206

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171114

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20171115

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180213

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180514

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20181023

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20181122

R150 Certificate of patent or registration of utility model

Ref document number: 6441818

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250