JP6246995B2 - Needleless syringe - Google Patents

Description

  The present invention relates to a needleless syringe that injects a substance to be injected into an injection target region of a living body without using an injection needle.

  A needleless syringe that performs injection without going through an injection needle employs a configuration in which injection components are ejected by applying pressure to an injection solution containing a drug or the like with a pressurized gas or a spring. Then, the pressure applied to the injection solution is adjusted so that the injection solution can be sent to a desired region in the living body. Here, when a drug is injected into a living body via a needleless syringe or the like, the ability to administer the drug to Langerhans cells in the skin is particularly noted. Langerhans cells are dendritic cells that are normally present in the upper spinous layer of the skin. These cells are involved in the immune response of the skin and are known to migrate from the skin to the lymph nodes, have a common receptor for macrophages, and function as antigen-presenting cells for T and B lymphocytes. Therefore, Langerhans cells are of particular importance in immune system research related to facilitating vaccine development and treatment for autoimmune disease and rejection prevention therapy. However, since the Langerhans cells are present at a relatively shallow site under the skin, in a needleless syringe that does not have an injection needle that carries the injection solution directly into the living body, administration of the injection solution to the Langerhans cell is efficient. It is very effective to do.

  On the other hand, in a needleless syringe, control for transporting an injection solution to a region to be injected such as the skin of a living body is required so that the injection solution can be more efficiently administered to a relatively shallow site under the skin. This control is realized by appropriately adjusting the pressing force and the diameter of the injection port of the injection solution. Further, in a needleless syringe, when an injection port for injecting an injection solution is pressed against an injection target region such as the skin of a living body, the injection port and the injection target region are in close contact, and the injection solution can be efficiently carried to the injection target region. It is necessary.

  Here, Patent Document 1 discloses a jet injection drug delivery device that does not use a needle as a related technique of a needleless syringe. In the technique described in Patent Document 1, the contact end surface with the eyeball has a curved shape so that a drug can be injected into the eyeball.

JP 2007-44531 A

In a needleless syringe, it is necessary to appropriately adjust the applied pressure and the diameter of the injection port of the injection solution so that the injection solution can be more efficiently administered to a relatively shallow site under the skin. Further, in a needleless syringe, when the injection solution is pressed against the injection target region, the injection port and the injection target region are in close contact with each other, and the injection solution needs to be efficiently carried to the injection target region. Further, in order to ensure convenience as a syringe, it is necessary that the configuration is simple and the handling is easy. In this regard, there is a conventional technique in which the contact end surface with the eyeball is a curved surface. However, when this needleless syringe according to the prior art is used in a part other than a spherical surface such as an eyeball, there is a concern that a gap may be formed between the contact end surface and the injection target region. In addition, this conventional technique has a plurality of nozzles, but if the storage part for storing the drug and the positions of the plurality of nozzles do not correspond appropriately, the injection solution can be efficiently conveyed to the injection target area. become unable. Further, when assembling the syringe, it is necessary that the positions of the storage unit for storing the drug and the plurality of nozzles are appropriately fixed, and this operation is assumed to be complicated.

  In the present invention, in view of the above-described problems, an object of the present invention is to provide a needleless syringe that can more efficiently administer an injection solution to a relatively shallow site of an injection target region such as a living body and that is easy to handle. To do.

  In order to solve the above problems, in the present invention, in order to more efficiently administer the injection target substance to a relatively shallow site of the injection target region such as a living body, the shape of the contact end surface of the needleless syringe is injected. Providing a member that can control the shallowness of the injection target substance by reducing the diameter of the pores (micropores) for supplying the injection solution to the injection target region, while corresponding to the shape of the target region did. In addition, the member in which the hole is formed can be easily held by a holding portion made of a separate member in a state where it is appropriately disposed on the flow path of the injection target substance.

  Specifically, the present invention is a syringe for injecting an injection target substance into an injection target region of a living body without going through an injection needle, and includes a sealing part for sealing the injection target substance, and a sealing part enclosed in the sealing part. A pressurizing unit that pressurizes the injection target substance, and a flow path through which the injection target substance pressurized by the pressurization part flows, and an injection target outside the syringe from the opening end of the flow path An injection part for injecting the injection target substance to a region, and a microporous part having a pore diameter smaller than that of the injection part is a plate-like micropore part penetrating from one surface to the opposite surface, and the injection The injection target substance injected from the part passes through the fine pores and reaches the injection target region side, and is arranged on the outside of the injection part and on the outside of the injection part The micropore portion formed on the outer side of the micropore portion. A holding portion configured by a member different from the micropore portion, the holding portion including an end surface in contact with the injection target region, wherein at least a part of the end surface has a shape corresponding to the injection target region A section.

  In the needleless syringe according to the present invention, pressure is applied by the pressurizing unit to the injection target substance sealed in the sealing part, so that the injection target substance is flown from the flow path of the sealing part to the flow path of the injection part. You are prompted to move. As a result, the injection target substance is injected from the injection unit to the injection target area. This injection target substance contains a component expected to have an effect inside the injection target region, and the pressure applied by the pressurizing unit as described above is a driving source at the time of injection. Therefore, if injection by the pressurizing unit is possible, the state of accommodation of the injection target substance in the needleless syringe and the specific physics of the injection target substance such as liquid, gel-like fluid, powder, granular solid, etc. The form is not asked.

  For example, the injection target substance is a liquid, and even if it is a solid, it may be a gel-like solid as long as fluidity enabling injection is ensured. Furthermore, the injection target substance may be in a powder state. The injection target substance includes a component to be sent to the injection target region of the living body, and the component may exist in a state dissolved in the injection target substance, or the component is simply mixed without being dissolved. It may be in the state where it was done. For example, as ingredients to be delivered, there are vaccines for antibody enhancement, proteins for cosmetics, cultured cells for hair regeneration, etc., so that these can be injected into fluids such as liquids and gels. By inclusion, a substance for injection is formed.

  Various pressurization sources can be used as the pressurization source for the injection target substance as long as injection by pressurization is possible. For example, those using elastic force from springs, using pressurized gas, using gas pressure generated by combustion of explosives, electric actuators for pressurization (motors, piezo elements, etc.) ) Is used as a pressure source. Moreover, the form which achieves pressurization by a user's manual may be employ | adopted.

The injection part is preferably formed so that the opening area of the opening end is smaller than the flow path area of the enclosing part. The area here is an area in a direction perpendicular to the flow of the injection target substance. By setting the opening area of the opening end in this manner, the pressurized injection target substance is concentrated at the opening end having a smaller flow path area, and the pressure and flow rate applied to the injection target substance at the time of injection are increased. be able to. As a result, the injected injection target substance can penetrate the surface of the injection target region of the living body and erode the inside thereof.

  And in the needleless syringe which concerns on this invention, the micropore part is arrange | positioned on the outer side of the injection | emission part. A micropore part has a micropore as a "hole" as a structure different from an injection | pouring part. The micropore has a smaller pore diameter than the injection portion pore diameter (corresponding to the opening area described above). The injection target substance injected from the opening end of the injection part passes through the micropore part before reaching the injection target area. The micropore portion may be formed by a plurality of micropores. In other words, in this case, a single flow injected from the injection portion is divided into a plurality of thinner flows (liquid columns) by the micropore portion. ). Therefore, the injection target substance that has become a thin liquid column reaches the surface of the injection target region. As a result, it is possible to adjust the depth in the injection target area where the injection target substance reaches to be shallow.

  In the needleless syringe according to the present invention, the micropore portion is held from the outside of the micropore portion. In other words, the holding means that the state in which the micropores are connected to the needleless syringe is maintained. The needleless syringe and the holding part may be fixed by the holding part itself or by another member. The holding portion includes an end surface that is in contact with the injection target region, and a part of the holding portion has a shape corresponding to the injection target region. The shape corresponding to the injection target region is a shape formed in order to improve the adhesion between the end face and the injection target region, and does not need to be completely coincident with the injection target region.

  In the needleless syringe according to the present invention, the injection target substance can be injected into a shallow site by adopting a simple configuration in which the micropore part and the holding part are arranged outside the injection part. Therefore, a needleless syringe can be supplied at low cost. That is, it is technically difficult to process the hole corresponding to the injection portion for injecting the injection target substance as much as possible, and the lower limit of the diameter that can be processed is naturally determined. However, in the present invention, since micropores for injecting the injection target substance are formed in the relatively thin plate-like micropores, the degree of freedom in processing is increased, and drilling with a smaller diameter is also possible. As a result, since the injection target substance can be injected into a desired site including a shallow portion of the injection target region, it is possible to efficiently inject the injection target substance, that is, to suppress consumption of the useless injection target substance at the time of injection. In addition, by appropriately selecting the flow channel area of the micropores, the injection depth in the injection target region can be easily controlled without adjusting the pressure applied to the injection target substance by the pressurizing unit. Since it becomes possible, the utilization degree as a syringe improves by using properly the micropore part of a different specification (a diameter, the number of holes, etc.) according to the objective. Moreover, in order to ensure the convenience as a needleless syringe, it is necessary that the configuration is simple and the handling is easy. In this regard, in the needleless syringe according to the present invention, the end surface of the holding portion has a shape corresponding to the injection target region, and the adhesion between the end surface of the holding portion and the injection target region can be improved. Therefore, the injection target substance can be efficiently injected into the injection target region regardless of the skill level of the user. Further, in order to efficiently carry the injection target substance to the injection target region, it is necessary to appropriately correspond the positions of the injection portion and the micropore portion. In this regard, the needleless syringe according to the present invention can be fixed by a holding portion made of a member different from the micropore portion. That is, the position of the injection part and the minute pore part can be appropriately matched and held by the holding part. That is, since the alignment and fixing (holding) can be performed separately, the assembly operation of the needleless syringe is also facilitated. Moreover, the needleless syringe optimal for a use can be provided by changing the structure of a micropore part and a holding | maintenance part according to an injection object area | region and an injection target substance.

Here, in the needleless syringe according to the present invention, at least a part of the holding portion is in contact with the micropore portion, and only the micropore and the one surface in the vicinity thereof are exposed from the opening portion. The plate-like micropores may be prevented from being lifted during pressurization by the pressurization unit. During pressurization by the pressurizing unit, the plate-shaped micropores are lifted (that is, the micropores are separated from the injection port under the pressure of the injection target substance discharged from the injection unit) It is feared that it will deform. If the micropores are lifted, the injection target substance ejected from the ejection part cannot be efficiently moved to the injection target area. In the needleless syringe according to the present invention, lifting can be suppressed by the holding unit, and as a result, the injection target substance ejected from the ejection unit can be efficiently moved to the injection target region.

  Further, in the needleless syringe according to the present invention, the holding portion has a strip-shaped recess as a shape corresponding to the injection target region, and the micropore portion is disposed along the strip-shaped recess. It has a plurality of micropores, and the strip-shaped recess has an opening that exposes the plurality of micropores and allows the injection target substance that has passed through the plurality of micropores to reach the injection target region It may be. By setting it as a strip | belt-shaped recessed part, the adhesiveness of aspherical injection object area | regions, such as an arm and a leg, and a holding | maintenance part can be improved. In addition, by forming a plurality of micropores, it is possible to inject a substance to be injected over a wide range. Examples of the arrangement pattern of the plurality of micropores include linear, staggered, and random. One opening may be formed for a plurality of micropores, or may be formed for each of the plurality of micropores. By forming the opening for each micropore, it is possible to more efficiently suppress the lifting when the plate-like micropore is pressed.

  Further, in the needleless syringe according to the present invention, the band-shaped recess includes a bottom surface portion having the opening and an inclined portion continuously connected to the bottom surface, and the inside of the bottom surface portion is the micropore portion. The plate-like micropores may be prevented from rising when pressed by the pressure unit. The needleless syringe according to the present invention is an example in which the shape of the recess is more concrete. By providing the inclined portion, it is possible to further improve the adhesion with the injection target region such as an arm or a leg.

Further, in the needleless syringe according to the present invention, the micropore portion is configured so that the injection target substance injected from the injection portion passes through the micropore and reaches the injection target region side. A positioning portion of the micropore portion that determines the position of the micropore with respect to the portion may be included. Further, the holding part may include a positioning part of the holding part that determines a position of the opening part with respect to the injection part so that the opening part of the strip-shaped concave part exposes the plurality of micropores. . By providing the positioning part of the micropore part and the positioning part of the holding part, the position of the micropore part relative to the injection part and the position of the opening formed in the holding part can be easily determined. Is further improved.

  In addition, the needleless syringe according to the present invention can be configured to further include a holding portion and a fixing portion that fixes the micropore portion in a state where the holding portion holds the micropore portion. Examples of the fixing portion include snap fitting by an engaging method, screwing by a screwing method, and fastening by an elastic member.

Here, the present invention can also be specified as a method of operating a needleless syringe. That is, the present invention is an operation method of the needleless syringe described above, which includes a step of pressurizing the injection target substance enclosed in the enclosing portion by the pressurizing portion and an injection outside the syringe. A step of pouring the injection target substance pressurized by the pressurizing unit into an injection part for injecting the injection target substance to the target region; and the injection target substance injected from the injection part is further arranged outside the Passing through plate-like micropores having pores. At this time, the micropores may be perforated from one surface to the opposite end surface so that the pore size of the micropores is smaller than that of the injection part. The operation method may further include a step of holding the micropores from the outside and fixing the micropores by a holding portion having a shape corresponding to the injection target region at least a part of the end face. By operating the needleless syringe in this way, as described above, it is possible to efficiently inject a relatively shallow portion of the injection target region such as a living body. The technical idea related to the needleless syringe according to the present invention can also be applied to an invention related to an operation method of the needleless syringe.

  Moreover, this invention can also be specified as a usage method of a needleless syringe. That is, the present invention is a method of using the needleless syringe described above, which includes a step of arranging the micropore portion outside the injection portion, and a step of holding the holding portion from the outside of the micropore portion. Including. In addition, the method of use includes a step of pressurizing the injection target substance enclosed in the enclosing part by the pressurization part, and pressurizing the injection part for injecting the injection target substance to the injection target region outside the syringe. Pouring the injection target substance pressurized by the part, passing the injection target substance injected from the injection part further through the plate-like micropore part having the micropores arranged on the outside thereof, and , May be included. At this time, the micropores may be perforated from one surface to the opposite end surface so that the pore size of the micropores is smaller than that of the injection part. Further, the method of use may include a step of holding the micropores from the outside and fixing the micropores with a holding portion having a shape corresponding to the injection target region at least a part of the end face. By using the needleless syringe in this way, as described above, it is possible to efficiently inject a relatively shallow portion of the injection target region such as a living body. The technical idea related to the needleless syringe can also be applied to the invention relating to the method of using the needleless syringe.

  It is possible to provide a needleless syringe that can more efficiently administer an injection solution to a relatively shallow region of an injection target region such as a living body and that is easy to handle.

It is a figure showing a schematic structure of a needleless syringe concerning a first embodiment. It is a figure which shows schematic structure of the pressurization part (initiator) which concerns on 1st embodiment. It is a disassembled perspective view of the front-end | tip part of the needleless syringe which concerns on 1st embodiment. It is a perspective view after the assembly of the front-end | tip part of the needleless syringe which concerns on 1st embodiment. It is a figure explaining the front-end | tip part of the needleless syringe which concerns on 1st embodiment. It is sectional drawing of the recessed part of the front-end | tip part of the needleless syringe which concerns on 1st embodiment. It is sectional drawing of the recessed part of the front-end | tip part of the needleless syringe which concerns on a 1st modification. It is a side view of the tip part of the needleless syringe concerning a first embodiment. It is a figure explaining the board member in the case of pressurization rising. It is a figure which shows schematic structure of the needleless syringe which concerns on 2nd embodiment. It is a disassembled perspective view of the front-end | tip part of the needleless syringe which concerns on 2nd embodiment. It is a figure explaining the nozzle of the needleless syringe concerning a modification.

  Hereinafter, a needleless syringe 1 (hereinafter simply referred to as “syringe 1”) according to an embodiment of the present invention will be described with reference to the drawings. The configuration of the following embodiment is an exemplification, and the present invention is not limited to the configuration of this embodiment.

<First embodiment>
Here, FIG. 1 is a diagram showing a schematic configuration of the needleless syringe according to the first embodiment. In the following description, the injection target substances injected into the injection target by the syringe 1 are collectively referred to as “injection solution”. However, this is not intended to limit the content or form of the injected substance. In the injection target substance, the component to be delivered to the skin structure which is the injection target region may or may not be dissolved. Also, the injection target substance can be applied to the skin structure from the nozzle 4 by pressurization. As long as it can be ejected, its specific form is not limited, and various forms such as liquid and gel can be adopted.

The syringe 1 has a syringe body 2, and a through-hole 14 extending in the axial direction and having a constant diameter along the axial direction is provided in the central portion of the syringe body 2. One end of the through hole 14 communicates with the combustion chamber 29 having a diameter larger than the diameter of the through hole 14, and the other end reaches the nozzle holder 5 side where the nozzle 4 is formed. Furthermore, a pressurizing part (initiator) 20 is installed on the opposite side of the combustion chamber 29 from the communicating part with the through hole 14 so that the ignition part faces the communicating part.

  The pressurizing unit 20 serves as a driving force source for injection in the syringe 1, and the pressure generated by the pressurizing unit 20 is transmitted to the injection liquid ML via the piston 6 and the sealing member 7. Injection of the liquid ML is started. FIG. 2 shows an example of the pressure unit (initiator) 20. The pressurizing unit 20 is an electric ignition device, and a space for arranging the ignition agent 22 is defined in the cup 21 by a cup 21 whose surface is covered with an insulating cover. And the metal header 24 is arrange | positioned in the space, and the cylindrical charge holder 23 is provided in the upper surface. The charge holder 23 holds the ignition agent 22. A bridge wire 26 that electrically connects one conductive pin 28 and the metal header 24 is wired at the bottom of the ignition agent 22. The two conductive pins 28 are fixed to the metal header 24 via the insulator 25 so that they are insulated from each other. Furthermore, the opening of the cup 21 from which the two conductive pins 28 insulated by the insulator 25 extend is protected by the resin 27 in a state in which the insulation between the conductive pins 28 is well maintained.

  In the pressurizing unit 20, when a voltage is applied between the two conductive pins 28 by an external power source, a current flows through the bridge wire 26, and the igniting agent 22 is burned. At this time, the combustion products resulting from the combustion of the igniting agent 22 are ejected from the opening of the charge holder 23. Therefore, in the pressurization unit 20, the relative positional relationship of the pressurization unit 20 with respect to the syringe body 2 is designed so that the combustion product of the igniting agent 22 in the pressurization unit 20 flows into the combustion chamber 29. The initiator cap 15 is formed in a hook shape so as to be hooked on the outer surface of the pressurizing unit 20, and is screwed to the syringe body 2. As a result, the pressurizing unit 20 is fixed to the syringe main body 2 by the initiator cap 15, so that the pressurizing unit 20 itself is dropped from the syringe main body 2 by the pressure generated when the pressurizing unit 20 is ignited. Can be prevented.

  The igniting agent 22 used in the syringe 1 is preferably an explosive containing zirconium and potassium perchlorate (ZPP), an explosive containing titanium hydride and potassium perchlorate (THPP), titanium and potassium perchlorate. Gunpowder containing (TiPP), Gunpowder containing aluminum and potassium perchlorate (APP), Gunpowder containing aluminum and bismuth oxide (ABO), Gunpowder containing aluminum and molybdenum oxide (AMO), Gunpowder containing aluminum and copper oxide (ACO) ), Explosives containing aluminum and iron oxide (AFO), or explosives composed of a combination of these explosives. These explosives generate high-temperature and high-pressure plasma at the time of combustion immediately after ignition. However, when the combustion product is condensed at a normal temperature and does not contain a gas component, the generated pressure rapidly decreases. As long as appropriate injection is possible, other explosives may be used as igniting agents.

Here, in the combustion chamber 29, a columnar gas generating agent 30 is disposed that burns with combustion products generated by the combustion of the igniting agent 22 and generates gas. As an example of the gas generating agent 30, a single base smokeless gunpowder composed of 98% by mass of nitrocellulose, 0.8% by mass of diphenylamine and 1.2% by mass of potassium sulfate can be mentioned. It is also possible to use various gas generating agents that are used in gas generators for airbags and gas generators for seat belt pretensioners. The gas generating agent 30 is different from the igniting agent 22 in that the predetermined gas generated at the time of combustion contains a gas component even at room temperature, and therefore the rate of decrease in the generated pressure is smaller than that of the igniting agent 22. Furthermore, although the combustion completion time at the time of combustion of the gas generating agent 30 is longer than that of the igniting agent 22, the size, size and shape of the gas generating agent 30 when disposed in the combustion chamber 29, especially the surface It is possible to change the combustion completion time of the gas generating agent 30 by adjusting the shape. This is because the state of contact of the igniting agent 22 flowing into the combustion chamber 29 with the combustion product is generated due to the surface shape of the gas generating agent 30 and the arrangement of the gas generating agent 30 in the combustion chamber 29. This is because it is considered to change depending on the relative positional relationship between the agent 30 and the ignition agent 22.

  Next, a metal piston 6 is disposed in the through hole 14 so as to be slidable in the through hole 14 along the axial direction, one end of which is exposed to the combustion chamber 29 side, and the other end is exposed to the other end. The sealing member 7 is integrally attached. The injection liquid ML injected by the syringe 1 is accommodated in a space formed in the through hole 14 between the sealing member 7 and another sealing member 8. Therefore, the sealing members 7 and 8 and the through-hole 14 form the sealed portion of the needleless syringe according to the present invention. The sealing members 7 and 8 prevent the injection liquid from leaking out when the injection liquid ML is sealed, and the injection liquid ML can smoothly move in the through hole 14 as the piston 6 slides. It is made of rubber with a thin coating of silicon oil on the surface.

  Further, a nozzle holder 5 to which a nozzle 4 (shown by a dotted line) for injecting the injection liquid ML is mounted is provided on the distal end side (right side in FIG. 1) of the syringe 1. In the syringe 1, the nozzle 4 is a so-called disposable type nozzle, and is configured to be detachably held with respect to the nozzle holder 5 so as to be replaced with a new nozzle each time the injection liquid ML is injected. ing. The nozzle holder 5 is connected to the end face of the syringe body 2 with the gasket 3 interposed therebetween, and further, a plate member 50, a holding member 60, and a fixing member 70 are provided in this order from the syringe body 2 side to the outside. It is fixed with. The plate member 50, the holding member 60, and the fixing member 70 will be described later.

When the nozzle holder 5 is attached to the syringe main body 2, a housing portion 10 capable of housing the sealing member 8 is formed at a location facing the sealing member 8 of the nozzle holder 5. The accommodating portion 10 has substantially the same diameter as the sealing member 8 and has a depth slightly longer than the length of the sealing member 8. Thereby, when pressure is applied to the piston 6 and the injection liquid ML moves to the distal end side of the syringe 1 together with the sealing members 7 and 8, the sealing member 8 can be accommodated in the accommodating portion 10. When the sealing member 8 is accommodated in the accommodating portion 10, the pressurized injection solution ML is released from the enclosed state. In view of this, the flow path 11 is formed so that the released injection liquid ML is guided to the nozzle 4 at a portion of the nozzle holder 5 that contacts the syringe body 2 side. In the first embodiment shown in FIG. 1, the flow path 11 is formed in the nozzle holder 5 so as to bypass the accommodating portion 10. The flow path diameter in the nozzle 4 is smaller than the flow path diameters of the through hole 14 and the flow path 11, so that the released injection liquid ML flows into the nozzle 4 through the flow path 11. Therefore, a flow having a relatively narrow flow diameter is formed and injected into the skin of a living body that is an injection target. Moreover, it can avoid that injection | pouring of the injection liquid ML is inhibited by the sealing member 8 because the accommodating part 10 has the depth which accommodates the sealing member 8. FIG.

A plurality of nozzles 4 may be formed on the nozzle holder 5 or one nozzle 4 may be formed. When a plurality of nozzles are formed, a flow path corresponding to each nozzle is formed so that the injection liquid ML released to each nozzle is fed. Further, when a plurality of nozzles 4 are formed, the arrangement is not particularly limited. In the present embodiment, as shown in FIG. 3 or the like, three nozzles 4 in the nozzle holder 5 are arranged linearly at equal intervals. The diameter of the nozzle 4 (the diameter of the opening end) is appropriately set in consideration of the injection object, the injection pressure applied to the injection liquid ML, the physical properties (viscosity) of the injection liquid ML, the injection depth to the injection object, and the like. However, since the nozzle 4 is manufactured from a resin material using, for example, injection molding, the diameter is sub-millimeter order, for example, 0.2 mm even if the diameter is small.

Next, the configuration of the distal end portion of the syringe 1 will be described with reference to FIGS. In the syringe 1 according to the first embodiment, the plate member 50 is held from the side of the syringe body 2 toward the outside so as to cover the open end of the nozzle 4 with respect to the nozzle holder 5 connected to the end surface of the syringe body. A member 60 and a fixing member 70 are provided. The distal end portion of the syringe 1 is formed with an outer diameter smaller than the outer diameter of the syringe body 2, a screw groove portion provided with a screw groove 43 around it, and an outer diameter smaller than the outer diameter of the screw groove portion. A nozzle holder 5 having a circular end surface is provided.

  The plate member 50 (corresponding to the micropore portion of the present invention) has micropores 51 at positions corresponding to the respective nozzles 4. The plate member 50 according to the first embodiment has a circular shape having the same diameter as the nozzle holder 5 in accordance with the nozzle holder 5 whose end surface is circular. In addition, the plate member 50 according to the first embodiment has three micropores 51 at positions corresponding to the three nozzles 4 provided in a straight line. The diameter of the micropore 51 is smaller than the diameter of the nozzle 4. For this reason, in the pressurized injection solution ML, the pressure applied to the injection solution ML at the time of injection is increased, and the injected injection solution ML penetrates the surface of the injection target region of the living body and erodes the inside thereof. It becomes possible. The micropore 51 is generally circular, and has a size of 50 μm to 100 μm, for example. Three micropores 51 having such a size and shape are regularly arranged on the plane at intervals of 10 mm.

  In the first embodiment, the plate member 50 is provided with a positioning hole 52 for accommodating the protrusion 41 provided at the opening end of the nozzle 4. The positioning hole 52 provided in the plate member 50 corresponds to the positioning portion of the micropore portion of the present invention. By aligning the protrusion 41 with the positioning hole 52 (accommodating the protrusion 41 in the positioning hole 52), alignment can be performed easily. In addition, it is possible to suppress a positional shift after the alignment (in the first embodiment, a positional shift in the rotation direction particularly when the fixing member 70 is screwed).

  The holding member 60 holds the plate member 50 and has a belt-like recess 61 at a position corresponding to the micropore 51. The strip-shaped recess 61 is assumed to be a long and narrow injection target region such as a human arm or foot. The strip-shaped recess 61 is formed by a bottom surface and an inclined portion connected to the bottom surface. The bottom surface of the strip-shaped recess 61 is rectangularly open, and the minute pores 51 of the plate member 50 are exposed from this opening. As shown in FIG. 5, the width B of the bottom surface of the recess 61 can be 5 mm to 10 mm. By doing in this way, from this opening, it will be in the state where only the fine pore 51 and the surface of the vicinity among plate members 50 were exposed. When an injection target area having elasticity such as an arm is pressed against the recess 61, the injection target area is pressed by the inner side surface of the recess 61 and deforms toward the bottom surface. Therefore, the contact between the bottom surface and the injection target area is increased, and the injection can be performed without leaking the injection liquid ML.

  FIG. 6 shows a cross-sectional view of the recess. In the first embodiment, the recessed portion 61 has an inclined portion (inner side surface) forming an angle θ with respect to the end surface. θ is an obtuse angle, and is formed to be 110 ° to 170 °, more preferably 120 ° to 160 °. The angle formed between the bottom surface and the inclined portion is also an obtuse angle, and is formed to be 110 ° to 170 °, more preferably 120 ° to 160 °.

  Here, as shown in FIG. 7, the recessed part 61 may comprise the cross section of an inclined part with a curved surface. The curved surface is a curved surface that is convex toward the syringe body 2 side. By making the inclined portion a curved surface, the adhesion between the inclined portion and the injection target area such as an arm is further improved. The bottom surface may be a flat surface or a curved surface in accordance with the curvature of the inner side surface.

FIG. 8 is a side view of the distal end portion of the syringe 1 according to the first embodiment. As shown in FIG. 8, by providing the holding member 60 with a band-shaped recess 61, adhesion to an injection target region such as an arm is improved. Further, the back surface (syringe body 2) of the bottom surface of the recess 61 is in contact with the surface of the plate member 50, and suppresses the floating of the micropores 51 of the plate member 50 during pressurization. That is, as shown in FIG. 9, there is a concern that the plate member 50 is lifted during pressurization, but in the syringe 1 according to the first embodiment, from the opening formed in the recess 61 of the holding member 60. In the plate member 50, only the fine pores 51 and the surface in the vicinity thereof are exposed, and most of the plate member 50 is sandwiched between the nozzle holder 5 and the holding member 60. Yes, such lifting of the plate member 50 can be suppressed.

  In addition, a positioning hole 63 for receiving the protrusion 41 provided at the opening end of the nozzle 4 is provided inside the end surface of the holding member 60 (shown by a dotted line in FIG. 3). The positioning hole 63 provided in the holding member 60 corresponds to the positioning portion of the holding portion of the present invention. By aligning the protrusion 41 and the positioning hole 52 of the plate member, and further aligning the protrusion 41 and the positioning hole 63 of the holding member 60, alignment can be easily performed.

  A step 62 is provided around the holding member 60 to come into contact with the flange 72 of the fixing member 70 when the fixing member 70 is fixed. The step 62 projects in an annular shape in the radial direction from the circular end surface of the holding member 60. When the fixing member 70 is fixed, the step 62 and the flange 72 come into contact with each other, so that the holding state of the holding member 60 is maintained. That is, it is possible to suppress the plate member and the holding member 60 from being detached from the syringe body 2 due to pressurization. The outer diameter of the step 62 is the same as the outer diameter of the screw groove portion in which the screw groove 43 is provided. The outer diameter of the holding member 60 other than the step 62 (main body portion) is formed to be smaller than the outer diameter of the step 62 and slightly smaller than the inner diameter of the flange 72 of the fixing member 70. The inner diameter of the main body of the holding member 60 is slightly larger than the outer diameters of the plate member 50 and the nozzle holder 5. Accordingly, the plate member 50 and the nozzle holder 5 can be accommodated inside the main body portion of the holding member 60.

  The fixing member 70 fixes the nozzle holder 5, the holding member 60, and the plate member 50 in a state where the nozzle holder 5 is connected to the end face of the syringe body 2 and the holding member 60 holds the nozzle holder 5 and the plate member 50. To do. A screw groove 43 is provided around the distal end side of the syringe body 2, and a screw groove 73 connected to the screw groove 43 is provided in the fixing member 70. Specifically, the fixing member 70 includes a cylindrical portion 71 and a flange 72 that protrudes inward from the upper portion of the cylindrical portion 71. The inner diameter of the cylindrical portion 71 is slightly larger than the outer diameter of the step 62 of the nozzle holder 5. Further, a screw groove 73 (shown by a dotted line) that is screwed into the screw groove 43 of the syringe main body 2 is provided inside the tube portion 71. Further, the inner diameter of the collar 72 is formed slightly larger than the outer diameter of the end face of the holding member 60 so that the end face of the holding member 60 is exposed. On the other hand, since the inner diameter of the collar 72 is a diameter that does not allow the step 62 to pass through, the detachment of the holding member 60 from the syringe body 2 can be suppressed. By rotating the fixing member 70 and connecting the screw groove 43 of the syringe body 2 and the screw groove 73 of the fixing member 70, the nozzle holder 5, the holding member 60 and the plate member 50 are fixed to the syringe body 2. be able to.

<How to use>
Next, the usage method of the syringe 1 which concerns on this Embodiment is demonstrated. First, when the assembly of the syringe 1 is not completed, the assembly of the syringe 1 is performed. Specifically, the plate member 50, the holding member 60, and the fixing member 70 are attached to the end surface of the distal end of the syringe body 2 (from above the nozzle holder 5). A protrusion 41 is provided on the end surface of the tip of the nozzle holder 5, and positioning is performed by aligning the positioning hole 52 provided in the plate member 50 with the positioning hole provided in the holding member 60. Can be easily performed. After the positioning is completed, the fixing member 70 is rotated, and the screw groove 43 formed at the tip of the syringe body 2 and the screw groove 73 of the fixing member 70 are connected, so that the nozzle holder 5 is held with respect to the syringe body 2. The member 60 and the plate member 50 can be fixed.

When the injection target region such as an arm is brought into contact with the recess 61 in the assembled state of the syringe 1 and is pressurized by the pressurizing unit 20, the injection solution ML becomes the micropore 51 of the opening end of the nozzle 4 and the plate member 50.
After that, it is injected into the skin of the living body.

  Here, when the injection liquid ML flows out from the nozzle 4, the injection liquid ML becomes a liquid column having a diameter corresponding to the diameter of the nozzle 4. Pass through the micropores 51 of the. As a result, the flow of the injection liquid ML is subdivided according to the micropores 51 arranged in the plate member 50. In other words, the flow of the injection liquid ML from the nozzle 4 is divided into a plurality of smaller flows by the micropores 51, and the plurality of divided flows are finally used as the injection liquid ML from the syringe 1. Reach the skin.

  As for the flow of the injection liquid ML injected from the syringe 1, if the flow rate of the injection liquid ML is the same, the distance that the injection liquid ML advances in the skin, that is, the injection depth becomes smaller as the liquid column diameter of the injection liquid becomes smaller. Become. Therefore, the injection solution ML subdivided by the plate member 50 has a shallow injection depth in the skin that is the injection target compared to the case where the injection solution ML is not subdivided, and is effective for a relatively shallow part of the skin. The injection solution ML can be delivered. And as for the injection depth, by appropriately selecting the size of the micropores 51 of the plate member 50, it is possible to effectively realize the injection particularly in the shallow part of the skin where the Langerhans cells are present.

<Effect>
According to the syringe 1 according to the first embodiment, by adopting a simple configuration in which the plate member 50 having the minute pores 51, the holding member 60, and the fixing member 70 are arranged outside the nozzle 4, injection into a shallow region is performed. Injection of liquid ML is possible. Moreover, since the micropore 51 is formed in the plate member 50 having a relatively small thickness, and the drilling process is easy, the syringe 1 can be supplied at low cost. Further, since the injection liquid ML can be injected into a desired site, efficient injection of the injection liquid ML, that is, consumption suppression of the useless injection liquid ML at the time of injection can be achieved. In addition, by appropriately selecting the diameter of the micropore 51, the injection depth in the injection target region can be easily controlled without adjusting the pressure applied to the injection liquid ML by the pressurizing unit 20. It becomes. In the syringe 1 according to the first embodiment, the holding member 60 has a recess 61, and the recess 61 has a shape corresponding to the injection target region, and is between the end surface of the holding member 60 and the injection target region. Adhesion can be increased. In addition, since the plate member 50 is held by the holding member 60 so that only the minute pores 51 and the vicinity thereof are exposed, the floating of the plate member 50 during the operation of the syringe can be suppressed. Therefore, the injection solution ML can be efficiently injected into the injection target region regardless of the skill level of the user. Further, in order to efficiently transport the injection liquid ML to the injection target region, it is necessary to appropriately correspond the positions of the nozzle 4 and the micropore 51. However, in the syringe 1 according to the first embodiment, the micropore 51 The formed plate member 50 can be fixed by holding members 60 made of different members. That is, the positions of the nozzles 4 and the minute pores 51 are appropriately matched by using the projections 41 and the plate member positioning holes 52, and the projections 41 and the positioning holes 63 of the holding members 60 are appropriately matched and fixed. It can be fixed by the member 70. That is, since positioning and fixing (holding) can be performed separately, the complexity of performing both positioning and fixing simultaneously is reduced, and the assembly operation of the syringe 1 is facilitated.

<Second embodiment>
The syringe 1 which concerns on 2nd embodiment differs in the structure of the front-end | tip part of the syringe 1 from the syringe 1 which concerns on 2nd embodiment. In addition, about the structure similar to the syringe 1 which concerns on 1st embodiment, the same code | symbol is attached | subjected and description is omitted.

FIG. 10 is a diagram showing a schematic configuration of a needleless syringe according to the second embodiment. FIG. 11 is an exploded perspective view of the distal end portion of the needleless syringe according to the second embodiment. In the syringe 1 according to the second embodiment, the nozzle holder 5 is fixed to the end surface of the syringe body 2 with the gasket 3 interposed therebetween via the holder cap 13. The holder cap 13 is formed in a hook shape so as to be hooked to the nozzle holder 5, and is screwed to the syringe body 2. Thereby, the nozzle holder 5 is prevented from dropping from the syringe body 2 due to the pressure applied to the injection liquid ML when the injection liquid ML is ejected.

  In the syringe 1 according to the second embodiment, the plate member 50 is held from the side of the syringe body 2 toward the outside so as to cover the open end of the nozzle 4 with respect to the nozzle holder 5 fixed by the holder cap 13. A member 60 and a fixing member 70 are provided. The fixing member 70 is connected to the screw groove 43 provided around the holder cap 13 in a state where the nozzle holder 5 is connected to the end face of the syringe body 2 and the holding member 60 holds the plate member 50. The holding member 60 and the plate member 50 are fixed to the syringe 1. The outer diameters of the holder cap 13, the plate member 50, and the step 62 are substantially the same, and are slightly smaller than the inner diameter of the cylindrical portion 71 of the fixing member 70.

  The usage method of the syringe 1 according to the second embodiment is basically the same as the usage method of the syringe 1 according to the first embodiment. When the assembly of the syringe 1 is not completed, the assembly of the syringe 1 is performed as in the first embodiment. At this time, the end surface of the distal end of the syringe body 2 is more Specifically, the plate member 50, the holding member 60, and the fixing member 70 are attached from above the nozzle holder 5 and the holder cap 13. A protrusion 41 is provided on the end surface of the tip of the nozzle holder 5, and positioning is performed by aligning the positioning hole 52 provided in the plate member 50 with the positioning hole provided in the holding member 60. Can be easily performed. After the positioning, the fixing member 70 is rotated, and the screw groove 43 formed around the holder cap 13 and the screw groove 73 of the fixing member 70 are connected to each other, so that the holding member 60 and the plate with respect to the syringe body 2 are connected. The member 50 can be fixed.

  The effect similar to the syringe 1 of 1st embodiment can be acquired also with the syringe 1 which concerns on 2nd embodiment. That is, by adopting a simple configuration, the injection solution ML can be injected into a shallow site. Moreover, since the drilling process is easy, the syringe 1 can be supplied at low cost. Further, it is possible to suppress consumption of the useless injection liquid ML at the time of injection. Moreover, the injection depth in the injection target area can be easily controlled. Moreover, the adhesiveness between the end surface of the holding member 60 and the injection target region can be enhanced. Moreover, the floating of the plate member 50 at the time of operation of the syringe can be suppressed, and the injection solution ML can be efficiently injected into the injection target region regardless of the skill level of the user. In addition, since positioning and fixing (holding) can be performed separately, the complexity of performing both positioning and fixing at the same time is reduced, and the assembly operation of the syringe 1 is facilitated.

<Modification>
The micropores 51 of the plate member 50 have a substantially circular shape. However, if the area of the micropores is smaller than the area of the open end of the nozzle 4, it is preferable that the number of the micropores 51 at the open end of the nozzle 4 It may be a micropore having a shape other than a circular shape as long as it is small enough to contain a small number of micropores. For example, the micropore 51 may have an elliptical shape, a square shape, a rectangular shape, or a polygonal shape. In the above-described embodiments (the first embodiment and the second embodiment), the micropores 51 are arranged in a straight line at a predetermined interval from each other, but the injecting injection ML has micropores. The arrangement of the micropores 51 in the plate member 50 is not limited as long as the micropores are penetrated so that they can flow out.

  In the first embodiment, the syringe body 2 is connected. In the second embodiment, the holder cap 13 and the fixing member 70 are connected by the screw grooves 43 and 73. For example, instead of the screw grooves, grooves are provided on the outer periphery. The syringe body 2 and the fixing member 70 may be connected by a snap fit in which a claw that engages with the fixing member 70 is provided. Further, tightening with an elastic member may be used.

In the above-described embodiment, the case where the three nozzles 4 are arranged in a straight line has been described, but one nozzle 4 may straddle the three micropores 51 of the plate member 50. FIG.
Shows a nozzle according to a modification. The nozzle 4a according to this modification is different from the nozzle 4 described in the first embodiment, for example, and the shape of the nozzle 4a is rectangular. The single rectangular nozzle 4 a straddles the three micropores 51 of the plate member 50. A seal member is provided along the edge of the rectangular nozzle 4a to prevent the injection liquid ML from leaking. In the modification shown in FIG. 11, the flow of the injection liquid ML ejected from the nozzle 4 a is divided into three micropores 51, and the divided flow finally reaches the skin as the injection liquid ML from the syringe 1. To do. In addition, the area of the open end of the rectangular nozzle 4a should be the minimum across the three micropores 51, and the depth should be the minimum that can form a flow in which the injection solution ML is divided into three micropores. Is preferred. By minimizing the area and depth, in other words, by minimizing the volume of the recess at the opening end of the nozzle 4a, the amount of the injection liquid ML remaining in the syringe 1 can be reduced. Furthermore, since the number and arrangement of the micropores 51 can be changed within a range that can correspond to the nozzle 4a, the plate member 50 in which the optimal micropores 51 are appropriately formed according to the injection target region is provided. It is exchangeable.

  In the above-described embodiment, the syringe 1 provided with an initiator (ignition device) is described as an example of the pressurizing unit 20, but the syringe 1 may be in a form using the elastic force of a spring. In this case, the pressurization by the pressurization unit 20 is based on a form using the elastic force of the spring. For example, the user presses one end of the pressurization unit 20 from the portion protruding from the syringe body 2, A configuration in which the spring compressed in the pressurizing unit 20 is released and the elastic force generated thereby is transmitted to the piston 6 can be mentioned. The pressurizing configuration using the elastic force of the spring is based on the prior art as shown in, for example, Japanese Patent Laid-Open No. 2000-14780. From the viewpoint of appropriately adjusting the applied pressure according to the purpose of injection, the convenience of the user Various modifications can be adopted from the standpoint of safety. The syringe 1 may adopt a form using a pressurized gas, a form using an electrical actuator (such as a motor or a piezoelectric element) for pressurization, or a form in which pressurization is achieved manually by a user. .

<Application>
In addition to the case of injecting the injection solution ML into the skin structure, the syringe 1 according to the embodiment and the modified example, for example, in the field of regenerative medicine for humans, the cells to be injected and the cultured cells in the scaffold tissue / scaffold, It becomes possible to seed stem cells and the like. For example, as disclosed in JP-A-2008-206477, cells that can be appropriately determined by those skilled in the art depending on the site to be transplanted and the purpose of recellularization, such as endothelial cells, endothelial precursor cells, bone marrow cells, and prebones Blast cells, chondrocytes, fibroblasts, skin cells, muscle cells, liver cells, kidney cells, intestinal cells, stem cells, and any other cells considered in the field of regenerative medicine can be injected with the syringe 1. .

  Furthermore, the syringe 1 according to the embodiment or the modification can be used for delivery of DNA or the like to cells, scaffolding tissue, scaffolds, or the like as described in JP-T-2007-525192. In this case, it can be said that the use of the syringe 1 according to the present invention is more preferable than the case of delivery using a needle because the influence on the cells, the scaffold tissue, the scaffold and the like can be suppressed.

  Furthermore, the syringe according to the embodiment or the modified example is also used when various genes, tumor suppressor cells, lipid envelopes and the like are directly delivered to a target tissue or an antigen gene is administered to enhance immunity against a pathogen. 1 is preferably used. In addition, in the field of various disease treatments (fields described in JP2008-508881, JP2010-503616, etc.), immunomedicine (fields described in JP2005-523679, etc.), etc. The syringe 1 can be used, and the field in which the syringe 1 can be used is not intentionally limited.

The various contents described above can be combined as much as possible without departing from the technical idea of the present invention.

DESCRIPTION OF SYMBOLS 1 ... Syringe 2 ... Syringe main body 4 ... Nozzle 5 ... Holder 6 ... Piston 7, 8 ... Sealing member 20 ... Pressure part 22 ... ... Ignition agent 29 ... Combustion chamber 30 ... Gas generating agent 50 ... Plate member 51 ... Micropore 60 ... Holding member 61 ... Recess 62 ... Step part 70 ... fixing member 71 ... cylinder part 72 ... 鍔

Claims (6)

A syringe for injecting an injection target substance into an injection target region of a living body without going through an injection needle,
An enclosing portion for enclosing the injectable substance;
A pressurizing unit that pressurizes the injection target substance enclosed in the encapsulating unit;
An injection unit having a flow path through which the injection target substance pressurized by the pressurization unit flows, and for injecting the injection target substance from an open end of the flow path to an injection target region outside the syringe;
A microporous portion having a pore diameter smaller than that of the injection portion penetrated from one surface to the opposite surface, and the injection target substance injected from the injection portion passes through the micropore. So as to reach the injection target region side, the micropores arranged outside the injection part,
A holding part configured by a member different from the micropore part, which holds the micropore part arranged outside the injection part from the outside of the micropore part, and the injection target region A holding portion that includes an end surface in contact with the at least one end surface, and at least a part of the end surface has a shape corresponding to the injection target region;
With
The holding part has an opening that exposes only the micropore and the one surface in the vicinity thereof, and allows the injection target substance that has passed through the micropore to reach the injection target region.
The holding portion holds at least a part of the inside thereof so as to be in contact with the micropore portion, and to expose only the micropore and the one surface in the vicinity thereof from the opening portion. Suppresses the lifting of the plate-like micropores during pressurization,
Needleless syringe. The holding part has a band-shaped recess as a shape corresponding to the injection target area,
The micropore portion has a plurality of micropores arranged along the strip-shaped recess,
The strip-shaped recess has the opening that exposes the plurality of micropores ,
The needleless syringe according to claim 1. The band-shaped recess includes a bottom surface portion having the opening and an inclined portion provided continuously to the bottom surface portion ,
The inside of the bottom surface portion is in contact with the micropore portion, and suppresses the lifting of the plate-like micropore portion during pressurization by the pressurizing portion.
The needleless syringe according to claim 2. The micropore portion determines the position of the micropore with respect to the injection portion so that the injection target substance injected from the injection portion passes through the micropore and reaches the injection target region side. Including the positioning part of the micropore part,
The needleless syringe according to any one of claims 1 to 3. The micropore portion determines the position of the micropore with respect to the injection portion so that the injection target substance injected from the injection portion passes through the micropore and reaches the injection target region side. Including the positioning part of the micropore part,
The holding part includes a positioning part of the holding part that determines a position of the opening part with respect to the injection part so that the opening part of the band-shaped concave part exposes the plurality of micropores.
The needleless syringe according to claim 2 or 3. 6. The device according to claim 1, further comprising a fixing portion that fixes the holding portion and the micropore portion to a syringe body of the needleless syringe in a state where the holding portion holds the micropore portion. The needleless syringe according to item.

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