JP6359032B2 - 経皮薬物送達用のマルチポリマー組成物 - Google Patents

経皮薬物送達用のマルチポリマー組成物 Download PDF

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Publication number
JP6359032B2
JP6359032B2 JP2015550786A JP2015550786A JP6359032B2 JP 6359032 B2 JP6359032 B2 JP 6359032B2 JP 2015550786 A JP2015550786 A JP 2015550786A JP 2015550786 A JP2015550786 A JP 2015550786A JP 6359032 B2 JP6359032 B2 JP 6359032B2
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polymer
amine
drug
polymer matrix
composition
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JP2016504368A (ja
JP2016504368A5 (cg-RX-API-DMAC7.html
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ジョシュア クラコフスキー
ジョシュア クラコフスキー
プチュン リュウ
プチュン リュウ
Original Assignee
ノーヴェン ファーマシューティカルズ インコーポレイテッド
ノーヴェン ファーマシューティカルズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015550786A 2012-12-28 2013-12-27 経皮薬物送達用のマルチポリマー組成物 Active JP6359032B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261747117P 2012-12-28 2012-12-28
US61/747,117 2012-12-28
PCT/US2013/077934 WO2014106016A1 (en) 2012-12-28 2013-12-27 Multi-polymer compositions for transdermal drug delivery

Publications (3)

Publication Number Publication Date
JP2016504368A JP2016504368A (ja) 2016-02-12
JP2016504368A5 JP2016504368A5 (cg-RX-API-DMAC7.html) 2017-02-09
JP6359032B2 true JP6359032B2 (ja) 2018-07-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015550786A Active JP6359032B2 (ja) 2012-12-28 2013-12-27 経皮薬物送達用のマルチポリマー組成物

Country Status (8)

Country Link
US (2) US9295726B2 (cg-RX-API-DMAC7.html)
EP (1) EP2938335B1 (cg-RX-API-DMAC7.html)
JP (1) JP6359032B2 (cg-RX-API-DMAC7.html)
AU (1) AU2013370297A1 (cg-RX-API-DMAC7.html)
CA (1) CA2896347A1 (cg-RX-API-DMAC7.html)
ES (1) ES2864327T3 (cg-RX-API-DMAC7.html)
MX (1) MX366230B (cg-RX-API-DMAC7.html)
WO (1) WO2014106016A1 (cg-RX-API-DMAC7.html)

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US8614716B2 (en) 2010-10-01 2013-12-24 Apple Inc. Recording a command stream with a rich encoding format for capture and playback of graphics content
TW201431554A (zh) 2012-12-28 2014-08-16 Noven Pharma 左炔諾孕酮（ｌｅｖｏｎｏｒｇｅｓｔｒｅｌ）及乙烯雌二醇之經皮藥物遞送系統
US11337936B2 (en) 2013-03-14 2022-05-24 Noven Pharmaceuticals, Inc. Amphetamine transdermal compositions with acrylic block copolymer
AR095259A1 (es) 2013-03-15 2015-09-30 Noven Pharma Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria
AR095260A1 (es) 2013-03-15 2015-09-30 Noven Pharma Composiciones de anfetaminas transdérmicas estables y métodos de fabricación
CN105607772B (zh) * 2014-11-13 2020-11-03 现代自动车株式会社 触摸输入装置以及包括该装置的车辆
US10406116B2 (en) 2015-02-06 2019-09-10 Noven Pharmaceuticals, Inc. Pressure-sensitive adhesives for transdermal drug delivery
MX371044B (es) 2015-02-06 2020-01-13 Noven Pharma Adhesivos sensibles a la presión para suministro transdérmico de fármaco.
RU2764443C2 (ru) 2016-12-20 2022-01-17 Лтс Ломанн Терапи-Систем Аг Трансдермальная терапевтическая система, содержащая азенапин и полисилоксан или полиизобутилен
WO2018115001A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
CN110799180A (zh) 2017-06-26 2020-02-14 罗曼治疗系统股份公司 含阿塞那平和硅氧烷丙烯酸杂化聚合物的经皮治疗系统
AU2019291060B2 (en) 2018-06-20 2024-09-05 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
CN112533593A (zh) 2018-06-20 2021-03-19 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
CN116997330A (zh) 2021-01-07 2023-11-03 诺芬药品公司 具有低水平氨基甲酸盐的透皮安非他命组合物
WO2022150431A2 (en) 2021-01-07 2022-07-14 Noven Pharmaceuticals, Inc. Amphetamine carbamate compounds and methods

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JPH0676321B2 (ja) * 1987-02-18 1994-09-28 久光製薬株式会社 クロニジン経皮投与製剤
US5474783A (en) 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5234957A (en) 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5446070A (en) 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5719197A (en) 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
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CN101431988A (zh) 2006-02-27 2009-05-13 诺芬药品公司 包含东莨菪碱的透皮治疗系统
US7989496B2 (en) 2006-10-27 2011-08-02 Noven Pharmaceuticals, Inc. Transdermal delivery of ketoprofen polar derivatives
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Also Published As

Publication number Publication date
US20140186424A1 (en) 2014-07-03
ES2864327T3 (es) 2021-10-13
CA2896347A1 (en) 2014-07-03
EP2938335A1 (en) 2015-11-04
MX2015008286A (es) 2015-12-09
MX366230B (es) 2019-07-03
JP2016504368A (ja) 2016-02-12
US20170007548A1 (en) 2017-01-12
AU2013370297A1 (en) 2015-07-16
EP2938335B1 (en) 2021-03-17
US9295726B2 (en) 2016-03-29
WO2014106016A1 (en) 2014-07-03

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