JP6309511B2 - 上昇したａｖｐレベルおよび上昇したコペプチンレベルの少なくとも一方を有する患者の治療における使用のためのｖ１ｂ受容体アンタゴニスト - Google Patents

上昇したａｖｐレベルおよび上昇したコペプチンレベルの少なくとも一方を有する患者の治療における使用のためのｖ１ｂ受容体アンタゴニスト Download PDF

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JP6309511B2
JP6309511B2 JP2015516647A JP2015516647A JP6309511B2 JP 6309511 B2 JP6309511 B2 JP 6309511B2 JP 2015516647 A JP2015516647 A JP 2015516647A JP 2015516647 A JP2015516647 A JP 2015516647A JP 6309511 B2 JP6309511 B2 JP 6309511B2
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JP2015522565A (ja
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ホルスボール、フローリアン
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HMNC Value GmbH
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C12Q2600/00—Oligonucleotides characterized by their use
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JP2015516647A 2012-06-15 2013-06-17 上昇したａｖｐレベルおよび上昇したコペプチンレベルの少なくとも一方を有する患者の治療における使用のためのｖ１ｂ受容体アンタゴニスト Active JP6309511B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1210686.0A GB201210686D0 (en) 2012-06-15 2012-06-15 V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
GB1210686.0 2012-06-15
PCT/EP2013/062552 WO2013186399A1 (en) 2012-06-15 2013-06-17 V1b receptor antagonist for use in the treatment of patients having an elevated avp level and/or an elevated copeptin level

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JP2017175482A Division JP6608891B2 (ja) 2012-06-15 2017-09-13 うつ症状および不安症状の少なくとも一方を有する患者におけるｖ１ｂ受容体アンタゴニストに対する治療応答を予測する方法

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JP6309511B2 true JP6309511B2 (ja) 2018-04-11

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JP2015516647A Active JP6309511B2 (ja) 2012-06-15 2013-06-17 上昇したａｖｐレベルおよび上昇したコペプチンレベルの少なくとも一方を有する患者の治療における使用のためのｖ１ｂ受容体アンタゴニスト
JP2017175482A Active JP6608891B2 (ja) 2012-06-15 2017-09-13 うつ症状および不安症状の少なくとも一方を有する患者におけるｖ１ｂ受容体アンタゴニストに対する治療応答を予測する方法

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US (3) US20150150846A1 (https=)
EP (2) EP3276010B1 (https=)
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ES (1) ES2873926T3 (https=)
GB (1) GB201210686D0 (https=)
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GB201310782D0 (en) 2013-06-17 2013-07-31 Max Planck Innovation Gmbh Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms

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EP3276010B1 (en) 2021-02-24
JP6608891B2 (ja) 2019-11-20
US20150150846A1 (en) 2015-06-04
ES2873926T3 (es) 2021-11-04
WO2013186399A1 (en) 2013-12-19
US20190365708A1 (en) 2019-12-05
US10857129B2 (en) 2020-12-08
EP2861253A1 (en) 2015-04-22
US20180042898A1 (en) 2018-02-15
JP2015522565A (ja) 2015-08-06
JP2018004657A (ja) 2018-01-11
EP3276010A1 (en) 2018-01-31
GB201210686D0 (en) 2012-08-01

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