JP6353669B2 - Acne-improving composition - Google Patents

Description

The present invention relates to acne improving composition.

  Conventionally, as an acne improving composition, for example, a composition containing a plant extract obtained by subjecting a plant to an extraction treatment with an extraction solvent is known.

  As this type of acne-improving composition, for example, there is known a composition containing a saxifrage extract obtained by subjecting saxifraga to an extraction treatment with an extraction solvent (Patent Document 1).

  The composition for improving acne described in Patent Document 1 can improve acne by being applied to the skin.

  However, the composition for improving acne described in Patent Document 1 has a problem that it is not necessarily excellent in the performance of improving acne.

JP 2013-177439 A

This invention makes it a subject to provide the composition for acne improvement which is excellent in an acne improvement performance in view of said problems .

  The composition for improving acne according to the present invention is characterized by containing an artichoke extract and a saxifrage extract.

Acne improving composition according to the present invention preferably further comprises a bactericidal agent. Further, by including a bactericidal agent, there is an advantage that the acne improving performance becomes more excellent.

Oite acne improving composition according to the present invention, the sterilizing agent (antibacterial agent) is preferably at least one of isopropyl methyl phenol and ethylhexylglycerin. By using at least one of isopropylmethylphenol and ethylhexylglycerin as the bactericidal agent (antibacterial agent), there is an advantage that the acne improving performance is more excellent.

Acne improving composition of the present invention, an effect that excellent acne improve performance.

  Hereinafter, an embodiment of the composition for improving acne according to the present invention will be described.

The composition for improving acne according to the present embodiment includes an artichoke extract and a saxifrage extract.
Since the composition for acne improvement of this embodiment contains an artichoke extract and a saxifrage extract, it is excellent in acne improvement performance. For example, the acne-improving composition of the present embodiment can be sufficiently reduced by being applied to a portion of the skin where acne has occurred.
The composition for improving acne according to this embodiment is prepared, for example, in a liquid, semi-solid, or solid form.

The artichoke extract is an extract obtained by subjecting an artichoke (also known as Korean thistle) to extraction with an extraction solvent.
The artichoke is a perennial that belongs to the genus Chrysanthemum. Artichoke's scientific name is Cynara scolymus L.

  The extraction part of the artichoke is not particularly limited, and examples thereof include a flower part, a leaf part, and a root part. Especially, as a site | part extracted, a leaf part is preferable at the point that the acne improvement performance becomes a more excellent thing. That is, the artichoke extract is preferably an artichoke leaf extract.

Examples of the extraction solvent for the artichoke extract include water, aliphatic monohydric alcohols such as methanol, ethanol, and propanol; aliphatic polyhydric alcohols such as glycerin, propylene glycol, and 1,3-butylene glycol; ketones such as acetone. Organic solvents such as ethers such as diethyl ether and dioxane; nitriles such as acetonitrile; esters such as ethyl acetate; aromatics such as xylene, benzene and toluene; and alkyl halides such as chloroform.
These extraction solvents may be used alone or in combination of two or more. The mixing ratio of the extraction solvents formed by mixing a plurality of types of solvents is not particularly limited and can be adjusted as appropriate.

The extraction solvent for the artichoke extract is preferably an extraction solvent containing at least an organic solvent.
In addition, as such an extraction solvent, an extraction solvent containing an aliphatic alcohol such as an aliphatic monohydric alcohol or an aliphatic polyhydric alcohol is more preferable in terms of improving acne improvement performance. An extraction solvent containing a divalent aliphatic alcohol is more preferable, and an extraction solvent containing at least one selected from the group consisting of ethanol, 1,3-butylene glycol, and propylene glycol is most preferable.

  Specifically, as an extraction solvent for the artichoke extract, at least one aliphatic alcohol selected from the group consisting of ethanol, 1,3-butylene glycol, and propylene glycol and water, an aliphatic alcohol: An extraction solvent mixed at a volume ratio of water = 8: 2 to 2: 8 is preferable, and the extraction solvent contains only at least one aliphatic alcohol selected from the group consisting of ethanol, 1,3-butylene glycol, and propylene glycol. A solvent is more preferable.

  The Yukinoshita extract is an extract obtained by subjecting a plant of the genus Saxifraga stolonifera to an extraction treatment with an extraction solvent.

  The extraction site of the plant belonging to the genus Yukinoshita is not particularly limited, and examples thereof include a flower part, a leaf part, and a root part. Especially, as a site | part extracted, a leaf part is preferable at the point that the acne improvement performance becomes a more excellent thing. That is, as the Yukinoshita extract, a leaf extract of Yukinoshita is preferable.

Examples of the extraction solvent for the Yukinoshita extract include water or aliphatic monohydric alcohols such as methanol, ethanol, and propanol; aliphatic polyhydric alcohols such as glycerin, propylene glycol, and 1,3-butylene glycol; ketones such as acetone. Organic solvents such as ethers such as diethyl ether and dioxane; nitriles such as acetonitrile; esters such as ethyl acetate; aromatics such as xylene, benzene and toluene; and alkyl halides such as chloroform.
These extraction solvents may be used alone or in combination of two or more. The mixing ratio of the extraction solvents formed by mixing a plurality of types of solvents is not particularly limited and can be adjusted as appropriate.

As the extraction solvent for the Yukinoshita extract, an extraction solvent containing water and an organic solvent is preferable.
In addition, as such an extraction solvent, an extraction solvent containing an aliphatic alcohol such as an aliphatic monohydric alcohol or an aliphatic polyhydric alcohol and water is more preferable in that the acne improving performance becomes more excellent, More preferable is an extraction solvent containing a monovalent or divalent aliphatic alcohol and water, and at least one aliphatic alcohol selected from the group consisting of ethanol, 1,3-butylene glycol, and propylene glycol, and water. The extraction solvent containing is most preferred.

  Specifically, as an extraction solvent for the Yukinosita extract, at least one aliphatic alcohol selected from the group consisting of ethanol, 1,3-butylene glycol, and propylene glycol, and water, an aliphatic alcohol: An extraction solvent mixed at a volume ratio of water = 8: 2 to 2: 8 is preferable, and 1,3-butylene glycol and water are mixed at a volume ratio of 1,3-butylene glycol: water = 8: 2 to 2: 8. A mixed extraction solvent is more preferred.

  The extraction method for performing the extraction treatment on the above-described plants (Artichoke, Yukinoshita) is not particularly limited, and a conventionally known general extraction method can be employed. In the extraction, the extraction site of each plant can be used as it is or after drying as an extraction raw material. Moreover, extraction solvent amount is 5-15 times amount (mass ratio) of an extraction raw material normally, extraction temperature is 20 degreeC-80 degreeC, and extraction time is 2 hours-3 days. After extraction, purification treatment such as filtration, deodorization, and decolorization can be appropriately performed as necessary.

Each extract of the above-mentioned plants (Artichoke, Yukinoshita) can usually be in the form of an extract with the extraction solvent, a diluted solution thereof, a concentrated solution thereof, or a dried product from which the extraction solvent has been removed. Specifically, each extract can be in the form of, for example, a solution, a paste, a gel, or a powder.
As each extract, for example, a commercially available one is used.

The said composition for acne improvement normally contains 0.00001-0.2 mass% of said each extract in dry matter conversion, respectively.
In addition, dry matter conversion is converting into the mass of the dry matter which is a residue remove | excluding the extraction solvent from the extract.

The acne-improving composition preferably contains 0.00008% by mass or more, more preferably 0.0004% by mass or more of the artichoke extract in terms of dry matter.
Moreover, it is preferable to contain 0.006 mass% or less of artichoke extract in dry matter conversion, and it is more preferable to prefer 0.004 mass% or less.
By including the artichoke extract in an amount of 0.00008% by mass or more in terms of dry matter, a more sufficient effect can be obtained. Moreover, the stability of a composition will become more excellent by including artichoke extract 0.006 mass% or less in conversion of a dry matter.

The acne-improving composition preferably contains 0.002% by mass or more, more preferably 0.01% by mass or more, of a duckweed extract in terms of dry matter.
The acne-improving composition preferably contains 0.15% by mass or less, more preferably 0.1% by mass or less, of the extract of cypress, in terms of dry matter.
By including the Yukinoshita extract in an amount of 0.002% by mass or more in terms of dry matter, a more sufficient effect can be obtained. Moreover, the stability of a composition will become more excellent by including a Yukinoshita extract 0.15 mass% or less in conversion of a dry matter.

  The acne-improving composition preferably contains 0.00208 to 0.156% by mass, and 0.0104 to 0.104% by mass, in total, of artichoke extract and saxifrage extract in terms of dry matter. More preferred.

  The mass ratio of the artichoke extract and the saxifrage extract contained in the acne-improving composition is preferably artichoke extract: yukinoshita extract = 1: 3.5 to 1: 175 in terms of dry matter.

  The composition for improving acne further includes plant extracts other than the above plant extracts, solvents such as water, pH buffers, surfactants, vitamins, whitening agents, bactericides (antibacterial agents), ultraviolet absorption Agents, ultraviolet scattering agents, thickeners, oils, polyhydric alcohols, water-soluble polymer compounds, antioxidants, and the like.

  It is preferable that the said composition for acne improvement contains a disinfectant further in the point that the acne improvement performance becomes a more excellent thing.

  The bactericidal agent (antibacterial agent) is a compound having an action of killing bacteria or an action of suppressing the growth of bacteria.

  Examples of the disinfectant (antibacterial agent) include isopropylmethylphenol (3-methyl-4-isopropylphenol), ethylhexylglycerin (glycerin mono-2-ethylhexyl ether), benzoic acid or a salt thereof, benzoic acid alkyl ester, and salicylic acid or There may be mentioned at least one selected from the group consisting of the salts.

  As the fungicide, at least one of isopropylmethylphenol and ethylhexylglycerin is preferable.

The composition for improving acne preferably contains 0.001% by mass or more of isopropylmethylphenol, more preferably 0.01% by mass or more. By including 0.01% by mass or more of isopropylmethylphenol, there is an advantage that the acne improvement performance becomes more excellent.
The composition for improving acne preferably contains 5.0% by mass or less of isopropylmethylphenol, and more preferably 1.0% by mass or less. By containing isopropyl methylphenol in an amount of 5.0% by mass or less, there is an advantage that irritation to the skin becomes smaller.

The composition for improving acne preferably contains 0.01% by mass or more, and more preferably contains 0.05% by mass or more of ethylhexylglycerin. By including 0.05% by mass or more of ethylhexyl glycerin, there is an advantage that the acne improving performance becomes more excellent.
Moreover, it is preferable that the said composition for acne improvement contains 10.0 mass% or less of ethylhexyl glycerol, and it is more preferable that 5.0 mass% or less is included. By containing 10.0% by mass or less of ethylhexyl glycerin, there is an advantage that irritation to the skin is further reduced.

  The composition for improving acne preferably contains isopropylmethylphenol and ethylhexylglycerin as fungicides. By including isopropyl methyl phenol and ethyl hexyl glycerin, there is an advantage that the acne improving performance becomes more excellent.

  The composition for improving acne preferably contains 0.001 to 10.0% by mass in total of isopropylmethylphenol and ethylhexylglycerin as fungicides, and 0.01 to 5.0% by mass in total. More preferred.

As described above, the composition for improving acne may contain a plant extract other than the artichoke extract and the saxifrage extract.
As such a plant extract, those having a bactericidal action and an antibacterial action are preferable. An extract, a rosemary extract, a Clara extract, a gill extract, a licorice extract, an enamel extract and the like can be mentioned.

The composition for improving acne is produced by a general method.
Specifically, the acne-improving composition is prepared by, for example, mixing a solvent such as water, an artichoke extract, a yukinoshita extract, and a water-soluble polymer compound using a mixing device such as a homomixer. Can be manufactured.

  The composition for improving acne is used by being applied to a living body of a human body or a non-human animal body. For example, the composition for improving acne is used by bringing it into contact with the skin or orally ingesting it. The acne improving composition is preferably used non-therapeutically for cosmetic purposes.

  Next, an embodiment of the external preparation for skin of the present invention will be described.

  The external preparation for skin of this embodiment contains an artichoke extract and a yukinoshita extract, and is used by bringing it into contact with the skin.

  The external preparation for skin can be prepared, for example, in a liquid, semi-solid or solid form and applied to the skin or applied to the skin to improve the acne produced.

As the amount of artichoke extract and saxifrage extract contained in the external preparation for skin, the same amount as the above-mentioned composition for improving acne is employed.
In the same manner as the above-mentioned composition for improving acne, the external preparation for skin includes a solvent such as water, a pH buffer, a surfactant, a fungicide, oils, polyhydric alcohols, It may further contain a water-soluble polymer compound, an antioxidant and the like.

  The external preparation for skin preferably contains an artichoke extract, a yukinoshita extract, and a bactericide such as isopropylmethylphenol and ethylhexylglycerin in the same amount as the above-mentioned composition for improving acne.

  It is preferable that the mass ratio of the artichoke extract, the saxifrage extract, and the disinfectant contained in the external preparation for skin is the same mass ratio as that of the composition for improving acne described above.

  The skin external preparation is produced by the same method as the above-described composition for improving acne.

  The skin external preparation is used in contact with human skin or non-human animal skin. The external preparation for skin is preferably used non-therapeutically for cosmetic purposes.

  Subsequently, an embodiment of the cosmetic of the present invention will be described.

  The cosmetic of the present embodiment includes an artichoke extract and a yukinoshita extract, and is used by bringing it into contact with a part of the human body for cosmetic purposes.

  For example, the cosmetic can be prepared in a liquid, semi-solid, or solid form, applied to the skin, or applied to the skin to improve the acne produced.

As the amount of artichoke extract and saxifrage extract contained in the cosmetic, the same amount as the above-mentioned composition for improving acne is employed.
In addition to the above-mentioned plant extract, the cosmetics include solvents such as water, pH buffering agents, surfactants, fungicides, oils, polyhydric alcohols, It may further contain a functional polymer compound, an antioxidant and the like.

  The cosmetic preferably contains an artichoke extract, a saxifrage extract, and a bactericide such as isopropylmethylphenol and ethylhexylglycerin in the same amount as the above-mentioned composition for improving acne.

  The mass ratio of the artichoke extract, the saxifrage extract, and the fungicide contained in the cosmetic is preferably the same mass ratio as that of the above-described composition for improving acne.

  The cosmetic is produced by the same method as the above-described composition for improving acne.

  The cosmetic is used by being applied to a human living body, for example, by bringing it into contact with human skin or orally ingesting it by a human. The cosmetic is used non-therapeutically.

  The composition for improving acne, the external preparation for skin, and the cosmetic of this embodiment are as exemplified above, but the present invention is limited to the above-exemplified composition for improving acne, external preparation for skin, and cosmetic. It is not something. Moreover, in this invention, the various forms employ | adopted in the composition for general acne improvement, skin external preparation, and cosmetics can be employ | adopted in the range which does not impair the effect of this invention.

  Next, although an Example is given and this invention is demonstrated in more detail, this invention is not limited to these.

Example 1
Gel-shaped acne-improving compositions (external preparations for skin, cosmetics) having the compositions shown in Table 1 were produced.
The details of the artichoke extract and the saxifrage extract are as follows.
[Artichoke extract]
Extract obtained by extracting leaf of artichoke with ethanol (extraction solvent) Product name “Biobenefie” made by Ichimaru Falcos Co., Ltd. (0.08 mass% dry matter concentration)
[Yukinoshita extract]
An extract obtained by extracting the leaf portion of Yukinoshita with an aqueous solution (extraction solvent) of 50% by volume of 1,3-butylene glycol Product name “Yukinoshita Extract BG” manufactured by Maruzen Pharmaceutical Co., Ltd. (2.0% by mass dry matter concentration)
Specifically, hectorite and hydroxyethyl cellulose dispersed in purified water were mixed with polysorbate-80 and zinc oxide at room temperature to prepare a dispersion. On the other hand, a transparent solution was prepared by mixing isopropylmethylphenol (cymen-5-ol), ethylhexylglycerin (glycerin mono-2-ethylhexyl ether), dipropylene glycol, and methylparaben while heating. Separately, an artichoke extract, a yukinoshita extract, and EDTA-2Na were dissolved in purified water to prepare an aqueous solution.
The above dispersion and the organic solution were mixed and stirred at 3,000 rpm for 2 minutes at room temperature with a homomixer, and then the above aqueous solution was gradually added. A gel-like acne-improving composition was produced by stirring at 3,000 rpm for 2 minutes while adding the above aqueous solution.

(Example 2, Comparative Examples 1-3)
A gel-like acne-improving composition was produced in the same manner as in Example 1 except that the composition was changed to the compositions shown in Table 1, respectively.

(Examples 3-11, Comparative Example 4)
A gel-like acne-improving composition was produced in the same manner as in Example 1 except that the composition was changed to the compositions shown in Table 2, respectively.

  Using the manufactured examples and compositions for improving acne in each comparative example, evaluations for acne improvement were performed by women in their 20s who have acne symptoms. Details of the evaluation method are as follows.

<Evaluation method 1>
About the five acne improving compositions of Examples 1 and 2 and Comparative Examples 1 to 3, 60 women in their 20s were divided into 5 groups of 12 people, and each group was evaluated as a subject (N = 12).
Specifically, after applying the makeup base, the act of applying the composition for improving acne to an acne disease site was performed twice a day. The composition for improving acne was continued for 20 days, and the acne improving performance before and after use (6 items) and the skin irritation feeling during use (2 items) were evaluated by a questionnaire.
At each evaluation, A. I think so, B. I think so, C. I don't know, D. I didn't think so at all.
The results of the evaluation are shown in Table 3. In addition, each number in Table 3 is the above-mentioned A. ~ D. Represents the number of subjects evaluated.

  As can be seen from Table 3, the compositions for improving acne in the examples have excellent acne improving performance. Moreover, the composition for acne improvement of an Example has an effect which suppresses the burden (stimulation to skin) with respect to skin.

<Evaluation method 2>
On the other hand, about the composition for an acne improvement of the comparative example 4 and Examples 3-11, 30 females in their 20s were divided into 10 groups by 3 persons, and each group was evaluated as a subject (N = 3).
And the composition for acne improvement was evaluated like the said evaluation method 1 except the point which made the use period into 14 days. Also, the questionnaire was scored as follows.
A. I think so-3 points I think it is somewhat -2 points I don't know-1 point Table 4 shows the results of the above evaluation. The numbers in Table 4 represent the total number of points scored as described above.

As can be seen from Table 4, the compositions for improving acne in the examples have excellent acne improving performance. Since the composition for improving acne in Examples includes an artichoke extract and a saxifrage extract, it is considered that the acne improving performance is synergistically exhibited.
Moreover, the composition for acne improvement of an Example has an effect which suppresses the burden (stimulation to skin) with respect to skin.

  Further, a gel-like acne improving composition (external preparation for skin, cosmetics) having the composition shown in Table 5 and a cream-like acne improving composition (external preparation for skin, cosmetics) having the composition shown in Table 6 were prepared. Each was manufactured.

(Examples 12 to 16)
Except for the change to the composition shown in Table 5, the gel-like acne-improving composition was prepared in the same manner.

(Examples 17 to 22, Comparative Example 5)
On the other hand, the creamy acne-improving composition was produced as follows so as to have the composition shown in Table 6.
That is, first, carbomer was added to purified water so as to be 2% by mass, and then stirred to prepare a viscous solution.
Moreover, the Yukinoshita extract and the artichoke extract were added to purified water and stirred to prepare a uniform extract solution.
Further, sodium hydroxide was added to purified water and stirred to prepare a uniform 2% alkaline solution.
Furthermore, isopropylmethylphenol, ethylhexylglycerin, glycerin, 1,3-butylene glycol, phenoxyethanol, methylparaben, and the remainder of purified water were mixed and heated to 70 ° C. or higher to prepare a dispersion solution.
Vaseline, octyldodecyl myristate, hydrogenated lecithin, tocopherol, dilauroyl glutamate (cholesteryl / octyldodecyl), and squalane were mixed and heated to 70 ° C. or higher to prepare a uniform oil phase solution.
The dispersion solution and the oil phase solution were mixed, homogenized at 4,000 rpm for 2 minutes, and then cooled to 50 ° C. or lower.
After cooling, the viscous solution and the extract solution were added, homogenized at 4,000 rpm for 2 minutes, and then cooled to room temperature.
Further, an alkaline solution was added and stirred until uniform to produce a creamy acne improving composition.

<A method for evaluating the stability of a gel-like and cream-like acne-improving composition>
The stability of the gel-like acne-improving composition shown in Table 5 and the cream-like acne-improving composition shown in Table 6 were evaluated.
Specifically, on the next day after production, the acne-improving composition was stored at 50 ° C. for 20 days to conduct an accelerated test, and the state after storage was evaluated according to the following.
○ No change. Or slightly change.
△ Change, but no problem in use.
× Changed significantly, hindering use.
The stability evaluation results are shown in Tables 5 and 6.

  Furthermore, the manufacture example of the composition for acne improvement (skin external preparation, cosmetics) is shown below.

(Production Example 1)
A cosmetic (skin lotion) having the composition shown in Table 7 was produced.

  Manufacture of the lotion of the manufacture example 1 (skin lotion for acne) was performed as follows. In other words, a polyoxyethylene hydrogenated castor oil is gradually added to an aqueous phase composed of a yukinoshita extract, artichoke extract, glycerin, etc., uniformly dispersed and dissolved, and further subjected to a filtration treatment, thereby producing a cosmetic. (Lotion) was obtained.

(Production Example 2)
Cosmetics (milky lotion) having the composition shown in Table 8 were produced.

  Manufacture of the milky lotion (milky liquid for acne) of manufacture example 2 was performed as follows. That is, the oil phase is composed of squalane, cetyl ethylhexanoate, octyldodecyl myristate, etc. heated at 75 ° C. and then dissolved in a yukinoshita extract, artichoke extract, hydrogenated lecithin, glycerin, etc. The oil phase was gradually added to the aqueous phase heated and dissolved at 0 ° C., and uniformly dispersed with a homomixer (3,000 rpm, treatment for 2 minutes). Furthermore, cosmetics (milky lotion) were obtained by deaerating and filtering.

(Production Example 3)
Cosmetics (makeup bases) having the compositions shown in Table 9 were produced.

  Manufacture of the makeup base (production base for acne) of Production Example 3 was performed as follows. That is, after uniformly stirring cyclomethicone, octyl methoxycinnamate, dimethicone, octyldodecyl myristate, titanium oxide, etc. constituting the oil phase, it is composed of a yukinoshita extract, artichoke extract, citric acid, sodium chloride, etc. The oil phase was gradually added to the aqueous phase and uniformly dispersed with a homomixer (5,000 rpm, 5 minutes treatment). Further, a cosmetic (makeup base) was obtained by deaeration and filtration.

  The composition for improving acne, the external preparation for skin, and the cosmetic of the present invention are suitably used for promoting disappearance of acne once generated, for example, when applied to the skin. The composition for improving acne, the external preparation for skin, and the cosmetic of the present invention are also suitably used for the purpose of suppressing the enlargement of acne that is occurring when applied to the skin, for example.

Claims (3)

  A composition for improving acne, comprising an artichoke extract and a yukinoshita extract.   Furthermore, the composition for acne improvement of Claim 1 containing a disinfectant. The composition for acne improvement according to claim 2, wherein the fungicide is at least one of isopropylmethylphenol and ethylhexylglycerin.