JP6293258B2 - 化学療法誘発認知障害の処置 - Google Patents

化学療法誘発認知障害の処置 Download PDF

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Publication number
JP6293258B2
JP6293258B2 JP2016502690A JP2016502690A JP6293258B2 JP 6293258 B2 JP6293258 B2 JP 6293258B2 JP 2016502690 A JP2016502690 A JP 2016502690A JP 2016502690 A JP2016502690 A JP 2016502690A JP 6293258 B2 JP6293258 B2 JP 6293258B2
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Japan
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composition
chemotherapy
alkyl
cognitive impairment
treatment
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Expired - Fee Related
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JP2016502690A
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Japanese (ja)
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JP2016513723A5 (enExample
JP2016513723A (ja
Inventor
ホッセイン エー. ガンバリ,
ホッセイン エー. ガンバリ,
ジ−ガン ジアン,
ジ−ガン ジアン,
Original Assignee
パナシア ファーマシューティカルズ, インコーポレイテッド
パナシア ファーマシューティカルズ, インコーポレイテッド
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Publication of JP2016513723A publication Critical patent/JP2016513723A/ja
Publication of JP2016513723A5 publication Critical patent/JP2016513723A5/ja
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B60VEHICLES IN GENERAL
    • B60TVEHICLE BRAKE CONTROL SYSTEMS OR PARTS THEREOF; BRAKE CONTROL SYSTEMS OR PARTS THEREOF, IN GENERAL; ARRANGEMENT OF BRAKING ELEMENTS ON VEHICLES IN GENERAL; PORTABLE DEVICES FOR PREVENTING UNWANTED MOVEMENT OF VEHICLES; VEHICLE MODIFICATIONS TO FACILITATE COOLING OF BRAKES
    • B60T7/00Brake-action initiating means
    • B60T7/02Brake-action initiating means for personal initiation
    • B60T7/04Brake-action initiating means for personal initiation foot actuated
    • B60T7/042Brake-action initiating means for personal initiation foot actuated by electrical means, e.g. using travel or force sensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B60VEHICLES IN GENERAL
    • B60TVEHICLE BRAKE CONTROL SYSTEMS OR PARTS THEREOF; BRAKE CONTROL SYSTEMS OR PARTS THEREOF, IN GENERAL; ARRANGEMENT OF BRAKING ELEMENTS ON VEHICLES IN GENERAL; PORTABLE DEVICES FOR PREVENTING UNWANTED MOVEMENT OF VEHICLES; VEHICLE MODIFICATIONS TO FACILITATE COOLING OF BRAKES
    • B60T13/00Transmitting braking action from initiating means to ultimate brake actuator with power assistance or drive; Brake systems incorporating such transmitting means, e.g. air-pressure brake systems
    • B60T13/10Transmitting braking action from initiating means to ultimate brake actuator with power assistance or drive; Brake systems incorporating such transmitting means, e.g. air-pressure brake systems with fluid assistance, drive, or release
    • B60T13/12Transmitting braking action from initiating means to ultimate brake actuator with power assistance or drive; Brake systems incorporating such transmitting means, e.g. air-pressure brake systems with fluid assistance, drive, or release the fluid being liquid
    • B60T13/14Transmitting braking action from initiating means to ultimate brake actuator with power assistance or drive; Brake systems incorporating such transmitting means, e.g. air-pressure brake systems with fluid assistance, drive, or release the fluid being liquid using accumulators or reservoirs fed by pumps
    • B60T13/142Systems with master cylinder
    • B60T13/145Master cylinder integrated or hydraulically coupled with booster
    • B60T13/146Part of the system directly actuated by booster pressure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B60VEHICLES IN GENERAL
    • B60TVEHICLE BRAKE CONTROL SYSTEMS OR PARTS THEREOF; BRAKE CONTROL SYSTEMS OR PARTS THEREOF, IN GENERAL; ARRANGEMENT OF BRAKING ELEMENTS ON VEHICLES IN GENERAL; PORTABLE DEVICES FOR PREVENTING UNWANTED MOVEMENT OF VEHICLES; VEHICLE MODIFICATIONS TO FACILITATE COOLING OF BRAKES
    • B60T13/00Transmitting braking action from initiating means to ultimate brake actuator with power assistance or drive; Brake systems incorporating such transmitting means, e.g. air-pressure brake systems
    • B60T13/10Transmitting braking action from initiating means to ultimate brake actuator with power assistance or drive; Brake systems incorporating such transmitting means, e.g. air-pressure brake systems with fluid assistance, drive, or release
    • B60T13/66Electrical control in fluid-pressure brake systems
    • B60T13/662Electrical control in fluid-pressure brake systems characterised by specified functions of the control system components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B60VEHICLES IN GENERAL
    • B60TVEHICLE BRAKE CONTROL SYSTEMS OR PARTS THEREOF; BRAKE CONTROL SYSTEMS OR PARTS THEREOF, IN GENERAL; ARRANGEMENT OF BRAKING ELEMENTS ON VEHICLES IN GENERAL; PORTABLE DEVICES FOR PREVENTING UNWANTED MOVEMENT OF VEHICLES; VEHICLE MODIFICATIONS TO FACILITATE COOLING OF BRAKES
    • B60T13/00Transmitting braking action from initiating means to ultimate brake actuator with power assistance or drive; Brake systems incorporating such transmitting means, e.g. air-pressure brake systems
    • B60T13/10Transmitting braking action from initiating means to ultimate brake actuator with power assistance or drive; Brake systems incorporating such transmitting means, e.g. air-pressure brake systems with fluid assistance, drive, or release
    • B60T13/66Electrical control in fluid-pressure brake systems
    • B60T13/68Electrical control in fluid-pressure brake systems by electrically-controlled valves
    • B60T13/686Electrical control in fluid-pressure brake systems by electrically-controlled valves in hydraulic systems or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mechanical Engineering (AREA)
  • Neurology (AREA)
  • Transportation (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
JP2016502690A 2013-03-14 2014-03-14 化学療法誘発認知障害の処置 Expired - Fee Related JP6293258B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/803,482 2013-03-14
US13/803,482 US20140271812A1 (en) 2013-03-14 2013-03-14 Treatment for chemotherapy-induced cognitive impairment
PCT/US2014/028039 WO2014152864A1 (en) 2013-03-14 2014-03-14 Treatment for chemotherapy-induced cognitive impairment

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018013721A Division JP2018062537A (ja) 2013-03-14 2018-01-30 化学療法誘発認知障害の処置

Publications (3)

Publication Number Publication Date
JP2016513723A JP2016513723A (ja) 2016-05-16
JP2016513723A5 JP2016513723A5 (enExample) 2017-04-13
JP6293258B2 true JP6293258B2 (ja) 2018-03-14

Family

ID=51528048

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016502690A Expired - Fee Related JP6293258B2 (ja) 2013-03-14 2014-03-14 化学療法誘発認知障害の処置
JP2018013721A Withdrawn JP2018062537A (ja) 2013-03-14 2018-01-30 化学療法誘発認知障害の処置

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018013721A Withdrawn JP2018062537A (ja) 2013-03-14 2018-01-30 化学療法誘発認知障害の処置

Country Status (5)

Country Link
US (1) US20140271812A1 (enExample)
EP (1) EP2968319B1 (enExample)
JP (2) JP6293258B2 (enExample)
CA (1) CA2905403A1 (enExample)
WO (1) WO2014152864A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2984379C (en) 2015-04-28 2024-06-11 Newsouth Innovations Pty Limited Targeting nad+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies, and inactivity
WO2019147839A1 (en) * 2018-01-24 2019-08-01 Sensei Biotherapeutics, Inc. Methods and compositions for preserving neurogenesis
KR20230124625A (ko) * 2020-12-24 2023-08-25 산텐 세이야꾸 가부시키가이샤 에피나스틴 또는 그의 염과 황계 항산화제를 함유하는경피 투여용 의약 조성물

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447427A (en) 1979-01-04 1984-05-08 The United States Of America As Represented By The Secretary Of The Army Method for treating bacterial infections with 2-acetyl- and 2-propionylpyridine thiosemicarbazones
US5180831A (en) * 1990-08-10 1993-01-19 Georgia Tech Research Corporation Quaternary pyridinium compounds
US5281715A (en) 1992-05-13 1994-01-25 Yale University 2-formylpyridine thiosemicarbazone compounds
US6114376A (en) * 1997-04-30 2000-09-05 Mcgill University Methods for using macrocyclic lactone compounds as multidrug resistance reversing agents in tumor and other cells
US5869676A (en) 1997-05-15 1999-02-09 Vion Pharmaceuticals, Inc. Process for the synthesis of ribonucleotide reductase inhibitors 3-AP and 3-AMP
US5767134A (en) 1997-05-15 1998-06-16 Vion Pharmaceuticals, Inc. Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3-AMP
CA2525298A1 (en) 2003-05-01 2004-11-18 Panacea Pharmaceuticals, Inc. Methods of treating ischemic related conditions
US20060194810A1 (en) 2004-04-30 2006-08-31 Bijan Almassian Methods of treating ischemic related conditions
US20070243132A1 (en) * 2005-12-22 2007-10-18 Apollo Life Sciences Limited Transdermal delivery of pharmaceutical agents
US20080039471A1 (en) * 2006-08-14 2008-02-14 Ghanbari Hossein A Composition and method to inhibit tissue plasminogen activator (tPA) - potentiated neurotoxicity
US8034815B2 (en) * 2007-01-11 2011-10-11 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
WO2009139925A1 (en) * 2008-05-16 2009-11-19 Panacea Pharmaceuticals, Inc. Methods for the treatment of brain edema
US20100120763A1 (en) * 2008-11-07 2010-05-13 Wyeth Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases
AU2009326867B2 (en) * 2008-12-12 2015-10-29 The University Of Melbourne Process for the preparation of asymmetrical bis(thiosemicarbazones)
US9700579B2 (en) * 2011-04-27 2017-07-11 Yale University Drug therapy to inhibit chemotherapy-induced adverse effects and related pharmaceutical compositions, diagnostics, screening techniques and kits

Also Published As

Publication number Publication date
JP2018062537A (ja) 2018-04-19
EP2968319A4 (en) 2016-10-19
EP2968319B1 (en) 2020-01-08
WO2014152864A1 (en) 2014-09-25
EP2968319A1 (en) 2016-01-20
CA2905403A1 (en) 2014-09-25
US20140271812A1 (en) 2014-09-18
JP2016513723A (ja) 2016-05-16

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