JP2019099520A - Blood pressure lowering composition - Google Patents

Abstract

To provide blood pressure lowering compositions.SOLUTION: Provided is a blood pressure lowering composition containing mumefural-highly containing Prunus mume extract.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a blood pressure lowering composition, and more particularly to a blood pressure lowering composition containing mumefural-rich plum extract.

  BACKGROUND ART [0002] An ume extract high-plum extract granular product is known (Patent Document 1). However, nothing is known or even suggested that mumefural-rich plum extract lowers blood pressure or improves the duration of blood pressure lowering action.

Patent No. 4566978 gazette

  An object of the present invention is to provide a blood pressure lowering composition.

  The present inventors have found that a composition containing a mumefural-rich plum extract lowers blood pressure and improves the duration of blood pressure-lowering action, and has conducted further studies to complete the present invention.

That is, the present invention is as follows.
[1] A composition for lowering blood pressure, characterized by containing a mumefural-rich plum extract.
[2] The composition according to the above [1], wherein the content of mumefural in the ume extract is 0.2 to 2% by mass.
[3] The composition according to the above [1] or [2], wherein the blood pressure lowering action is sustained during the administration period of the high mumefural plum extract administration or for 2 weeks after the administration is stopped.
[4] The composition according to any one of the above [1] to [3], wherein the subject to be applied is a human with I-degree hypertension.
[5] A display showing that the blood pressure is lowered, a display showing that the blood pressure lowering action duration is improved, or a blood pressure-enhancing human or I containing the composition according to any one of the above [1] to [4] Food and drink for lowering blood pressure with an indication that it is suitable for humans with high blood pressure.
[6] The composition according to any one of the above [1] to [4], wherein the composition lowers blood pressure, improves the duration of blood pressure lowering action, or increases blood pressure or a human with I-degree hypertension An antihypertensive product packaged with instructions describing that it is suitable for humans.

  The composition of the present invention has a blood pressure lowering action, and preferably can improve (preferably prolong or prolong) the duration of the blood pressure lowering action. The composition of the present invention can improve the duration of action (preferably prolong or prolong) without adopting a sustained release preparation technology such as beads or continuous administration (dose), for example, every day It is particularly excellent in that even if you forget to

FIG. 1 is a graph showing the mean visit diastolic blood pressure change amount.

  The present disclosure includes a blood pressure lowering composition (hereinafter, also referred to as a composition of the present invention) containing a mumefural-rich plum extract.

  The composition of the present invention contains a mumefural-rich plum extract. The composition of the present invention may contain other components in addition to the mumefural-rich plum extract. The component is not particularly limited as long as the effect of the present invention is not lost, and any component known in the field of, for example, medicine, medicine, food and the like can be used. In one embodiment of the present invention, as components other than the mumefural-rich plum extract, for example, sweeteners such as sorbitol, stevia, saccharin, aspartame, neotame, neotame, advantame, acesulfame potassium, sucralose, xylitol, erythritol etc; pectin, guar gum, xanthan gum Thickeners such as tamarind gum, carrageenan, propylene glycol, carboxymethylcellulose, etc .; honey; citric acid; flavoring agents; flavors; preservatives; pH adjusters; additives such as food ingredients such as plum flesh, ginger, and yam Be

A commercially available product, plum pearl (trade name, manufactured by Nakano BC Co., Ltd.) may be used as the mumefural-rich plum extract. In addition, the mumefural high ume extract is obtained by mixing the plum-derived extract obtained by simmering in the plum juice obtained by squeezing plum flesh and the plum-derived component including dried plum flesh in a desired ratio It can be manufactured. The method of producing the mumefural-rich plum extract may be referred to the description of Japanese Patent No. 4566978.
For example, the content of mumefural relative to the whole plum extract is preferably about 0.2 to 2% by mass, more preferably 1 to 2% by mass, and still more preferably 1.5 to 2% by mass . Within the above range, more excellent effects of the present invention can be exhibited.
Furthermore, it is preferable that citric acid is contained in the mumefural high content plum extract in this invention. The citric acid content ratio to the whole plum extract is, for example, preferably about 1 to 80% by mass, more preferably 10 to 70% by mass, and still more preferably 20 to 60% by mass. Within the above range, more excellent effects of the present invention can be exhibited.
The content of the mumefural-rich plum extract in the composition of the present invention is not particularly limited as long as the effects of the present invention are exhibited, but for example, about 0.001 to 100% by mass in 100% by mass of the composition It may be in the range, preferably about 10 to 100% by mass.

The route of administration of the composition of the present invention is not particularly limited, and may be administered to a mammal, for example, by either oral or parenteral route. In particular, the composition of the present invention is excellent in that it can be administered to humans (more preferably, humans with I-high blood pressure) and diastolic blood pressure and / or systolic blood pressure can be reduced, or the reduction time can be sustained. There is. Degree I hypertension usually refers to a systolic blood pressure at visit 140 or more and less than 160 and / or a diastolic blood pressure at visit 90 or more and less than 100. In addition, blood pressure at the time of visit (doctor's office blood pressure) usually refers to the blood pressure measured at a hospital or clinic or the like. In addition, the home blood pressure described below is usually measured within 1 hour after getting up in the morning, after urination, after sitting for 1 to 2 minutes, before taking antihypertensive drugs, before taking breakfast, before going to bed at night, sitting down Blood pressure measured after 1 to 2 minutes of rest.
In the case of oral or injection administration, the intake of the mumefural-rich plum extract can be determined depending on the age and body weight of the user, symptoms, administration time, dosage form, administration method, drug combination and the like. For example, it is preferable to set so as to be preferably ingested about 0.5 to 5 g, more preferably about 1 to 4 g of mumefural-rich plum extract per adult (about 60 kg) per day. Where the extract contains a high proportion of mumefural, preferably about 10 to 50 mg, more preferably about 20 to 40 mg, still more preferably about 25 to 35 mg of mumefural per adult (about 60 kg) per day It is preferable to set so as to be ingested. The intake frequency can be divided into one or more times a day. In addition, the above dose can be administered or applied daily for several days (2 to 3 days).
Or, in the case of application for external use, the application amount of the mumefural high ume extract can be appropriately selected according to the skin area to be applied, but generally, the application amount is about 10 cm ² of the application area. Preferably it is about 0.01 to 100 mg, more preferably about 0.02 to 30 mg per day. The dose described above can be administered or applied once or several times a day. In addition, the above dose can be administered or applied daily for several days (2 to 3 days).

  When the composition of the present invention is orally administered, it may be a solid preparation such as powder, granule, pill, tablet, capsule and the like, or may be liquid such as syrup. When these formulations are produced, carriers or additives can be used according to the formulation form. The preparation of these formulations is well established in the art and may be followed according to the invention. Examples of carriers or additives used for producing such a preparation include excipients (sodium polyacrylate, calcium polyacrylate, carboxymethylcellulose, lactose, dextrin, corn starch, crystalline cellulose, sucrose, sodium chloride, Glucose, urea, starch, calcium carbonate, kaolin, silicic acid, potassium phosphate etc., lubricant (magnesium stearate, sucrose fatty acid ester, glycerin fatty acid ester, purified talc, polyethylene glycol etc), disintegrant (carboxymethyl cellulose Calcium, anhydrous calcium hydrogen phosphate, sodium carboxymethylcellulose, low substituted hydroxypropyl cellulose, dry starch, sodium alginate, agar powder, sodium hydrogen carbonate, calcium carbonate etc.) Binder (hydroxypropylcellulose, gum arabic solution, water, ethanol, propanol, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethylcellulose, methylcellulose, polyvinylpyrrolidone etc.), solubilizer (eg gum arabic, polysorbate 80 etc.) Absorption accelerator (sodium lauryl sulfate etc.), buffer (phosphate buffer, acetate buffer, borate buffer, carbonate buffer, citrate buffer, tris buffer etc), preservative (methyl parahydroxybenzoate) , Ethyl parahydroxybenzoate, propyl parahydroxybenzoate, butyl parahydroxybenzoate, chlorobutanol, benzyl alcohol, benzalkonium chloride, sodium dehydroacetate, sodium edetate etc., thickeners (propylene glycol, glycerin, hydroxy Chill cellulose, hydroxypropyl cellulose, polyvinyl alcohol, polyethylene glycol etc., stabilizers (sodium bisulfite, sodium thiosulfate, sodium edetate, sodium citrate, ascorbic acid, dibutylhydroxytoluene etc.) or pH adjusters (hydrochloric acid, Sodium hydroxide, phosphoric acid, acetic acid etc. can be mentioned. If necessary, it may be coated with a coating agent (sucrose, gelatin, hydroxypropyl cellulose, hydroxypropyl methylcellulose phthalate or the like) or may be coated with two or more layers.

  The composition of the present invention is not particularly limited, and may be, for example, food and drink, feed, food additive, feed additive, medicine, cosmetic, etc., preferably food and the like. That is, the present disclosure contains a composition of the present invention, and displays an indication that the blood pressure lowering action duration is improved, or displays an indication that the blood pressure is elevated or that it is suitable for humans with degree I hypertension. Include food and drink for improving the duration.

  When the composition of the present invention is a food or drink, food additives generally used for food and drink, such as sweeteners, colorants, preservatives, thickeners, thickeners, antioxidants, color formers Bleaching agents, fungicides, gum bases, bitter agents, enzymes, brighteners, acidulants, seasonings, emulsifiers, enhancers, manufacturing agents, flavors, spice extracts and the like may be added. The food and drink include functional indication food, food for specified health use, health food, food for sick people. The said food-drinks can be processed and manufactured using the manufacturing method of a general food-drinks including the process of adding a mumefural high content plum extract in food-drinks.

  Specific examples of the food and drink suitable for the present invention include tablets, granules, powders, drinks and the like as so-called nutraceuticals (supplements). Other than this, for example, beverages such as tea beverages, soft drinks, carbonated beverages, nutritional beverages, fruit beverages, lactic acid beverages, soba noodles, udon noodles, Chinese noodles, instant noodles etc., candy, candies, gums, chocolates, snacks, Biscuits, jellies, jams, creams, baked goods, pastries such as bread, breads, fish and fish processed foods such as kamabo, ham, sausages, dairy products such as processed milk and fermented milk, salad oil, tempura oil, margarine, mayonnaise , Shortening, whipped cream, fats and oils such as dressings and processed foods, sauces, seasonings such as sauce, curry, stew, chopsticks, rice cakes, retort pouch food such as risotto, ice cream, sherbet, frozen desserts such as shaved ice It can be mentioned.

  When the composition of the present invention is prepared in the form of a food or drink, the food or drink, the attached instruction or the packaging box, etc., improves the duration of blood pressure lowering action in view of the action of the composition of the present invention. (Preferably to prolong or prolong) (2) to lower blood pressure, (3) to be suitable for human with high blood pressure or a person with I high blood pressure, and (4) to prevent or improve metabolic syndrome , (5) to suppress obesity, and (6) to display one or more selected from the effect of having a diet effect.

  Examples of feeds include feeds for livestock such as cattle, horses and pigs, feeds for poultry such as chicken, and feeds for pets such as dogs and cats. The feed can be processed and manufactured using a general feed production method, including the step of adding a mumefural-rich plum extract to the feed.

  The pharmaceutical preparation can be prepared by combining mumefural-rich plum extract with known pharmaceutical additives and the like.

  Examples of cosmetics include body cleansers, hand cleansers, cleansers such as face cleansers, basic cosmetics such as lotions, emulsions and creams, and cosmetics such as foundations, under make-up, makeups such as white powder. A dosage form etc. are mentioned. Cosmetics can be processed and manufactured using the manufacturing method of a general cosmetics including the process of adding a mumefural high content plum extract in cosmetics.

  The composition of the present invention has (1) an effect of improving (preferably prolonging or prolonging) the blood pressure lowering action duration, (2) an effect of lowering blood pressure, (3) a human with high blood pressure or a human with I high blood pressure One or more effects selected from the effects of (4) effects of preventing or improving metabolic syndrome, (5) effects of suppressing obesity, and (6) effects of diet may be exhibited.

The blood pressure at the time of visit (medical office blood pressure) or home blood pressure was measured with a blood pressure measurement device such as, for example, a sphygmomanometer HEM-7080-IC (manufactured by Omron Healthcare Co., Ltd.) or Terumo Electronic Sphygmomanometer W300 (manufactured by Terumo Corporation). As a result, when the systolic blood pressure or the diastolic blood pressure (preferably, the diastolic blood pressure) is decreased compared to before administration of the composition of the present invention, it is determined that the composition of the present invention has an effect of lowering blood pressure. can do. In the present disclosure, the blood pressure lowering action may be exhibited during the mumefural high content plum extract administration period (for example, after a fixed period after administration start or throughout the administration period), It may also be shown, and it may exhibit an antihypertensive effect during the period of high mumefural plum extract-containing plum extract administration (for example, after a fixed period of time from the start of administration or throughout the period of administration) and after the administration is stopped. In the above case, it is preferred to administer the composition of the present invention daily, preferably every morning, day and night before meals, during the administration period.
The blood pressure lowering period may be one day, two days, three days, one week, two weeks, or three weeks. It may be 4 weeks, 6 weeks, 8 weeks, 10 weeks, 12 weeks, 14 weeks. May be
The fixed period in the above “after a fixed period from the start of administration” may be 1 day, 2 days, 3 days, 1 week, 2 weeks May be, 3 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks, 12 weeks 14 weeks may be sufficient.
In addition, when the blood pressure lowering action is shown after cessation of administration of ume extract containing high mumefural, the cessation date of administration may be the day of administration of the composition of the present invention, even one day after the administration of the composition of the present invention Well, after two days, after three days, after one week, after two weeks, after three weeks, after four weeks It may be after 6 weeks, after 8 weeks, after 10 weeks, after 12 weeks or after 14 weeks.
For example, when the blood pressure lowering action is shown after cessation of administration of the mumefural-rich plum extract administration, the composition of the present invention is judged to have the effect of improving the blood pressure lowering action duration when the period showing the blood pressure lowering action is the above period. It is also useful as a composition for improving blood pressure lowering action duration.
Preferably, for example, if the composition of the present invention containing 20 to 40 mg of mumefural is taken for 1 day, the effect may last for several days thereafter (for example 2 to 3 days).

  The present disclosure describes the composition of the present invention as said composition lowering blood pressure, improving blood pressure lowering duration, or being suitable for high blood pressure humans or people with I high blood pressure. It includes a product for improving the duration of blood pressure lowering action packaged with the instructions.

  EXAMPLES The present invention will be more specifically described below with reference to examples, but the present invention is not limited to these.

  As described below, a placebo-controlled, double-blind, parallel-group comparative study was conducted on the blood pressure ameliorating effect of intake of a mumefural-rich plum extract.

1. Test subject Age: 30 to 69 years, I high blood pressure (systolic blood pressure at visit 140 or more and less than 160), 80 men and women who do not need high blood pressure treatment are adjusted randomly by adjusting sex, age and systolic blood pressure The test food intake group of Example 1 and the test food intake group of placebo were divided into two groups.

2. Test food The raw materials described in the following table were mixed and heat-sterilized at 90 ° C. to produce a test food of Example 1 or placebo.

3. The test subjects in each group orally ingested 10 g of the test food of Example 1 or placebo daily for 12 weeks every morning, day and night. The test food is not taken from 12 weeks after the start of test food intake until 14 weeks after the start of test food intake.
The daily test food intake is 30 g. The nutritional composition contained in the 30 g test food is as shown in Table 2 below.

  Test systolic blood pressure and diastolic blood pressure were measured on the day 0, 4 weeks, 8 weeks, 12 weeks and 14 weeks after the start of the test food intake, and t-tests of 2 independent samples were evaluated at each evaluation time point Statistical processing was performed to compare between groups.

4. Results The average visit diastolic blood pressure results are shown in FIG. In FIG. 1, the average visit diastolic blood pressure value 84.27 mmHg on day 0 after the start of the test food intake of the test food intake group of Example 1 and the test food intake group of the placebo on day 0 after the start of food intake The average visit diastolic blood pressure is 80.07 mmHg as the standard value for each group at 0,07, 4, 8, 8, 12, and 14 weeks after the start of test food intake. The amount of change of the value relative to the value on day 0 after the start of the test food intake was shown.
In the group I high blood pressure group, the test food intake group of Example 1 was shown to have a lower diastolic blood pressure at the time of visit for 14 weeks from the start of test food intake compared with the test food intake group of placebo. The In particular, at 12 weeks and 14 weeks after the start of the test food intake, the test food intake group of Example 1 had a significant reduction in visiting diastolic blood pressure as compared with the placebo test food intake group.

  The mean visit systolic blood pressure results are shown in Table 3. At 8 weeks and 14 weeks after the start of the test food intake, the test food intake group of Example 1 had a lower systolic blood pressure at the time of visit as compared with the test food intake group of the placebo. In addition, in the test food intake group of Example 1, the visit systolic blood pressure at 8 weeks and 14 weeks after the start of the test food intake was lower than that at day 0 after the start of the test food intake.

  From these results, it has been shown that mumefural-rich plum extract has an antihypertensive action on humans, and the action lasts for a long time.

  The composition of the present invention is useful as food and drink, medicine, feed and the like for the purpose of lowering blood pressure.

Claims (6)

  A composition for lowering blood pressure, characterized by comprising a mumefural high ume extract.   The composition according to claim 1, wherein the content of mumefural in the ume extract is 0.2 to 2% by mass.   The composition according to claim 1 or 2, wherein the blood pressure lowering action is sustained during the period of administration of the mumefural high ume extract or for 2 weeks after the administration is stopped.   The composition according to any one of claims 1 to 3, wherein the subject of application is a human with I-degree hypertension.   A composition for containing a composition according to any one of claims 1 to 4, and an indication to lower blood pressure, an indication to improve the duration of blood pressure lowering action, or a person whose blood pressure is elevated or a person with high blood pressure is suitable Food and drink for lowering blood pressure with an indication of   The composition according to any one of claims 1 to 4, which is suitable for lowering blood pressure, improving blood pressure lowering duration, or for raising blood pressure or for people with high-grade hypertension Product for lowering blood pressure packaged with instructions describing.

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