JP6302496B2 - Blister pack push-cover foil as a through foil - Google Patents
Blister pack push-cover foil as a through foil Download PDFInfo
- Publication number
- JP6302496B2 JP6302496B2 JP2016009208A JP2016009208A JP6302496B2 JP 6302496 B2 JP6302496 B2 JP 6302496B2 JP 2016009208 A JP2016009208 A JP 2016009208A JP 2016009208 A JP2016009208 A JP 2016009208A JP 6302496 B2 JP6302496 B2 JP 6302496B2
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- JP
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- Prior art keywords
- desiccant
- foil
- cover foil
- cover
- plastic material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000011888 foil Substances 0.000 title claims description 69
- 239000002274 desiccant Substances 0.000 claims description 47
- 229910052782 aluminium Inorganic materials 0.000 claims description 28
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 28
- 239000000463 material Substances 0.000 claims description 28
- 229920003023 plastic Polymers 0.000 claims description 24
- 239000004033 plastic Substances 0.000 claims description 24
- 238000007789 sealing Methods 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000004698 Polyethylene Substances 0.000 claims description 12
- 230000004888 barrier function Effects 0.000 claims description 12
- 229920000573 polyethylene Polymers 0.000 claims description 12
- 238000004806 packaging method and process Methods 0.000 claims description 11
- 239000002585 base Substances 0.000 claims description 10
- -1 polyethylene Polymers 0.000 claims description 10
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 7
- 238000010521 absorption reaction Methods 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000002318 adhesion promoter Substances 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- 150000001340 alkali metals Chemical class 0.000 claims description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 2
- 150000001342 alkaline earth metals Chemical class 0.000 claims description 2
- 229910000323 aluminium silicate Inorganic materials 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- 235000000346 sugar Nutrition 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 2
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical group [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000000741 silica gel Substances 0.000 claims 1
- 229910002027 silica gel Inorganic materials 0.000 claims 1
- 239000010408 film Substances 0.000 description 12
- 229920001684 low density polyethylene Polymers 0.000 description 9
- 239000004702 low-density polyethylene Substances 0.000 description 9
- 239000004922 lacquer Substances 0.000 description 5
- 230000035515 penetration Effects 0.000 description 5
- 239000004743 Polypropylene Substances 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 4
- 239000000292 calcium oxide Substances 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 229920001903 high density polyethylene Polymers 0.000 description 4
- 239000004700 high-density polyethylene Substances 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 229920000098 polyolefin Polymers 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 2
- 239000004594 Masterbatch (MB) Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 241000255925 Diptera Species 0.000 description 1
- 229920010126 Linear Low Density Polyethylene (LLDPE) Polymers 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000013039 cover film Substances 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000004715 ethylene vinyl alcohol Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 229920000554 ionomer Polymers 0.000 description 1
- 239000011140 metalized polyester Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 229920000131 polyvinylidene Polymers 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
- B32B27/308—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising acrylic (co)polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/06—Coating on the layer surface on metal layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/26—Polymeric coating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2264/00—Composition or properties of particles which form a particulate layer or are present as additives
- B32B2264/10—Inorganic particles
- B32B2264/102—Oxide or hydroxide
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2264/00—Composition or properties of particles which form a particulate layer or are present as additives
- B32B2264/10—Inorganic particles
- B32B2264/104—Oxysalt, e.g. carbonate, sulfate, phosphate or nitrate particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/30—Properties of the layers or laminate having particular thermal properties
- B32B2307/31—Heat sealable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
- B32B2307/7242—Non-permeable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
- B32B2307/7242—Non-permeable
- B32B2307/7246—Water vapor barrier
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/726—Permeability to liquids, absorption
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/80—Medical packaging
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/28—Web or sheet containing structurally defined element or component and having an adhesive outermost layer
- Y10T428/2804—Next to metal
Description
本発明は、感湿性の製品を包装するためのブリスターパック用プッシュ―スルーホイルとしてのカバーホイルに関し、水蒸気と気体の透過を防止するバリア層として、及び、ブリスター基底部品を密封するための密封層として、アルミニウムホイルを有する、カバーホイルに関するものである。 The present invention relates to a cover foil as a push-through foil for blister packs for packaging moisture-sensitive products, as a barrier layer for preventing permeation of water vapor and gas, and a sealing layer for sealing blister base parts As for a cover foil having an aluminum foil.
湿気と酸素に敏感な製品をプラスチック材料で包装することによって、これらの製品を有害な大気の諸影響から保護することは、一般に知られている。例えば、湿気に弱い製品は、水分子を事実上透過させないプラスチック材料フィルムによって、包装することができる。例えば、湿気の浸透に対するバリアとして、高密度ポリエチレン(HDPE)のフィルムやポリ塩化ビニリデン−アクリル酸メチル共重合体(PVDC−MA)のフィルムを使用することができる。また、湿気の浸透に対するバリア材料として、延伸ポリプロピレン(oPP)フィルム、金属化延伸ポリプロピレン(oPP)フィルム、又は、金属化ポリエステルフィルムも使用される。更に、湿気及び酸素のうちのいずれか一方又は双方の浸透に対するバリア材料として、金属フィルムが知られており、これらの金属フィルムは、しばしば、プラスチック材料フィルムを有する複合材料に使用される。水蒸気及び気体に対する優れた障壁効果は、又、エチレン−ビニルアルコール共重合体(EVOH)の層によって達成することができる。 It is generally known to protect these products from harmful atmospheric effects by packaging them with plastic materials that are sensitive to moisture and oxygen. For example, a product that is sensitive to moisture can be packaged by a plastic material film that is virtually impermeable to water molecules. For example, a high-density polyethylene (HDPE) film or a polyvinylidene chloride-methyl acrylate copolymer (PVDC-MA) film can be used as a barrier against moisture penetration. In addition, a stretched polypropylene (oPP) film, a metallized stretched polypropylene (oPP) film, or a metallized polyester film is also used as a barrier material against moisture penetration. Furthermore, metal films are known as barrier materials against the penetration of either or both of moisture and oxygen, and these metal films are often used in composite materials with plastic material films. Excellent barrier effects against water vapor and gases can also be achieved with a layer of ethylene-vinyl alcohol copolymer (EVOH).
現在では、湿気及び酸素の浸透に対する遮断効果が高いバリア層を備えたラミネートが知られているが、これらのラミネートの端縁部は、このバリア層によって保護されていないから、特に密封包装において、湿気の浸透を完全に防止することはできない。湿気と酸素は、密封領域におけるこれらの保護されていない端縁部を通って、熱シールされた包装体の内部に浸透可能であるから、湿気に弱い製品の品質が損なわれるおそれがある。 At present, although the laminate blocking effect against the penetration of moisture and oxygen with a high barrier layer are known, edge portions of the laminate, since not protected by the barrier layer, in particular a sealed package, Moisture penetration cannot be completely prevented. Moisture and oxygen can penetrate through these unprotected edges in the sealed area and into the interior of the heat sealed package, which can impair the quality of moisture sensitive products.
バリア層と、吸湿材を含有する密封層とを有する、多層フィルムは、国際公開WO−A−2004/080808号公報に開示されている。これらのフィルムは、例えば、診断用の試験片のような感湿性の物品の包装に使用され、これらのフィルムは、折り畳まれた後に、これらのフィルム自体に対して熱シールされ、或いは、第二のフィルムに対して熱シールされる。水結合作用の強い吸湿材として、酸化カルシウム(CaO)を使用するのが好ましい。 A multilayer film having a barrier layer and a sealing layer containing a hygroscopic material is disclosed in International Publication WO-A-2004 / 080808. These films are used, for example, for packaging moisture sensitive articles such as diagnostic test strips, which are folded and then heat sealed to the films themselves or second The film is heat sealed. It is preferable to use calcium oxide (CaO) as a hygroscopic material having a strong water binding action.
錠剤や粉体のような感湿性の製品を包装するために、水蒸気及び気体に対するバリア層を有するラミネートで作られたブリスター基底部品を備えたブリスターパックを使用することは、国際公開WO−A−2007/104344号公報から既知である。乾燥剤として、例えば、CaOを含有する、ポリオレフィンの層が、ブリスター基底部品の内側とこのブリスター基底部品を閉鎖するカバーホイルとに向けられたバリア層の側面に、更に配置されている。プッシュ―スルーホイルとして設計されたカバーフィルムは、例えば、密封層/アルミニウムホイル/印刷下塗りラッカー/印刷/印刷上塗りラッカーという構成を有する。 The use of blister packs with a blister base part made of a laminate having a barrier layer against water vapor and gas for packaging moisture sensitive products such as tablets and powders is described in WO-A- Known from 2007/104344. As a desiccant, a layer of polyolefin, for example containing CaO, is further arranged on the side of the barrier layer facing the inside of the blister base part and the cover foil closing the blister base part. A cover film designed as a push-through foil has, for example, the structure sealing layer / aluminum foil / printing undercoat lacquer / printing / printing overcoat lacquer.
ブリスターパックのプッシュ―スルーホイルは、典型的には、「硬質の」状態における厚さが20μmのアルミニウムホイルを有する。例えば、高齢者のように力が弱い人に対しても、プッシュ―スルーによる開放を保証するため、ブリスター基底部品を密封するために必要な内側層は、とりわけ、ある特定の厚さを超えてはならない。密封層としてLDPEコーティングを有する従来のプッシュ―スルーホイルは、例えば、ラッカー、1乃至2g/m 2 / アルミニウムホイル、硬質、20μm / プライマー、1g/m 2 / LDPE、15g/m 2 という構成を有する。 Blister pack push-through foils typically have an aluminum foil with a thickness of 20 μm in the “hard” state . For example, the inner layer required to seal the blister base part, in particular to a certain thickness, to ensure push-through opening, even for weak people such as the elderly Must not. Conventional push-through foil with LDPE coating as sealing layer has, for example, lacquer, 1 to 2 g / m 2 / aluminum foil , rigid, 20 μm / primer , 1 g / m 2 / LDPE , 15 g / m 2 .
乾燥剤を含有する内側層を備えたブリスター基底部品の最大吸水能力は、この内側層の厚さによって限定される。その理由は、この内側層の厚さが、典型的には約35乃至65g/m 2 の乾燥剤を含有するこの内側層の単位面積当たりの重量に限定されるためである。乾燥剤の割合は、典型的には、乾燥剤が積載された層の単位面積当たりの全重量の約30乃至50%である。しかし、乾燥剤の助けによって「湿った錠剤」をも乾燥させるためには、基本的に、ブリスターパック内の吸水能力をできる限り高くするべきである。 The maximum water absorption capacity of a blister base part with an inner layer containing a desiccant is limited by the thickness of this inner layer . This is because the thickness of the inner layer is limited to the weight per unit area of the inner layer, which typically contains about 35 to 65 g / m 2 of desiccant. The proportion of desiccant is typically about 30-50% of the total weight per unit area of the layer loaded with desiccant. However, in order to dry “wet tablets” with the aid of a desiccant, basically the water absorption capacity in the blister pack should be as high as possible.
本発明の目的は、感湿性の製品を包装するためのブリスターパックの吸水能力を更に増大させることができる、プッシュスルーホイルとしてのカバーホイルを提供することにある。 An object of the present invention is to provide a cover foil as a push-through foil that can further increase the water absorption capability of a blister pack for packaging moisture-sensitive products.
前述の目的を達成するため、本発明のカバーホイルは、感湿性の製品を包装するためのブリスターパック用のプッシュ―スルーホイルとしてのカバーホイルであって、前記カバーホイルは、水蒸気及び気体の透過を防止するバリア層としてのアルミニウムホイルと、ブリスター基底部品に対して密封を行うための密封層と、前記アルミニウムホイルの前記密封層を備えた側の面に配され、かつ、粒子状の粉末剤で構成された吸湿性乾燥剤を含有する、プラスチック材料層を有する、前記カバーホイルにおいて、前記乾燥剤を含有する前記プラスチック材料層をポリエチレン(PE)によって構成し、前記乾燥剤の粒子が前記アルミニウムホイルに押し付けられて前記アルミニウムホイルを突き破らないように、前記アルミニウムホイルと前記乾燥剤を含有する前記プラスチック材料層との間に、低密度ポリエチレン(LDPE)によって構成された緩衝層を配置し、前記緩衝層と、前記乾燥剤を含有する前記プラスチック材料層と、前記密封層とを、前記アルミニウムホイルに適用された共押出し層によって形成し、前記乾燥剤によって前記乾燥剤を含有する前記プラスチック材料層に脆性を付与し、前記ブリスターパックの吸水能力を増大させ、かつ、前記カバーホイルのプッシュ―スルー性能が保持されるように、前記乾燥剤を含有する前記プラスチック材料層の単位面積当たりの重量を設定したことを特徴とする。 To achieve the foregoing objects, mosquito Bahoiru of the present invention, push blister packs for packaging moisture-sensitive product - a cover foil as through the wheel, the cover foil, permeation of water vapor and gases An aluminum foil as a barrier layer for preventing the above, a sealing layer for sealing against a blister base part, and a particulate powder agent disposed on the side of the aluminum foil provided with the sealing layer containing configured hygroscopic desiccant in, to have a plastics material layer, in the cover foil, the said plastic material layer containing a drying agent constituted by polyethylene (PE), the particles of the drying agent is the so as not to break through the aluminum foil is pressed against the aluminum foil, the said aluminum foil A buffer layer made of low density polyethylene (LDPE) is disposed between the plastic material layer containing a desiccant, the buffer layer, the plastic material layer containing the desiccant, and the sealing layer. Are formed by a coextrusion layer applied to the aluminum foil, the brittleness is imparted to the plastic material layer containing the desiccant by the desiccant, the water absorption capacity of the blister pack is increased, and The weight per unit area of the plastic material layer containing the desiccant is set so that the push-through performance of the cover foil is maintained .
本発明は、全体として、WO−A−2004/080808による包装用ホイルと、これらの包装用ホイルから製造される包装と、WO−A−2007/104344によるブリスター基底部品とから得られた知識を利用している。 The present invention generally takes the knowledge gained from packaging foils according to WO-A-2004 / 080808, packaging produced from these packaging foils, and blister base parts according to WO-A-2007 / 104344. We are using.
この内側層は、すなわち、ブリスター基底部品に対して密封するように設けられたアルミニウムホイルの側の面に配置され、かつ、乾燥剤を含有する、プラスチック材料層は、このホイルのプッシュ―スルー性能を減少させることなく、従来技術によるプッシュ―スルーホイルに用いられている密封可能な内側層と比較して、驚くべきことに、二倍乃至三倍の厚さを有することができることが見出された。この理由は、乾燥剤を保持する層が、保持しない層に比べて、はるかに高い脆性を有するためである。かかる認識によって、十分な量の乾燥剤を含有し、したがって、経済的に理にかなった量の乾燥剤を含有する、本発明によるカバーホイルの開発の道筋が、初めて明らかになったのである。 This inner layer is placed on the side of the aluminum foil provided to seal against the blister base part, and the plastic material layer containing the desiccant is the push-through performance of this foil It has been surprisingly found that it can have a thickness of 2 to 3 times compared to the sealable inner layer used in prior art push-through foils without reducing It was. This is because the layer holding the desiccant is much more brittle than the layer not holding it. This recognition for the first time reveals the path to the development of a cover foil according to the present invention that contains a sufficient amount of desiccant and, therefore, an economically reasonable amount of desiccant.
乾燥剤を含有するプラスチック材料層は、この乾燥剤として、アルカリ金属及びアルカリ土類金属の群から選ばれた少なくとも一つの酸化物を含有することが好ましい。乾燥剤を含有するプラスチック材料層として、特に好ましいものは、その乾燥剤として、酸化カルシウム(CaO)を含有し、特に、0.5乃至95重量%のCaOを含有し、好ましくは、10乃至65重量%のCaOを含有する。 The plastic material layer containing a desiccant preferably contains at least one oxide selected from the group of alkali metals and alkaline earth metals as the desiccant. Particularly preferable as the plastic material layer containing the desiccant contains calcium oxide (CaO) as the desiccant, particularly 0.5 to 95% by weight of CaO, preferably 10 to 65. Contains wt% CaO.
しかし、例えば、シリケート、シリカ・ゲル、アルミノシリケート、物理的乾燥物質、結晶水吸収物質、糖及びヒドロキシル基(水酸基)を担持した化合物等の乾燥剤として適した他の物質を使用することもできる。 However, other materials suitable as desiccants such as silicates, silica gels, aluminosilicates, physical drying materials, crystal water absorbing materials, sugars and compounds carrying hydroxyl groups (hydroxyl groups) can also be used. .
一般に、乾燥剤は粒子状の粉末剤として存在しているから、乾燥剤の粒子がアルミニウムホイルに押し付けられてアルミニウムホイルを突き破らないように、注意しなければならない。このようにしてアルミニウムホイルに穴が開くと、ブリスターパックの一体性が破壊され、目的としている高い防湿性が損なわれるためである。通常、乾燥剤は、乾燥剤を担持するマスターバッチの形態で、押し出し法又は共押出し法によってアルミニウムホイルに塗布される。この場合は、この乾燥剤を担持する層の厚さは大き過ぎてはならない。さもないと、高齢者にとってはとりわけ重要なことであるが、比較的小さな力で錠剤を押し出すことができなくなり、カバーホイルのプッシュ―スルー性能が失われるからである。乾燥剤を担持したマスターバッチは、例えば、ポリエチレン(PE)とCaOで作られて市販されているが、この乾燥剤の粒度(d100)は10乃至20μmよりも大きい。この粒度は、一般に、「硬質の」状態のプッシュ―スルーホイルに使用される、例えば、厚さ20μmのアルミニウムホイルを突き破る域にある。 In general, since the desiccant is present as a particulate powder, care must be taken so that the desiccant particles are not pressed against the aluminum foil and break through the aluminum foil. This is because when the hole is formed in the aluminum foil in this manner, the integrity of the blister pack is destroyed and the intended high moisture resistance is impaired. Usually, the desiccant is applied to the aluminum foil in the form of a masterbatch carrying the desiccant by an extrusion or coextrusion method. In this case, the thickness of the layer carrying the desiccant must not be too large. Otherwise, especially important for the elderly, it is impossible to push out the tablets with a relatively small force, and the push-through performance of the cover foil is lost. A master batch carrying a desiccant is made of, for example, polyethylene (PE) and CaO and is commercially available. The particle size (d100) of the desiccant is larger than 10 to 20 μm. This grain size is generally in the region of breaking through a 20 μm thick aluminum foil used for “hard” push-through foils, for example.
したがって、このアルミニウムホイルと、乾燥剤を含有するこのプラスチック材料層との間に、プラスチック材料で作られた緩衝層を配置することが好都合であることが分かる。 It can therefore be seen that it is advantageous to place a buffer layer made of plastic material between the aluminum foil and the plastic material layer containing the desiccant.
乾燥剤を含むプラスチック材料層及び/又は緩衝層及び/又は密封層は、ポリオレフィンで構成されることが好ましく、特に、ポリエチレン(PE)で構成されることが好ましく、とりわけ、高密度ポリエチレン(HDPE)及び/又は直鎖状低密度ポリエチレン(LLDPE)及び/又は低密度ポリエチレン(LDPE)及び/又はポリプロピレン(PP)で構成されることが好ましく、そして、随意に、アイオノマー、EAA又はPP−MSA等の酸改質ポリオレフィンの成分を包含する。これらの酸改質ポリオレフィンは接着促進剤として機能するから、場合によっては、個別のプライマーを省略することができる。 The plastic material layer and / or the buffer layer and / or the sealing layer containing the desiccant is preferably made of polyolefin, particularly preferably made of polyethylene (PE), and in particular, high density polyethylene (HDPE). And / or preferably composed of linear low density polyethylene (LLDPE) and / or low density polyethylene (LDPE) and / or polypropylene (PP), and optionally such as ionomer, EAA or PP-MSA Includes components of acid-modified polyolefins. Since these acid-modified polyolefins function as adhesion promoters, individual primers can be omitted in some cases.
これらの緩衝層と、乾燥剤を含有するプラスチック層と、密封層とは、アルミニウムホイルに塗布された共押出し層によって形成されるのが好ましい。 These buffer layers, the plastic layer containing the desiccant, and the sealing layer are preferably formed by a co-extruded layer applied to the aluminum foil.
このアルミニウムホイルの密封層を設けた側の面を接着促進剤によって被覆することが可能であり、特に、水ベースのプライマー又は溶剤ベースのプライマーによって、又は、高分子接着促進剤によって、被覆することができる。 This is the aluminum surface of the sealing layer provided side of the foil can be coated with an adhesion promoter, in particular, by the water-based primer or solvent-based primer, or by a polymeric adhesion promoter, can be coated Can do.
代表的なカバーホイルの構造は、例えば、
ラッカー、1乃至2g/m2
アルミニウムホイル、20μm、硬質
プライマー、1g/m2
LDPE、緩衝層として12g/m2
PE+乾燥剤、30g/m2
LDPE、密封層として4g/m2
である。
A typical cover foil structure is, for example,
Lacquer, 1 to 2 g / m 2
Aluminum foil , 20μm, hard primer, 1g / m 2
LDPE, 12g / m 2 as buffer layer
PE + desiccant , 30 g / m 2
LDPE, 4 g / m 2 as sealing layer
It is.
更に、このカバーホイルは印刷することが可能であり、この印刷には、選択的に、上塗りを施すことができる。 Furthermore, the cover foil can be printed, and this can optionally be overcoated.
測定値は、
ラッカー、1乃至2g/m2
アルミニウムホイル、20μm、硬質
プライマー、1g/m2
LDPE、密封層として15g/m2
という層構成を有する、基準となるプッシュ―スルーホイルと比較して、乾燥剤を含有するプラスチック材料層では、単位面積当りの重量が約38g/m2に至るまで、プッシュ―スルー性能の悪化が確認されないことを示している。
The measured value is
Lacquer, 1 to 2 g / m 2
Aluminum foil , 20μm, hard primer, 1g / m 2
LDPE, 15 g / m 2 as sealing layer
Compared with the standard push-through foil having the layer structure, the plastic material layer containing the desiccant deteriorates the push-through performance until the weight per unit area reaches about 38 g / m 2. Indicates that it will not be confirmed.
Claims (7)
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CH00433/09 | 2009-03-20 | ||
CH00433/09A CH700645A2 (en) | 2009-03-20 | 2009-03-20 | Coversheet as press-through foil for a blister pack. |
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JP2016009208A Active JP6302496B2 (en) | 2009-03-20 | 2016-01-20 | Blister pack push-cover foil as a through foil |
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JP5671397B2 (en) * | 2011-03-30 | 2015-02-18 | 共同印刷株式会社 | Lids, packaging containers and packages |
DE202014002192U1 (en) * | 2014-03-13 | 2015-06-17 | Va-Q-Tec Ag | Vacuum insulation panel and container with vacuum insulation panels |
CN106042552B (en) * | 2016-06-12 | 2018-06-26 | 苏州海顺包装材料有限公司 | Moisture absorption type high-barrier blister package stiff sheet |
CN111465497A (en) * | 2017-10-24 | 2020-07-28 | 达纳帕克软包装有限公司 | Sheet laminate, blister package and method of manufacture |
JP7002298B2 (en) | 2017-11-10 | 2022-01-20 | 共同印刷株式会社 | Blister pack lid material |
EP3975972A1 (en) | 2019-06-03 | 2022-04-06 | Amcor Flexibles Singen GmbH | Process for the conditioned packaging of hard gelatin capsules |
WO2023285952A1 (en) | 2021-07-10 | 2023-01-19 | Auxilius Pharma Spolka Z Ograniczona Odpowiedzialnoscia | Modified release nicorandil compound formulations |
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JPS5886347U (en) * | 1981-12-07 | 1983-06-11 | 住友ベークライト株式会社 | Moisture-proof lid material |
JPH0241930U (en) * | 1988-09-12 | 1990-03-22 | ||
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CH684788A5 (en) * | 1993-03-04 | 1994-12-30 | Alusuisse Lonza Services Ag | Free metal foil lidding film for blister packs. |
US6063503A (en) | 1995-12-28 | 2000-05-16 | Mitsubishi Gas Chemical Company, Inc. | Oxygen-absorbing multi-layer film and method for preparing same |
US20050079306A1 (en) | 1996-10-18 | 2005-04-14 | Toyo Seikan Kaisha, Ltd. | Oxygen-absorbing resin composition and packaging container, packaging material, cap or liner material having oxygen absorbability |
US6119853A (en) * | 1998-12-18 | 2000-09-19 | Glaxo Wellcome Inc. | Method and package for storing a pressurized container containing a drug |
JP2001009985A (en) | 1999-07-02 | 2001-01-16 | Hisamitsu Pharmaceut Co Inc | Packaging bag for sticking agent and packaged sticking agent |
US8003179B2 (en) * | 2002-06-20 | 2011-08-23 | Alcan Packaging Flexible France | Films having a desiccant material incorporated therein and methods of use and manufacture |
US20030235664A1 (en) * | 2002-06-20 | 2003-12-25 | Rick Merical | Films having a desiccant material incorporated therein and methods of use and manufacture |
US20040131805A1 (en) | 2002-06-20 | 2004-07-08 | Merical Rick L. | Films having a desiccant material incorporated therein and methods of use and manufacture |
GB0225621D0 (en) * | 2002-11-02 | 2002-12-11 | Glaxo Group Ltd | Medicament carrier |
US7758936B2 (en) * | 2003-09-18 | 2010-07-20 | Boehringer Ingelheim Gmbh | Pharmaceutical blister |
JP4659523B2 (en) * | 2005-04-26 | 2011-03-30 | 共同印刷株式会社 | Blister film and blister packaging container |
EP1733872A1 (en) * | 2005-06-15 | 2006-12-20 | Alcan Technology & Management Ltd. | Cold formable laminate |
JP3979542B1 (en) | 2006-08-30 | 2007-09-19 | 佐々木化学薬品株式会社 | Desiccant composition, desiccant molded product, equilibrium humidity control method thereof, and control method of equilibrium humidity maintenance time |
WO2008041663A1 (en) | 2006-09-25 | 2008-04-10 | Takeda Pharmaceutical Company Limited | Medicinal package |
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CH700645A2 (en) | 2010-09-30 |
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US9834356B2 (en) | 2017-12-05 |
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