JP5628698B2 - Needleless syringe nozzle and needleless syringe - Google Patents

Description

  The present invention relates to a needleless syringe that injects a substance to be injected into an injection target region of a living body without using an injection needle.

  In a needleless syringe that performs injection without going through an injection needle, a configuration in which an injection component is ejected by applying pressure to a storage chamber in which an injection solution is stored by a pressurized gas or a spring may be employed. For example, in the needleless syringe shown in Patent Document 1, a nozzle assembly is installed at the tip of the syringe body in a replaceable manner. The nozzle assembly includes an ampoule that contains the injection component, and the nozzle assembly is replaced every time the user uses it. Here, in consideration of the pressure applied at the time of injection of the injection solution, the nozzle assembly uses a member that can withstand high pressure. Examples thereof include not only metal materials but also resin materials such as polycarbonate and polypropylene. ing.

  On the other hand, for example, Patent Document 2 discloses a molding technique for forming a nozzle portion located at a tip portion of a needleless syringe. In particular, the orifice member of the nozzle portion shown in FIG. 7 is disclosed to be formed of a plastic material, but regarding the strength of the plastic material, the diameter of the orifice portion is extremely smaller than the other portions. It is suggested that the strength of the nozzle part does not become a big problem at the time of injection.

US Pat. No. 5,599,302 US Pat. No. 5,312,577

  In a needleless syringe, a nozzle for injecting a substance to be injected into an injection target area in the form of an injection solution or the like may be detachable, that is, disposable, for example, from the viewpoint of hygiene. Therefore, in order to easily manufacture a large number of nozzles, for example, a molding technique is used, and a resin nozzle may be manufactured.

  In the above prior art, no consideration is given to the strength problem in applying a resin nozzle to a needleless syringe. However, the present applicant uses a resin nozzle for a needleless syringe. In the meantime, in the category of the prior art, it has been found that there is still a possibility that the nozzle is deformed and broken by the pressurized injection target substance. If the nozzle is deformed or broken, it becomes difficult to inject the injection target substance into an appropriate site in the injection target region as a result.

  In the present invention, in view of the above-described problems, a nozzle made of a resin that can be attached and detached in a needleless syringe, and that can secure an appropriate strength to avoid deformation and destruction by injection of an injection target substance, or the nozzle is provided. An object is to provide a needleless syringe provided.

In order to solve the above-described problems, the present invention provides a nozzle that is configured to be detachable from a holding member of a needleless syringe, the position of a contact portion that comes into contact with the holding member when the nozzle is attached to the holding member. The structure determined based on the relative relationship with the flow path formed in the main body was adopted. When the injection target substance flows through the flow path in the nozzle and is injected to the injection target region, the pressurized injection target substance gives an impact due to the flow path shape to the nozzle side including the flow path. Is taken into account.

  Specifically, the present invention forms an injection port to the injection target region of a needleless syringe that injects a pressurized injection target substance into the injection target region of a living body without going through the injection needle, A nozzle made of resin that is configured to be detachable from a holding member on the needleless syringe side, the nozzle main body having a side surface that is detachable from the holding member, and a flow provided in the nozzle main body. A first flow path through which the pressurized injection target substance flows from the needleless syringe side through an introduction port located at an end, and a flow path provided inside the nozzle body, A second flow path having a flow path diameter smaller than that of the first flow path and including the injection port at an end different from the end, and a flow path provided in the nozzle body, the first flow path Connected to the second flow path, the flow of the pressurized injection target substance Comprising a connecting flow path diameter of the channel is reduced, the I. And, the nozzle body is a contact portion that contacts the nozzle body with the holding member so that the injection port is exposed and opposed to the injection target region, and is connected from a side surface of the nozzle body, And a planar or curved contact portion extending in a predetermined direction intersecting the flow direction of the pressurized injection target substance, and the contact portion in the flow direction of the pressurized injection target substance, It is located at any position on the injection port side from a predetermined position on the connection flow path in the vicinity of the connection site between the connection flow path and the second flow path.

  In the needleless syringe according to the present invention, the pressure of the injection target substance is applied, and the movement of the injection target substance is promoted. As a result, the injection target substance flows into the nozzle body through the introduction port included in the first flow path, and the injection target substance is injected from the nozzle body to the injection target region through the injection port included in the second flow path. Is done. This injection target substance contains a component expected to have an effect inside the injection target region, and the pressure applied as described above is a driving source at the time of injection. Therefore, if injection by pressurization is possible, the physical state of the injectable substance in the needle-free syringe and the specific physical substance of the injectable substance such as liquid, gel-like fluid, powder, granular solid, etc. The form is not asked.

  For example, the injection target substance is a liquid, and even if it is a solid, it may be a gel-like solid as long as fluidity enabling injection is ensured. The injection target substance includes a component to be sent to the injection target region of the living body, and the component may exist in a state dissolved in the injection target substance, or the component is simply mixed without being dissolved. It may be in the state where it was done. For example, as ingredients to be delivered, there are vaccines for antibody enhancement, proteins for cosmetics, cultured cells for hair regeneration, etc., so that these can be injected into fluids such as liquids and gels. By inclusion, a substance for injection is formed.

  Various pressurization sources can be used as the pressurization source for the injection target substance as long as injection by pressurization is possible. For example, those using elastic force by springs, those using pressurized gas, those using explosive combustion, those using electrical actuators (motors, piezo elements, etc.) for pressurization And as a pressure source.

  The injection target substance thus pressurized enters the first flow path through the introduction port, and connects the first flow path and the second flow path in the process of being injected from the second flow path through the injection port. Pass through the connection channel. Since this connection passage is a flow passage connecting the first flow passage and the second flow passage having different flow passage diameters, the flow passage diameter of the connection flow passage has a configuration that decreases along the flow of the injection target substance. ing. However, the rate of decrease need not be constant. Therefore, the connection flow path is a part where the pressure received from the injection target substance can increase as the pressurized injection target substance advances.

  On the other hand, the nozzle according to the present invention is configured to be detachable with respect to the holding member on the needleless syringe side, but in detail, by contact with the holding member by the contact portion having a planar shape or a curved surface shape as described above. The nozzle will be attached to a needleless syringe. Here, the surface formed by the contact portion extends in a predetermined direction that intersects the flow direction of the pressurized injection target substance, that is, extends in a direction that is not at least parallel to the flow direction. Thus, the force received by the nozzle body from the injection target substance flowing in the nozzle body as described above, in particular, the force received through the connection channel that is structurally susceptible to force is transmitted to the holding member side, and the nozzle is physically Can be held. Therefore, the contact portion is configured to have a contact surface for receiving a force from the pressurized injection target substance.

  In the nozzle according to the present invention, the contact portion is in the flow direction of the pressurized injection target substance from the predetermined position on the connection flow path in the vicinity of the connection site between the connection flow path and the second flow path. It is formed in the nozzle body so as to be located at any position on the injection port side. That is, the applicant of the present invention, in the nozzle having the flow path configuration of the first flow path, the connection flow path, and the second flow path described above, in the vicinity of the connection portion between the connection flow path and the second flow path, At the predetermined position on the connection flow path, in other words, the force that the nozzle body receives from the pressurized injection target substance at the predetermined position returned to the connection flow path side rather than the second flow path side from the connection site. It was found that the value becomes larger. If the nozzle is deformed and destroyed by the force received from the pressurized injection target substance, the predetermined position is considered to have a great influence on the deformation. Therefore, in the nozzle according to the present invention, by setting the contact portion at any position closer to the injection port than the predetermined position, the injection target substance acting via the inner wall of the flow path including the predetermined position is used. By securing the sufficient thickness of the nozzle so as to include the portion where the force received from the injection target substance is maximized in the vicinity of the connection site of the connection flow path, Therefore, it becomes possible to avoid deformation and destruction of the nozzle as much as possible.

  In the above needleless syringe nozzle, the contact portion may be positioned between the connection site and the injection port in the flow direction of the pressurized injection target substance. That is, the contact portion is positioned between the connection portion located further on the injection port side than the predetermined portion and the injection port, thereby more reliably via the inner wall of the flow path including the predetermined position. It is possible to receive the force from the acting injection target substance.

  In the needleless syringe nozzle described above, the nozzle body may be inserted from one end side of the holding member and the injection port exposed to the other end side of the holding member. In that case, the side surface of the nozzle main body forms a surface extending in parallel with the insertion direction into the holding member or inclined and extending in a direction intersecting with the insertion direction into the holding member. With such a configuration, when the nozzle body is inserted into the holding member, the insertion of the nozzle body is stopped by the contact between the nozzle body and the holding member via the contact portion. The stop state is a mounting state of the nozzle holding member via the contact portion. Further, since the side surface of the nozzle body is parallel to or inclined with respect to the insertion direction, the nozzle body can be smoothly inserted into the holding member.

  Moreover, in the nozzle for needleless syringes described above, the nozzle body includes a cylindrical first step portion having a first predetermined diameter or a first predetermined width, and a first predetermined diameter of the first step portion or A second step portion having a second predetermined diameter or a second predetermined width smaller than the first predetermined width, the second step portion being connected to one end face side of the first step portion. It is good also as a structure. In this case, the contact portion is formed by a surface not occupied by the second step portion at the one end surface of the first step portion, and the introduction port is formed by the first step portion. The injection port is formed on the other end surface side, and the injection port is formed on the end surface side of the end surface of the second step portion to which the first step portion is not connected. By adopting such a specific configuration of the nozzle body, the nozzle can be formed by a combination of the first step portion and the second step portion, and the surface generated by the difference in diameter between the first step portion and the second step portion. Can function as a contact portion.

  In addition, a needleless syringe nozzle up to the above, a storage section that stores the injection target substance, and a pressurization section that pressurizes and discharges the injection target substance stored in the storage section to the outside. It will be understood by those skilled in the art that the needleless syringe provided also belongs to the category of the present invention. In this needleless syringe, the injection target substance to be injected into the injection target area of the living body is stored in the storage section, and pressure is applied to the injection target substance stored in the storage section by the pressurizing section. Thus, the movement of the injection target substance is prompted. The form of pressurization by the pressurization part and the form of accommodation of the injection target substance by the storage part are as described for the nozzle for needleless syringe.

  Here, it is also possible to catch the present invention from the side of a needleless syringe different from the above. That is, the present invention is a needleless syringe for injecting an injection target substance into an injection target region of a living body without going through an injection needle, the storage part storing the injection target substance, and the storage part A pressurizing unit that pressurizes and discharges the injection target substance, and an injection port of the injection target substance pressurized by the pressurizing unit to the injection target region is formed on the needleless syringe side. A resin nozzle configured to be detachable from the holding member. The nozzle is a nozzle body and a flow path provided inside the nozzle body, and the pressurized injection target substance flows from the needleless syringe side through an introduction port located at an end portion. A first flow path and a flow path provided inside the nozzle body, wherein the flow path diameter is smaller than the first flow path, and the second flow path includes the injection port at an end different from the end; and A flow path provided inside the nozzle body, connecting the first flow path and the second flow path, and the diameter of the flow path decreases along the flow of the pressurized injection target substance. A contact portion for contacting the nozzle body with the holding member such that the connection channel and the injection port are exposed and opposed to the injection target region, and are connected from a side surface of the nozzle body, and In a predetermined direction that intersects the flow direction of the pressurized injection target substance A contact portion having an existing planar shape or curved shape, and the contact portion is projected from the connection portion between the connection channel and the first channel in the flow direction of the pressurized injection target substance. The nozzle body is located at any position on the outlet side, and the nozzle is in contact with the holding member via the contact portion. A side channel into which the pressurized injection target substance flows is formed between the side surface in the range from the contact portion to the contact position by the contact portion and the holding member.

  About the said accommodating part and a pressurization part, it is as above-mentioned. In the same manner as described above, the first flow path, the connection flow path, and the second flow path are formed inside the nozzle body, and the pressurized injection target substance passes through the introduction port to the first flow path. In the process of entering and injecting from the second flow path to the outside through the injection port, it passes through the connection flow path connecting the first flow path and the second flow path. Since this connection passage is a flow passage connecting the first flow passage and the second flow passage having different flow passage diameters, the flow passage diameter of the connection flow passage has a configuration that decreases along the flow of the injection target substance. ing. However, the rate of decrease need not be constant. Accordingly, the connection flow path including the connection portion between the first flow path and the connection flow path where the flow path diameter starts to decrease, the pressure received from the injection target substance increases as the pressurized injection target substance advances. It can be a part.

  On the other hand, the nozzle according to the present invention is configured to be detachable with respect to the holding member on the needleless syringe side, but in detail, by contact with the holding member by the contact portion having a planar shape or a curved surface shape as described above. The nozzle will be attached to a needleless syringe. Here, the surface formed by the contact portion extends in a predetermined direction that intersects the flow direction of the pressurized injection target substance, that is, extends in a direction that is not at least parallel to the flow direction. Thus, the force received by the nozzle body from the injection target substance flowing in the nozzle body as described above, in particular, the force received through the connection channel that is structurally susceptible to force is transmitted to the holding member side, and the nozzle is physically Can be held. Therefore, the contact portion is configured to have a contact surface for receiving a force from the pressurized injection target substance.

  And in the nozzle which concerns on this invention, a contact part is located in the position in the said injection port side from the connection site | part of a connection flow path and a 1st flow path in the flow direction of the pressurized injection target substance. As described above, the injection target substance formed in the nozzle body and pressurized to the contact position by the contact portion can flow into the side flow path formed between the outer side surface of the nozzle body and the holding member. Thus, a correlation between the nozzle and the holding member is formed. With this configuration, a pressurized injection that fills the side channel from the outside while receiving a force from the pressurized injection target substance from inside while sandwiching the channel wall surface of the connection channel inside the nozzle body It will be in a state of receiving power from the target substance. For this reason, the nozzle body can suppress a pressure difference formed between the inside and the outside of the connection channel, and as a result, the nozzle body particularly includes a connection channel that is structurally susceptible to force. The nozzle can be protected from the pressure from the injection target substance in the passage, and therefore, deformation and destruction of the nozzle can be avoided as much as possible.

  Here, in the above needleless syringe, the nozzle body may be inserted from one end side of the holding member and the injection port exposed to the other end side of the holding member. In that case, the side surface of the nozzle main body forms a surface extending in parallel with the insertion direction into the holding member or inclined and extending in a direction intersecting with the insertion direction into the holding member. With such a configuration, when the nozzle body is inserted into the holding member, the insertion of the nozzle body is stopped by the contact between the nozzle body and the holding member via the contact portion. The stop state is a mounting state of the nozzle holding member via the contact portion. Further, since the side surface of the nozzle body is parallel to or inclined with respect to the insertion direction, the nozzle body can be smoothly inserted into the holding member.

  In the needleless syringe described above, the nozzle body includes a cylindrical first step portion having a first predetermined diameter or a first predetermined width, and a first predetermined diameter or first of the first step portion. A second step portion having a second predetermined diameter or a second predetermined width smaller than the predetermined width, the second step portion being connected to one end face side of the first step portion. Also good. In this case, the contact portion is formed by a surface not occupied by the second step portion at the one end surface of the first step portion, and the introduction port is the other end surface of the first step portion. The injection port is formed on an end surface side of the end surface of the second step portion to which the first step portion is not connected. By adopting such a specific configuration of the nozzle body, the nozzle can be formed by a combination of the first step portion and the second step portion, and the surface generated by the difference in diameter between the first step portion and the second step portion. Can function as a contact portion.

  In the needleless syringe described above, the contact portion may include a seal portion that prevents the pressurized holding member that has flowed into the side flow path from flowing out to the injection port side. Thereby, the injection target substance can be appropriately positioned inside and outside the nozzle body, thereby preventing an increase in pressure difference between inside and outside, and avoiding deformation and destruction of the nozzle. Furthermore, the amount of the injection target substance that is not used for injection into the injection target region can be suppressed, and waste thereof can be avoided.

  Further, in the needleless syringe described above, the pressurized holding member that has flowed into the side flow channel is disposed on the injection port side at a predetermined portion near the contact position by the contact portion on the side surface of the nozzle body. You may employ | adopt the structure provided with the seal | sticker part which prevents flowing out. By placing the seal portion at a predetermined site near the contact position by the contact portion, in a state where the nozzle is mounted on the holding member, sandwiching the connection flow path including the connection portion of the first flow path and the connection flow path, It becomes possible to arrange the injection target substance more accurately on the outside and inside of the nozzle body. Therefore, the deformation and destruction of the nozzle can be effectively avoided. In addition, the predetermined site | part of the contact position vicinity by a contact part also includes the site | part located in the same position as the said contact position, In that case, a seal part is arrange | positioned on the contact surface by a contact part. Further, the predetermined part may be a part at any position on the injection port side or the introduction port side with the contact position interposed therebetween.

  In the case of the needleless syringe described above, a deformable protrusion is provided at a predetermined portion near the contact position by the contact portion, and the protrusion is held when the nozzle is attached to the holding member. The seal portion may be formed by being deformed by contact with a member. A new seal part is formed for each injection of the injection target substance by adopting a configuration in which a projection part provided on a predetermined part of the detachable nozzle body forms a seal part for each attachment to the holding member. Therefore, effective sealing of the injection target substance is expected.

  Here, it is also possible to catch the present invention from the side of a needleless syringe different from the above. That is, the present invention is a needleless syringe for injecting an injection target substance into an injection target region of a living body without going through an injection needle, the storage part storing the injection target substance, and the storage part A pressurizing unit that pressurizes and discharges the injection target substance, and an injection port of the injection target substance pressurized by the pressurizing unit to the injection target region is formed on the needleless syringe side. A resin nozzle configured to be detachable from the holding member. The nozzle is a nozzle body and a flow path provided inside the nozzle body, and the pressurized injection target substance flows from the needleless syringe side through an introduction port located at an end portion. A first flow path and a flow path provided inside the nozzle body, wherein the flow path diameter is smaller than the first flow path, and the second flow path includes the injection port at an end different from the end; and A flow path provided inside the nozzle body, connecting the first flow path and the second flow path, and the diameter of the flow path decreases along the flow of the pressurized injection target substance. A contact portion that contacts the nozzle body with the holding member such that the connection channel and the injection port are exposed to and face each other in the injection target region, and is connected to a side surface of the nozzle body, and is It extends in a predetermined direction that intersects the flow direction of the pressurized injection target substance. A contact portion having a planar shape or a curved shape, wherein the contact portion is connected to the introduction port from a connection site between the connection channel and the first channel in the flow direction of the pressurized injection target substance. In a state where the nozzle is in contact with the holding member via the contact portion, from the contact position by the contact portion to the end portion on the injection port side in the state where the nozzle is in contact with the holding member via the contact portion A filling member that fills at least a part of the space between the side surface in the range and the holding member is provided.

  About the said accommodating part and a pressurization part, it is as above-mentioned. In the same manner as described above, the first flow path, the connection flow path, and the second flow path are formed inside the nozzle body, and the pressurized injection target substance passes through the introduction port to the first flow path. In the process of entering and injecting from the second flow path to the outside through the injection port, it passes through the connection flow path connecting the first flow path and the second flow path. Since this connection passage is a flow passage connecting the first flow passage and the second flow passage having different flow passage diameters, the flow passage diameter of the connection flow passage has a configuration that decreases along the flow of the injection target substance. ing. However, the rate of decrease need not be constant. Accordingly, the connection flow path including the connection portion between the first flow path and the connection flow path where the flow path diameter starts to decrease, the pressure received from the injection target substance increases as the pressurized injection target substance advances. It can be a part.

  On the other hand, the nozzle according to the present invention is configured to be detachable with respect to the holding member on the needleless syringe side, but in detail, by contact with the holding member by the contact portion having a planar shape or a curved surface shape as described above. The nozzle will be attached to a needleless syringe. Here, the surface formed by the contact portion extends in a predetermined direction that intersects the flow direction of the pressurized injection target substance, that is, extends in a direction that is not at least parallel to the flow direction. Thus, the force received by the nozzle body from the injection target substance flowing in the nozzle body as described above, in particular, the force received through the connection channel that is structurally susceptible to force is transmitted to the holding member side, and the nozzle is physically Can be held. Therefore, the contact portion is configured to have a contact surface for receiving a force from the pressurized injection target substance.

Further, in the nozzle according to the present invention, in a state where the nozzle is mounted on the holding member and the contact portion is in contact with the holding member, from the contact position by the contact portion to the end on the injection port side of the side surface of the nozzle body. A filling member that fills at least a part of the space between the side surface in the range and the holding member is provided. Thereby, not only the contact position by the contact portion but also the filling member can receive the force received by the flow path in the nozzle body, particularly the connection flow path, from the pressurized injection target substance. Deformation and breakage can be effectively prevented. That is, according to the present invention, when the nozzle is mounted, the deformation of the nozzle body is blocked by the filling member, thereby preventing the nozzle from being deformed. Therefore, if it is possible to effectively close the deformation allowance of the nozzle body, it is not always necessary to fill the entire space between the nozzle body and the holding member with the filling member, and only a part thereof is used. It doesn't matter.

  Here, in the above needleless syringe, the nozzle body may be inserted from one end side of the holding member and the injection port exposed to the other end side of the holding member. In that case, the side surface of the nozzle main body forms a surface extending in parallel with the insertion direction into the holding member or inclined and extending in a direction intersecting with the insertion direction into the holding member. With such a configuration, when the nozzle body is inserted into the holding member, the insertion of the nozzle body is stopped by the contact between the nozzle body and the holding member via the contact portion. The stop state is a mounting state of the nozzle holding member via the contact portion. Further, since the side surface of the nozzle body is parallel to or inclined with respect to the insertion direction, the nozzle body can be smoothly inserted into the holding member.

  In the needleless syringe described above, the nozzle body includes a cylindrical first step portion having a first predetermined diameter or a first predetermined width, and a first predetermined diameter or first of the first step portion. A second step portion having a second predetermined diameter or a second predetermined width smaller than the predetermined width, the second step portion being connected to one end face side of the first step portion. Also good. In this case, the contact portion is formed by a surface not occupied by the second step portion at the one end surface of the first step portion, and the introduction port is the other end surface of the first step portion. The injection port is formed on an end surface side of the end surface of the second step portion to which the first step portion is not connected. By adopting such a specific configuration of the nozzle body, the nozzle can be formed by a combination of the first step portion and the second step portion, and the surface generated by the difference in diameter between the first step portion and the second step portion. Can function as a contact portion.

  In the needleless syringe described above, the filling member may be formed by curing an adhesive that bonds the nozzle body and the holding member. In this case, considering that the nozzle can be attached to and detached from the holding member, the cured adhesive has an adhesive strength that allows the nozzle to be removed from the holding member after injection of the injection target substance, and does not impair practicality. It is preferable that the adhesive hardened from the holding member is easily removed after injection.

  It is a removable resin nozzle used for a needleless syringe, and it is possible to avoid deformation and destruction by the pressure received during injection of the injection target substance.

It is a figure which shows schematic structure of the needleless syringe which concerns on this invention. It is a figure which shows schematic structure of the initiator (ignition apparatus) with which the needleless syringe shown in FIG. 1 is mounted | worn. It is a 1st figure which shows schematic structure of the nozzle part in the needleless syringe which concerns on this invention. It is a 2nd figure which shows schematic structure of the nozzle part in the needleless syringe which concerns on this invention. It is a figure which shows the model of a needleless syringe set when performing a finite element analysis regarding the needleless syringe which concerns on this invention. It is a figure which shows the result of the finite element analysis of the stress distribution concerning a nozzle based on the model of the needleless syringe shown to FIG. 4A. It is a 3rd figure which shows schematic structure of the nozzle part in the needleless syringe which concerns on this invention. It is a 4th figure which shows schematic structure of the nozzle part in the needleless syringe which concerns on this invention. It is a 5th figure which shows schematic structure of the nozzle part in the needleless syringe which concerns on this invention.

  Hereinafter, a needleless syringe 1 (hereinafter simply referred to as “syringe 1”) according to an embodiment of the present invention will be described with reference to the drawings. The configuration of the following embodiment is an exemplification, and the present invention is not limited to the configuration of this embodiment.

  Here, FIG. 1 (a) is a cross-sectional view of the syringe 1, FIG. 1 (b) is a side view of the syringe 1 seen from the initiator 20, and FIG. 1 (c) shows the syringe 1 with the injection solution. It is the side view seen from the nozzle 4 side to inject. In the following description of the present application, the injection target substances injected into the injection target by the syringe 1 are collectively referred to as “injection solution”. However, this is not intended to limit the content or form of the injected substance. In the injection target substance, the component to be delivered to the skin structure may or may not be dissolved, and the injection target substance can be injected from the nozzle 4 to the skin structure by pressurization. If it exists, the specific form is not ask | required and various forms, such as a liquid and a gel form, are employable. Here, the syringe 1 has a syringe body 2, and a through hole 14 extending in the axial direction and having a constant diameter along the axial direction is provided in the central portion of the syringe body 2. . One end of the through hole 14 communicates with the combustion chamber 9 having a diameter larger than the diameter of the through hole 14, and the other end reaches the nozzle holder 5 side where the nozzle 4 is formed. Furthermore, an initiator 20 is installed on the opposite side of the combustion chamber 9 from the communication location with the through-hole 14 so that the ignition part faces the communication location.

  Here, an example of the initiator 20 will be described with reference to FIG. The initiator 20 is an electric ignition device, and a space for arranging the ignition agent 22 is defined in the cup 21 by a cup 21 whose surface is covered with an insulating cover. And the metal header 24 is arrange | positioned in the space, and the cylindrical charge holder 23 is provided in the upper surface. The charge holder 23 holds the ignition agent 22. A bridge wire 26 that electrically connects one conductive pin 28 and the metal header 24 is wired at the bottom of the ignition agent 22. The two conductive pins 28 are fixed to the metal header 24 via the insulator 25 so that they are insulated from each other. Furthermore, the opening of the cup 21 from which the two conductive pins 28 supported by the insulator 25 extend is protected by the resin 27 in a state in which the insulation between the conductive pins 28 is well maintained.

  In the initiator 20 configured as described above, when a voltage is applied between the two conductive pins 28 by the external power source, a current flows through the bridge wire 26, thereby burning the igniting agent 22. At this time, the combustion products resulting from the combustion of the igniting agent 22 are ejected from the opening of the charge holder 23. Therefore, in the present invention, the relative positional relationship of the initiator 20 with respect to the syringe body 2 is designed so that the combustion product of the igniting agent 22 in the initiator 20 flows into the combustion chamber 9. The initiator cap 12 is formed in a hook shape so as to be hooked on the outer surface of the initiator 20 and is fixed to the syringe body 2 with screws. Thereby, the initiator 20 is fixed to the syringe main body 2 by the initiator cap 12, and therefore, the initiator 20 itself can be prevented from dropping from the syringe main body 2 due to the pressure generated when the initiator 20 is ignited.

  The igniting agent 22 used in the syringe 1 is preferably an explosive containing zirconium and potassium perchlorate (ZPP), an explosive containing titanium hydride and potassium perchlorate (THPP), titanium and potassium perchlorate. Gunpowder containing (TiPP), Gunpowder containing aluminum and potassium perchlorate (APP), Gunpowder containing aluminum and bismuth oxide (ABO), Gunpowder containing aluminum and molybdenum oxide (AMO), Gunpowder containing aluminum and copper oxide (ACO) ), Explosives containing aluminum and iron oxide (AFO), or explosives composed of a combination of these explosives. These explosives generate high-temperature and high-pressure plasma at the time of combustion immediately after ignition. However, when the combustion product is condensed at a normal temperature and does not contain a gas component, the generated pressure rapidly decreases. As long as appropriate injection is possible, other explosives may be used as igniting agents.

  Here, in the combustion chamber 9, a columnar gas generating agent 30 is disposed that burns with a combustion product generated by the combustion of the igniting agent 22 and generates gas. As an example of the gas generating agent 30, a single base smokeless gunpowder composed of 98% by mass of nitrocellulose, 0.8% by mass of diphenylamine and 1.2% by mass of potassium sulfate can be mentioned. It is also possible to use various gas generating agents that are used in gas generators for airbags and gas generators for seat belt pretensioners. The gas generating agent 30 is different from the igniting agent 22 in that the predetermined gas generated at the time of combustion contains a gas component even at room temperature, and therefore the rate of decrease in the generated pressure is smaller than that of the igniting agent 22. Furthermore, although the combustion completion time at the time of combustion of the gas generating agent 30 is longer than that of the igniting agent 22, the size, size and shape of the gas generating agent 30 when disposed in the combustion chamber 9, especially the surface It is possible to change the combustion completion time of the gas generating agent 30 by adjusting the shape. This is because the state of contact of the igniting agent 22 flowing into the combustion chamber 9 with the combustion product depends on the surface shape of the gas generating agent 30 and the arrangement of the gas generating agent 30 in the combustion chamber 9. This is because it is considered to change depending on the relative positional relationship between the agent 30 and the ignition agent 22.

  Next, a metal piston 6 is disposed in the through hole 14 so as to be slidable in the through hole 14 along the axial direction, one end of which is exposed to the combustion chamber 9 side, and the other end is exposed to the other end. The sealing member 7 is integrally attached. The injection liquid ML, which is an injection target substance injected by the syringe 1, is accommodated in a space formed in the through hole 14 between the sealing member 7 and another sealing member 8. Therefore, the sealing member 7, 8 and the through hole 14 form a housing portion of the syringe according to the present invention. The sealing members 7 and 8 prevent the injection liquid from leaking out when the injection liquid ML is sealed, and the injection liquid ML can smoothly move in the through hole 14 as the piston 6 slides. It is made of rubber with a thin coating of silicon oil on the surface.

  Here, on the distal end side (right side in FIG. 1) of the syringe 1, a holder 5 to which a nozzle 4 for injecting the injection liquid ML is mounted is provided. In the syringe 1, the nozzle 4 is a so-called disposable type nozzle, and is configured to be detachably held with respect to the holder 5 so that a new nozzle can be replaced each time the injection liquid ML is injected. Yes. Detailed configurations of the nozzle 4 and the holder 5 will be described later. The holder 5 is fixed to the end surface of the syringe body 2 with a gasket 3 interposed therebetween via a holder cap 13. The holder cap 13 is formed in a hook shape so as to be hooked to the holder 5, and is fixed to the syringe body 2 with screws. Thereby, the holder 5 is prevented from dropping from the syringe main body 2 due to the pressure applied to the injection liquid ML when the injection liquid ML is ejected.

In addition, when the holder 5 is attached to the syringe body 2, a recess 10 that can accommodate the sealing member 8 is formed at a location facing the sealing member 8. The recess 10 has substantially the same diameter as the sealing member 8 and has a depth slightly longer than the length of the sealing member 8. Thereby, when pressure is applied to the piston 6 and the injection liquid ML moves to the distal end side of the syringe 1 together with the sealing members 7 and 8, the sealing member 8 can be accommodated in the recess 10. When the sealing member 8 is accommodated in the recess 10, the pressurized injection solution ML is released. Therefore, the flow path 11 is formed at a portion of the holder 5 that contacts the syringe body 2 so that the released injection liquid ML is guided to the nozzle 4. Thereby, the released injection liquid ML is ejected from the nozzle 4 to the injection target through the flow path 11. Moreover, it can avoid that injection | pouring of the injection liquid ML is inhibited by the sealing member 8 because the recessed part 10 has the depth which accommodates the sealing member 8. FIG.

  A plurality of nozzles 4 may be formed on the holder 5 or one nozzle 4 may be formed. When a plurality of nozzles are formed, a flow path corresponding to each nozzle is formed so that the injection solution released to each nozzle is fed. Further, when a plurality of nozzles 4 are formed, it is preferable that the nozzles are arranged at equal intervals around the central axis of the syringe 1 as shown in FIG. In the present embodiment, the three nozzles 4 in the holder 5 are arranged around the central axis of the syringe 1 at equal intervals. The diameter of the nozzle 4 is appropriately set in consideration of the injection object, the injection pressure applied to the injection liquid ML, the physical properties (viscosity) of the injection liquid, the injection depth to the injection object, and the like.

  In the syringe 1 configured as described above, the combustion product or predetermined gas is generated in the combustion chamber 9 by the ignition agent 22 in the initiator 20 and the gas generating agent 30 disposed in the combustion chamber 9, and the piston 6. The pressure is applied to the injection liquid ML accommodated in the through-hole 14 via. As a result, the injection liquid ML is pushed out to the distal end side of the syringe 1 with the sealing members 7 and 8, and when the sealing member 8 is accommodated in the recess 10, the injection liquid ML passes through the flow path 11 and the nozzle 4. , It will be injected into the injection object. Since pressure is applied to the injected injection liquid ML, it can penetrate the surface of the injection target object and reach the inside of the injection liquid, thereby achieving the purpose of injection in the syringe 1.

  Here, based on FIG. 3A, the detailed structure of the nozzle 4 and the holder 5 in the syringe 1 which concerns on this invention is demonstrated. FIG. 3A is a cross-sectional view showing a state in which the nozzle 4 is mounted on the holder 5 in a vertical cross section (a cross section along the flow of the injection liquid ML). The nozzle 4 is attached to the holder 5 at a stage before being attached to the syringe body 2 together with the holder 5 by the holder cap 13. Specifically, it is inserted into the holder 5 from the end side of the holder 5 located on the syringe body 2 side when attached to the syringe body 2. The nozzle 4 has a shape in which a columnar first step portion 42 and a columnar second step portion 41 are arranged coaxially so that their central axes overlap each other. Here, since the diameter of the first step portion 42 is larger than the diameter of the second step portion 41, among the end faces of the first step portion 42, the end surface to which the second step portion 41 is connected is the second step portion. A surface 43 not occupied by 41 is formed, and the end surface of the other first step 42 is located on the syringe body 2 side and is spatially connected to the flow path 11.

  Further, the injection liquid ML pressurized by the combustion of the explosive in the initiator 20 flows into the inside of the nozzle 4 from the syringe body 2 side, and the flow of the injection liquid ML is adjusted in order to be ejected to the injection target. A flow path is formed. Specifically, a first flow path 45 having an introduction port 44 facing the flow path 11, a second flow path 47 having an injection port 48 of an injection solution ML exposed on the side facing the injection target, a first flow A connection channel 46 connecting the channel 45 and the second channel 47 is formed inside the nozzle 4. The first flow path 45 and the second flow path 47 are cylindrical flow paths having a constant cross-sectional area, and are arranged coaxially so that the central axes of both flow paths overlap. The inner diameter of the first channel 45 is larger than the inner diameter of the second channel 47. Accordingly, the connection flow path 46 connecting the first flow path 45 and the second flow path 47 has a reduced cross-sectional area along the flow of the injection liquid ML, that is, along the direction from the inlet 44 to the outlet 47. Go. In other words, in order to guide the injection liquid ML flowing through the first flow path 45 having a relatively large cross-sectional area to the second flow path 47 having a relatively small cross-sectional area, the cross-sectional area decreases along the flow of the injection liquid ML. A connecting flow path 46 is arranged.

  Thus, the nozzle 4 having a flow path for injecting the injection liquid ML therein and having a stepped side surface including the surface 43 is inserted into the holder 5 as shown in FIG. Is brought into contact with the surface 54 on the holder 5 side and hooked there, so that the holder 5 is mounted. Therefore, in the vicinity of the portion where the nozzle 4 is mounted on the holder 5, the holder-side first step portion 53 having a space 55 in which the first step portion 42 of the nozzle 4 is accommodated, and the second step portion 41 of the nozzle 4. A holder-side second step portion 52 having a space 51 in which is stored is formed. Therefore, the inner diameter of the accommodation space 55 on the holder side first step portion 53 side is larger than the inner diameter of the accommodation space 51 on the holder side second step portion 52 side. When the nozzle 4 is mounted on the holder 5, the surface 43 of the nozzle 4 is in contact with the surface 54 of the holder 5, and in this state, the injection port 47 of the nozzle 4 faces the injection target. It will be in the state exposed to the exterior of the holder 5 so that it may become possible. The injection port 47 and the outer surface of the holder 5 may be flush with each other, and the injection port 47 may be located inside the outer surface of the holder 5 depending on the purpose of injection performed on the injection object, or The reverse is also possible.

  Also, the nozzle 4 and the holder 5 shown in FIG. 3B are given the same reference numerals for the same configuration as that shown in FIG. 3A. Here, the difference between the two configurations is formed in the holder 4 at the position where the nozzle 4 and the holder 5 are contacted at the time of mounting, that is, the position where the surface 43 on the nozzle 4 side and the surface 54 on the holder 5 side are in contact. It is a relative position with respect to the flow path which is, especially the connection flow path 46. The configuration shown in FIG. 3A and the configuration shown in FIG. 3B having specific differences as described above are both configurations having the technical features of the present invention. Therefore, the technical features common to both configurations will be described with reference to FIGS. 4A and 4B.

  FIG. 4A shows that the nozzle 4 according to the present invention is set to correspond to the nozzle 4 in order to analyze the stress distribution received from the injection liquid ML pressurized by the explosive combustion during injection of the injection liquid ML. It is a model. Note that the model shown in FIG. 4A shows a half vertical sectional shape from the central axis in consideration of the symmetry of the nozzle 4. And the result of having analyzed stress distribution based on the model shown to FIG. 4A is each shown to FIG. 4B (a)-(f) for every analysis condition.

First, in the model of the nozzle 4 shown in FIG. 4A, each parameter is as follows.
Diameter of first flow path 45: φ0.8mm
Diameter of second flow path 47: φ0.1mm
Radius L1 of second step portion 41: 0.975 mm
Channel length L2 of second channel 47: 1.0 mm
(L2 is defined as the length along the injection fluid flow direction from the injection port 48 to the connection site of the second channel 47 and the connection channel 46)
Channel length L3 of connection channel 46: 3.5 mm
(L3 is defined as the length along the injection fluid flow direction from the connection site of the second flow channel 47 and the connection flow channel 46 to the connection site of the connection flow channel 46 and the first flow channel 45)
Length L4 of the first step portion 42: rmm (r is a variable)
(L4 is defined as the length of the first step portion 42 along the injection flow direction)
Radius L5 of the first step portion 42: 1.5 mm
From the above, the width of the surface 43 in the nozzle 4 is L5−L1 = 0.525 mm. Further, a position on the boundary between the first step portion 42 and the second step portion 41 and the edge of the surface 43 in FIG.

Here, regarding the finite element analysis of the stress distribution in the nozzle 4, the length L4 of the first step portion 42 is set to r = 7, 6. under a specific pressurizing condition in consideration of pressurization by combustion in the initiator 20. The test was carried out in six ways when changed to 5, 6, 5, 4, and 3. That is, in the state where the parameters other than the length L4 of the first step portion 42 are fixed and the conditions regarding the flow paths 45, 46, 47 in the nozzle 4 are maintained, the thick portion (the radial direction) by the first step portion 42 is maintained. The portion that is not occupied by the first flow channel 45 in the second step portion 41. Since the length in the radial direction of the portion that is not occupied by the second flow channel 47 and the connection flow channel 46 in the second step portion 41 is approximately “thickness” However, it is not intended to limit the thickness of the first step portion 42 to be thicker than that of the second step portion 41). The results are shown in FIG. 4B. Note that this pressurization condition assumes a pressure applied by the injection solution when the injection solution ML pressurized by the combustion of explosives flows into the flow path of the nozzle 4.

  4B (a) to 4 (f) show analysis results when the length L4 of the first step portion 42 is changed to r = 7, 6.5, 6, 5, 4, 3, respectively. In FIG. 4B, the stress from 0 MPa to 8 MPa is indicated by the hatched region D1, the stress from 8 MPa to 12 MPa is indicated by the hatched region D2, and the stress from 12 MPa to 16 MPa is indicated by the hatched region D3. Indicates from 16 MPa to 20 MPa in the hatched region of D4. In addition, the area | region where hatching is not given shows the flow path (The 1st flow path 45, the connection flow path 46, the 2nd flow path 47) formed in the nozzle 4. FIG. In the analysis result, the portion where the maximum stress is calculated is shown as the maximum stress position MX.

Here, the calculated stress at the maximum stress position MX and the calculated stress at the angular position CP in each case shown in FIG. 4B are shown in the following table.

  As can be understood from the above table and FIG. 4B, in each case, the maximum stress position MX is located on the inner wall surface on the connection flow path 46, and the stress there is substantially constant. What should be noted is the stress distribution in the region between the maximum stress position MX and the angular position CP. As the value of L4 decreases (for example, in the case of r = 5, 4, 3), a relatively high stress distribution can be found between the corner position CP and the connection channel 46. In other words, in these cases, a relatively high stress distribution is formed from the flow path in the nozzle near the maximum stress position MX to the angular position CP. On the other hand, the higher the value of L4 (for example, in the case of r = 6, 6.5, 7), the flow in the nozzle near the maximum stress position MX, which was seen in the above case where the value of L4 is relatively low. The relatively high stress distribution from the road side to the corner position CP is eliminated.

Based on the above, the applicant of the present invention is that the correlation between the vicinity of the maximum stress position MX on the connection flow path 46 and the length L4 of the first step portion 42 that forms the angular position CP is determined by the nozzle 4 when the injection solution is injected. It has been found that it affects the stress distribution formed inside. The connection channel 46 is a channel that narrows the channel diameter from the first channel 45 having a larger diameter to the second channel 47 having a smaller diameter, and one end of the second channel 47 has an injection port 48. Since it is normally opened to atmospheric pressure, the stress caused by the injection solution is maximized at a predetermined position returning from the connection portion of the second flow path 47 and the connection flow path 46 to the connection flow path side. The stress position MX is formed, and the vicinity thereof is a position where a relatively high stress is applied. Therefore, if the distance between the high stress position and the corner position CP is not sufficiently secured, that is, if the distance is too short, the position near the maximum stress position MX on the connection channel 46 extends from the position near the corner position CP. As a result, a high stress distribution is formed, and as a result, the nozzle 4 breaks in the cross-sectional direction, or deforms in the cross-sectional direction and decreases in strength, so that part of it deforms in the vertical direction, etc. It is considered that there is a high possibility that a malfunction occurs in the nozzle 4.

  Therefore, the applicant of the present invention is that the angular position CP is projected from its neighboring position including the maximum stress position MX so that the distance between the high stress position on the connection flow path 46 and the angular position CP is sufficiently secured. The length L4 of the first step portion 42 is set to be relatively long so as to be closer to the outlet 48 side (for example, cases (a) to (c) shown in FIG. 4B). The invention made by the present applicant based on this idea is the configuration disclosed in FIGS. 3A and 3B.

  Here, in FIGS. 3A and 3B, the straight line shown on the left is a schematic flow of the injection solution from the introduction port 44 to the injection port 48, and the introduction port 44 of the nozzle 4 with respect to the straight line, Points on which the injection port 48, the surface 43 (that is, the angular position CP), and the maximum stress position MX are projected are defined as P1, P2, P3, and P4, respectively. Therefore, in the configuration of the nozzle 4 and the holder 5 shown in FIG. 3A, the point P3 is a position that is closer to the point P2 side than the point P4 along the flow of the injection solution, and is in the middle of the connection flow path 46. The length of the first step portion 42 is set so as to be located at a position corresponding to (for example, the state shown in FIG. 4B (c) is formed). In the configuration of the nozzle 4 and the holder 5 shown in FIG. 3B, the point P3 is a position closer to the point P2 than the point P4 along the flow of the injection solution. The length of the first step portion 42 is set so as to be located at a position corresponding to the connection site with the two flow paths 47 (for example, the state shown in FIG. 4B (a) is formed). ). By setting the length of the first step portion 42 in this manner, the stress distribution in the nozzle 4 can be appropriately formed from the viewpoint of the strength of the nozzle 4, and thus deformation and breakage of the nozzle 4 can be prevented. It can be avoided.

  In the configuration shown in FIGS. 3A and 3B, the first step portion 42 and the second step portion 41 have a columnar shape, but may instead have a prismatic shape. 3A and 3B, the side surface of the nozzle 4, that is, the side surface of the first step portion 42 and the side surface of the second step portion 41 extend in parallel to the flow direction of the injection solution. The side surfaces may be formed as inclined surfaces by setting the extending direction of these side surfaces to a direction that intersects with the flow of the injection solution at a certain angle. In that case, the inner wall surfaces of the accommodation spaces 54 and 55 of the holder 5 holding the nozzle 4 are also formed as inclined surfaces so as to correspond to the side surfaces of the nozzle 4.

  The syringe 1 configured as described above can achieve a suitable injection for a target injection target by adjusting the pressure applied to the injection liquid ML by the initiator 20. The injection target of the syringe 1 according to the present invention is a skin structure of a living body such as a human being or a domestic animal. The human skin is composed of the epidermis, dermis, subcutaneous tissue / muscle tissue in layers from the skin surface side to the depth direction, and the epidermis can be distinguished into the stratum corneum, intradermal and layered. Each layer of the skin structure is different also in the main cells constituting the tissue and the characteristics of the tissue. As described above, the human skin structure is generally formed in a layered manner, and inherent anatomical functions are exhibited by cells, tissues, and the like mainly contained in each layer. This means that when a medical treatment or the like is performed on the skin, it is desirable to inject a therapeutic component at the location (depth) of the skin structure according to the treatment purpose. . For example, since dendritic cells are present in the skin, a more effective antigen-antibody reaction can be expected by performing a vaccine injection here.

In addition, since fibroblasts and collagen cells exist in the dermis, proteins, enzymes, vitamins, amino acids, minerals, sugars, nucleic acids, various growth factors (epithelial cells and fibroblasts) are used to remove skin wrinkles. ) Etc. are injected into the dermis, an effective beauty treatment effect is expected. Also, in hair regeneration treatment, since the hair root is located in the dermis, for hair regeneration treatment, stem cell injection method or stem cell in which hair dermal papilla cells, epidermal stem cells, etc. are self-cultured and autotransplanted into the scalp. It is said that it is preferable to inject several types of growth factors and nutritional components extracted from the above (for example, hair papilla cells, hair root stem cells, epidermal stem cells, HARG cocktail, and hair for transplantation) in the vicinity of the dermis.

  Further, according to the syringe 1 according to the present invention, in addition to the case where the above-mentioned injection solution is injected into the skin structure, for example, in the field of regenerative medicine, cells to be injected or cultured cells in a scaffold tissue / scaffold It is possible to seed stem cells and the like. For example, as disclosed in JP-A-2008-206477, cells that can be appropriately determined by those skilled in the art depending on the site to be transplanted and the purpose of recellularization, such as endothelial cells, endothelial precursor cells, bone marrow cells, and prebones Blast cells, chondrocytes, fibroblasts, skin cells, muscle cells, liver cells, kidney cells, intestinal cells, stem cells, and any other cells considered in the field of regenerative medicine can be injected with the syringe 1. .

  Furthermore, the syringe 1 according to the present invention can also be used for delivery of DNA or the like to cells, scaffold tissue, scaffolds, etc. as described in JP-T-2007-525192. In this case, it can be said that the use of the syringe 1 according to the present invention is more preferable than the case of delivery using a needle because the influence on the cells, the scaffold tissue, the scaffold and the like can be suppressed.

  Furthermore, the syringe 1 according to the present invention is suitable also when various genes, tumor suppressor cells, lipid envelopes, etc. are directly delivered to a target tissue or when an antigen gene is administered to enhance immunity against a pathogen. Used for. In addition, in the field of various disease treatments (fields described in JP2008-508881, JP2010-503616, etc.), immunomedicine (fields described in JP2005-523679, etc.), etc. The syringe 1 can be used, and the field in which the syringe 1 can be used is not intentionally limited.

  5A and 5B show a configuration relating to the second embodiment of the nozzle 4 and the holder 5 provided in the syringe 1 according to the present invention. In the nozzle 4 and the holder 5, the same components as those in the first embodiment are denoted by the same reference numerals, and detailed description thereof is omitted. FIG. 5A is a cross-sectional view showing a state in which the nozzle 4 is attached to the holder 5 in a vertical cross section (a cross section along the flow of the injection liquid ML), similarly to FIG. 3A. Here, the difference between the configuration shown in FIG. 5A and the configuration shown in FIG. 3A is that the configuration near the contact portion between the surface 43 of the nozzle 4 and the surface 54 of the holder 5, the side surface of the first step portion 42, and the holder side A side flow path 60 is formed between the first stage portion 53 and the first stage portion 53.

  More specifically, the straight line shown on the left side in FIGS. 5A and 5B schematically shows the flow of the injection solution from the introduction port 44 to the injection port 48 as in the case of FIG. 3A. On the other hand, the points where the introduction port 44, the injection port 48, the surface 43 (that is, the angular position CP), the maximum stress position MX, and the connection part of the first flow path 45 and the connection flow path 46 are projected are respectively indicated by P1 and P2. , P3, P4, and P5. Therefore, in the configuration of the nozzle 4 and the holder 5 shown in FIG. 5A, the first step portion is positioned so that the point P3 is located closer to the point P2 than the point P5 when the injection solution is flowed. A length of 42 is set.

Further, a seal portion 61 is provided to prevent the injection solution from leaking out at a portion where the surface 43 of the nozzle 4 corresponding to the point P3 is in contact with the surface 54 on the holder 5 side. At the same time, a side channel 60 is defined between the first step portion 42, the side surface, and the inner wall surface of the accommodation space 55, the upper channel being connected to the channel 11 and the lower channel being sealed by the seal unit 61. ing. The side channel 60 is configured such that a part of the pressurized injection solution that has flowed through the channel 11 due to the combustion of explosives flows into the side channel 60, but the injection solution that has flowed in through the seal portion 61 Leakage is suppressed. Therefore, when the injection solution is injected from the injection port 48, the injection solution flows into the flow path in the nozzle 4 so that pressure is applied to the nozzle body from the inside of the nozzle 4 as shown in the above embodiment. At the same time, pressure is applied to the nozzle body from the outside of the nozzle 4 by the injection solution flowing into the side flow path 60. Thereby, the pressure difference inside and outside the nozzle 4 can be suppressed as much as possible.

  In addition, the contact portion between the surface 43 and the surface 54 is closer to the injection port 48 than the connection portion between the first flow path 45 and the connection flow path 46 is that the pressure of the injection solution flowing through the first flow path 45 is Further, it means that the contact portion between the surface 43 and the surface 54 is arranged on the downstream side from the connection portion which is also a position to be further raised. Therefore, the injection solution flowing through the side flow path 60 can be guided to the vicinity of the connection site. That is, a state in which the above-described pressure difference between the inside and outside of the nozzle 4 is suppressed as much as possible is formed in the vicinity of the connection site, which is also a position where the pressure of the injection solution flowing through the first flow path 45 further increases. It becomes possible. As a result, in the configuration shown in FIG. 5A, compared to the prior art in which the injection solution does not flow into the side flow path 60, it is difficult to form a pressure state that deforms and destroys the nozzle 4 due to the internal and external pressure difference.

  Preferably, the depth of the side flow path 60, that is, the first of the nozzle 4 is set so that the point P3 is located on the point P2 side from the point P4 corresponding to the maximum stress position MX described in the first embodiment. The length of the step portion 42 is set. According to such a configuration, formation of a stress distribution that deforms the nozzle 4 can be effectively prevented by applying pressure from the inside and outside of the nozzle 4.

  Note that the seal configuration by the seal portion 61 may be formed by providing a member having a sealing function such as a gasket, packing, or O-ring between the surface 43 of the nozzle 4 and the surface 54 of the holder 5. Alternatively, a water-resistant adhesive may be applied between the surface 43 and the surface 54 and cured. In this case, in consideration of the fact that the nozzle 4 is a disposable type nozzle, it is preferable to use an adhesive that hardly affects the mounting of a new nozzle. Further, an annular protrusion is provided on the surface 43 side of the nozzle 4, and an annular recess is provided on the surface 54 side of the holder 5 corresponding thereto, and the seal portion 61 is formed by engaging the protrusion and the recess. You may do it. Of course, an annular protrusion may be provided on the surface 54 side of the holder 5 and an annular recess may be provided on the surface 43 side of the nozzle 4. Further, in the configuration in which the annular protrusion is provided on the surface 43 side of the nozzle 4, the seal portion 61 may be formed by crushing the protrusion with the surface 54 on the holder 5 side when the nozzle 4 is mounted. Similarly, such a crushing protrusion may be provided on the surface 54 side of the holder 5.

  In addition, as shown in FIG. 5B, the seal portion 61 is arranged at a position near the contact portion between the surface 43 of the nozzle 4 and the surface 54 of the holder 5, for example, the first stage corresponding to the lower end side of the side channel 60. You may arrange | position on the side surface of the part 42. FIG. In this case, in order to secure the space of the side flow path 60, it is difficult to use a general seal member such as a gasket, packing, or O-ring as the seal portion 61. Therefore, a deformable protrusion 62 is provided on the lower end side of the side flow path 60, and when the nozzle 4 is mounted on the holder 5, the nozzle 4 is inserted while deforming the protrusion 62, whereby the seal portion 61 is removed. It may be formed.

  In FIG. 6, the structure regarding the 3rd Example of the nozzle 4 provided to the syringe 1 which concerns on this invention and the holder 5 is shown. In the nozzle 4 and the holder 5, the same components as those in the first embodiment are denoted by the same reference numerals, and detailed description thereof is omitted. FIG. 6 is a cross-sectional view showing a state in which the nozzle 4 is mounted on the holder 5 in a vertical cross section (a cross section along the flow of the injection liquid ML), as in FIG. 3A. Here, the difference between the configuration shown in FIG. 6 and the configuration shown in FIG. 3A is that the configuration in the vicinity of the contact portion between the surface 43 of the nozzle 4 and the surface 54 of the holder 5, the side surface of the second step portion 41, and the holder side The filling member 63 is disposed between the two-stage portion 52.

  In detail, the straight line shown on the left side in FIG. 6 schematically shows the flow of the injection solution from the introduction port 44 to the injection port 48 as in the case of FIG. 3A. 4, the injection port 48, the surface 43 (that is, the angular position CP), the maximum stress position MX, and the points where the connection sites between the first flow channel 45 and the connection flow channel 46 are projected, P1, P2, P3, Let P4 and P5. Therefore, in the configuration of the nozzle 4 and the holder 5 shown in FIG. 6, the first stage is such that the point P3 is located closer to the point P1 than the point P5 when the injection solution is flowed. The length of the part 42 is set.

  Further, in the configuration shown in FIG. 6, the filling member 63 is disposed so as to close a part or the whole between the side surface of the second step portion 41 of the nozzle 4 and the inner wall surface of the accommodation space 51 of the holder 5. Yes. And since the contact part of the surface 43 and the surface 54 is arrange | positioned upstream from the connection site | part of the 1st flow path 45 and the connection flow path 46 as mentioned above (introduction port 44 side), the filling member 63 is a nozzle. 4, the side surface of the second step portion 41 in the vicinity of the connection channel 46 where the pressure received from the injection solution can be increased by decreasing the channel diameter is supported from the outside. For this reason, the deformation margin of the nozzle 4 due to the pressure from the injection solution is closed by the filling member 63, so that the nozzle 4 can be prevented from being deformed or broken during injection of the injection solution.

  Preferably, the filling member 63 is disposed so as to contact a portion on the side surface of the second step portion corresponding to the portion in the vicinity of the maximum stress position MX described in the first embodiment. According to such a configuration, the nozzle 4 can be effectively supported by the filling member 63. Of course, the entire space between the side surface of the second step portion 41 and the inner wall surface of the accommodation space 51 may be closed with the filling member 63.

  The filling member 63 may be formed by curing an adhesive that bonds the nozzle 4 and the holder 5 together. In this case, in consideration of the fact that the nozzle 4 is a disposable type nozzle, it is preferable to use an adhesive that hardly affects the mounting of a new nozzle.

DESCRIPTION OF SYMBOLS 1 ... Syringe 2 ... Syringe body 4 ... Nozzle 5 ... Holder 6 ... Piston 7, 8 ... Sealing member 9 ... Combustion chamber 10. ...... Concave part 11 ・ ・ ・ Flow path 20 ・ ・ ・ Initiator 22 ・ ・ ・ Ignition agent 30 ・ ・ ・ Gas generating agent 41 ・ ・ ・ First stage part 42 ・ ・ ・ ・ Second stage part 43... Face 44... Introduction port 45... First flow path 46... Connection flow path 47. Storage space 52... Holder side first step 53... Holder side second step 54... Surface 55. Seal part 62 ... Projection part 63 ... Filling member

Claims (14)

An injection port for a needleless syringe that injects a pressurized injection target substance into the injection target area of a living body without going through an injection needle is formed with respect to the holding member on the needleless syringe side. A resin nozzle configured to be removable.
A nozzle body having a side surface detachable from the holding member;
A flow path provided inside the nozzle body, a first flow path through which the pressurized injection target substance flows from the needleless syringe side through an inlet located at an end;
A flow path provided inside the nozzle body, wherein the flow path diameter is smaller than the first flow path, and the second flow path includes the injection port at an end different from the end; and
A flow path provided inside the nozzle body, connecting the first flow path and the second flow path, and the diameter of the flow path decreases along the flow of the pressurized injection target substance. A connection flow path,
The first flow path and the second flow path are cylindrical flow paths having a constant cross-sectional area, and are arranged coaxially so that the central axes of both flow paths overlap.
The nozzle body is
A cylindrical first step portion having a first predetermined diameter or a first predetermined width;
A second step portion having a second predetermined diameter or a second predetermined width that is smaller than the first predetermined diameter or first predetermined width of the first step portion, on one end face side of the first step portion A connected cylindrical second step, and
A contact portion that contacts the holding member with the holding member so that the injection port is exposed and opposed to the injection target region, and is connected to a side surface of the nozzle body and is pressurized. A planar or curved contact portion extending in a predetermined direction intersecting the flow direction of the target substance ,
The first step portion and the second step portion are arranged coaxially so that the respective central axes overlap,
The introduction port is formed on the other end face side of the first step portion,
The injection port is formed on an end surface side of the end surface of the second step portion to which the first step portion is not connected,
In the flow direction of the pressurized injection target substance, the contact portion is either on the injection port side from a predetermined position on the connection channel in the vicinity of the connection site between the connection channel and the second channel. Located at
Needle for needleless syringe.   The needle for a needleless syringe according to claim 1, wherein the contact portion is located between the connection site and the injection port in a flow direction of the pressurized injection target substance. The contact portion is formed by a surface not occupied by the second step portion at the one end surface of the first step portion.
The nozzle for needle-free injectors of Claim 1 or Claim 2. Nozzle for needleless syringe according to any one of claims 1 to 3 ,
A container containing the substance for injection;
A pressurizing unit that pressurizes and discharges the injectable substance contained in the containing unit to the outside;
Needleless syringe. A needleless syringe for injecting an injection target substance into an injection target region of a living body without going through an injection needle,
A container containing the substance for injection;
Pressurizing the injectable substance contained in the containing part and pressurizing it to the outside;
A resin nozzle configured to form an injection port to the injection target region of the injection target substance pressurized by the pressurizing unit and configured to be detachable from the holding member on the needleless syringe side;
With
The nozzle is
A nozzle body;
A flow path provided inside the nozzle body, a first flow path through which the pressurized injection target substance flows from the needleless syringe side through an inlet located at an end;
A flow path provided inside the nozzle body, wherein the flow path diameter is smaller than the first flow path, and the second flow path includes the injection port at an end different from the end; and
A flow path provided inside the nozzle body, connecting the first flow path and the second flow path, and the diameter of the flow path decreases along the flow of the pressurized injection target substance. A connecting flow path;
A contact portion that contacts the holding member with the holding member so that the injection port is exposed and opposed to the injection target region, and is connected to a side surface of the nozzle body and is pressurized. A planar or curved contact portion extending in a predetermined direction intersecting the flow direction of the target substance;
Have
The contact portion is located at any position on the injection port side from the connection site between the connection channel and the first channel in the flow direction of the pressurized injection target substance,
The side surface in the range from the end surface side of the nozzle body where the introduction port is located to the contact position by the contact portion among the side surfaces of the nozzle body in a state where the nozzle is in contact with the holding member via the contact portion. If, between the holding member, the side passage injection objective substance wherein pressurized flows are formed,
When the injection target substance is pressurized by the pressurizing unit and the injection target substance is ejected from the injection port, the injection target substance is the first flow path, the connection flow path, and the second flow path. And also flows into the side flow path,
Needleless syringe. The nozzle body is configured to be inserted from one end side of the holding member so that the injection port is exposed to the other end side of the holding member,
The side surface of the nozzle body extends parallel to the direction of insertion into the holding member, or extends in a direction that intersects with the direction of insertion into the holding member,
The needleless syringe according to claim 5 . The nozzle body has a cylindrical first step portion having a first predetermined diameter or first predetermined width, and a second predetermined diameter smaller than the first predetermined diameter or first predetermined width of the first step portion. Or a second step portion having a second predetermined width, the second step portion connected to one end face side of the first step portion, and
The contact portion is formed by a surface not occupied by the second step portion at the one end surface of the first step portion,
The introduction port is formed on the other end face side of the first step portion,
The injection port is formed on an end surface side of the end surface of the second step portion to which the first step portion is not connected.
The needleless syringe according to claim 5 . The contact portion includes a seal portion that prevents the pressurized holding member that has flowed into the side flow path from flowing out to the injection port side.
The needleless syringe according to any one of claims 5 to 7 . A seal portion that prevents the pressurized holding member that has flowed into the side flow path from flowing out to the injection port side is provided at a predetermined portion in the vicinity of the contact position by the contact portion on the side surface of the nozzle body. ,
The needleless syringe according to any one of claims 5 to 7 . The predetermined portion near the contact position by the contact portion is provided with a deformable protrusion,
When the nozzle is attached to the holding member, the protruding portion is deformed by contact with the holding member to form the seal portion.
The needleless syringe according to claim 9 . A needleless syringe for injecting an injection target substance into an injection target region of a living body without going through an injection needle,
A container containing the substance for injection;
Pressurizing the injectable substance contained in the containing part and pressurizing it to the outside;
A resin nozzle configured to form an injection port to the injection target region of the injection target substance pressurized by the pressurizing unit and configured to be detachable from the holding member on the needleless syringe side;
With
The nozzle is
A nozzle body;
A flow path provided inside the nozzle body, a first flow path through which the pressurized injection target substance flows from the needleless syringe side through an inlet located at an end;
A flow path provided inside the nozzle body, wherein the flow path diameter is smaller than the first flow path, and the second flow path includes the injection port at an end different from the end; and
A flow path provided inside the nozzle body, connecting the first flow path and the second flow path, and the diameter of the flow path decreases along the flow of the pressurized injection target substance. A connecting flow path;
A contact portion that contacts the holding member with the holding member so that the injection port is exposed and opposed to the injection target region, and is connected to a side surface of the nozzle body and is pressurized. A planar or curved contact portion extending in a predetermined direction intersecting the material flow direction;
Have
The contact portion is located at any position on the inlet side from the connection site between the connection channel and the first channel in the flow direction of the pressurized injection target substance,
A side surface of the nozzle body in a range from a contact position by the contact portion to an end portion on the injection port side in a state where the nozzle is in contact with the holding member via the contact portion; and the holding member A filling member is provided for filling at least part of the space between
Needleless syringe. The nozzle body is configured to be inserted from one end side of the holding member so that the injection port is exposed to the other end side of the holding member,
The side surface of the nozzle body extends parallel to the direction of insertion into the holding member, or extends in a direction that intersects with the direction of insertion into the holding member,
The needleless syringe according to claim 11 . The nozzle body has a cylindrical first step portion having a first predetermined diameter or first predetermined width, and a second predetermined diameter smaller than the first predetermined diameter or first predetermined width of the first step portion. Or a second step portion having a second predetermined width, the second step portion connected to one end face side of the first step portion, and
The contact portion is formed by a surface not occupied by the second step portion at the one end surface of the first step portion,
The introduction port is formed on the other end face side of the first step portion,
The injection port is formed on an end surface side of the end surface of the second step portion to which the first step portion is not connected.
The needleless syringe according to claim 11 . The filling member is formed by curing an adhesive that bonds the nozzle body and the holding member.
The needleless syringe according to any one of claims 11 to 13 .

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