JP6253171B1 - ORP digitization determination apparatus and method of use - Google Patents

Abstract

[PROBLEMS] In a conventional drug reaction test for athletes in various sports competitions including the Olympics, athletes who take off their underwear in front of a drug inspector to collect urine have strong resistance, and it is easy to eliminate these resistances Therefore, it has been difficult to confirm the drug reaction in the living body with narcotics. The present invention provides a fine channel of saliva components by providing a narrow groove on the upper surface side that serves as a lid for an internal liquid tank that holds and stores the internal liquid of a reference electrode and a silver-silver chloride electrode. It is possible to capture the redox potential in units of 1 mV. Among the so-called narcotics, there are stimulants, cannabis, opium, morphine, heroin, MDMA / MDA, organic solvents such as cocaine, thinner, dangerous drugs, etc. Abuse of these intakes strengthens the oxidation reaction to the body cells. The paralysis of nerve cells by plants such as cannabis is a hallucinatory symptom, which crashes normal biological functions and becomes oxidized. He focused on the fact that screening of stimulant responses could be greatly expected. [Selection] Figure 1

Description

The present invention relates to an ORP digitization determination apparatus and method of use.

The oxidation-reduction potential measuring device includes an indicator electrode and a reference electrode, and the indicator electrode and the reference electrode are inserted into the sample solution, and the oxidation-reduction potential such as the concentration of the electrolyte in the solution and the ion concentration ratio of the oxidant / reductant is measured. . Conventionally, redox potential measurement is mainly for large quantities of solutions such as water quality inspection of wastewater and plant water. On the other hand, if the sample solution is small and the buffer capacity is low, the reproducibility of measurement is unstable and accurate. There was a drawback of calling. The redox potential is measured when the internal solution on the side of the reference electrode (silver-silver chloride) flowing out into the sample solution through the liquid junction comes into contact with the sample solution, but the distance from the platinum electrode as the indicator electrode Sample solution with low buffering capacity (biological fluid such as saliva etc.) due to the internal solution on the reference electrode (silver-silver chloride) side other than the sample solution coming into contact with the indicator electrode loaded in the sample tank ), Even if the internal solution of the reference electrode is small, it has a large effect on the sample solution. If it is in direct contact with the indicator electrode, the measurement is influenced by the internal solution, not the sample solution. This is because an accurate redox potential cannot be measured.

Patent Document 1 relates to a method for inspecting an electrode of an oxidation-reduction potential measuring device for measuring the oxidation-reduction potential of a test solution by immersing a measurement electrode and a comparison electrode in the test solution, and a standard solution used for the inspection It is something that provides.

Patent Document 2 relates to a technique for a persulfate treatment apparatus and a persulfate treatment method for reducing persulfate with activated carbon.

Patent Documents 3 and 4 both provide an apparatus for measuring the redox potential of saliva, which is a human biological fluid, according to the applicant's invention.

Japanese Patent No. 5157880 Japanese Patent No. 5980652 Japanese Patent No. 4151484 Japanese Patent No. 4650771

In the present invention, as shown in Patent Document 3 and Patent Document 4, the oxidation-reduction potential measuring device includes an indicator electrode and a reference electrode, the indicator electrode and the reference electrode are inserted into a sample solution, and the concentration and oxidation of the electrolyte in the solution are measured. This is a device for measuring the redox potential of human saliva that measures the redox potential such as the ion concentration ratio of the body / reductant. In addition, the redox potential is measured by loading a round bar-shaped indicator electrode with a platinum electrode attached externally to the measuring instrument body. There arises a problem that the rod-shaped platinum electrode is bent and finely scratched, thereby causing a large value difference in measurement accuracy.

Conventionally, calibration standard solutions used to check the performance of ORP electrodes are exposed to air, such as quincidrone solution in which the oxidant and reductant do not coexist, dissolved oxygen (DO), that is, the amount of oxygen contained in the water is extremely small. A standard solution for checking the performance of an ORP electrode using a quincidron solution is used because it is relatively stable, neither inclined nor oxidized or reduced.

In the ORP digitization determination apparatus and method of use of the present invention, it is a sample liquid in which an oxidant and a reductant are mixed in a sample to be measured, and the potential difference in electron transfer between the oxidant and the reductant is measured. In the ORP electrode performance check using a solution in which the oxidant and the reductant do not coexist, that is, there is no dissolved oxygen (DO), the requirement of the calibration standard solution of the ORP digitization judgment device and the method of use of the present invention cannot be fulfilled. I think.

In order to solve this problem, the oxidation-reduction potential measuring device according to the present invention includes a swab for collecting human saliva, which is a sample solution, or a cotton swab impregnated with various aqueous solutions, interposed between a reference electrode and an indicator electrode. It is configured to measure the redox potential such as the concentration of the electrolyte and the ion concentration ratio of the oxidant / reductant.

As shown in Fig. 1, the reference electrode and the silver-silver chloride electrode KCl 1 mol (the concentration of the KCl internal solution is not limited) are always in contact with the three parts of the indicator electrode built in the bottom of the sample tank. A constant distance is provided, and the indicator electrode is covered with a solution-impregnated cotton swab during measurement. mV) can be exchanged electronically stably.

Next, as shown in Fig. 2, the reference electrode, silver-silver chloride electrode KCl 1mol (KCl internal liquid concentration is not limited) is stored. By connecting the reference electrode and the indicator electrode through the KCl 1 mol solution, the indicator electrode is exposed to air and is not affected by oxidation. This will be described later with the data in Tables 1 and 2 as proof that conduction is accelerated.

Because the movement of water drops on the ceiling of the bathtub flows faster at the location where the groove is dug on the ceiling side than the ceiling plane, while the flow of electrons that can not be seen with the naked eye is also attracted to the attractive force, He thought that the transfer speed would be higher, the electron transfer would be stable, and the reproducibility of the redox potential measurement could be improved.

In order to achieve the above object, the present invention is configured to measure an oxidation-reduction potential such as the concentration of the electrolyte in the solution of the present invention and the ion concentration ratio of the oxidant / reductant. Yes, note that the movement of water drops on the ceiling of the bathtub flows faster at the location where the groove is dug on the ceiling side than the ceiling plane, and the flow of electrons that cannot be seen with the naked eye is also attracted to the attractive force As a result, it was found that the transfer speed is increased, the electron transfer is stable, and the reproducibility of the oxidation-reduction potential measurement can be improved. As shown in Table 1, the requirements for the calibration standard solution for the ORP quantification determination apparatus and method of use of the present invention are as follows. I was able to do it.

As is clear from the above description, the present invention has the following effects.

In order to prove the effectiveness of the present invention using the means for measuring redox potential (ORP) of human saliva, the present inventor The calibration standard solution used in the present invention is based on the human saliva ORP measurement device and the ORP quantification judgment device and method of use of the present invention that have been certified as medical devices by the Ministry of Health, Labor and Welfare developed based on the patents that have been acquired. The solution was an attempt to compare the measurement accuracy with a 1 mol KCl solution.

(2) According to the above (1), using the means for measuring redox potential (ORP) of human saliva with an indicator electrode (platinum) loaded on the bottom of the sample tank, it has already been certified as a medical device by the Ministry of Health, Labor and Welfare. With the cooperation of Dr. Mieko Okazawa, a pediatric physician in Yokohama who proved the physical condition by mV value limitation in saliva clinical practice that exceeds 8,000 cases using the human saliva ORP measuring device. Measurement of saliva ORP, which is the same solution of 20 people including Table 1 shows each storage-type sample tank provided in the apparatus of the present invention in order to establish a calibration standard solution used as a calibration standard solution in order to establish a calibration standard solution used for checking the performance of the ORP electrode. A comparison of ORP measurement accuracy was attempted using a 1 mol KCl solution in the BOX 1, the sample tank BOX 2, and the sample tank BOX 3. As a result, as shown in Table 1, the measurement results of 5 times each for 5 days with different dates and times show a reproducible value within ± 5 mV with reference to plus 60 mV, and it is not considered that it coincided by chance. It achieved the intended purpose as a calibration standard solution for the ORP quantification determination device and method of use of the invention, and was an essential condition of the saliva ORP measurement device (measured with almost the same value for the same solution) The intended purpose as a highly accurate measuring device is achieved.

(3) Similarly to the above (1) to (2), in claim 10 leading to claim 1, 15 stores the reference electrode and the silver-silver chloride electrode KCl 1 mol 15 The lower surface serving as the upper lid of the liquid tank storing the internal liquid A narrow groove is provided in the part so that the electronic conduction between both the reference electrode and the indicator electrode is communicated via a KCl 1 mol solution.
By providing a narrow groove in the lower surface part which becomes the upper lid, the reference electrode, the liquid junction where 1 mol of silver-silver chloride electrode KCl 1 mol contacts, and the indicator electrode built in the bottom of the sample tank as described above A constant distance is always provided, and the redox potential ORP value (mV) of only the solution impregnation as a measurement target sample can be stably exchanged. As shown in Table 2, the measuring device of the present invention is a storage-type sample tank BOX1, sample tank BOX2, and sample tank BOX3. The small salivary glands and local saliva components of the same subject are mixed, and the tongue in the oral cavity is mixed. The difference in the ORP value (mV) of the total saliva component collected by placing a cotton swab on top and closing the mouth was reproduced within plus or minus 5 mV, and it was not considered coincidental. In the salivary ORP measurement using an urine, it is proved that the ORP digitization determination device and the method of use of the present invention accurately capture the reaction that subtly causes the body to oxidize due to the incorporation of drugs such as narcotics. Therefore, with the cooperation of measurement by Dr. Mieko Okazawa, a pediatric physician who established the frequency distribution of oxidation and reduction in the body by limiting the numerical value of 8,000 cases by the redox potential (ORP) of saliva. Table 1 to Later in Table 6. Whether or not the saliva ORP value (mV) is due to ingestion of a drug such as narcotics as a measurement target sample, or is in a state where there is no significant oxidation stress in the body This made it possible to use such screening.

The reference electrode and silver-silver chloride electrode KCl 1 mol The inner surface of the liquid tank for storing the liquid is provided with a narrow groove on the lower surface, and the reference electrode and the indicator electrode are electrically connected via the KCl 1 mol solution. This makes it possible to obtain a more precise oxidation-reduction potential measurement device and accurately capture subtle oxidation-reduction reactions. As an example, the application of the sample to be measured includes purified water (pure water) Measurement of ORP value (mV) impregnated with water) and impregnation of purified water (pure water) into a cotton swab, and letting the air at the measurement location or the soil at the measurement location touch for a predetermined time, etc. Thus, it has become possible to measure the oxidation-reduction potential of a sample to be measured over a wide range. In addition, as shown in Table 6 leading to Table 3, the ORP quantification determination apparatus and method of use in which the stress value difference between the parotid left and right saliva and the total saliva collected on the tongue is clarified.

The measurement result of sample tank BOX3 to each storage-type sample tank BOX1 of the same sample liquid which is human saliva using the ORP digitization determination apparatus and usage method of the present invention. ORP unit (mV).

Changes in human saliva ORP over time before and after bodily sensation in a room constructed using a fermentation component blend wall material extracted from a plant extract that does not use agricultural chemicals. ORP unit (mV).

Changes in human saliva ORP over time before and after experiencing in a room constructed using a wall material mixed with a thinner solvent. ORP unit (mV).

Changes in saliva over time before and after ingesting lemons that are non-pesticide-grown lemons and are not used for preservatives, fungicides, anti-drying agents, etc. ORP unit (mV).

Pesticide-grown lemons used preservatives, fungicides, anti-drying agents, etc. for storage
Changes in saliva over time before and after ingestion of lemon. ORP unit (mV).

Table 3, Table 4, Table 5, and Table 6 will be described. Table 3 shows changes over time in saliva before and after experiencing in a fermentation component blend wall material room extracted from a plant extract that does not use agricultural chemicals. Table 4 shows changes with time of saliva before and after the experience in the room of the interior wall material paint using the thinner system. Table 5 shows the time-dependent changes in saliva before and after ingesting lemons that were not used for preservatives, such as preservatives, fungicides, and anti-drying agents. Table 6 shows the changes in saliva over time before and after ingesting lemons, which were preserved with pesticide-grown lemons and used preservatives, fungicides, anti-drying agents, etc. for storage. As shown in Table 6 leading to Table 3, as shown in the examples used for the wall material of the house and the examples used for the fruit, the effects of chemical substances on the body showed an oxidation reaction almost similarly. The ORP quantification determination apparatus and method of use of the present invention are those in which the body is in a highly oxidized state with significant oxidation due to the ingestion of drugs such as narcotics to be measured, or the reduction is extremely weak. This achieves the intended purpose of a highly accurate measuring device that can be expected to be used for screening whether it is in an oxidized state or not.

Since the present inventor cannot perform saliva clinical trials for regular users such as stimulants, cannabis, opium, etc. among the so-called narcotics, the number of cases in the body is limited to a total of 8,000 cases due to saliva redox potential (ORP). Under the cooperation of measurement by Dr. Mieda Okazawa, a pediatric physician who has established the frequency distribution of oxidation and reduction, human biological reactions are clearly strong in salivary components due to chemical substances as shown in Table 3 to Table 6. It showed an oxidation reaction. In other words, it is clear that active oxygen is generated in large quantities in the body due to chemical substances. Therefore, as shown in Table 6 to Table 3, the time-dependent changes in human salivary ORP oxidation coincided by chance. Unexpectedly, in the intake of indoor air using thinner chemicals and the intake of fruits containing chemicals such as agricultural chemicals, the internal solution of the reference electrode, 1 mol of silver-silver chloride electrode KCl, which is the present invention When a thin groove is provided in the lower surface part that serves as the upper lid of the liquid tank for storing the reference electrode and the indicator electrode, the electronic conduction between the two electrodes is communicated via a KCl 1 mol solution, thereby smoothing the electron transfer. The result of consideration is as shown in Table 6 leading to Table 1 above.

It is an ORP digitization determination apparatus provided with a sample tank portion into which a cotton swab impregnated with saliva of a subject is inserted and a method of use. Some of the so-called narcotics mentioned in the claims include stimulants, cannabis, opium, morphine, heroin, MDMA / MDA, cocaine, thinner, and other organic solvents, dangerous drugs, and so on. The oxidation reaction to becomes stronger. The paralysis of nerve cells by plants such as cannabis is a hallucinatory symptom, which crashes normal biological functions and becomes oxidized. Furthermore, the stimulant is methamphetamine mixed with artificial chemicals, and it is considered that a large amount of strong active oxygen is generated in the body by taking these artificial chemicals into the body. As proved in Table 6 through Table 3, the saliva redox reaction through the blood captures the characteristics of the biological reaction that appears dark after 30 minutes at the fastest after eating, drinking, or bodily sensation, and the screening utilization of the stimulant reaction can be greatly expected I focused on.

FIG. 1 of the present invention is an overall configuration diagram of an ORP quantification determination apparatus and method of use for transferring negative electrons and positive electrons through a solution of an indicator electrode and a reference electrode (reference electrode) of the oxidation-reduction potential measuring apparatus of the present invention. is there. FIG. 2 of the present invention is a cross-sectional view of the oxidation-reduction potential measuring apparatus according to the present invention, in which a narrow groove is provided on the lower surface portion serving as an upper lid of a liquid tank for storing a reference electrode and 1 mol of silver-silver chloride electrode KCl 1 It is.

As shown in Fig. 1, there is always a fixed distance between the reference electrode, the liquid junction where 1 mol of silver-silver chloride electrode KCl contacts, and the indicator electrode built in the bottom of the sample tank. Since the indicator electrode is covered with a solution-impregnated cotton swab, the oxidation-reduction potential ORP value (mV) of only the solution impregnation used as a measurement target sample can be stably exchanged without touching the air and receiving buffer for oxidation-reduction. It is doing so. The concentration of the internal liquid used in the measuring apparatus according to the present invention is not limited to 1 mol KCl.

Next, as shown in FIG. 2 of the present invention, a reference electrode, a silver-silver chloride electrode KCl 1 containing 15 mol, a narrow groove is provided in the lower surface portion serving as an upper lid of the liquid tank containing the internal liquid, and the reference electrode and instructions It is the block diagram which made the electronic conduction of the both electrodes which are electrodes communicate through the solution of 1 mol of KCl. This is because of the quick movement of water droplets in the ceiling groove in the bathtub room, and the provision of a narrow groove on the bottom surface, which is the upper lid of the liquid tank that stores the internal liquid, gave the groove to the ceiling in the bathtub room. In the same way, the crystallization caused by the outflow of 1 mol of KCl from the liquid junction can be minimized, and the outflow of the 1 mol of KCl using capillary phenomenon by inserting a saliva-impregnated cotton swab into the sample tank for measurement. Is suppressed to a minimum, the plus / minus electron transfer speed of the sample to be measured is increased, and stable reproducibility measurement is as shown in Tables 1 and 2.

The best mode for carrying out the present invention will be described. An ORP quantification judgment device that has a narrow groove in the lower surface part that serves as the upper lid of the liquid tank that stores the internal liquid, and allows the electronic conduction of both the reference electrode and the indicator electrode to communicate with each other via a 1 mol solution of KCl. And how to use. The biological reaction of saliva is the exchange of electrons between an oxidant and a reductant, and the flow of electrons changes from the negative electrode (minus) to the positive electrode (plus), meaning that negative electrons are taken away and oxidized. When the negative electrode (minus) electron is released (stolen), it is an oxidation reaction, and when the positive electrode (plus) which is taking place on the contrary receives the negative electrode (minus) electron, it is a reduction reaction. The human body is always made up of natural providence where negative (negative) electrons are taken away, and how to suppress the oxidation reaction is an important requirement for a healthy life.

With reference to FIG. 8 is a cross-sectional view of the configuration of electron exchange through the solution stored in the internal liquid of the indicator electrode and the reference electrode loaded in the bottom of the sample tank of the measuring device in the ORP digitization determination apparatus and method of use of the present invention; 9 is an oxidation-reduction potentiometer, 10 is a lead wire for conducting the indicator electrode and the reference electrode, 11 is a silver electrode serving as a reference electrode, 12 is a base for the sample tank, 13 is the top of the sample tank, and 14 samples An upper shallow portion of the tank portion, 15 is provided with an upper lid of the liquid tank for storing the internal liquid, 16 is an upper surface of the liquid tank for storing the internal liquid, and 17 stores potassium chloride. 18 is a lid of a 1 mol silver wire KCl 1 mol internal liquid tank of the reference electrode, and a narrow groove communicates with the lower surface portion, 19 is a silver wire built-in,
Reference numeral 20 denotes a silver powder that encloses the silver wire, and reference numeral 21 denotes a packing so that the KCl solution in the liquid tank that stores the internal liquid does not leak. 22 is provided with a cylindrical portion made of an inert material such as glass or carbon, and 23 is filled with cotton so that silver powder does not flow out. Reference numeral 24 denotes a bottom portion of a vertical cylindrical hole into which a porous material such as a cotton swab is inserted, and 4 platinum electrodes are fixed by an adhesive bond. No. 25 prevents the looseness from occurring by tightening the lower part of the indicator electrode bar with a nut. Reference numeral 26 is a handle made of a porous material such as a cotton swab inserted into the sample tank, and a wooden shaft and a paper shaft are provided. 27 is a liquid junction where the test solution impregnated with the cotton portion of the cotton swab is in contact with the 1 mol solution of KCl. 28 is an image of conduction to the liquid junction where the saliva impregnated on the indicator electrode and the cotton swab is in contact with the 1 mol solution of KCl, and 29 is the contact portion with the saliva-impregnated cotton swab by rounding the head of the indicator electrode. It is composed.

With reference to FIG. In FIG. 2, 10 of the present invention 8 is a lead wire for conducting the indicator electrode and the reference electrode, 11 is a silver electrode as a reference electrode, 15 is provided with an upper lid of a liquid tank for storing the internal liquid, and 16 is an internal electrode. It is the upper surface of the liquid tank which stores a liquid. Reference numeral 18 is a narrow groove for conducting the silver wire KCL solution of the reference electrode, and by providing a narrow groove on the lower surface of the upper lid of the liquid tank for storing the internal liquid, the electronic conduction of the sample to be measured is accelerated and stable redox potential measurement. As shown in Table 1 and Table 2 above.

The measuring device of the present invention is a single device that is secreted from the left and right of the parotid gland, which is susceptible to oxidative effects such as total saliva collected on the tongue and amylase, parotin, lactoperoxidase, histatin, etc. This enables screening of redox potential (mV) of human saliva components in three locations, and screening tests at the 2020 Olympics. Players from each country are resistant to doping tests after taking off their underwear due to differences in national character, and it takes a long time to test. By using a screening test with a simple act of saliva, in case of doubt, we narrowed down urine and blood tests. It is possible to proceed to the inspection system, and industrial use such as prevention of stimulant drug abuse at an early stage, social life of the general public, and compliance with group organization regulations can be greatly expected.

8 Cross-sectional view of the configuration of electron exchange through the solution stored in the internal solution of the indicator electrode and the reference electrode of the sample tank 9 Redox potentiometer 10 Lead wire for indicating electrode and reference electrode conduction 11 Silver electrode 12 serving as reference electrode Sample Tank base 13 Sample tank upper surface 14 Sample tank upper shallow part 15 Upper lid surface of the liquid tank for storing the internal liquid 16 Upper surface of the liquid tank for storing the internal liquid 17 Potassium chloride 18 Silver wire KCl 1 mol of the reference electrode internal liquid A narrow groove communicates with the bottom of the tank, which is a lid for the tank. 19 Silver wire 20 Silver powder that wraps the silver wire 21 Packs the packing so that the 1 mol solution of KCl in the liquid tank that contains the internal liquid does not leak 22 Inactive glass or carbon Tube made of material
23 Cotton 24 The bottom of the vertical cylindrical hole into which a porous material such as a cotton swab is inserted is fixed with an adhesive bond to fix the platinum electrode. 25 The lower part of the indicator electrode bar is fastened to the bottom of the sample tank with a nut. The handle composed of a porous material such as a cotton swab is inserted into a wooden shaft and a paper shaft. 27 The liquid junction portion where the test liquid impregnated with the cotton portion of the cotton swab contacts the 1 mol solution of KCl.
28 Conductive part to liquid junction where saliva solution impregnated with indicator electrode and cotton swab contacts with KCl 1 mol solution 29 Contact part with saliva-impregnated cotton swab with rounded tip of indicator electrode

Claims (10)

Reference electrode,
Keeping the internal liquid of the reference electrode, and stores, it is provided as a narrow groove in the underside of the lid of the inner tank
A liquid junction, which is in contact with a cotton swab impregnated with the sample to be measured in communication with the internal liquid tank ,
Between the three of the indicator electrode that the measurement object sample contacts,
Electronically conductive at the liquid junction between the narrow groove for holding the internal solution,
Comprises a redox potentiometer the indicator electrode and the reference electrode is connected,
During the measurement, the indicator electrode does not directly touch the air, and the liquid junction communicates.
By inserting the sample to be measured into the sample tank,
The measurement of oxidation-reduction potential (mV) of the measurement target sample,
An ORP digitization determination measurement apparatus characterized by comparing and verifying. And local saliva component is a parotid left of the same specimen's
The value of the redox potential (ORP) value (mV) of human saliva at three locations of the total saliva components collected by placing a cotton swab on the tongue in the mouth, which also contains small salivary glands and local salivary components and of comparing the difference, in said sample vessel portion kicked set before Symbol ORP numerical assessment apparatus, by inserting the sample for measurement,
Due to the fact that the ingestion of drugs such as narcotics, or saliva ORP value (mV) is the stress state of the strong oxidizing of significant oxide, or without such intake drugs,
Whether or not there is no significant oxidative stress,
So that screening can be used to identify
The measurement of oxidation-reduction potential (mV) of the measurement target sample,
2. The ORP digitization determination measurement apparatus according to claim 1, wherein the comparison verification is performed. The reference electrode is a silver-silver chloride electrode,
And local saliva component is a parotid left of the same specimen's
Similarly, small salivary glands and local saliva components are mixed,
Compare the difference between the total saliva component collected by placing a cotton swab on the tongue in the oral cavity and the redox potential (ORP) value (mV) of human saliva,
In said sample vessel portion kicked set before Symbol ORP digitizing determination device,
By inserting the sample for measurement,
Due to the fact that the ingestion of drugs such as narcotics and the measurement target sample,
The parotid gland saliva redox potential (ORP) value (mV)
In the range from plus 1 mV or more to plus 70 mV,
Oxidation is a significant weak oxidative stress state,
Or the redox potential (ORP) value (mV) of the parotid gland saliva
In the range from plus 71 mV or more to plus 250 mV,
Whether or not it is a strong oxidative stress state,
So that screening can be used to identify
In the ORP digitization determination apparatus according to claim 1 or 2,
A method of use characterized by comparing and verifying measured values. The reference electrode is a silver-silver chloride electrode,
And local saliva component is a parotid left of the same specimen's
Similarly, small salivary glands and local saliva components are mixed,
Compare the difference between the total saliva component collected by placing a cotton swab on the tongue in the oral cavity and the redox potential (ORP) value (mV) of human saliva,
In said sample vessel portion kicked set before Symbol ORP digitizing determination device,
By inserting the sample for measurement,
Due to the fact that the ingestion of drugs such as narcotics and the measurement target sample,
The redox potential (ORP) value (mV) of total saliva collected on the tongue is
In the range from +41 mV to +110 mV,
Oxidation is a significant weak oxidative stress state,
Or the redox potential (ORP) value (mV) of the total saliva collected on the tongue,
In the range from plus 111 mV to plus 250 mV,
Whether or not it is a strong oxidative stress state,
So that screening can be used to identify
In the ORP digitization determination apparatus according to claim 1 or 2,
A method of use characterized by comparing and verifying measured values. The reference electrode is a silver-silver chloride electrode,
And local saliva component is a parotid left of the same specimen's
Similarly, small salivary glands and local saliva components are mixed,
Compare the difference between the total saliva component collected by placing a cotton swab on the tongue in the oral cavity and the redox potential (ORP) value (mV) of human saliva,
In said sample vessel portion kicked set before Symbol ORP digitizing determination device,
By inserting the sample for measurement,
Due to the fact that the ingestion of drugs such as narcotics and the measurement target sample,
In the range of the redox potential (ORP) value (mV) of the parotid gland left and right saliva in the direction from plus or minus 0 mV or less to minus 30 mV,
Reduction significant oxidative stress is very weak,
Or the redox potential (ORP) value (mV) of the parotid gland saliva
In the range from minus 31 mV or less to minus 250 mV,
Whether or not there is no significant oxidative stress,
So that screening can be used to identify
The ORP digitization determination apparatus according to claim 1, 2, or 3,
A method of use characterized by comparing and verifying measured values. The reference electrode is a silver-silver chloride electrode,
And local saliva component is a parotid left of the same specimen's
Similarly, small salivary glands and local saliva components are mixed,
Compare the difference between the total saliva component collected by placing a cotton swab on the tongue in the oral cavity and the redox potential (ORP) value (mV) of human saliva,
In said sample vessel portion kicked set before Symbol ORP digitizing determination device,
By inserting the sample for measurement,
Due to the fact that the ingestion of drugs such as narcotics and the measurement target sample,
In the range of the oxidation-reduction potential (ORP) value (mV) of the total saliva collected on the tongue in a direction from plus 40 mV or less to minus 10 mV,
Reduction significant oxidative stress is very weak,
Or the redox potential (ORP) value (mV) of the total saliva collected on the tongue,
In the range from minus 11 mV or less to minus 250 mV,
Whether or not there is no significant oxidative stress,
So that screening can be used to identify
The ORP digitization determination apparatus according to claim 1, 2, or 4,
A method of use characterized by comparing and verifying measured values. In said sample vessel portion kicked set before Symbol ORP digitizing determination device,
By inserting a 1 mol solution of KCl as a calibration standard solution as a sample to be measured,
It can be used for the calibration and performance check of the electrode of the oxidation-reduction potential measuring device,
In the ORP digitization determination apparatus according to claim 1 or 2,
A method of use characterized by comparing and verifying the reproducibility of measured values. In said sample vessel portion kicked set before Symbol ORP digitizing determination device,
By inserting a 1 mol solution of KCl as a calibration standard solution as a sample to be measured,
It can be used for calibration and performance check of the measurement operation of the oxidation-reduction potential measuring device,
In the ORP digitization determination apparatus according to claim 1 or 2,
A method of use characterized by comparing and verifying the reproducibility of measured values. Measurement of ORP value (mV) by impregnating purified water (pure water) into a cotton swab to be measured;
Also impregnating purified water (pure water) to swab and air measurement location as the measurement target sample in a state that gave mentioned predetermined time,
The measured value difference with the oxidation-reduction potential (ORP) value (mV) and the value difference with time are simultaneously measured and compared.
In said sample vessel portion kicked set before Symbol ORP digitizing determination device,
By inserting each of the measurement target samples,
The numerical determination apparatus according to claim 1,
A method of use characterized by comparing and verifying measured values. Measurement of ORP value (mV) by impregnating purified water (pure water) into a cotton swab to be measured;
Also impregnating purified water (pure water) to swab and the soil of the measurement location as the measurement target sample in a state that gave mentioned predetermined time,
The measured value difference with the oxidation-reduction potential (ORP) value (mV) and the value difference with time are simultaneously measured and compared.
In said sample vessel portion kicked set in oxidation-reduction potential measuring device,
By inserting each of the measurement target samples,
The numerical determination apparatus according to claim 1,
A method of use characterized by comparing and verifying measured values.