JP2009161534A - Antidepressant-antistress agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an antidepressant-antistress agent and a beverage and a foodstuff having excellent antidepressant and antistress activity for dissolving a fact that in this dizzyingly changing society, it is difficult to live without having stress, and therefore depression said to be caused by the stress, etc., becomes a big social issue as one of recent diseases. <P>SOLUTION: This antidepressant-antistress agent contains ornithine or its salt as the active ingredient, and the beverage and foodstuff containing the antidepressant-antistress agent are also provided. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to an antidepressant / antistress agent and a food or drink containing the same.

  It is difficult to live without stress in today's rapidly changing society. For this reason, depression, which is said to be caused by stress or the like, has become a major social problem as one of the modern diseases. Drugs such as tranquilizers, antidepressants, and anxiolytics are used for the treatment of neurosis, depression, schizophrenia, etc., and their effects have been recognized.

  On the other hand, ornithine is known to have various activities such as a collagen synthesis promoting action (Patent Document 1), a cooling symptom improving action (Patent Document 2), and a sleeping or waking up improving action (Patent Document 3).

JP 2008-214232 A JP 2007-119348 A JP 2006-342148 A

  An object of the present invention is to provide an anti-depressant / anti-stress agent having high safety and an excellent anti-depressant / anti-stress effect, and a food and drink using the same.

The invention described in claim 1 is an antidepressant / antistress agent characterized by containing ornithine or a salt thereof as an active ingredient.
Invention of Claim 2 contains the antidepressant and anti-stress agent of Claim 1, It is food-drinks characterized by the above-mentioned.

  According to the present invention, it is possible to provide an antidepressant / antistress agent having high safety and an excellent antidepressant / antistress effect, and a food or drink using the same.

Hereinafter, the present invention will be described in more detail.
The ornithine used in the present invention may be either L- or D-ornithine, but L-ornithine is preferred.
Ornithine can be produced by a known chemical synthesis method or fermentation method. Moreover, you may utilize a commercial item. The method for producing ornithine is disclosed in Patent Document 1 described above.

  Examples of ornithine salts include acid addition salts, metal salts, ammonium salts, organic amine addition salts, amino acid addition salts, and the like.

Acid addition salts include inorganic acid salts such as hydrochloride, sulfate, nitrate, phosphate, acetate, maleate, fumarate, citrate, malate, lactate, α-ketoglutarate And organic acid salts such as gluconate and caprylate.
Examples of the metal salt include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as magnesium salt and calcium salt, aluminum salt and zinc salt.

Examples of ammonium salts include salts such as ammonium and tetramethylammonium. Examples of the organic amine addition salt include salts of morpholine, piperidine and the like.
Examples of amino acid addition salts include salts of glycine, phenylalanine, lysine, aspartic acid, glutamic acid and the like.

  Of the above ornithine salts, hydrochloride, citrate, malate, α-ketoglutarate and aspartate are preferably used, but other salts or two or more salts may be used in appropriate combination. Good.

  The antidepressant / antistress agent of the present invention can be appropriately prepared by a known method in the form of a solid or solution (hereinafter also referred to as a preparation) such as tablets, pills, capsules, granules, powders, powders, and liquids. That is, a solid preparation or a liquid preparation useful in the present invention is produced by mixing ornithine or a salt thereof and, if desired, an additive and using a well-known preparation method that has been well established. Examples of additives include excipients, pH adjusting agents, cooling agents, suspending agents, diluents, antifoaming agents, thickeners, solubilizers, disintegrating agents, binders, lubricants, antioxidants. Agents, coating agents, coloring agents, flavoring agents, surfactants, plasticizers or fragrances.

  Examples of the excipient include sugar alcohols such as D-sorbitol, D-mannitol or xylitol, sugars such as glucose, sucrose, lactose or fructose, crystalline cellulose, carmellose sodium, calcium hydrogen phosphate, wheat starch, rice Examples include starch, corn starch, potato starch, dextrin, cyclodextrin, light anhydrous silicic acid, titanium oxide, and magnesium aluminate metasilicate.

Examples of the pH adjuster include citric acid, malic acid, sodium hydrogen phosphate, and dipotassium phosphate.
Examples of the refreshing agent include l-menthol or mint water.
Examples of the suspending agent include kaolin, carmellose sodium, xanthan gum, methylcellulose, and tragacanth.
Examples of the diluent include purified water, ethanol, vegetable oil, and emulsifier.
Examples of the antifoaming agent include dimethylpolysiloxane or silicon antifoaming agent.

Examples of the thickener include xanthan gum, tragacanth, methylcellulose, and dextrin.
Examples of the solubilizer include ethanol, sucrose fatty acid ester, and macrogol.
Examples of the disintegrant include low-substituted hydroxypropylcellulose, carboxymethylcellulose calcium, croscarmellose sodium, hydroxypropyl starch, or partially pregelatinized starch.

  Examples of the binder include methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, gelatin, gum arabic, ethylcellulose, polyvinyl alcohol, pullulan, pregelatinized starch, agar, tragacanth, sodium alginate, or propylene glycol alginate. Can be mentioned.

Examples of the lubricant include stearic acid, magnesium stearate, calcium stearate, polyoxyl stearate, cetanol, talc, hydrogenated oil, sucrose fatty acid ester, dimethylpolysiloxane, beeswax and white beeswax.
Examples of the antioxidant include ascorbic acid, dibutylhydroxytoluene (BHT), propyl gallate, butylhydroxyanisole (BHA), tocopherol, ascorbic acid, and citric acid.

Examples of the coating agent include hydroxypropylmethylcellulose, hydroxypropylcellulose, methylcellulose, ethylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, carboxymethylethylcellulose, cellulose acetate phthalate, polyvinyl acetal diethylaminoacetate, aminoalkyl methacrylate. Copolymer, hydroxypropyl methylcellulose acetate succinate, methacrylic acid copolymer, polyvinyl acetate diethylaminoacetate or shellac.
Examples of the colorant include turmeric extract, riboflavin, titanium oxide, or carotene solution.

Examples of the flavoring agents include citric acid, adipic acid, ascorbic acid, fructose, D-sorbitol, glucose, sodium saccharin, simple syrup, sucrose, honey, amacha, licorice, citric acid, adipic acid, ascorbic acid, orange oil, Spruce tincture, fennel oil, mint or menthol.
Examples of the surfactant include polyoxyethylene hydrogenated castor oil, glyceryl monostearate, sorbitan monostearate, sorbitan monolaurate, polyoxyethylene polyoxypropylene, polysorbates, sodium lauryl sulfate, macrogol or sucrose. Examples include fatty acid esters.
Examples of the plasticizer include triethyl citrate, polyethylene glycol, triacetin, and cetanol.
As said fragrance | flavor, synthetic fragrance | flavors, such as natural fragrance | flavors, such as an animal fragrance | flavor or a vegetable fragrance | flavor, or an isolated fragrance | flavor etc. are mentioned, for example.

In the above-mentioned various preparation forms, the amount of ornithine or a salt thereof is usually about 1 to 80% by weight, preferably about 2 to 50% by weight based on the whole preparation.
The administration method of the preparation of the present invention may be oral or parenteral. The dose of ornithine or a salt thereof, which is the active ingredient of the present invention, varies depending on the type, dosage form, age, weight, indication symptoms, etc. of the patient. Ornithine or a salt thereof per day is usually 50 mg to 30 g, preferably 100 mg to 10 g, particularly preferably 200 mg to 3 g.

  The food / beverage products of this invention are manufactured by mix | blending ornithine or its salt, or the said ornithine or its salt containing formulation with food / beverage product material at the time of food-drinks manufacture. For example, solid foods such as bread, chewing gum, cookies, chocolate, cereals, jams, ice cream, yogurt, jelly and other jams, creams or gels, juices, coffee, cocoa, green tea, oolong tea, tea and other beverages Any food form can be used. Moreover, it can also mix | blend with a seasoning, a food additive, etc. The amount of ornithine or a salt thereof or the above-mentioned ornithine or a salt-containing preparation added to a food or drink material is not particularly limited, but is usually about 0.0001 to 80% by weight, preferably about 0.005 to 50% by weight. Moreover, especially in the case of a drink, it is 1 mg / L-20 g / L, Preferably it is 2 mg / L-10 g / L.

  In addition, when the present invention is a food or drink, the intake of ornithine or a salt thereof may be the same amount as the dose of the above-mentioned internal preparation because there is no worry about side effects.

  EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited to this.

Example 1
The anti-depressant and anti-stress effects of ornithine hydrochloride powder (hereinafter referred to as powder 1) were examined.
Evaluation of tranquilizing effect by mouse forced swimming test For the evaluation of the antidepressant / antistress agent of the present invention, a mouse forced swimming test developed by Porsolt in 1977 was adopted. This is one of the most frequently used animal model experiments for depression. In this test, the mouse is forced to swim in a limited space to cause “immobility”. This immobility state is thought to reflect a kind of “despair state” in which stressed animals abandon their escape from water, and is associated with depression and stress in humans. In fact, antidepressants have been found to specifically reduce the duration of immobility in this situation, and this shortening has been found to have a significant correlation with clinical titer.

The test method is as follows.
Mice are forced to swim in a plastic cylinder containing 25 ° C. water to a depth of 15 cm. After forced swimming for 5 minutes, dry in a dryer at 30 ° C. for 15 minutes and return to the home cage. On the next day, the test sample is intraperitoneally administered to the mouse, one hour later, forced swimming for 5 minutes is imposed again, and the duration of the immobility that appears is measured using a stopwatch. A state in which the mouse floats on the water and is stationary is determined as an immobile state. For the duration of stationary state, a significant difference test is performed, and a statistically significant difference is tested. For the experiment, male ddY mice are used, and there are 6 mice per group. All tests are conducted between 1pm and 6pm. A test using imipramine, an antidepressant, as a positive control will also be conducted.

  As a result, the duration of immobility of the mouse administered with Powder 1 at 30 mg / kg was 177.7 ± 5.1 seconds. The control (saline only) was 220.0 ± 2.2 seconds. The duration of immobility in positive control mice (30 mg / kg dose) was 176.5 ± 4.0 seconds. The duration of immobility in this example and the positive control is significantly different at a risk rate of 1%. Similar results were obtained when other metal salts, ammonium salts, organic amine addition salts, and amino acid addition salts were used instead of ornithine hydrochloride.

Example 2
Deionized water was added so that the tea leaf usage rate was 0.8% by weight with respect to the extract of oolong tea, black tea, green tea, hoji tea and jasmine tea extracted with hot water at 85 ° C. At that time, ascorbic acid was added so that it might become 0.025 weight%, and then it adjusted to pH which was easy to drink using baking soda. Furthermore, after adding the said powder 1 with respect to 100 g of the said preparation liquids so that it might become 5 mg, it performed UHT sterilization as usual, and it filled with the 350 ml capacity | capacitance PET bottle, and obtained various drinks.

Example 3
Juice was prepared according to the following formulation.
Frozen concentrated orange juice 5.0 parts by weight Fructose glucose liquid sugar 1.0 part by weight Citric acid 0.10 parts by weight L-ascorbic acid 0.09 parts by weight Powder 1 0.05 parts by weight

  The antidepressant / antistress agent of the present invention is useful as a pharmaceutical, food or feed form.

Claims (2)

  An antidepressant / antistress agent comprising ornithine or a salt thereof as an active ingredient.   A food or drink comprising the antidepressant / antistress agent according to claim 1.