JP6335121B2 - 固定化によって引き起こされた筋萎縮後の筋肉回復の促進 - Google Patents
固定化によって引き起こされた筋萎縮後の筋肉回復の促進 Download PDFInfo
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Description
したがって、筋肉の回復を向上するために栄養学上の戦略などのさらなる戦略が必要である。
ヘスペレチン−7−グルコシド 0.5〜1.5g
クルクミン 1〜2g
緑茶カテキン 1〜3g
ルチン 1〜3g
ビタミンE: 300IU
ビタミンA: 8000IU
セレン: 4〜6μg
亜鉛: 90〜100μg
L−ロイシン 40〜50g
L−バリン 3〜8g、及び
L−イソロイシン 8〜12g
を含むことができる。
乳漿タンパク 20g
クルクミン 0.5g
ルチン 0.5g
多価不飽和脂肪酸 2g
を含むことができる。
乳漿タンパク 300g/kg
脂質 170g/kg
炭水化物 500g/kg
遊離ロイシン 20g
遊離バリン 2.5g
遊離イソロイシン 3.0g
ヘスペレチン−7−グルコシド、クルクミン、緑茶カテキン、ルチン、ビタミンE、ビタミンA、Zn、Seの群から選ばれた抗酸化物質 5g
を含むことができる。
Claims (11)
- 固定化によって引き起こされる筋萎縮の治療又は予防に使用するための、
組成物の全乾燥重量に基づいた2〜10重量%の量のロイシン並びに、イソロイシン、バリン及び少なくとも1種の抗酸化物質を含む組成物であって、
1kg当たり
ヘスペレチン−7−グルコシド 0.5〜1.5g
クルクミン 1〜2g
緑茶カテキン 1〜3g
ルチン 1〜3g
ビタミンE: 300IU
ビタミンA: 8000IU
セレン: 4〜6μg
亜鉛: 90〜100μg
L−ロイシン 40〜50g
L−バリン 3〜8g、及び
L−イソロイシン 8〜12g
を含む、組成物。 - 固定化が、床上安静及び/又はギプスをすることにより引き起こされる、請求項1に記載の組成物。
- ロイシン及び少なくとも1種の抗酸化物質を25:1〜1:1の範囲の重量比で含む、請求項1又は2に記載の組成物。
- 体重1kg当たりロイシン0.03〜0.2gに対応する量で投与されることを含む、請求項1〜3のいずれか一項に記載の組成物。
- ロイシンが、L−ロイシンである、請求項1〜4のいずれか一項に記載の組成物。
- 少なくとも14日間連続して毎日投与される、請求項1〜5のいずれか一項に記載の組成物。
- 固定化直後に投与される、請求項1〜6のいずれか一項に記載の組成物。
- 経口投与、経腸投与又は非経口投与される、請求項1〜7のいずれか一項に記載の組成物。
- ヒト又はヒトを除く動物に投与される、請求項1〜8のいずれか一項に記載の組成物。
- 健康補助食品、栄養組成物、栄養補助食品、摂取の前に水又はミルク中で復元される粉末化した栄養製品、食品添加物、医薬品、飲料、及びペットフードからなる群から選択される、請求項1〜9のいずれか一項に記載の組成物。
- 筋肉が、腓腹筋、脛骨筋、ヒラメ筋、足の長指伸筋(EDL)、大腿二頭筋、半腱様筋、半膜様筋、大殿筋又はそれらの組み合わせからなる群から選択される骨格筋である、請求項1〜10のいずれか一項に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11184580.6A EP2580967A1 (en) | 2011-10-11 | 2011-10-11 | Accelerating muscle recovery after immobilization-induced muscle atrophy |
EP11184580.6 | 2011-10-11 | ||
PCT/EP2012/070121 WO2013053795A1 (en) | 2011-10-11 | 2012-10-11 | Accelerating muscle recovery after immobilization-induced muscle atrophy |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2014534960A JP2014534960A (ja) | 2014-12-25 |
JP6335121B2 true JP6335121B2 (ja) | 2018-05-30 |
Family
ID=47008610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014535068A Active JP6335121B2 (ja) | 2011-10-11 | 2012-10-11 | 固定化によって引き起こされた筋萎縮後の筋肉回復の促進 |
Country Status (9)
Country | Link |
---|---|
US (1) | US9867391B2 (ja) |
EP (2) | EP2580967A1 (ja) |
JP (1) | JP6335121B2 (ja) |
CN (1) | CN103974631A (ja) |
AU (1) | AU2012323019B2 (ja) |
BR (1) | BR112014008666B1 (ja) |
CA (1) | CA2851579C (ja) |
MX (1) | MX350869B (ja) |
WO (1) | WO2013053795A1 (ja) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112015025490B1 (pt) * | 2013-04-15 | 2022-05-03 | Société des Produits Nestlé S.A. | Uso de uma fonte de aminoácidos em combinação com o estímulo muscular elétrico |
JP2016520603A (ja) * | 2013-05-29 | 2016-07-14 | ネステク ソシエテ アノニム | 軟骨破壊における使用のための組成物 |
US20140357576A1 (en) * | 2013-05-31 | 2014-12-04 | Nestec S.A. | Methods for enhancement of muscle protein synthesis |
CA2945587A1 (en) | 2014-04-18 | 2015-10-22 | Omniactive Health Technologies Limited | Curcumin compositions and uses thereof |
MY194893A (en) * | 2014-04-28 | 2022-12-22 | Suntory Holdings Ltd | Muscle atrophy inhibitor containing quercetin glycoside |
WO2016044272A1 (en) * | 2014-09-16 | 2016-03-24 | Abbott Laboratories | Methods of preserving muscle strength during a period of muscle disuse by administering beta-hydroxy-beta-methylbutyrate and green tea extract |
CA2963182C (en) * | 2014-10-14 | 2023-10-17 | Nestec S.A. | Improvement in muscle functionality of elderly males |
US10744100B2 (en) * | 2015-11-17 | 2020-08-18 | Societe Des Produits Nestle S.A. | Compositions and methods using a polyphenol for musculoskeletal health |
EP3376881B1 (en) * | 2015-11-17 | 2020-03-11 | Société des Produits Nestlé S.A. | Compositions and methods using a polyphenol for musculoskeletal health |
GB201600990D0 (en) * | 2016-01-19 | 2016-03-02 | Abbott Lab | Pharmaceutical or nutritional combination |
JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
US11617731B2 (en) | 2017-04-28 | 2023-04-04 | Axcella Health, Inc. | Amino acid compositions and their use for the treatment of traumatic brain injury |
PE20200747A1 (es) | 2017-08-14 | 2020-07-24 | Axcella Health Inc | Composiciones de aminoacidos para el tratamiento de enfermedad hepatica |
AU2018373653B2 (en) * | 2017-11-21 | 2024-09-12 | Societe Des Produits Nestle S.A. | Compositions and methods using oleuropein or curcumin for muscle quality and/or muscle mass |
CA3097629A1 (en) * | 2018-04-18 | 2019-10-24 | Worlds Greatest Ingredients, LP | Compositions and methods of use thereof to promote muscle growth and function |
MA52971A (fr) | 2018-06-20 | 2021-04-28 | Axcella Health Inc | Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle |
AU2021249461A1 (en) * | 2020-04-01 | 2022-08-25 | Société des Produits Nestlé S.A. | Compositions containing amino acids and methods of using such compositions for treating sarcopenia |
EP4129404A4 (en) * | 2020-04-03 | 2023-06-21 | Mitsubishi Gas Chemical Company, Inc. | MUSCLE BUILDING AGENT |
CN112535718B (zh) * | 2020-12-28 | 2022-03-08 | 中国人民解放军总医院第七医学中心 | 一种治疗心身应激引起肌肉消减萎缩的中药组合物 |
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US6589948B1 (en) * | 2000-11-28 | 2003-07-08 | Eukarion, Inc. | Cyclic salen-metal compounds: reactive oxygen species scavengers useful as antioxidants in the treatment and prevention of diseases |
JP4846141B2 (ja) * | 2001-08-31 | 2011-12-28 | 東洋精糖株式会社 | 即効性および持続性を有するフラボノイド配糖体を含有する経口栄養補給剤 |
US20080254130A1 (en) * | 2003-08-29 | 2008-10-16 | Bioderm Research | Skin Antiaging & Brightening via Multi-function Treatment of Enzyme Dysfunction |
PT1750651T (pt) * | 2003-12-18 | 2018-02-16 | Nestec Sa | Composição para melhorar a saúde da pele, cabelo e pelo contendo flavanonas |
CA2586936C (en) * | 2004-11-09 | 2019-08-20 | Hill's Pet Nutrition, Inc. | Use of antioxidants for gene modulation |
US20090117197A1 (en) * | 2005-03-21 | 2009-05-07 | Vicus Therapeutics Llc | Compositions and methods for ameliorating cachexia |
JP4902151B2 (ja) * | 2005-08-01 | 2012-03-21 | 株式会社林原生物化学研究所 | ヘスペレチン−7−β−マルトシド及びその製造方法並びにその用途 |
WO2007134867A2 (en) * | 2006-05-24 | 2007-11-29 | Dsm Ip Assets B.V. | Treating muscular disorders and improving muscular function |
US20070280997A1 (en) * | 2006-05-31 | 2007-12-06 | Pacifichealth Laboratories, Inc. | Composition for enhancing muscle recovery |
JP2008013473A (ja) * | 2006-07-05 | 2008-01-24 | Kao Corp | 筋機能低下抑制剤 |
EP2036552B1 (en) * | 2006-07-05 | 2018-08-08 | Kao Corporation | Senescence inhibitor |
US20090214712A1 (en) * | 2008-02-21 | 2009-08-27 | The Coca Cola Company | Milk-Based Beverage and Method for Preventing Off-Flavors in a Milk-Based Beverage |
JP5419366B2 (ja) * | 2008-03-03 | 2014-02-19 | 東洋精糖株式会社 | 生体吸収性に優れたヘスペレチン組成物 |
MX2012000943A (es) | 2009-07-20 | 2012-02-28 | Nestec Sa | Metodos para atenuar la perdida de estatus funcional. |
WO2011078654A1 (en) * | 2009-12-24 | 2011-06-30 | N.V. Nutricia | Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis |
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EP2765873A1 (en) | 2014-08-20 |
MX350869B (es) | 2017-09-22 |
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