JP6271545B2 - 組織内照射療法と電気化学療法との複合治療用カテーテル - Google Patents

組織内照射療法と電気化学療法との複合治療用カテーテル Download PDF

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JP6271545B2
JP6271545B2 JP2015523645A JP2015523645A JP6271545B2 JP 6271545 B2 JP6271545 B2 JP 6271545B2 JP 2015523645 A JP2015523645 A JP 2015523645A JP 2015523645 A JP2015523645 A JP 2015523645A JP 6271545 B2 JP6271545 B2 JP 6271545B2
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hollow tube
medical device
conductive
electrode
distal end
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JP2015527120A5 (https=
JP2015527120A (ja
Inventor
トーマス エリック アムソー
トーマス エリック アムソー
サシャ クルーガー
サシャ クルーガー
ステッフェン ウェイス
ステッフェン ウェイス
フォーク ウーレマン
フォーク ウーレマン
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Koninklijke Philips NV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1007—Arrangements or means for the introduction of sources into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
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    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/25—User interfaces for surgical systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
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    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
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    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61B2018/00994—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound
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    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/1425—Needle
    • A61B2018/143—Needle multiple needles
    • A—HUMAN NECESSITIES
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    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1472—Probes or electrodes therefor for use with liquid electrolyte, e.g. virtual electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/374—NMR or MRI
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/376—Surgical systems with images on a monitor during operation using X-rays, e.g. fluoroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/376—Surgical systems with images on a monitor during operation using X-rays, e.g. fluoroscopy
    • A61B2090/3762—Surgical systems with images on a monitor during operation using X-rays, e.g. fluoroscopy using computed tomography systems [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
    • A—HUMAN NECESSITIES
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    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1007—Arrangements or means for the introduction of sources into the body
    • A61N2005/1008—Apparatus for temporary insertion of sources, e.g. afterloaders
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    • A61N2005/1019—Sources therefor
    • A61N2005/1024—Seeds

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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Medical Informatics (AREA)
  • Cardiology (AREA)
  • Robotics (AREA)
  • Plasma & Fusion (AREA)
  • Otolaryngology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Human Computer Interaction (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Radiation-Therapy Devices (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
JP2015523645A 2012-07-23 2013-07-23 組織内照射療法と電気化学療法との複合治療用カテーテル Expired - Fee Related JP6271545B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261674411P 2012-07-23 2012-07-23
US61/674,411 2012-07-23
PCT/IB2013/056019 WO2014016762A1 (en) 2012-07-23 2013-07-23 Combined brachytherapy and electrochemotherapy catheters

Publications (3)

Publication Number Publication Date
JP2015527120A JP2015527120A (ja) 2015-09-17
JP2015527120A5 JP2015527120A5 (https=) 2016-09-08
JP6271545B2 true JP6271545B2 (ja) 2018-01-31

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JP2015523645A Expired - Fee Related JP6271545B2 (ja) 2012-07-23 2013-07-23 組織内照射療法と電気化学療法との複合治療用カテーテル

Country Status (5)

Country Link
US (1) US10537748B2 (https=)
EP (1) EP2874706B1 (https=)
JP (1) JP6271545B2 (https=)
CN (1) CN104507536B (https=)
WO (1) WO2014016762A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102023206383A1 (de) 2023-07-05 2025-01-09 Siemens Healthineers Ag Kombinierte Interventionelle und Strahlen-Tumortherapie

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104507536B (zh) 2012-07-23 2017-11-14 皇家飞利浦有限公司 组合的短程治疗和电化学治疗导管
CN110461261A (zh) 2017-04-03 2019-11-15 堃博生物科技公司 电手术接入鞘
CA3132682A1 (en) * 2019-03-18 2020-09-24 Rambam Medtech Ltd. Alternating charge to inhibit sorption to surfaces exposed to biological materials
CN111772776B (zh) * 2020-07-16 2024-12-17 嘉兴市第二医院 一种射频与化学一体化消融装置

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3078850A (en) 1960-08-26 1963-02-26 Imp Electronics Inc Electrochemotherapeutic cardiac device
US6032061A (en) * 1997-02-20 2000-02-29 Boston Scientifc Corporation Catheter carrying an electrode and methods of assembly
US5458597A (en) * 1993-11-08 1995-10-17 Zomed International Device for treating cancer and non-malignant tumors and methods
JPH10277163A (ja) 1997-04-03 1998-10-20 Olympus Optical Co Ltd ハイパーサーミア用アプリケータ
JP4583604B2 (ja) 1998-12-18 2010-11-17 ツェロン・アクチェンゲゼルシャフト・メディカル・インストゥルメンツ 組織内の熱電凝固用外科器具のための電極配置体
US8024048B2 (en) * 2000-03-13 2011-09-20 Ionix Medical Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US6428504B1 (en) * 2000-04-06 2002-08-06 Varian Medical Systems, Inc. Multipurpose template and needles for the delivery and monitoring of multiple minimally invasive therapies
CA2445392C (en) * 2001-05-10 2011-04-26 Rita Medical Systems, Inc. Rf tissue ablation apparatus and method
DE10327237A1 (de) * 2003-06-17 2005-01-13 Trumpf Medizin Systeme Gmbh + Co. Kg Elektrochirurgisches Instrument für ein Endoskop
US7742809B2 (en) * 2003-08-25 2010-06-22 Medtronic, Inc. Electroporation catheter with sensing capabilities
CN100421743C (zh) 2004-07-07 2008-10-01 中国原子能科学研究院 治疗肿瘤用的放射性电疗电极
US20060112343A1 (en) 2004-11-23 2006-05-25 Palo Alto Research Center Incorporated Methods, apparatus, and program products for aligning presentation of separately recorded experiential data streams
US7945331B2 (en) * 2005-01-11 2011-05-17 Bradley D. Vilims Combination electrical stimulating and infusion medical device and method
WO2008034103A2 (en) 2006-09-14 2008-03-20 Lazure Technologies, Llc Device and method for destruction of cancer cells
CN104507536B (zh) 2012-07-23 2017-11-14 皇家飞利浦有限公司 组合的短程治疗和电化学治疗导管

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102023206383A1 (de) 2023-07-05 2025-01-09 Siemens Healthineers Ag Kombinierte Interventionelle und Strahlen-Tumortherapie

Also Published As

Publication number Publication date
US20150174427A1 (en) 2015-06-25
EP2874706A1 (en) 2015-05-27
US10537748B2 (en) 2020-01-21
WO2014016762A1 (en) 2014-01-30
EP2874706B1 (en) 2019-09-11
CN104507536A (zh) 2015-04-08
JP2015527120A (ja) 2015-09-17
CN104507536B (zh) 2017-11-14

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