JP6329317B1 - Blood pressure lowering composition - Google Patents

Abstract

An object of the present invention is to provide a composition for lowering blood pressure. A composition for lowering blood pressure containing a plum extract containing a high content of umefural. [Selection] Figure 1

Description

  The present invention relates to a composition for lowering blood pressure, and more specifically to a composition for lowering blood pressure containing a plum extract containing a high amount of umefural.

  A plum product with a high content of umefural is known (Patent Document 1). However, there is no known or even suggested that a plum extract containing a high content of memefural reduces blood pressure or improves the duration of blood pressure lowering action.

Japanese Patent No. 4566978

  An object of the present invention is to provide a composition for lowering blood pressure.

  The present inventors have found that a composition containing a plum extract containing a high content of umefural reduces blood pressure and improves the duration of blood pressure lowering action, and further studies have been made to complete the present invention.

That is, the present invention is as follows.
[1] A composition for lowering blood pressure, comprising a plum extract containing a high content of umefural.
[2] The composition according to [1] above, wherein the content of umefural in the plum extract is 0.2 to 2% by mass.
[3] The composition according to [1] or [2] above, wherein the blood pressure lowering action is sustained during the administration period of the plum extract containing a high amount of umefural or for 2 weeks after the administration is stopped.
[4] The composition according to any one of [1] to [3], wherein the application target is a person with grade I hypertension.
[5] The composition according to any one of [1] to [4] above, an indication that the blood pressure is lowered, an indication that the blood pressure lowering action duration is improved, or a human or I degree that increases blood pressure A food and drink for lowering blood pressure, which is labeled as suitable for humans with high blood pressure.
[6] The composition according to any one of [1] to [4], wherein the composition lowers blood pressure, improves blood pressure lowering action duration, or increases blood pressure in humans or I-degree hypertension A blood pressure lowering product packaged with instructions describing its suitability for humans.

  The composition of the present invention has a blood pressure lowering action, and preferably can improve (preferably prolong or extend) the duration of the blood pressure lowering action. The composition of the present invention can improve the duration of action (preferably prolonged or extended) without adopting sustained release preparation technology such as beads, or continuous administration (taken) such as daily. Even if you forget to do it, it is particularly excellent in that the blood pressure lowering effect can be achieved without hindrance.

FIG. 1 is a graph showing average visit diastolic blood pressure change.

  The present disclosure includes a composition for lowering blood pressure (hereinafter also referred to as the composition of the present invention) containing a plum extract containing a high amount of umefural.

  The composition of the present invention contains a plum extract high in umefural. The composition of the present invention may contain other components in addition to the plum extract with a high content of umefural. The component is not particularly limited as long as the effects of the present invention are not lost. For example, any component known in the field of medicine, pharmacy, food, etc. can be used. In one embodiment of the present invention, as a component other than the high-memefural plum extract, sweeteners such as sorbitol, stevia, saccharin, aspartame, neotame, advantame, acesulfame potassium, sucralose, xylitol, erythritol; pectin, guar gum, xanthan gum , Tamarind gum, carrageenan, propylene glycol, carboxymethylcellulose and other thickeners; honey; citric acid; corrigents; flavorings; preservatives; pH adjusters; and additives such as food ingredients such as plum pulp, ginger, yam It is done.

Plum pearl (trade name, manufactured by Nakano BC Co., Ltd.), which is a commercially available product, may be used as the plum extract containing a high content of memefural. In addition, plum extract with high content of umefural can be obtained by mixing ume extract obtained by squeezing plum juice obtained by squeezing plum pulp and ume-derived components including dried plum powder in a desired ratio. Can be manufactured. You may refer description of the patent 4566978 for the manufacturing method of a plum extract containing high memefural.
The content ratio of umefural with respect to the whole plum extract is, for example, preferably about 0.2 to 2% by mass, more preferably 1 to 2% by mass, and further preferably 1.5 to 2% by mass. . If it is in the said range, the more excellent effect of this invention may be show | played.
Furthermore, it is preferable that citric acid is contained in the plum extract with high content of memefural in the present invention. For example, the citric acid content in the plum extract is preferably about 1 to 80% by mass, more preferably 10 to 70% by mass, and further preferably 20 to 60% by mass. If it is in the said range, the more excellent effect of this invention may be show | played.
In the composition of the present invention, the content of the plum extract with high content of memefural is not particularly limited as long as the effect of the present invention is exhibited, but in 100% by mass of the composition, for example, about 0.001 to 100% by mass. It may be in the range, preferably about 10 to 100% by weight.

The administration route of the composition of the present invention is not particularly limited, and for example, it may be administered to a mammal by either oral or parenteral route. In particular, the composition of the present invention is excellent in that it can be administered to humans (more preferably, humans with grade I hypertension), and the diastolic blood pressure and / or systolic blood pressure can be reduced or the reduction time can be sustained. Yes. Grade I hypertension usually refers to visit systolic blood pressure of 140 to less than 160 and / or visit diastolic blood pressure of 90 to less than 100. In addition, blood pressure at visit (consultation room blood pressure) usually refers to blood pressure measured at a hospital or clinic. In addition, home blood pressure, which will be described later, is usually the blood pressure measured within 1 hour after getting up in the morning, after urination, after sitting for 1 to 2 minutes after sitting, before taking antihypertensive drugs, before breakfast, in the evening, before going to bed, sitting The blood pressure measured after resting for 1 to 2 minutes.
The intake amount of the plum extract containing a high content of umefural can be determined depending on the age and weight of the intake person, symptoms, administration time, dosage form, administration method, combination of drugs and the like in the case of oral or injection administration. For example, it is preferable to set so that about 0.5 to 5 g, more preferably about 1 to 4 g of the high-plum umefural plum extract is taken per day per adult (about 60 kg). When the extract contains a high proportion of umefural, the amount of umefural is preferably about 10 to 50 mg, more preferably about 20 to 40 mg, more preferably about 25 to 35 mg per day per adult (about 60 kg). It is preferable to set it to be ingested. The number of intakes can be performed once a day or divided into multiple times. In addition, the above-mentioned administration dose can be administered or applied every few days (2 to 3 days).
Or, in the case of external application, the application amount of the plum extract containing a high amount of umefural can be appropriately selected according to the skin area to be applied, but the application amount is usually about 10 cm ² for the area of the application site, It is preferably about 0.01 to 100 mg, more preferably about 0.02 to 30 mg per day. The aforementioned administration dose can be administered or applied once or several times per day. In addition, the above-mentioned administration dose can be administered or applied every few days (2 to 3 days).

  When the composition of the present invention is administered orally, it may be a solid preparation such as a powder, granule, pill, tablet, capsule or the like, or may be a liquid such as a syrup. When these preparations are produced, carriers or additives depending on the form of the preparation can be used. Since the production of these preparations has been well established in the past, the present invention may be followed. Carriers or additives used in the manufacture of such formulations include, for example, excipients (sodium polyacrylate, calcium polyacrylate, carboxymethylcellulose, lactose, dextrin, corn starch, crystalline cellulose, sucrose, sodium chloride, Glucose, urea, starch, calcium carbonate, kaolin, silicic acid, potassium phosphate, etc.), lubricant (magnesium stearate, sucrose fatty acid ester, glycerin fatty acid ester, purified talc, polyethylene glycol, etc.), disintegrant (carboxymethylcellulose) Calcium, anhydrous calcium hydrogen phosphate, sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, dried starch, sodium alginate, agar powder, sodium bicarbonate, calcium carbonate, etc.) Binder (hydroxypropylcellulose, gum arabic solution, water, ethanol, propanol, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethylcellulose, methylcellulose, polyvinylpyrrolidone, etc.), solubilizer (gum arabic, polysorbate 80, etc.) , Absorption enhancers (sodium lauryl sulfate, etc.), buffers (phosphate buffer, acetate buffer, borate buffer, carbonate buffer, citrate buffer, Tris buffer, etc.), preservatives (methyl parahydroxybenzoate) , Ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, chlorobutanol, benzyl alcohol, benzalkonium chloride, sodium dehydroacetate, sodium edetate, etc., thickener (propylene glycol, glycerin, hydroxy) Chill cellulose, hydroxypropyl cellulose, polyvinyl alcohol, polyethylene glycol, etc.), stabilizers (sodium bisulfite, sodium thiosulfate, sodium edetate, sodium citrate, ascorbic acid, dibutylhydroxytoluene, etc.) or pH adjusters (hydrochloric acid, Sodium hydroxide, phosphoric acid, acetic acid, etc.). If necessary, it may be coated with a coating agent (sucrose, gelatin, hydroxypropylcellulose, hydroxypropylmethylcellulose phthalate, etc.), or may be coated with two or more layers.

  Although the composition of this invention is not specifically limited, For example, food / beverage products, a feed, a food additive, a feed additive, a pharmaceutical, or cosmetics etc. may be sufficient, Preferably it is food / beverage products. That is, the present disclosure includes the composition of the present invention, and has a blood pressure lowering action with an indication that the blood pressure lowering action duration is improved, or an indication that the blood pressure is increased or a person with I degree hypertension is suitable. Includes food and drink for improving duration.

  When the composition of the present invention is a food or drink, the food or drink generally includes food additives generally used in food and drink, such as sweeteners, colorants, preservatives, thickening stabilizers, antioxidants, colorants. Bleaching agents, fungicides, gum bases, bittering agents, enzymes, brighteners, acidulants, seasonings, emulsifiers, strengthening agents, manufacturing agents, fragrances, spice extracts and the like may be added. The food and drink includes functional display foods, foods for specified health use, health foods, and foods for the sick. The said food / beverage products can be processed and manufactured using the manufacturing method of a general food / beverage products including the process of adding a plum extract containing high memefural in food / beverage products.

  Specific examples of the food and drink suitable for the present invention include tablets, granules, powders, drinks and the like as so-called nutritional supplements (supplements). Other than this, for example, beverages such as tea beverages, soft drinks, carbonated beverages, nutritional beverages, fruit beverages, lactic acid beverages, noodles such as buckwheat, udon, Chinese noodles, instant noodles, strawberries, candy, gum, chocolate, snacks, Biscuits, jellies, jams, creams, baked confectionery, confectionery such as bread, bakery products, fishery products such as kamaboko, ham, sausage, processed foods, dairy products such as processed milk, fermented milk, salad oil, tempura oil, margarine, mayonnaise , Shortening, whipped cream, dressing and other fats and oils and processed foods, seasonings such as sauces and sauces, retort pouch foods such as curry, stew, rice cakes, rice cakes, miscellaneous foods, ice cream, sorbets, shaved ice and other frozen desserts Can be mentioned.

  When the composition of the present invention is prepared in the form of a food or drink, the food or drink, attached instructions or packaging box, etc., in view of the action of the composition of the present invention, (1) Improve blood pressure lowering action duration (Preferably prolonged or prolonged), (2) Decrease blood pressure, (3) Appropriate for humans with high blood pressure or those with I-degree hypertension, (4) Prevent or improve metabolic syndrome One or more selected from (5) suppressing obesity and (6) having a diet effect can be displayed.

  Examples of the feed include feed for livestock such as cattle, horses and pigs, feed for poultry such as chickens, and feed for pets such as dogs and cats. The feed can be processed and produced using a general method for producing a feed, including a step of adding a plum extract containing a high content of memefural to the feed.

  A pharmaceutical can be produced by blending a plum extract containing a high content of umefural and a known pharmaceutical additive.

  Cosmetics such as body cleansers, hand cleansers, facial cleansers, and other basic cosmetics such as lotions, emulsions and creams, foundations, under-makeups, white powders, and other cosmetics Examples include dosage forms. The cosmetics can be processed and manufactured using a general cosmetic manufacturing method, including the step of adding the plum extract containing high memefural in the cosmetics.

  The composition of the present invention comprises (1) an effect of improving (preferably prolonging or prolonging) the blood pressure lowering action duration, (2) an effect of lowering blood pressure, (3) a human having high blood pressure, or a human having I hypertension One or more effects selected from (4) effects that prevent or improve metabolic syndrome, (5) effects that suppress obesity, and (6) effects that have a diet effect.

Blood pressure at the time of visit (consultation room blood pressure) or home blood pressure was measured with a blood pressure measuring instrument such as a sphygmomanometer HEM-7080-IC (manufactured by OMRON Healthcare Co., Ltd.) or a Terumo electronic sphygmomanometer W300 (manufactured by Terumo Co., Ltd.). As a result, when the systolic blood pressure or diastolic blood pressure (preferably diastolic blood pressure) is decreased as compared to before administration of the composition of the present invention, it is determined that the composition of the present invention has an effect of lowering blood pressure. can do. In the present disclosure, a blood pressure lowering action may be exhibited during the administration period of the plum extract containing a high amount of umefural (for example, after a certain period from the start of administration or throughout the administration period). The blood pressure lowering effect may be exhibited during the administration of the plum extract containing a high amount of umefural (for example, after a certain period from the start of administration or throughout the administration period) and after the administration is stopped. In the above case, it is preferred to administer the composition of the present invention daily during the administration period, preferably before each meal in the morning, noon and night.
The period of blood pressure lowering action may be 1 day, 2 days, 3 days, 1 week, 2 weeks, 3 weeks 4 weeks, 6 weeks, 8 weeks, 10 weeks, 12 weeks, or 14 weeks. May be.
In the above “after a certain period from the start of administration”, the certain period may be one day, two days, three days, one week, or two weeks. 3 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks, or 12 weeks. Or 14 weeks.
Moreover, when the blood pressure lowering effect is exhibited after the administration of the plum extract containing a high amount of umefural, the administration stop date may be the start date of administration of the composition of the present invention, or one day after the start of administration of the composition of the present invention. It may be 2 days later, 3 days later, 1 week later, 2 weeks later, 3 weeks later, 4 weeks later It may be 6 weeks later, 8 weeks later, 10 weeks later, 12 weeks later, or 14 weeks later.
For example, in the case of showing blood pressure lowering action after stopping administration of umefural high-containing plum extract, when the period of blood pressure lowering action is the above period, it is determined that the composition of the present invention has an effect of improving the blood pressure lowering action duration. It is also useful as a composition for improving the duration of blood pressure lowering action.
Preferably, for example, when the composition of the present invention containing 20 to 40 mg of umefural is taken for 1 day, the effect can last for several days thereafter (eg 2 to 3 days).

  The present disclosure described the composition of the present invention as being suitable for humans who have increased blood pressure, improved blood pressure lowering action duration, or increased blood pressure, or humans with grade I hypertension. Includes products for improving duration of hypotensive action packaged with instructions.

  Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited thereto.

  As described below, a placebo-controlled double-blind parallel group comparison test on the blood pressure improving effect of ingestion of plum extract containing a high amount of umefural was conducted.

1. Test subjects Age 30-69 years, Grade I hypertension (visiting systolic blood pressure 140 to less than 160), and no need for hypertension treatment, randomly adjusting gender, age and systolic blood pressure The test food intake group of Example 1 and the placebo test food intake group were divided into two groups.

2. Test meal The raw materials listed in the following table were mixed and pasteurized at 90 ° C. to prepare a test meal of Example 1 or placebo.

3. Test Subjects in each group were orally ingested 10 g of the test meal of Example 1 or placebo daily for 12 weeks before each meal in the morning, noon and night. No test food was consumed from 12 weeks after the start of test food intake until 14 weeks after the start of test food intake.
The daily test meal intake is 30 g. The nutritional composition contained in the 30 g test meal is as shown in Table 2 below.

  Day 0, 4 weeks, 8 weeks, 12 weeks, and 14 weeks after the start of test food intake, the systolic blood pressure and diastolic blood pressure at visit were measured. Statistical processing was performed and comparison between groups was performed.

4). Results The results of mean visit diastolic blood pressure are shown in FIG. In FIG. 1, the mean visit diastolic blood pressure value 84.27 mmHg on the 0th day after the start of the test meal intake of the test meal intake group of Example 1, and the 0th day after the start of the test meal intake of the placebo test meal intake group The average visit diastolic blood pressure of 80.07 mmHg was set to a reference value of 0 for each group, and the mean diastolic blood pressure at visit at 4 weeks, 8 weeks, 12 weeks, and 14 weeks after the start of test food intake The amount of change with respect to the value on the 0th day after the start of intake of the test meal was shown.
In the first-degree hypertension group, the test meal intake group of Example 1 has been shown to have lower diastolic blood pressure at the visit for 14 weeks from the start of the test meal intake compared to the placebo test meal intake group. It was. In particular, at 12 weeks and 14 weeks after the start of test meal intake, the test meal intake group of Example 1 significantly decreased diastolic blood pressure at the visit compared to the placebo test meal intake group.

  The average visit systolic blood pressure results are shown in Table 3. At 8 weeks and 14 weeks after the start of test food intake, the test food intake group of Example 1 had lower systolic blood pressure at visit compared to the placebo test food intake group. In the test meal intake group of Example 1, the systolic blood pressure at visit 8 weeks and 14 weeks after the start of the test meal intake was lower than that on day 0 after the start of the test meal intake.

  From these results, it was shown that the plum extract with high content of umefural showed a blood pressure lowering action on humans and the action lasted for a long time.

  The composition of the present invention is useful as a food / beverage product, a pharmaceutical product, and feed for the purpose of lowering blood pressure.

Claims (5)

A composition for improving blood pressure lowering action duration , comprising a plum extract containing a high amount of umefural , wherein the content of umefural in the ume extract is 0.2 to 2% by mass . Mumefuraru rich plum in extract administration period or the administration stopped after two weeks, the composition according to claim 1, characterized in that antihypertensive effect persists. The composition according to claim 1 or 2 , wherein the subject of application is a person with grade I hypertension. It contains the composition according to any one of claims 1 to 3 , and is suitable for an indication of lowering blood pressure, an indication of improving blood pressure lowering action duration, or a human having high blood pressure or a human with I-degree hypertension. A food and drink for improving the duration of blood pressure lowering with an indication to the effect. The composition according to any one of claims 1 to 3 , wherein the composition lowers blood pressure, improves blood pressure lowering action duration, or is suitable for a human having high blood pressure or a person with I-degree hypertension. A product for improving the duration of hypotensive action packaged with instructions describing the above.

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