JP6401156B2 - イミダゾ［２，１−ｂ］チアゾール誘導体、その製造方法、および医薬品としての使用 - Google Patents

イミダゾ［２，１−ｂ］チアゾール誘導体、その製造方法、および医薬品としての使用 Download PDF

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Publication number
JP6401156B2
JP6401156B2 JP2015519224A JP2015519224A JP6401156B2 JP 6401156 B2 JP6401156 B2 JP 6401156B2 JP 2015519224 A JP2015519224 A JP 2015519224A JP 2015519224 A JP2015519224 A JP 2015519224A JP 6401156 B2 JP6401156 B2 JP 6401156B2
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Prior art keywords
general formula
compound
phenylimidazo
following general
maleate
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Japanese (ja)
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JP2015521994A5 (enExample
JP2015521994A (ja
Inventor
アルカルデ‐パイス，マリア，デ・ラス・エルミタス
ディアス‐フェルナンデス，ホセ‐ルイス
メスクィダ‐エステヴェス，マリア，デ・レス・ノイス
パロマ‐ロメウ，ラウラ
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Esteve Pharmaceuticals SA
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Esteve Pharmaceuticals SA
Laboratorios del Dr Esteve SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/06—Antiarrhythmics
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    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2015519224A 2012-07-04 2013-07-04 イミダゾ［２，１−ｂ］チアゾール誘導体、その製造方法、および医薬品としての使用 Expired - Fee Related JP6401156B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12382269.4 2012-07-04
EP12382269.4A EP2682395A1 (en) 2012-07-04 2012-07-04 Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments
PCT/EP2013/064113 WO2014006130A1 (en) 2012-07-04 2013-07-04 IMIDAZO[2,1-b]THIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS

Publications (3)

Publication Number Publication Date
JP2015521994A JP2015521994A (ja) 2015-08-03
JP2015521994A5 JP2015521994A5 (enExample) 2017-07-27
JP6401156B2 true JP6401156B2 (ja) 2018-10-03

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ID=48741189

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JP2015519224A Expired - Fee Related JP6401156B2 (ja) 2012-07-04 2013-07-04 イミダゾ［２，１−ｂ］チアゾール誘導体、その製造方法、および医薬品としての使用

Country Status (10)

Country Link
US (1) US9617281B2 (enExample)
EP (2) EP2682395A1 (enExample)
JP (1) JP6401156B2 (enExample)
CN (1) CN104520304B (enExample)
CA (1) CA2878339A1 (enExample)
ES (1) ES2607183T3 (enExample)
IN (1) IN2015MN00068A (enExample)
MX (1) MX2015000056A (enExample)
PT (1) PT2870164T (enExample)
WO (1) WO2014006130A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017121645A1 (en) * 2016-01-15 2017-07-20 Laboratorios Del Dr. Esteve, S.A. 3-ethyl-3-phenylazepane derivatives having multimodal activity against pain
WO2020127735A1 (en) * 2018-12-20 2020-06-25 Intervet International B.V. New methods of producing (2-amino-4-[6-(4-fluorophenyl)-2-[(4-methyl-1-piperazinyl)methyl]imidazo[2,1-b]thiazol-5-yl]-pyrimidine
WO2023093700A1 (zh) * 2021-11-29 2023-06-01 中国海洋大学 咪唑并噻唑衍生物及其制备方法与应用
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH621126A5 (enExample) 1974-02-07 1981-01-15 Plantex Ltd
DE2823686A1 (de) * 1978-05-31 1979-12-06 Bayer Ag Imidazo eckige klammer auf 2.1-b eckige klammer zu eckige klammer auf 1.3.4 eckige klammer zu -thiadiazole
DE3329621A1 (de) * 1983-08-17 1985-02-28 Bayer Ag, 5090 Leverkusen Aminoalkyl-imidazothiadiazol-alkencarbonsaeureamide, neue zwischenprodukte zu ihrer herstellung, ihre herstellung und ihre verwendung in arzneimitteln
US7229480B2 (en) 2004-02-13 2007-06-12 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
EP1634873A1 (en) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
CA2576144C (en) * 2004-08-27 2012-12-11 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
US20060156484A1 (en) 2005-01-14 2006-07-20 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
CN101277963A (zh) * 2005-08-04 2008-10-01 西特里斯药业公司 作为sirtuin调节剂的噁唑并吡啶衍生物
CA2618360C (en) 2005-08-04 2015-06-09 Sirtris Pharmaceuticals, Inc. Benzothiazoles and thiazolopyridines as sirtuin modulators
EP1829869A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands
EP1847542A1 (en) 2006-04-21 2007-10-24 Laboratorios del Dr. Esteve S.A. Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor
EP1982714A1 (en) * 2007-04-16 2008-10-22 Laboratorios del Dr. Esteve S.A. Pyrano-pyrazole-amines
EA200971077A1 (ru) 2007-05-21 2010-04-30 ЭсДжиЭкс ФАРМАСЬЮТИКАЛЗ, ИНК. Гетероциклические модуляторы киназы
ES2548768T3 (es) 2007-09-27 2015-10-20 Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii Imidazolotiadiazoles para su uso como inhibidores de proteína quinasa
EP2053052A1 (en) * 2007-10-23 2009-04-29 Laboratorios del Dr. Esteve S.A. Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide
EP2070933A1 (en) 2007-12-07 2009-06-17 Laboratorios del Dr. Esteve S.A. Tricyclic triazolic compounds
EP2395003A1 (en) * 2010-05-27 2011-12-14 Laboratorios Del. Dr. Esteve, S.A. Pyrazole compounds as sigma receptor inhibitors

Also Published As

Publication number Publication date
PT2870164T (pt) 2016-12-21
US9617281B2 (en) 2017-04-11
MX2015000056A (es) 2015-07-17
EP2682395A1 (en) 2014-01-08
EP2870164A1 (en) 2015-05-13
EP2870164B1 (en) 2016-09-14
ES2607183T3 (es) 2017-03-29
CN104520304A (zh) 2015-04-15
IN2015MN00068A (enExample) 2015-10-16
US20150166574A1 (en) 2015-06-18
WO2014006130A1 (en) 2014-01-09
CA2878339A1 (en) 2014-01-09
HK1210149A1 (en) 2016-04-15
JP2015521994A (ja) 2015-08-03
CN104520304B (zh) 2017-02-22

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