JP6252567B2 - Release sheet, release sheet manufacturing method and laminate - Google Patents

Description

  The present invention relates to a release sheet, a release sheet manufacturing method, and a laminate. Specifically, this invention relates to the peeling sheet used for patches, such as a compress sheet, the manufacturing method of this peeling sheet, and the laminated body (patch) which has this peeling sheet.

  Conventionally, patches (such as poultice sheets) containing various medicinal ingredients have been distributed. Such a patch usually comprises a support, a pressure-sensitive adhesive layer containing a transdermally absorbable drug, and a release sheet that is releasably attached to the surface of the pressure-sensitive adhesive layer. When using the patch, the release sheet is peeled off from the pressure-sensitive adhesive layer, and the exposed pressure-sensitive adhesive layer is bonded to the affected area.

  Generally, a patch has a problem that it is flexible and easily wrinkled. For this reason, after peeling the release sheet, the pressure-sensitive adhesive layers adhere to each other at an unintended location, resulting in a problem that the exposed area of the pressure-sensitive adhesive layer is reduced. In addition, there is a problem that it is difficult to peel the release sheet from the pressure-sensitive adhesive layer, and there has been a demand for improved handling when using a patch.

  In order to solve the above problems, it has been proposed to increase the rigidity of the release sheet or to devise the shape of the cut line provided in the release sheet. For example, Patent Document 1 describes that the rigidity of the release sheet is increased, and the shape of the score line is a wave shape. Here, it has been proposed to increase the rigidity of the release sheet by using a resin release sheet, and to further improve the easy peelability of the release sheet by devising the shape of the score line.

  In order to increase the rigidity of the release sheet, it is preferable to use a thick resin base material. However, there are problems such as an increase in the manufacturing cost of the release sheet and an environmental load at the time of disposal. For this reason, it has also been proposed to use a paper substrate for the release sheet. In such a case, in the production process of the release sheet, the paper substrate may be curled, and a technique for suppressing the curling has been devised. For example, Patent Document 2 discloses a release sheet substrate in which the moisture content of a paper substrate is defined, and the release sheet substrate curled on the side opposite to the side to which the release agent layer is applied. . Here, it has been proposed to increase the curl resistance of the release sheet by giving the release sheet substrate a certain curl. In addition, the base material for peeling sheets disclosed by patent document 2 aims at providing the peeling sheet and patch with few curls.

JP-A-10-265372 JP-A-3-227499

  As described above, in order to improve the peelability of the release sheet, when a resin release sheet with increased rigidity is used, the manufacturing cost of the release sheet itself increases, and there is a problem that the environmental load during disposal is large. It was. On the other hand, in the conventional release sheet using a paper base material, there existed a problem that it was difficult to peel a release sheet from an adhesive layer, and the improvement was calculated | required.

  Therefore, in order to solve such problems of the prior art, the present inventors are a release sheet using a paper base material, which is easy to peel from the pressure-sensitive adhesive layer and has excellent handling properties. The study was advanced with the aim of providing seats.

As a result of earnest studies to solve the above problems, the present inventors, in a release sheet having a release agent layer, a first resin layer, a paper substrate, and a second resin layer in order, in a specific direction It was found that easy peeling from the pressure-sensitive adhesive layer can be improved by imparting curl to the adhesive layer.
Specifically, the present invention has the following configuration.

[1] A release having a release agent layer, a first resin layer, a paper base material, and a second resin layer in this order, and curled in a convex direction toward the release agent layer Sheet.
[2] In a state where at least a part of the release agent layer of the release sheet cut to a width of 30 mm is placed in contact with the horizontal flat surface, a pair of curl edges facing each other with a width of 30 mm and the horizontal flat surface The release sheet according to [1], in which an average distance between and is 2 mm or more.
[3] The release sheet according to [1] or [2], wherein the water content of the paper substrate is 5.5 to 10% by mass with respect to the total mass of the paper substrate.
[4] The release sheet according to any one of [1] to [3], wherein the thickness of the first resin layer is 5 to 30 μm.
[5] The release sheet according to any one of [1] to [4], wherein the first resin layer is thicker than the second resin layer.
[6] The release sheet according to any one of [1] to [5], wherein the entire thickness is 70 to 300 μm.
[7] The release sheet according to any one of [1] to [6], wherein the paper substrate contains polyethyleneimine.
[8] A layer forming step of forming a first resin layer on one surface of the paper substrate and forming a release agent layer on one surface of the first resin layer, and moisture in the paper substrate layer The manufacturing method of the peeling sheet which has the humidity control process which adjusts content, and the process of forming a 2nd resin layer on the other surface of a paper base material in this order.
[9] The humidity control step is a step of adjusting the moisture content of the paper base material so that the moisture content of the paper base material is 5.5 to 10% by mass relative to the total mass of the paper base material. Sheet manufacturing method.
[10] The method for producing a release sheet according to [8] or [9], wherein the humidity adjustment step is a step of humidifying the paper substrate.
[11] The method for producing a release sheet according to any one of [8] to [10], wherein the humidity adjustment step further includes a step of causing the paper base material to contain polyethyleneimine.
[12] A release sheet produced by the method according to any one of [8] to [11].
[13] A laminate having the release sheet, the pressure-sensitive adhesive layer, and the support according to any one of [1] to [7] and [12] in this order.
[14] The laminated body according to [13], which is curled in a convex direction toward the support.
[15] The laminate according to [13] or [14], wherein the release sheet has a score line, and an average center line of the score lines is substantially parallel to the pair of curl edges.
[16] In a state where at least a part of the support of the laminate cut to a width of 30 mm is placed in contact with the horizontal flat surface, a pair of curl edges facing each other with a width of 30 mm, a horizontal flat surface, The laminate according to any one of [13] to [15], in which the average distance is 1.5 mm or more.
[17] The laminate according to any one of [13] to [16], wherein the pressure-sensitive adhesive layer contains a transdermally absorbable drug.

  According to the present invention, it is possible to obtain a release sheet that is excellent in easy peelability from the pressure-sensitive adhesive layer. By using the release sheet of the present invention, the release sheet can be easily picked at the time of release, and the release operation can be performed smoothly.

FIG. 1 is a schematic cross-sectional view illustrating the configuration of the release sheet of the present invention. FIG. 2 is a schematic cross-sectional view illustrating the configuration of the release sheet of the present invention. FIG. 3 is a perspective view illustrating the configuration of the laminate of the present invention. FIG. 4 is a side view for explaining the state when the release sheet is peeled from the laminate of the present invention. FIG. 5 is a front view of the laminate of the present invention as viewed from the release sheet side. FIG. 6 is a front view of the laminate of the present invention as viewed from the release sheet side.

  Hereinafter, the present invention will be described in detail. The description of the constituent elements described below may be made based on representative embodiments and specific examples, but the present invention is not limited to such embodiments. In the present specification, a numerical range expressed using “to” means a range including numerical values described before and after “to” as a lower limit value and an upper limit value.

(Peeling sheet)
The release sheet of the present invention has a release agent layer, a first resin layer, a paper base material, and a second resin layer in this order. In addition, the release sheet of the present invention is characterized in that it has a curl in a convex direction toward the release agent layer. The release sheet of the present invention has a curl in itself, and by adopting such a configuration, easy peelability from the pressure-sensitive adhesive layer can be improved. In particular, when the release sheet starts to be peeled off from the pressure-sensitive adhesive layer, the release sheet can be easily picked up. Moreover, such an effect is exhibited even when the paper substrate included in the release sheet is thinned. For this reason, the release sheet of the present invention can be thinned, and the production cost of the release sheet can be suppressed.

  FIG. 1 is a schematic cross-sectional view illustrating the configuration of the release sheet of the present invention. As shown in FIG. 1, the release sheet 10 of the present invention has a release agent layer 12, a first resin layer 14, a paper substrate 16, and a second resin layer 18 in this order. The release sheet 10 of the present invention is curled in a direction that protrudes toward the release agent layer 12, and has, for example, a curl as shown in FIG. In addition, as FIG. 1 shows, it is preferable that the peeling sheet 10 of this invention has a curl especially in the curl edge vicinity. Specifically, when the release sheet 10 is placed on the horizontal flat surface, it is preferable that both curl edges rise from the horizontal flat surface. Further, as shown in FIG. 1, the release sheet 10 of the present invention may have a curled portion and a horizontal portion, and in such a case, the curled shape is formed at both ends with the horizontal portion interposed therebetween. It is preferable that the part is formed.

  In the release sheet of the present invention, it is preferable that the curl height of the curled edge side is a certain distance or more. Specifically, in a state where at least a part of the release agent layer of the release sheet cut to a width of 30 mm is placed in contact with the horizontal flat surface, a pair of curl edges facing each other with a width of 30 mm and a horizontal The average distance from the flat surface is preferably 2 mm or more, more preferably 3 mm or more, further preferably 5 mm or more, and particularly preferably 6 mm or more.

  Here, the width direction in the release sheet is a direction orthogonal to the curl edge in the plane of the release sheet. When the release sheet is cut to a width of 30 mm, the release sheet is cut parallel to the curl edge so that the distance in the width direction is 30 mm. The distance in the width direction in this case is the distance from the end side measured by extending the curl. The curled end sides are a pair of end sides facing each other through a curled convex portion.

  When measuring the curl height, any part in the width direction of the release sheet is cut to obtain a release sheet having a width of 30 mm. For example, when the release sheet is cut to have a width of 30 mm from one curl edge, the release sheet is divided into two. And a new curl edge will arise in the position of 30 mm in width from one curl edge, and the edge part of the remaining part of the release sheet. That is, in the release sheet of the present invention, a curled shape appears at the end portion even when cut at any position in the width direction.

The release sheet cut to a width of 30 mm is placed on a horizontal flat surface. In this case, the release agent layer is placed so as to be in contact with the horizontal flat surface. Since the curled edge rises from the horizontal flat surface when placed in this manner, the distance between the curled edge and the horizontal flat surface (the height of the curled edge (curl height)) is measured. Since there are two curled edges in the release sheet, the curl height is measured at any five locations (10 locations in total) on each side, and the average value is obtained. In this specification, the average value of the curl heights thus determined is defined as the average distance between the pair of curl edges and the horizontal flat surface.
The curl height is measured after standing for 8 hours under the conditions of 23 ° C. and 50% relative humidity.

  FIG. 2 is a schematic cross-sectional view of a release sheet for curl height measurement according to the present invention. In FIG. 2, the horizontal flat surface is represented as P, and the distance between the curl edge and the horizontal flat surface P is represented as P1 and P2, respectively. P1 is the average height of any five curl heights on one curl edge, and P2 is the average height of any five curl heights on the other curl edge. The distance between the curled edge and the horizontal flat surface is an average distance between P1 and P2. Normally, P1 and P2 are approximately the same value.

  In the release sheet of the present invention, the water content of the paper substrate is preferably 4 to 7% by mass with respect to the total mass of the paper substrate, the first resin layer, and the release agent layer, It is more preferable that it is 7 mass%, and it is still more preferable that it is 5-6.5 mass%. The water content of the paper substrate is preferably 5.5 to 10% by mass, more preferably 6 to 9.8% by mass, and 6.5 to the mass of the paper substrate. More preferably, it is -9.5 mass%. By setting the water content of the paper substrate within the above range, the curl height of the release sheet can be set within a desired range.

The amount of moisture can be calculated from the change in mass before and after drying under a predetermined condition (30 minutes at 130 ° C.). Specifically, the amount of water a (g) is (the total mass of the paper base material before drying, the first resin layer, and the release agent layer) − (the paper base material after drying at 130 ° C. for 30 minutes and the first The total mass of the resin layer and the release agent layer) can be calculated, and the water content a (% by mass) can be calculated by the following formula.
Water content a (mass%) = water content a (g) / (total mass of paper base material, first resin layer and release agent layer before drying) × 100
Similarly, the water content b (g) contained in the paper base material can be calculated by (mass of paper base material before drying) − (mass of paper base material after drying at 130 ° C. for 30 minutes). Content b (mass%) is computable with a following formula.
Water content b (mass%) of paper base material = water content b (g) / (mass of paper base material before drying) × 100

In order to make the water content of the paper substrate within the above range, it is preferable to humidify the paper substrate after forming the release agent layer, as will be described later. In this case, it is preferable to humidify the three-layer structure in which the release agent layer, the first resin layer, and the paper base material are laminated in this order. And it is preferable to laminate | stack a 2nd resin layer, after setting it as desired moisture content. Since the second resin layer functions to keep the moisture of the paper substrate within a desired range, it can also be called a moisture transpiration suppression layer.
In addition, in the release sheet which has the conventional paper base material, the release agent layer was formed after providing the resin layer on both surfaces of the paper base material. Usually, when forming a release agent layer, after applying a coating solution containing a silicone release agent, etc., heat treatment is performed at 130 to 200 ° C., and in this heat treatment step, it is included in the paper substrate. Moisture is evaporated. However, in a release sheet having a conventional paper substrate, since resin layers are provided on both surfaces of the paper substrate, bubbles may be generated between the paper substrate and the resin layer when moisture evaporates. In some cases, flare occurs at both ends. Moreover, it has been difficult to strictly define the water content of the paper base material.
In the present invention, the manufacturing process of the release sheet is different from the conventional process, and since the humidity control process (humidification process) is provided before the second resin layer is laminated on the surface of the paper base, the paper base and the resin layer There will be no problems such as the generation of air bubbles. In addition, it is easy to adjust the water content of the paper substrate within a desired range.

<Paper base material>
The paper substrate contains pulp. Examples of the pulp that can be used in the present invention include wood pulp, cotton, hemp, waste paper pulp, and non-wood pulp. Among these, wood pulp is preferably used, and examples of wood pulp include softwood derived pulp (NKP) and hardwood derived pulp (LKP). The paper base material used in the present invention contains 90% by mass or more of pulp. Specifically, high-quality paper, glassine paper, coated paper, cast coated paper, craft paper, and the like can be used as the paper substrate.

The basis weight of the paper substrate is preferably 45~200g / m ^2, more preferably from 50~180g / m ^2, further preferably 60 to 160 / m ^2. Moreover, it is preferable that the thickness of a paper base material is 45-230 micrometers, It is more preferable that it is 50-172 micrometers, It is further more preferable that it is 55-143 micrometers. Usually, in a release sheet having a paper base material, when the basis weight or thickness of the paper base material is small, there is a problem that followability to the pressure-sensitive adhesive layer is increased and it is difficult to peel from the pressure-sensitive adhesive layer. For this reason, such a problem has been avoided by increasing the basis weight of the paper substrate. However, in the release sheet of the present invention, since the release sheet itself is curled in a predetermined direction, even if the basis weight and thickness of the paper base material are kept low, easy release from the adhesive layer Can be demonstrated. That is, the release sheet of the present invention can be thinned, and the cost for manufacturing the release sheet can be suppressed. In addition, the thinned release sheet can be easily disposed of after use, and can reduce the burden on the environment.

<Resin layer>
In the release sheet of the present invention, the first resin layer and the second resin layer may be composed of different resin species, but are preferably composed of the same type of resin. As resin which comprises the 1st resin layer and the 2nd resin layer, a thermoplastic resin can be mentioned, for example. Examples of the thermoplastic resin include olefin-based thermoplastic resins. Among these, polyethylene or polypropylene is preferable, and polyethylene is particularly preferable. Moreover, it is also preferable to use EVA (ethylene-vinyl acetate copolymer resin) as the thermoplastic resin.

  The thickness of the first resin layer is preferably 5 to 30 μm, more preferably 10 to 25 μm, and still more preferably 15 to 25 μm. The thickness of the second resin layer is also preferably within the above range, but the first resin layer is preferably thicker than the second resin layer. By setting the thicknesses of the first resin layer and the second resin layer to the above relationship, even when foaming occurs from the paper substrate when laminating the pressure-sensitive adhesive layer on the release sheet in a later step, bubbles are generated. Since it does not escape to the first resin layer on the release agent layer side but to the second resin layer side, there is an advantage that bubbles (defects) can be easily found and defective products can be easily eliminated. Moreover, when a defect does not occur on the release agent layer side, the function as a release sheet can be sufficiently exerted, so that there is also an advantage that it is not a fatal defect.

<Release agent layer>
When forming the release agent layer, after applying a coating solution containing a silicone release agent or the like, heat treatment is performed at 130 to 200 ° C. In the present invention, a coating solution containing a release agent or the like is applied to the resin layer side of the two-layer structure in which the first resin layer is laminated on the paper substrate, and heat treatment is performed. In such heat treatment, the first resin layer undergoes heat shrinkage. The curl of the release sheet is formed by the first resin layer thus contracted. In the present invention, a step of conditioning the paper base material is provided after the heat treatment step, and further, a second resin layer that is not thermally shrunk is laminated to obtain a desired degree of curling of the release sheet. It can be a range.

  Examples of the release agent constituting the release agent layer include silicone-based, fluorine-based, alkyd-based, long-chain alkyl-based, unsaturated polyester-based, polyolefin-based, rubber-based elastomer, wax-based, TPX-based (methylpente copolymer), etc. The release agent. Of these, silicone release agents are preferred.

<Overall thickness>
The total thickness of the release sheet is preferably 70 to 300 μm, more preferably 100 to 300 μm, and still more preferably 100 to 250 μm. Note that the release sheet of the present invention can be thinned. For example, even when the entire thickness of the release sheet is less than 100 μm, the easy release from the pressure-sensitive adhesive layer may be made favorable. it can.

<Other ingredients>
In the release sheet of the present invention, the paper substrate may contain polyethyleneimine. For example, polyethylene imine may be included when paper making a paper base, or a polyethylene imine-containing solution may be applied to the surface of the paper base after the paper making process. Further, after forming a three-layer structure of a release agent layer, a first resin layer, and a paper substrate, in a step of humidifying the paper substrate, polyethyleneimine may be impregnated in addition to moisture. In the present invention, when the paper base material contains polyethyleneimine, when the three-layer structure of the release agent layer, the first resin layer, and the paper base material is wound into a roll, the silicone type of the release agent layer Even if the release agent adheres to the paper substrate, the adhesion between the paper substrate and the second resin layer can be improved. Thus, polyethyleneimine can effectively enhance the adhesion between the paper substrate and the second resin layer.

The polyethyleneimine is preferably a polymer obtained by polymerizing ethyleneimine or a polymer having polyethyleneimine in the side chain. Examples of the polymer having polyethyleneimine in the side chain include a primary amino group-containing acrylic polymer obtained by grafting polyethyleneimine to the side chain.
In addition, it is preferable that content of polyethyleneimine is 0.01-0.1 mass% with respect to the total mass of a paper base material, and it is more preferable that it is 0.02-0.08 mass%.

  As will be described later, the release sheet of the present invention is laminated so that the release agent layer side is attached to the adhesive layer. The release sheet of the present invention is preferably used as a release sheet for protecting the surface of an adhesive layer such as a patch such as a compress sheet.

(Manufacturing method of release sheet)
The present invention provides a layer forming step of forming a first resin layer on one surface of a paper substrate and forming a release agent layer on one surface of the first resin layer; The present invention relates to a method for producing a release sheet having a humidity control step for adjusting the water content and a step for forming a second resin layer on the other surface of the paper substrate in this order.
In the release sheet having a conventional paper base material, the release agent layer was formed after forming the first resin layer and the second resin layer on both sides of the paper base material. The second resin layer is laminated in the final step. Moreover, the manufacturing method of this invention has the moisture-control process of a paper base material layer. By setting it as such a manufacturing process, the curl which has a desired curl degree can be provided to a peeling sheet.

  In the layer forming step, first, a first resin layer is formed on one surface of the paper substrate. The first resin layer is laminated on one surface of the paper substrate. In this case, it is preferable to laminate by extruding and laminating the molten resin constituting the first resin layer to the paper substrate. Moreover, you may bond both using an adhesive agent etc. as needed.

  After the two-layer structure of the paper base and the first resin layer is formed, a step of forming a release agent layer on one surface of the first resin layer is provided. In this way, a three-layer structure in which the release agent layer, the first resin layer, and the paper base material are laminated in this order is formed. The release agent layer can be formed by applying a coating solution containing a release agent and performing a heat treatment. In the production process of the present invention, heat treatment is preferably performed in the step of forming the release agent layer. In such a heat treatment process, moisture contained in the paper base material is evaporated. Thereafter, the humidification process causes the paper fibers to expand and contract, and the release sheet curls.

  After the three-layer structure in which the release agent layer, the first resin layer, and the paper base material are laminated in this order is formed, a humidity control step is provided. In the humidity adjustment step, it is preferable that the water content of the paper substrate is adjusted to 4 to 7% by mass with respect to the total mass of the paper substrate, the first resin layer, and the release agent layer. In the humidity control step, the water content of the paper substrate is preferably adjusted to 5.5 to 10% by mass with respect to the mass of the paper substrate, and is preferably 6 to 9.8% by mass. It is more preferable to adjust so that it may become, and it is still more preferable to adjust so that it may become 6.5-9.5 mass%. The moisture conditioning step may be a drying step when the moisture content contained in the paper substrate is greater than the above moisture content range, but usually the moisture in the paper substrate in the release agent layer forming step. The moisture conditioning process is preferably a humidifying process.

In the humidity control step, when the paper substrate is humidified, moisture may be directly applied to the paper substrate, and a three-layer structure in which the release agent layer, the first resin layer, and the paper substrate are laminated in this order. Steam may be sprayed on the paper substrate side. It is preferable to use a humidifier in the humidity adjustment process. Examples of the humidifier include an application facility using a roll such as a gravure and a facility for spraying steam or the like. Especially, it is preferable to apply | coat a water | moisture content on the paper base material surface using a gravure coater. When humidifying using a gravure coater, the coating speed is preferably 50 to 400 m / min. The coating amount varies depending on the basis weight of the paper substrate, but is preferably 2.0 to 6.0 g / m ² .

  In addition, in the manufacturing process of a peeling sheet, it is good also as performing simultaneously the process of applying the coating liquid containing a release agent, and a humidity control process. In this case, it is possible to apply a coating solution containing a release agent and apply moisture using a two-head coater or the like.

  The humidity control step may further include a step of causing the paper base material to contain polyethyleneimine. When such a process is further included, for example, a humidification process and a polyethyleneimine impregnation process may be combined by mixing polyethyleneimine with moisture applied to the paper substrate surface. Moreover, you may apply | coat a polyethyleneimine containing solution separately on the surface of a paper base material after a humidification process.

The production process of the release sheet may further include a printing process. In the printing process, printing is performed on the paper substrate. Printing is applied to one surface of the paper substrate. As a printing method in the printing process, a known printing method can be adopted, and among them, a gravure printing method is preferable.
The printing process may be performed simultaneously with at least one of the process of applying a coating solution containing a release agent and the humidity control process. When the step of applying the coating solution containing the release agent and the humidity control step are provided simultaneously, the three steps including the printing step may be performed simultaneously.
When a printing process is not performed simultaneously with the said process, it is preferable that a printing process is provided in the pre-process of the process of coating the coating liquid containing a release agent, or a post-humidity control process. Especially, it is more preferable that a printing process is provided in the post process of a humidity control process. That is, the printing process is preferably provided after the humidity adjustment process and before the process of forming a second resin layer described later.

  After the humidity control step, a step of forming a second resin layer on the other surface of the paper base is provided. The second resin layer is laminated on the other surface of the paper substrate. Here, the other surface of the paper substrate refers to one surface of the paper substrate that is located on the opposite side of the surface on which the first resin layer is laminated. In the step of forming the second resin layer, lamination is preferably performed by extruding and laminating the molten resin constituting the second resin layer to the other surface of the paper substrate. Moreover, you may bond both using an adhesive agent etc. as needed.

  The present invention also relates to a release sheet produced by the above method. The release sheet produced by the above method has a curl in a direction that protrudes toward the release agent layer, and can exhibit easy peelability when bonded to the adhesive layer. . In the release sheet of the present invention, the state of curling in the direction that protrudes toward the release agent layer can be said to be a state of curling in a tunnel shape with the release agent layer side up.

(Laminate)
The present invention relates to a laminate having the above-described release sheet, pressure-sensitive adhesive layer, and support in this order. The laminate of the present invention is preferably curled in a direction that protrudes toward the support. In the present invention, it is preferable that the laminate also has a curl as described above, whereby the release sheet can be easily peeled from the pressure-sensitive adhesive layer. In particular, when the release sheet starts to be peeled off from the pressure-sensitive adhesive layer, the release sheet can be easily picked up.
The laminate of the present invention is preferably a patch such as a poultice.

  FIG. 3 is a perspective view illustrating the configuration of the laminate of the present invention. As shown in FIG. 3, the laminate 100 has a structure in which the release sheet 10, the pressure-sensitive adhesive layer 20, and the support 30 are sequentially laminated. The laminated body 100 has a curl in the direction described by a dotted arrow in FIG. 3, for example.

  In the laminated body of the present invention, it is preferable that the curl height of the curled end side is a certain distance or more. Specifically, in a state where at least a part of the support of the laminate cut to a width of 30 mm is placed in contact with the horizontal flat surface, a pair of curl edges facing each other with a width of 30 mm and a horizontal flat The average distance from the surface is preferably 1.5 mm or more, more preferably 2 mm or more, and further preferably 3 mm or more. In addition, the measurement of the average distance between a pair of curl edges facing each other with a width of 30 mm of the laminate and the horizontal flat surface can be performed by the same method as the measurement of the curl height of the release sheet.

  As shown also in FIG. 3, the release sheet 10 of the laminate 100 preferably has a score line 40. The score line 40 is preferably formed so as to connect a pair of pieces forming the release sheet 10. Thus, when a peeling sheet has a score line, the easy peelability of a peeling sheet can be improved, and also when sticking a laminated body, it becomes easy to stick to a to-be-adhered object.

  FIG. 4 is a side view for explaining the state when the release sheet is peeled from the laminate of the present invention. As shown in FIG. 4, when using the laminated body 100, the release sheet 10 is divided at the cut line 40, and the release sheet 10 is peeled off from the cut portion. When the release sheet 10 of the present invention is used, the release sheet 10 curls on the outer surface at a location where the cut line 40 is divided. In FIG. 4, the state of the release sheet 10 at the divided location can be confirmed at a location surrounded by a dotted line. Thus, when a parting part curls in release sheet 10, it becomes easy to pick up release sheet 10, and it can improve easy peelability. Moreover, it is preferable that the laminated body 100 itself has a curl shape, and the present invention also has an advantage that division is likely to occur at a portion where a cut line is provided.

  In the prior art, especially when a release sheet having a paper substrate is used, even if a cut line is provided, the release sheet is easy to follow the pressure-sensitive adhesive layer, so the release sheet does not turn up at the parting point. There was a problem that occurred. For this reason, there was a problem that the picking when the release sheet was peeled from the pressure-sensitive adhesive layer was not successful, and it took time to peel the release sheet. However, in the present invention, even when the release sheet has a paper substrate, the release sheet has a curled shape, and therefore does not follow the pressure-sensitive adhesive layer, so that the release sheet can be easily separated at the dividing portion. Can be picked. Furthermore, in this invention, even if it is a case where a peeling sheet is made into a thin film, following an adhesive layer is suppressed and easy peelability can be improved.

  The cut line 40 provided in the release sheet 10 may be linear, but may be other shapes. For example, as shown in FIG. 5A, a wave shape may be used. By adopting such a shape, the picking portion becomes a projecting piece, so that easy peelability can be further improved. In addition, the shape of the cut line 40 may be an arc shape, an S shape, or a saw blade shape.

  As shown in FIGS. 5B and 5C, a plurality of cut lines 40 may be provided. FIG. 5B shows an example in which two straight cut lines 40 are provided. FIG. 5C shows an example in which two wavy cut lines 40 are provided. By providing the two cut lines 40 in this manner, the remaining area can be peeled after the area surrounded by the cut line 40 is peeled off. In this case, after peeling the area surrounded by the score line 40, the adhesive layer in the area surrounded by the score line 40 is temporarily adhered to the adherend, and the release sheet in the residual area is peeled off, thereby applying the adhesive layer. The joint work can also be performed smoothly.

Here, the score line is preferably provided so as to be substantially parallel to the pair of curl edges. When the score line is not linear, it is preferable that the average center line of the score lines is provided so as to be substantially parallel to the pair of curl edges. The average center line is a line that is a rotationally symmetric axis in the shape of a cut line, and is represented by a C segment in FIG. When the cut line is a single straight line segment, the average center line and the cut line completely coincide.
In this specification, “substantially parallel” means a state in which the average center line of the cut lines is 0 ± 10 ° with respect to the pair of curled edges. Thus, by providing a score line, the easy peelability of a peeling sheet can be improved more.

  The 180-degree peeling force between the release sheet and the pressure-sensitive adhesive layer is preferably 0.03 to 0.4 N / 40 mm, and more preferably 0.05 to 0.3 N / 40 mm. By setting the peeling force within the above range, the release sheet can be prevented from being unintentionally peeled during storage, and the handleability when using the laminate can be improved.

<Adhesive layer>
In the present invention, the pressure-sensitive adhesive layer preferably contains a transdermally absorbable drug. The transdermally absorbable drug is not particularly limited as long as it exhibits a pharmacological effect after absorption. For example, local stimulants, anti-inflammatory agents and analgesics, central nervous agents (sleep sedatives, antiepileptics, Mental and neurological agents), diuretics, antihypertensive agents, coronary vasodilators, antitussive expectorants, antihistamines, arrhythmic agents, cardiotonic agents, sex hormone agents, corticosteroid agents, local anesthetics, antifungal agents, etc. Can do. These medicinal ingredients can be used alone or in combination of two or more depending on the purpose of treatment.

  As local stimulants, anti-inflammatory agents and analgesics, for example, salicylic acid, methyl salicylate, glycol salicylate, 1-menthol, camphor, peppermint oil, thymol, nicotinic acid benzyl ester, capsicum extract, capsaicin, nonylic acid vanillylamide, felbinac, Butyl flufenamate, piroxicam, indomethacin, ketoprofen, pranoprofen, feprazone, loxoprofen, ampenac sodium, oxaprozin, emorphazone, fentazac, diclofenac sodium, diflunisal, ibuprofen, bendazac, suprofen, ester derivatives thereof, buprenorphine hydrochloride, Examples thereof include pentazocine and butorphanol tartrate.

  Examples of the central nervous agent include fluphenazine, thioridazine, diazepam, chlorpromazine, nitrazepam, estazolam, triazolam, nimetazepam, flunitrazepam, flurazepam, clonazepam, propericazine, oxazepam, oxazolam, cloxazolam, prazepamazepam, fluxazolam, prazepam Examples include fludiazepam, promazepam, and metazepam.

  Examples of the diuretic include hydrothiazide, pendroflunathiazide, ethiazide, cyclopenthiazide, hydrochlorothiazide, penfluzide, methycloazide, furosemide, metolazone, polythiazide, bendroflumethiazide and the like.

  Examples of antihypertensive agents include clonidine, dihydroergotoxin mesylate, reserl, pinprazosin, captopril, pindolol, enalapril maleate, and the like.

  Examples of the coronary vasodilator include nitroglycerin, isosorbite dinitrate, papaperine hydrochloride, dipyridamole, efloxate, trimethazine, nicorandil, cinnarizine, molsidomine, nifedipine and the like.

  Antitussive expectorant, for example, codeine phosphate, dihydrocodeine phosphate, ephedrine hydrochloride, chlorprenalin hydrochloride, phenothenol hydrobromide, salbutamol sulfate, dimemorphan phosphate, azelastine hydrochloride, clenpterol hydrochloride, tulobuterol hydrochloride, hydrochloric acid Examples include trimethoquinol, procaterol hydrochloride, bromhexine hydrochloride, tranilast, tipepidine hibenzate, ketotifen fumarate, formoterol fumarate, and oxatomide.

  Examples of the antihistamine include diphenhydramine hydrochloride, triprolidine hydrochloride, istipendyl hydrochloride, promethazine hydrochloride, chlorpheniramine maleate, cyproheptadine hydrochloride, clemastine fumarate, carbinoxamine maleate, dimethidene maleate, and the like.

  Examples of the arrhythmic agent include alprenolol hydrochloride, oxprenolol hydrochloride, bucmolol hydrochloride, bupranolol hydrochloride, pindolol, indenolol hydrochloride, carteolol hydrochloride, bufetrol, hydrochloride, propranolol hydrochloride, timolol maleate and the like. .

  Examples of the cardiotonic agent include diquitaris, ubidecalenone, digoxin, methyldigoxin, and destranoside. Examples of the sex hormone agent include estradiol, estriol, progesterone, norethisterone and the like.

  Examples of corticosteroids include hydrocortisone acetate, hydrocortisone, prednisolone, triamcinolone acetonide, methylprednisolone, dexamethasone acetate, dexamethasone, fluorometholone, betamethasone phosphate sodium, betamethasone, betamethasone valerate, beclomethasone propionate, fludroxycortide , Hydrocortisone acetate, fluocinonide, clobetasol propionate, diflucortron valerate, halcinonide, amsinonide, prednisolone valerate and the like.

  Examples of the local anesthetic include lidocaine hydrochloride, ethyl aminobenzoate, procaine hydrochloride, dipcaine hydrochloride and the like. Examples of the antifungal agent include amorolfine, terbinafine, butenafine, ranoconazole, ketoconazole, neticonazole, fluconazole, miconazole, riranaphthate, omoconazole nitrate and the like.

  It is preferable that an adhesive layer is comprised from the adhesive which can be stuck on the to-be-adhered surface. Examples of the pressure sensitive adhesive include rubber pressure sensitive adhesive, acrylic pressure sensitive adhesive, polyester pressure sensitive adhesive, polyurethane pressure sensitive adhesive, and silicone pressure sensitive adhesive. Although only 1 type of the said adhesive may be used for an adhesive, 2 or more types may be used together.

As the rubber-based pressure-sensitive adhesive, either natural rubber or synthetic rubber can be used. Examples of the synthetic rubber include styrene-based block copolymers and polyisobutylene.
Examples of styrenic block copolymers include styrene-butylene-styrene block copolymer (SBS), styrene-isoprene-styrene block copolymer (SIS), styrene-ethylene / butylene-styrene block copolymer (SEBS), and styrene-ethylene / propylene-styrene block. A copolymer (SEPS) etc. are mentioned. Specific examples of the styrenic block copolymer include Kraton D-1112, D-1111, D-1107 (trade name, manufactured by Kraton Polymer Co., Ltd.), JSR5000 or JSR5002 (trade name, manufactured by Nippon Synthetic Rubber Co., Ltd.), Linear triblock copolymers such as Quintac 3530, 3421 or 3570C (trade name, manufactured by ZEON CORPORATION), Clayton D-KX401CS or D-1107CU (trade name, manufactured by Clayton Polymer Co., Ltd.), Clayton D-1124 (Brand name, manufactured by Kraton Polymer Co., Ltd.), Sorprene 418 (Brand name, manufactured by Philippe Petroleum Co., Ltd.) and the like.

  As the polyisobutylene, for example, a polymer or a low molecular weight one is used. For example, Opanol B10, B12, B12SF, B15, B15SF, B30SF, B50, B50SF, B80, B100, B120, B150, B200 (trade name, BASF (Made by Co., Ltd.), Vistanex LM-MS, LM-MH, LM-H, MM L-80, MM L-100, MM L-120, MM L-150 (trade name, manufactured by Exxon Chemical Co., Ltd.) Etc.

  In addition, as the acrylic pressure-sensitive adhesive, as a monomer unit, for example, (meth) acrylic typified by 2-ethylhexyl acrylate, methyl acrylate, butyl acrylate, hydroxyethyl acrylate, 2-ethylhexyl methacrylate, etc. A polymer or copolymer containing at least one acid ester is used. For example, acrylic acid / octyl acrylate ester copolymer, acrylic acid-2-ethylhexyl / N-vinyl-2-pyrrolidone / dimethacrylic acid-1,6-hexane glycol copolymer, acrylic acid-2-ethylhexyl / acetic acid Examples thereof include vinyl copolymers, 2-ethylhexyl acrylate / vinyl acetate / acrylic acid copolymers, and 2-ethylhexyl acrylate / 2-ethylhexyl methacrylate / dodecyl methacrylate copolymers. Specifically, adhesives such as methyl acrylate / acrylic acid-2-ethylhexyl copolymer resin emulsion, acrylic polymer contained in acrylic resin alkanolamine liquid, Duro-Tak acrylic adhesive series (National Starch and Chemical Co., Ltd.) Manufactured), GELVA acrylic pressure-sensitive adhesive series (manufactured by Monsanto), SK Dyne Matriderm (Soken Chemical), Eudragit series (Higuchi Shokai) and the like can be used.

  The pressure-sensitive adhesive layer may further contain a tackifier, a plasticizer, a filler, a stabilizer and the like.

  The thickness of the pressure-sensitive adhesive layer is preferably 0.05 to 0.30 mm, and more preferably 0.10 to 0.30 mm. By setting the pressure-sensitive adhesive layer within the above range, it is possible to make the pressure-sensitive adhesive force with the adherend within a preferable range.

<Support>
Examples of the support include paper, film, woven fabric, knitted fabric, nonwoven fabric, and knit. The support is preferably one having elasticity, and a sheet-like member having elasticity is preferably used. The support is selected in consideration of physical properties such as thickness, elongation, tensile strength, and workability of application, touch at the time of application, skin tightness, transfer of medicinal components to the support, and the like.

  Materials for the support include bast fibers such as paper, cotton, cannabis and jute, cellulose fibers such as leaf fibers of manila hemp, animal fibers such as wool, and natural fibers such as protein fibers such as silk and feather fibers. Regenerated cellulose fibers such as rayon and cupra, regenerated fibers such as regenerated protein fibers, semi-synthetic fibers such as cellulose acetate fibers and promix, nylon aramid fibers, polyethylene terephthalate fibers, polyester fibers, acrylic fibers, polyethylene and polypropylene, etc. Polyolefin fiber, polyvinyl alcohol fiber, polyvinyl chloride fiber, polyvinylidene chloride fiber, polyvinyl chloride fiber, polyurethane fiber, polyoxymethylene fiber, polytetrafluoroethylene fiber, polyparaphenylene benzbisthiazole (PBT) fiber, polyimide fiber Etc. are available . Especially, it is preferable to use the nonwoven fabric which consists of a polyester-type polyethylene terephthalate fiber with little interaction with the medicinal component contained in an adhesive layer.

  Moreover, it is preferable that the thickness of the support body used for this invention is 0.3-3 mm, and when using a polyester nonwoven fabric, it is preferable that it is 0.5-2 mm.

  The features of the present invention will be described more specifically with reference to examples and comparative examples. The materials, amounts used, ratios, processing details, processing procedures, and the like shown in the following examples can be changed as appropriate without departing from the spirit of the present invention. Therefore, the scope of the present invention should not be construed as being limited by the specific examples shown below.

(Examples 1-9)
<Preparation of release sheet>
A first resin layer was formed by extruding and laminating a polyethylene resin to the paper substrate (quality paper) described in Table 1. The thickness of the 1st resin layer was formed so that it might become the thickness of Table 1. Next, a coating solution containing addition type solvent silicone (manufactured by Shin-Etsu Chemical Co., Ltd., KS778) was applied onto the first resin layer, and heat treatment was performed at 60 to 150 ° C. for 2 to 10 seconds. Thereafter, using a humidifier, a solution containing polyethyleneimine was applied to the paper substrate, and humidity was adjusted so that the water content shown in Table 1 was obtained with respect to the total mass of the paper substrate. Humidification was performed using a gravure coater, and the coating speed was set to 50 to 400 m / min. The coating amount was adjusted to be 2.0 to 6.0 g / m ² . Further, the concentration of polyethyleneimine in the solution containing polyethyleneimine was adjusted so that the final concentration in the paper substrate was the content shown in Table 1.

  A second resin layer was formed by extruding and laminating a polyethylene resin to one surface of the paper substrate opposite to the surface on which the first resin layer was provided. The thickness of the 2nd resin layer was formed so that it might become thickness given in Table 1. Thus, the release sheet of the example was obtained. The release sheet is curled in the direction shown in Table 1, and the distance between the curl edge of the release sheet and the horizontal flat surface (the height of the curl edge (curl height)) is as shown in Table 1. It was.

<Production of laminate>
A pressure-sensitive adhesive layer having a thickness of 100 to 300 μm was formed on the surface provided with the first resin layer of the release sheet obtained above. The pressure-sensitive adhesive layer was formed by applying a coating solution obtained by mixing glycolic salicylate and an acrylic pressure-sensitive adhesive on a release sheet, and then drying it. Subsequently, the nonwoven fabric (support body) which consists of a polyester fiber with a thickness of 700-1200 micrometers was laminated | stacked on the adhesive layer, and the laminated body was obtained. In addition, the height (curl height) of the curl edge side in the laminated bodies obtained in Examples 1 to 9 was 1.5 mm or more.

(Comparative Examples 1 and 2)
<Preparation of release sheet>
A first resin layer was formed by extruding and laminating a polyethylene resin to the paper substrate (quality paper) described in Table 1. The thickness of the 1st resin layer was formed so that it might become the thickness of Table 1. Next, a second resin layer was formed by extruding and laminating a polyethylene resin to one surface of the paper substrate opposite to the surface on which the first resin layer was provided. The thickness of the 2nd resin layer was formed so that it might become thickness given in Table 1. Thereafter, a coating liquid containing addition type solvent silicone (manufactured by Shin-Etsu Chemical Co., Ltd., KS778) was applied onto the first resin layer, and heat treatment was performed at 60 to 150 ° C. for 2 to 10 seconds. Thus, the release sheet of the comparative example was obtained. The moisture content of the paper substrate and the distance between the curl edge of the release sheet and the horizontal flat surface (the height of the curl edge (curl height)) are shown in Table 1.

<Production of laminate>
Using the release sheet obtained above, a laminate was formed in the same manner as in the example. In the laminated body, the height of the curled edge (curl height) was 0 mm.

(Evaluation)
<Measurement of curl amount>
The release sheets obtained in Examples and Comparative Examples were cut into a width of 30 mm, and left for 8 hours under conditions of 23 ° C. and relative humidity of 50%, and then placed on a horizontal flat surface. The distance between the curl edge of the release sheet and the horizontal flat surface (the height of the curl edge (curl height)) was measured using a ruler. In addition, since there are two curled edges in the release sheet, the curl height at any five locations (10 locations in total) on each side was measured to obtain an average value.

<Peelability>
After making the same cut line as FIG. 5C in the release sheet of the laminate obtained in the examples and comparative examples, as shown in FIG. 4, it becomes convex toward the release sheet side (the curl direction of the release sheet and Was folded to the opposite side. And peelability was evaluated as follows. In addition, an inner side release sheet means the release sheet of the area | region enclosed by two cut lines in FIG.5 (c).
○: Immediately after bending, the end of the inner release sheet was peeled off from the support.
(Triangle | delta): The edge part of an inner side peeling sheet peeled from the support body after progress for 3 second or more after bending.
X: The edge part of the inner side peeling sheet did not peel from a support body even if it bent.

  As can be seen from Table 1, since the release sheets of the examples have a predetermined curl, it is understood that they are excellent in easy peelability.

DESCRIPTION OF SYMBOLS 10 Release sheet 12 Release agent layer 14 1st resin layer 16 Paper base material 18 2nd resin layer 20 Adhesive layer 30 Support body 40 Cut line 100 Laminate C Average center line H Horizontal flat surface P1 Horizontal flat surface and curl Edge distance P2 Distance between the horizontal flat surface and the curl edge

Claims (10)

A layer forming step of forming a first resin layer on one surface of the paper substrate and forming a release agent layer on one surface of the first resin layer;
A humidity control step of adjusting the water content of the paper base layer to 5.5 to 10% by weight with respect to the total weight of the paper base ;
A method of manufacturing a release sheet which chromatic forming a second resin layer on the other surface of the paper substrate, in this order,
The first resin layer is rather thick than the second resin layer,
In a state after placing at least a part of the release agent layer of the release sheet cut to a width of 30 mm so as to be in contact with the horizontal flat surface, and after standing at 23 ° C. and a relative humidity of 50% for 8 hours, A method for producing a release sheet , wherein an average distance between a pair of curl edges facing each other with a width of 30 mm and the horizontal flat surface is 2 mm or more . The humidity The method for manufacturing a release sheet according to claim 1, wherein the step of humidifying the paper substrate. The said humidity control process is a manufacturing method of the peeling sheet of Claim 1 or 2 which further includes the process of making the said paper base material contain a polyethyleneimine. A release sheet having a release agent layer, a first resin layer, a paper base material, and a second resin layer in this order, curled in a convex direction toward the release agent layer,
In a state after placing at least a part of the release agent layer of the release sheet cut to a width of 30 mm so as to be in contact with the horizontal flat surface, and after standing at 23 ° C. and a relative humidity of 50% for 8 hours, An average distance between a pair of curl edges facing each other across a width of 30 mm and the horizontal flat surface is 2 mm or more;
The first resin layer is rather thick than the second resin layer,
The moisture content of the said paper base material is a peeling sheet which is 5.5-10 mass% with respect to the total mass of the said paper base material . The release sheet according to claim 4 , wherein the first resin layer has a thickness of 5 to 30 μm. The release sheet according to claim 4 or 5 , wherein the entire thickness is 70 to 300 µm. The release sheet according to any one of claims 4 to 6 , wherein the paper substrate contains polyethyleneimine. A laminate having a release sheet, an adhesive layer, and a support in this order,
The release sheet has a release agent layer, a first resin layer, a paper base, and a second resin layer in this order,
The laminate is curled in a direction that is convex toward the support,
In the state after placing at least a part of the support of the laminate cut to a width of 30 mm so as to be in contact with the horizontal flat surface and leaving it to stand at 23 ° C. and a relative humidity of 50% for 8 hours. The average distance between the pair of curled edges facing each other with a gap of 30 mm and the horizontal flat surface is 1.5 mm or more,
The first resin layer is rather thick than the second resin layer,
The laminated body whose water content of the said paper base material is 5.5-10 mass% with respect to the total mass of the said paper base material . The release sheet has a score line,
The laminate according to claim 8 , wherein an average center line of the cut lines is substantially parallel to the pair of curled edges. The laminate according to claim 8 or 9 , wherein the pressure-sensitive adhesive layer contains a transdermally absorbable drug.

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