JP6310939B2 - 4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリネートの調製方法 - Google Patents
4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリネートの調製方法 Download PDFInfo
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- JP6310939B2 JP6310939B2 JP2015547527A JP2015547527A JP6310939B2 JP 6310939 B2 JP6310939 B2 JP 6310939B2 JP 2015547527 A JP2015547527 A JP 2015547527A JP 2015547527 A JP2015547527 A JP 2015547527A JP 6310939 B2 JP6310939 B2 JP 6310939B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C251/12—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton being acyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
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- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Description
本出願は、その開示が参照により本明細書に明確に組み込まれている、2012年12月13日出願の米国仮特許出願第61/736,835号の利益を主張する。
(式中、
R1は、C1〜C4アルキル、シクロプロピル、C2〜C4アルケニル、または1〜4つのハロゲン、C1〜C4アルキル、C1〜C4ハロアルキル、C1〜C4アルコキシまたはC1〜C4ハロアルコキシから独立して選択される置換基により置換されたフェニルを表し、
R2は、C1〜C12アルキル、または無置換もしくは置換C7〜C11アリールアルキルを表す)
を調製する方法であって、
以下のステップ:
a) 四塩化炭素溶媒中、トリアリールホスフィンおよびトリアルキルアミン塩基の存在下、トリフルオロ酢酸をp−メトキシアニリンと接触させて、式Aの塩化アセトイミドイル
を生成するステップ、
b) 極性非プロトン性溶媒中、ヨウ化銅(I)、アルカリ金属ヨウ化物、およびアルカリ金属リン酸塩の存在下、式Aの塩化アセトイミドイルを3,3−ジアルコキシプロパ−1−イン(式B)
(式中、R3はC1〜C4アルキルを表す)
と接触させて、式Cの(イミノ)ペンタ−2−インジアルキルアセタール
(式中、R3は、先に定義した通りである)
を生成するステップ、
c) 極性非プロトン性溶媒中、無機アルカリ金属塩基の存在下、およそ周囲温度から約100℃の温度で、式Cの(イミノ)ペンタ−2−インジアルキルアセタールを式Dのアミン
(式中、R1は、先に定義した通りである)
により環化させて、式Eの4−(4−メトキシフェニル)アミノ−5−フルオロ−6−(置換)ピリジン−2−ジアルキルアセタール
(式中、R1およびR3は、先に定義した通りである)
を生成するステップ、
d) 極性溶媒中、式Eの4−(4−メトキシフェニル)アミノ−5−フルオロ−6−(置換)ピリジン−2−ジアルキルアセタールを、1,3−ジクロロ−5,5−ジメチルイミダゾリジン−2,4−ジオン(式F)
により塩素化して、式Gの保護4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピリジン−2−ジアルキルアセタール
(式中、R1およびR3は先に定義した通りである)
を生成するステップ、
e) 極性溶媒中、式Gの保護4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピリジン−2−ジアルキルアセタールを無機酸により脱保護および加水分解して、式Hの4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリンアルデヒド
(式中、R1は、先に定義した通りである)
を生成するステップ、
f) 水性アルコール溶媒中、無機酸および次亜塩素酸捕捉剤の存在下、式Hの4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリンアルデヒドをアルカリ金属亜塩素酸塩により酸化して、式Jの4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリン酸
(式中、R1は、先に定義した通りである)
を生成するステップ、および
g) 式Jの4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリン酸を以下の式の化合物
R2X
(式中、
Xは、OH、Cl、BrまたはIを表し、
R2は、先に定義した通りである)
でエステル化することにより、式Iの4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリネートを生成するステップ、
を含む
方法が本明細書において提供される。
(式中、R3は、C1〜C4アルキルを表す)
である。
(式中、
R1は、C1〜C4アルキル、シクロプロピル、C2〜C4アルケニル、または1〜4つのハロゲン、C1〜C4アルキル、C1〜C4ハロアルキル、C1〜C4アルコキシまたはC1〜C4ハロアルコキシから独立して選択される置換基により置換されたフェニルを表し、
R3は、C1〜C4アルキルを表す)
である。
R1は、C1〜C4アルキル、シクロプロピル、C2〜C4アルケニル、または1〜4つのハロゲン、C1〜C4アルキル、C1〜C4ハロアルキル、C1〜C4アルコキシまたはC1〜C4ハロアルコキシから独立して選択される置換基により置換されたフェニルを表し、
R3は、C1〜C4アルキルを表す)
である。
(式中、
R1は、C1〜C4アルキル、シクロプロピル、C2〜C4アルケニル、または1〜4つのハロゲン、C1〜C4アルキル、C1〜C4ハロアルキル、C1〜C4アルコキシまたはC1〜C4ハロアルコキシから独立して選択される置換基により置換されたフェニルを表す)
である。
2,2,2−トリフルオロ−N−(4−メトキシフェニル)アセトイミドイルクロリド
[実施例2]
[実施例3]
[実施例4]
[実施例5]
[実施例6]
[実施例8]
Claims (5)
- 式Iの4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリネート
(式中、
R1は、C1〜C4アルキル、シクロプロピル、C2〜C4アルケニル、または1〜4つのハロゲン、C1〜C4アルキル、C1〜C4ハロアルキル、C1〜C4アルコキシまたはC1〜C4ハロアルコキシから独立して選択される置換基により置換されたフェニルを表し、
R2は、C1〜C12アルキル、または無置換もしくは置換C7〜C11アリールアルキルを表す)
を調製する方法であって、
以下のステップ:
a) 四塩化炭素溶媒中、トリアリールホスフィンおよびトリアルキルアミン塩基の存在下、トリフルオロ酢酸をp−メトキシアニリンに接触させて、式Aの塩化アセトイミドイル
を生成するステップ、
b) 極性非プロトン性溶媒中、ヨウ化銅(I)、アルカリ金属ヨウ化物、およびアルカリ金属リン酸塩の存在下、式Aの塩化アセトイミドイルを3,3−ジアルコキシプロパ−1−イン(式B)
(式中、R3は、C1〜C4アルキルを表す)
に接触させて、式Cの(イミノ)ペンタ−2−インジアルキルアセタール
(式中、R3は先に定義した通りである)
を生成するステップ、
c) 極性非プロトン性溶媒中、無機アルカリ金属塩基の存在下、およそ周囲温度から約100℃の温度で、式Cの(イミノ)ペンタ−2−インジアルキルアセタールを式Dのアミン
(式中、R1は先に定義した通りである)
により環化させて、式Eの4−(4−メトキシフェニル)アミノ−5−フルオロ−6−(置換)ピリジン−2−ジアルキルアセタール
(式中、R1およびR3は先に定義した通りである)
を生成するステップ、
d) 極性溶媒中、式Eの4−(4−メトキシフェニル)アミノ−5−フルオロ−6−(置換)ピリジン−2−ジアルキルアセタールを、1,3−ジクロロ−5,5−ジメチルイミダゾリジン−2,4−ジオン(式F)
により塩素化して、式Gの保護4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピリジン−2−ジアルキルアセタール
(式中、R1およびR3は先に定義した通りである)
を生成するステップ、
e) 極性溶媒中、式Gの保護4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピリジン−2−ジアルキルアセタールを無機酸により脱保護および加水分解して、式Hの4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリンアルデヒド
(式中、R1は先に定義した通りである)
を生成するステップ、
f) 水性アルコール溶媒中、無機酸および次亜塩素酸捕捉剤の存在下、式Hの4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリンアルデヒドをアルカリ金属亜塩素酸塩により酸化して、式Jの4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリン酸
(式中、R1は先に定義した通りである)
を生成するステップ、および
g) 式Jの4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリン酸を以下の式の化合物
R2X
(式中、
Xは、OH、Cl、BrまたはIを表し、
R2は先に定義した通りである)
でエステル化することにより、式Iの4−アミノ−5−フルオロ−3−クロロ−6−(置換)ピコリネートを生成するステップ、
を含む
方法。 - 式Cの化合物
(式中、
R3は、C1〜C4アルキルを表す)。 - 式Eの化合物
(式中、
R1は、C1〜C4アルキル、シクロプロピル、C2〜C4アルケニル、または1〜4つのハロゲン、C1〜C4アルキル、C1〜C4ハロアルキル、C1〜C4アルコキシまたはC1〜C4ハロアルコキシから独立して選択される置換基により置換されたフェニルを表し、
R3は、C1〜C4アルキルを表す)。 - 式Gの化合物
(式中、
R1は、C1〜C4アルキル、シクロプロピル、C2〜C4アルケニル、または1〜4つのハロゲン、C1〜C4アルキル、C1〜C4ハロアルキル、C1〜C4アルコキシまたはC1〜C4ハロアルコキシから独立して選択される置換基により置換されたフェニルを表し、
R3は、C1〜C4アルキルを表す)。 - 式Hの化合物
(式中、
R1は、C1〜C4アルキル、C 2〜C4アルケニル、または1〜4つのハロゲン、C1〜C4アルキル、C1〜C4ハロアルキル、C1〜C4アルコキシまたはC1〜C4ハロアルコキシから独立して選択される置換基により置換されたフェニルを表す)。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261736835P | 2012-12-13 | 2012-12-13 | |
US61/736,835 | 2012-12-13 | ||
PCT/US2013/074600 WO2014093588A1 (en) | 2012-12-13 | 2013-12-12 | Process for the preparation of 4-amino-5-fluoro-3-chloro-6-(substituted)picolinates |
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JP2016504319A JP2016504319A (ja) | 2016-02-12 |
JP6310939B2 true JP6310939B2 (ja) | 2018-04-11 |
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US (3) | US9212141B2 (ja) |
EP (1) | EP2931043B1 (ja) |
JP (1) | JP6310939B2 (ja) |
KR (1) | KR20150093799A (ja) |
CN (1) | CN104994733B (ja) |
AR (1) | AR093977A1 (ja) |
AU (1) | AU2013359255B2 (ja) |
BR (1) | BR102013032003A2 (ja) |
CA (1) | CA2895180A1 (ja) |
IL (1) | IL239225A (ja) |
MX (1) | MX2015007526A (ja) |
NZ (1) | NZ708680A (ja) |
PL (1) | PL2931043T3 (ja) |
RU (1) | RU2653855C2 (ja) |
WO (1) | WO2014093588A1 (ja) |
ZA (1) | ZA201504166B (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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PL2931043T3 (pl) * | 2012-12-13 | 2018-01-31 | Dow Agrosciences Llc | Sposób wytwarzania 4-amino-5-fluoro-3-chloro 6-(podstawionych) pikolinianów |
BR102014028162A2 (pt) | 2013-11-12 | 2015-09-08 | Dow Agrosciences Llc | processo para fluoração de compostos |
TW201609651A (zh) | 2013-11-12 | 2016-03-16 | 陶氏農業科學公司 | 用於氟化化合物之過程(一) |
BR102014028164A2 (pt) * | 2013-11-12 | 2015-09-08 | Dow Agrosciences Llc | processo para fluoração de compostos |
TWI726900B (zh) | 2015-08-04 | 2021-05-11 | 美商陶氏農業科學公司 | 用於氟化化合物之過程 |
CN108495845A (zh) * | 2016-01-22 | 2018-09-04 | 美国陶氏益农公司 | 制备4-烷氧基-3-乙酰氧基吡啶甲酸的方法 |
KR102384529B1 (ko) * | 2016-07-07 | 2022-04-08 | 코르테바 애그리사이언스 엘엘씨 | 4-알콕시-3-(아실 또는 알킬)옥시피콜린아미드의 제조 방법 |
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SU680613A3 (ru) * | 1971-12-07 | 1979-08-15 | Циба-Гейги Аг (Фирма) | Средство борьбы с насекомыми и клещами |
PT1246802E (pt) * | 2000-01-14 | 2007-06-18 | Dow Agrosciences Llc | 4-aminopicolinatos e sua utilização como herbicidas. |
AR037228A1 (es) | 2001-07-30 | 2004-11-03 | Dow Agrosciences Llc | Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada |
TW200307669A (en) * | 2002-04-15 | 2003-12-16 | Nippon Soda Co | Novel oxime o-ether compound, production process thereof, and agricultural or horticultural bactericide |
UA82358C2 (uk) * | 2003-04-02 | 2008-04-10 | Дау Агросайенсиз Ллс | 6-алкіл або алкеніл-4-амінопіколінати гербіцидна композиція, спосіб боротьби з небажаною рослинністю |
WO2006062979A1 (en) * | 2004-12-06 | 2006-06-15 | E.I. Dupont De Nemours And Company | Herbicidal 6-cyclopropyl-substitute 4-aminopicolinic acid derivatives |
CN102731382B (zh) | 2006-01-13 | 2015-09-02 | 美国陶氏益农公司 | 6-(多取代芳基)-4-氨基吡啶甲酸酯及其作为除草剂的用途 |
PL2621903T3 (pl) * | 2010-09-29 | 2017-08-31 | Intervet International B.V. | Związki n-heteroarylu |
TWI596088B (zh) | 2011-01-25 | 2017-08-21 | 陶氏農業科學公司 | 4-胺基-6-(經取代的苯基)吡啶甲酸酯及6-胺基-2-(經取代的苯基)-4-嘧啶羧酸酯之芳烷酯以及其等作為除草劑之用途 |
TWI529163B (zh) * | 2011-01-25 | 2016-04-11 | 陶氏農業科學公司 | 用於製備4-胺基-5-氟-3-鹵素-6-(經取代之)吡啶甲酸酯的方法 |
PL2931043T3 (pl) * | 2012-12-13 | 2018-01-31 | Dow Agrosciences Llc | Sposób wytwarzania 4-amino-5-fluoro-3-chloro 6-(podstawionych) pikolinianów |
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PL2931043T3 (pl) | 2018-01-31 |
AR093977A1 (es) | 2015-07-01 |
EP2931043A4 (en) | 2016-06-08 |
BR102013032003A2 (pt) | 2014-10-21 |
ZA201504166B (en) | 2016-11-30 |
MX2015007526A (es) | 2015-10-14 |
US20140171653A1 (en) | 2014-06-19 |
IL239225A (en) | 2017-12-31 |
US20170349549A1 (en) | 2017-12-07 |
US20140296533A1 (en) | 2014-10-02 |
EP2931043A1 (en) | 2015-10-21 |
CN104994733B (zh) | 2017-03-15 |
JP2016504319A (ja) | 2016-02-12 |
AU2013359255B2 (en) | 2017-01-05 |
KR20150093799A (ko) | 2015-08-18 |
CN104994733A (zh) | 2015-10-21 |
US9981911B2 (en) | 2018-05-29 |
NZ708680A (en) | 2018-05-25 |
RU2653855C2 (ru) | 2018-05-15 |
CA2895180A1 (en) | 2014-06-19 |
WO2014093588A1 (en) | 2014-06-19 |
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