JP6403688B2 - 全身性抗炎症反応を提供する複数のプロスタグランジン受容体で作用する化合物 - Google Patents

全身性抗炎症反応を提供する複数のプロスタグランジン受容体で作用する化合物 Download PDF

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Publication number
JP6403688B2
JP6403688B2 JP2015553902A JP2015553902A JP6403688B2 JP 6403688 B2 JP6403688 B2 JP 6403688B2 JP 2015553902 A JP2015553902 A JP 2015553902A JP 2015553902 A JP2015553902 A JP 2015553902A JP 6403688 B2 JP6403688 B2 JP 6403688B2
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Prior art keywords
methyl
benzyl
pyrazol
propionic acid
chloro
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Active
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JP2015553902A
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English (en)
Japanese (ja)
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JP2016505047A (ja
JP2016505047A5 (th
Inventor
ディヴィッド エフ ウッドワード
ディヴィッド エフ ウッドワード
ウィリアム アール カーリング
ウィリアム アール カーリング
ホセ エル マルトス
ホセ エル マルトス
ジェニー ダブリュ ワン
ジェニー ダブリュ ワン
ユッシ ジェイ カンガスメトサ
ユッシ ジェイ カンガスメトサ
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Allergan Inc
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Allergan Inc
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Priority claimed from US13/746,023 external-priority patent/US8859606B2/en
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of JP2016505047A publication Critical patent/JP2016505047A/ja
Publication of JP2016505047A5 publication Critical patent/JP2016505047A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015553902A 2013-01-21 2014-01-21 全身性抗炎症反応を提供する複数のプロスタグランジン受容体で作用する化合物 Active JP6403688B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/746,023 US8859606B2 (en) 2010-07-01 2013-01-21 Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response
US13/746,023 2013-01-21
PCT/US2014/012389 WO2014113814A1 (en) 2013-01-21 2014-01-21 Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response

Publications (3)

Publication Number Publication Date
JP2016505047A JP2016505047A (ja) 2016-02-18
JP2016505047A5 JP2016505047A5 (th) 2017-03-02
JP6403688B2 true JP6403688B2 (ja) 2018-10-10

Family

ID=50031640

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015553902A Active JP6403688B2 (ja) 2013-01-21 2014-01-21 全身性抗炎症反応を提供する複数のプロスタグランジン受容体で作用する化合物

Country Status (8)

Country Link
EP (1) EP2945932B1 (th)
JP (1) JP6403688B2 (th)
CN (1) CN105008331B (th)
AU (2) AU2014207266C1 (th)
CA (1) CA2898720A1 (th)
ES (1) ES2711356T3 (th)
HK (1) HK1216888A1 (th)
WO (1) WO2014113814A1 (th)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106146400A (zh) * 2015-03-20 2016-11-23 四川大学 苄基-1h-吡唑、苄基-1h-吡咯衍生物及其制备方法和用途
ES2674128B1 (es) * 2016-12-27 2019-04-10 Univ Salamanca Método para diagnosticar sensibilización alérgica en un sujeto

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US7217725B2 (en) 2000-09-14 2007-05-15 Allergan, Inc. Prostaglandin D2 antagonist
US7273883B2 (en) 2000-09-14 2007-09-25 Allergan, Inc. Prostaglandin EP4 antagonist
US6511999B2 (en) 2000-09-14 2003-01-28 Allergan, Inc. Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2α antagonists
ATE386725T1 (de) 2003-10-24 2008-03-15 Glaxo Group Ltd Heterocyclylverbindungen
GB0508472D0 (en) * 2005-04-26 2005-06-01 Glaxo Group Ltd Compounds
US8492424B2 (en) * 2010-07-01 2013-07-23 Allergan, Inc. Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response
WO2013101598A1 (en) * 2011-12-27 2013-07-04 Allergan, Inc. Compounds acting at multiple prostaglandin receptors giving a general anti-inflammatory response

Also Published As

Publication number Publication date
HK1216888A1 (zh) 2016-12-09
JP2016505047A (ja) 2016-02-18
AU2014207266B2 (en) 2018-05-24
CN105008331A (zh) 2015-10-28
EP2945932A1 (en) 2015-11-25
AU2014207266A1 (en) 2015-08-13
WO2014113814A1 (en) 2014-07-24
CN105008331B (zh) 2018-02-16
EP2945932B1 (en) 2018-11-21
AU2014207266C1 (en) 2018-11-08
CA2898720A1 (en) 2014-07-24
AU2018217252A1 (en) 2018-08-30
ES2711356T3 (es) 2019-05-03
AU2018217252B2 (en) 2020-01-30

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