JP6678130B2 - Syringe - Google Patents

Description

  The present invention relates to a syringe for injecting a substance to be injected into a region to be injected.

  2. Description of the Related Art A syringe for injecting an injection component using energy of combustion gas generated by ignition of a gunpowder has been widely disclosed. For example, in the syringe described in Patent Literature 1, the propellant is burned to pressurize the propulsion surface formed integrally with the piston, and the propellant is moved in the course defined by the outer peripheral surface of the propulsion surface and the inner surface of the housing. Along which the propulsion surface will be propelled. Then, the piston formed integrally with the propulsion surface protrudes along another path defined by the outer peripheral surface of the piston and the inner surface of the housing as the propulsion surface protrudes. This final propulsion of the piston ejects an injection component located in front of the piston.

JP 2004-500933 A

  When the injection target substance is sent to the injection target area, a driving unit that applies energy to the injected injection target substance is provided in the syringe to deliver the injection target substance to a predetermined place. Then, by transmitting the energy imparted by the driving unit to the injection target substance, efficient and accurate injection can be realized. Here, the components contained in the injection target substance and the target sites in the injection target region to which the components are to be injected, particularly the sites to be recognized in the depth direction to be sent, differ depending on the injection purpose. For example, when an injection is performed on a living body, the injection target region of the living body includes various structures such as skin, muscles, and internal organs, and the living tissue constituting these structures has a surface (injection). In this case, the function differs depending on the depth from the surface where the syringe touches the structure), and if the component in the injection solution does not reach the target biological tissue (target site), its effect will be reduced. This is because it is difficult to properly exert it.

  On the other hand, the injection target substance ejected from the syringe is housed in a predetermined space in the syringe before the energy from the driving unit is transmitted, but at this time, if the injection target substance coexists with air. In addition, air that coexists with the injection target substance is also ejected together. As a result, the injection target substance to be propelled toward the injection target area is diffused under the influence of the air ejected together, and it becomes difficult to deliver the injection target substance to a desired site in the living body. In particular, depending on the amount of the injection target substance to be contained in the predetermined space and the manner of filling the syringe with the injection target substance, the injection target substance may coexist with a relatively large amount of air in the predetermined space. In this case, the accuracy of the depth of the syringe is likely to deteriorate.

  In view of the above problems, an object of the present invention is to provide a syringe having a configuration capable of realizing appropriate injection of a substance for injection.

  In order to solve the above-mentioned problem, the present invention provides an accommodation space for accommodating a substance to be injected, which is ejected from a syringe, and an air passage connecting the outside thereof so that air communication is possible. By extruding the air pressurized at the time of injection to the outside of the accommodation space through the air passage, it is possible to suppress the injection of the air together with the injection target substance as much as possible.

  Specifically, the present invention relates to a syringe for injecting an injection target substance into an injection target area, wherein the driving section generates energy for injecting the injection target substance, and the energy generated by the driving section. A piston holder for defining a course of a propelling piston, and a flow path through which the injection target substance pressurized by the piston flows, and the injection target substance is ejected from an open end of the flow path to a region to be injected. A nozzle unit. Before the drive section generates energy, an accommodation space for accommodating the injection target substance is formed inside the nozzle section on the side of the piston in the traveling direction. Further, the syringe is an opening provided at a position where the injection target substance accommodated in the accommodation space does not flow when the syringe is used in the accommodation space, and the piston is actuated by energy from the driving unit. An air passage that connects the housing space and the outside of the housing space through an opening that is closed by a part of the piston when propelled and enters the housing space; .

  In the syringe according to the present invention, the drive unit generates energy for injecting the injection target substance, and employs various known energy generation modes as the energy source as long as the energy can be transmitted to the piston. can do. For example, an igniting charge ignited by an igniter or a gas generating agent that generates gas by combustion can be employed. Examples of the igniting powder include an explosive containing zirconium and potassium perchlorate, an explosive containing titanium hydride and potassium perchlorate, an explosive containing titanium and potassium perchlorate, and an explosive containing aluminum and potassium perchlorate. An explosive containing aluminum and bismuth oxide, an explosive containing aluminum and molybdenum oxide, an explosive containing aluminum and copper oxide, an explosive containing aluminum and iron oxide, or an explosive comprising a combination of a plurality of these It may be. As a feature of these igniters, even if the combustion product is a gas in a high temperature state, it does not contain a gas component at room temperature, so that the combustion product immediately condenses after ignition. When used for injection, efficient injection into a shallower part of the injection target region of the living body is possible. Further, as an aspect of the driving unit other than the above, energy of an elastic member such as a spring or energy of a compressed gas may be used as energy for injection.

  The energy for injection by the driving unit is directly or indirectly transmitted to the piston, and becomes a propulsive force of the piston. This piston propels the path defined in the piston holder toward the nozzle portion by the energy. Then, on the side of the piston in the traveling direction, the piston is directed toward the injection target substance accommodated in the accommodation space, whereby energy is transmitted to the injection target substance, and along the flow path formed in the nozzle portion. The injection target substance is extruded and finally ejected toward the injection target area.

  Here, before the injection is performed, the injection target substance is stored in the storage space. At this time, depending on the ratio of the injection target substance in the storage space, the injection target substance coexists with a relatively large amount of air. Placed in state. When a pressing force is applied to the injection target substance in such a state from the piston, the injection target substance is ejected to the outside of the syringe in a state of being diffused with air. When the injected injection target substance is diffused, the kinetic energy of the injection target substance is reduced, and for example, the penetration force through the injection target area is reduced, so that the injection target substance is delivered to a desired site. Can be difficult.

Therefore, the syringe according to the present invention is provided with an air passage that connects the housing space and the outside of the housing space so that air communication is possible. This air passage sends out air in the housing space, which is pressurized by the propulsion of the piston by energy from the driving unit, to the outside of the housing space through an opening provided on the housing space side. Is made possible. As a result, the amount of air ejected together with the injection target substance can be reduced, and the tendency of the injection target substance to diffuse due to air can be suppressed. The opening provided on the storage space side is provided at a position where the injection target substance in the storage space does not flow during use of the syringe, and when the piston is propelled by the energy from the driving unit and enters the storage space. Is closed by a part of the piston. Therefore, the pressurized air generated by the propulsion of the piston is discharged from the opening, and thereafter, the opening is closed by the piston, so that the injection target substance is prevented from leaking outside through the air passage, Suitable injection target injection can be achieved.

  In the syringe according to the present invention, the injection target substance contains a component expected to be effective at a target site in the injection target region. Therefore, if at least the injection with the energy by the driving unit is possible, the storage state of the injection target substance in the storage space or the specific liquid of the injection target substance such as a fluid such as a liquid or a gel, a powder, or a granular solid can be used. The physical form does not matter. For example, the injection target substance may be a liquid, and may be a solid in a gel state even if it is a solid as long as fluidity enabling injection is ensured. The target substance for injection contains a component to be delivered to the target site, and the component may exist in a state of being dissolved in the target substance for injection, or a state in which the component is simply mixed without being dissolved. It may be. To give an example, the components to be delivered include vaccines for antibody enhancement, proteins for beauty, cultured cells for hair regeneration, etc., so that these can be injected into liquids, fluids such as gels, etc. The inclusion target forms an injection target substance.

  Here, in the above-mentioned syringe, a rear end surface of the nozzle portion may be configured to be in contact with a front end surface of the piston holder. In this case, the air passage may be formed on the rear end surface of the nozzle portion or on the front end surface of the piston holder as a groove portion extending from a central portion to an outer surface. That is, in the syringe configured so that the piston holder and the nozzle portion are in contact with each other, the groove formed between the two functions as the air passage. Instead of such an embodiment, a configuration is also adopted in which the air passage is formed as a through hole in the piston holder or the nozzle portion, and connects the housing space and the outside of the housing space so that air communication is possible. be able to.

  Further, in the above-mentioned syringe, the air passage is formed by fixing the piston holder in the housing of the syringe in a non-contact state in which the piston holder does not directly contact the nozzle portion in the traveling direction of the piston. Is also good. A piston holder is a type in which a part of energy can be transmitted indirectly by frictional force from the piston or a part of energy by the drive unit can be transmitted directly by the piston propelling the internal path, but the nozzle By maintaining the piston holder and the nozzle portion in a non-contact state in a state where the portion is fixed to the housing, it is possible to avoid that the nozzle portion receives at least unnecessary energy via the piston holder. . As a result, deformation and breakage of the nozzle portion having a flow path for injection of the injection target substance can be suppressed as much as possible. By adopting such a configuration, the flow path can be maintained in a state appropriate for injection, and therefore, the injection of the substance to be injected by the syringe according to the present invention can always be maintained in a suitable state. Becomes In addition, since the air passage is formed by the non-contact state, the diffusion of the injection target substance by air can be suppressed, and a more suitable state for the injection target substance can be formed.

Here, in the above-mentioned syringe, a configuration may be adopted which further includes a nozzle holder fixed to the piston holder while holding the nozzle portion. Then, in that case, the piston holder is in contact with the nozzle holder in the traveling direction of the piston and is fixed in the housing, whereby the non-contact state between the piston holder and the nozzle portion is formed. Is also good. That is, the piston holder and the nozzle holder are fixed in the housing in contact with each other, but the piston holder and the nozzle portion held in the nozzle holder are in a state where the above-mentioned non-contact state is maintained. I have. Such a configuration is an exemplary configuration that can be applied to the syringe according to the present invention, but by adopting the configuration, the piston holder and the nozzle holder can be securely fixed in the housing, It is considered that this contributes to the formation of a suitable state for injection of the injection target substance described above.

  In the above-described syringe, the nozzle portion may be formed of resin in consideration of productivity and the like.

  It is possible to provide a syringe having a configuration capable of realizing injection of an appropriate injection target substance.

It is a figure showing the schematic structure of the syringe concerning a 1st example of the present invention. FIG. 2 is a diagram illustrating a schematic configuration of an igniter (ignition device) mounted on the syringe illustrated in FIG. 1. FIG. 2 is a diagram illustrating a state where components are loaded into a housing of the syringe illustrated in FIG. 1. FIG. 2 is a first diagram illustrating a configuration of a nozzle unit included in the syringe illustrated in FIG. 1. FIG. 2 is a second diagram illustrating a configuration of a nozzle unit included in the syringe illustrated in FIG. 1. FIG. 6 is a first diagram illustrating a schematic configuration of a syringe according to a second embodiment of the present invention. It is a 2nd figure showing the schematic structure of the syringe concerning a 2nd example of the present invention.

  Hereinafter, a syringe 1 according to an embodiment of the present invention will be described with reference to the drawings. The configuration of the following embodiment is an exemplification, and the present invention is not limited to the configuration of this embodiment.

  Here, FIG. 1 is a cross-sectional view of a syringe 1 in which the technology of the present invention is applied to a syringe for injecting a living body. The syringe 1 is a needleless syringe having no injection needle for directly delivering an injection solution corresponding to the injection target substance according to the present invention to an in-vivo region to be injected (for example, an animal skin structure). is there. In the present embodiment, the injection target substance is a liquid, but there is no intention to limit the content and form of the substance to be injected into the living body. As described above, for example, the substance to be injected into the skin structure varies depending on the therapeutic purpose, and so long as the components to be delivered to the skin structure are compatible with the therapeutic purpose, the substance is dissolved. The specific form of the injection target substance is not limited as long as it can be ejected from the syringe 1 to the skin structure by energy, such as a liquid or a gel. Various forms can be adopted.

  The syringe 1 has a housing 2 as a main body, in which a nozzle holder 5, a piston holder 3, and an igniter holder 12 are arranged in a line from a front end to a rear end. The cap 30 at the rear end of the housing 2 is screwed with a thread provided on the rear side surface of the housing 2 to apply a force to the nozzle holder 5, the piston holder 3, and the igniter holder 12, These components can be fixed in the housing 2 and the syringe 1 can be used. Specifically, the nozzle holder 5, the piston holder 3, and the igniter holder 12 are held by a cap 30 with respect to a step 2 c formed at the tip of the housing 2 as described later. In the present embodiment, the term "tip" means the end of the component in the injection direction of the injection liquid (propulsion direction of the piston 4), as will be described later. The term "end" means the end of the component on the side opposite the tip.

  Here, the housing 2 has an inner hole 2a defining a space for accommodating the nozzle holder 5, the piston holder 3, and the igniter holder 12, as described above. Further, a through hole 2b is formed at the tip of the housing 2 so as to communicate the inner hole 2a with the outside of the housing 2. The centers of the through hole 2b and the inner hole 2a are provided coaxially, and the inner diameter of the through hole 2b is set smaller than the inner diameter of the inner hole 2a. Therefore, a stepped portion 2c is formed inside the front end portion of the housing 2.

  Here, an example of the igniter 20 attached to the igniter holder 12 will be described with reference to FIG. The igniter 20 is an electric igniter, and a space for disposing the igniter 22 is defined in the cup 21 by a cup 21 whose surface is covered with an insulating cover. The metal header 24 is arranged in the space, and the cylindrical charge holder 23 is provided on the upper surface. The ignition charge 22 is held by the charge holder 23. A bridge wire 26 that electrically connects one conductive pin 28 and the metal header 24 is wired on the bottom of the ignition charge 22. The two conductive pins 28 are fixed to the metal header 24 via the insulator 25 so that they are insulated from each other when no voltage is applied. Further, the open side of the cup 21 from which the two conductive pins 28 extend is protected by the resin 27 while maintaining good insulation between the conductive pins 28.

  In the igniter 20 configured as described above, when a voltage is applied between the two conductive pins 28 by a power supply unit (not shown) connected to the cap 30, a current flows through the bridge wire 26, and thereby the igniter 22 burns. This voltage application is realized when the user presses a button of the power supply unit. Then, as a result of the voltage application, a combustion product by the combustion of the ignition charge 22 is ejected from the opening of the charge holder 23. Therefore, in the present invention, the relative position of the igniter 20 with respect to the igniter holder 12 is such that combustion products of the igniter 22 in the igniter 20 flow into the combustion chamber 11 formed inside the igniter holder 12. The positional relationship has been set.

  The igniter 22 used in the syringe 1 is preferably an explosive containing zirconium and potassium perchlorate (ZPP), an explosive containing titanium hydride and potassium perchlorate (THPP), titanium and potassium perchlorate. Explosive containing TiPP, explosive containing aluminum and potassium perchlorate (APP), explosive containing aluminum and bismuth oxide (ABO), explosive containing aluminum and molybdenum oxide (AMO), explosive containing aluminum and copper oxide (ACO) ), An explosive containing aluminum and iron oxide (AFO), or an explosive consisting of a combination of a plurality of these explosives. These explosives generate high-temperature and high-pressure plasma during combustion immediately after ignition, but exhibit a characteristic that when they reach room temperature and combustion products condense, they do not contain gaseous components and the generated pressure drops rapidly. Note that other explosives may be used as the ignition charge.

Here, although nothing is arranged in the combustion chamber 11 shown in FIG. 1, a known gas generating agent that generates gas by burning by a combustion product generated by the combustion of the ignition charge 22 is provided in the combustion chamber 11. It may be arranged. If the gas generating agent is disposed in the combustion chamber 11, one example is a single-base smokeless explosive comprising 98% by mass of nitrocellulose, 0.8% by mass of diphenylamine and 1.2% by mass of potassium sulfate. It is also possible to use various gas generating agents used in gas generators for airbags and gas generators for seatbelt pretensioners. Unlike the case where only the igniter 22 is used, such a combination use of the gas generating agent causes the predetermined gas generated at the time of combustion to contain a gas component even at room temperature, so that the rate of decrease in the generated pressure is small. Furthermore, the combustion completion time of the gas generating agent at the time of combustion is much longer than that of the ignition charge 22, but the size, size and shape of the gas generating agent when disposed in the combustion chamber 11, especially the surface By adjusting the shape, the combustion completion time of the gas generating agent can be changed. By adjusting the amount, shape, and arrangement of the gas generating agent in this manner, the pressure generated in the combustion chamber 11 can be appropriately adjusted.

  Next, a through hole 31 for holding the metal piston 4 is formed in the metal piston holder 3 before using the syringe 1 shown in FIG. The piston holder 3 has a body portion 32 having an outer diameter substantially matching the inner diameter of the inner hole 2a of the housing 2 and a neck portion 33 having an outer diameter smaller than the body portion 32 at the distal end side. Is a hole penetrating from the rear end side of the body 32 to the front end side of the neck 33. The piston 4 is disposed so as to be slidable in the through hole 31 along the axial direction. One end (rear end side) is exposed to the combustion chamber 11 side, and the other end (front end side). 4) is integrally provided with a sealing member 4a. The sealing member 4a is made of rubber whose surface is thinly coated with silicone oil so that the injection liquid can smoothly move through the through-hole 14 as the piston 4 slides. In order to reduce the friction between the piston 4 or the sealing member 4a and the through hole 31 in the piston holder 3, for example, a sealing member made of fluoro rubber can be used. Further, the surface of the through hole 31 can be subjected to silicon treatment.

  Further, a nozzle holder 5 for holding a nozzle portion 6 for injecting an injection liquid is arranged adjacent to the piston holder 3 on the distal end side of the syringe 1. The nozzle holder 5 has a body portion 51 having an outer diameter substantially matching the inner diameter of the inner hole 2a of the housing 2, and an outer diameter smaller than the body portion 51 and substantially matching the inner diameter of the through hole 2b of the housing 2. It has a neck 52 having a diameter on the tip side. Further, the nozzle holder 5 is formed with an inner hole 5a that defines a space for accommodating the nozzle portion 6, and the inner hole 5a has a tip portion of the nozzle portion 6 exposed to the outside at the tip portion side. The tapered portion 5b is formed in accordance with the surface shape of the nozzle portion 6 so as to be held in a state where the nozzle portion 6 is held.

  On the other hand, the nozzle portion 6 has an outer diameter substantially matching the inner diameter of the inner hole 5a of the nozzle holder 5, and a tapered portion corresponding to the tapered portion 5b of the nozzle holder 5 is formed on the tip end side. Thus, the nozzle portion 6 can be continuously held in the nozzle holder 5. Here, a flow path 6 a through which the injection liquid ejected from the syringe 1 finally flows is formed in the nozzle section 6, and the flow path 6 a has an opening 6 b that opens to the distal end side of the syringe 1. Further, in the central portion of the nozzle portion 6 and in the state shown in FIG. 1, a concave portion 6 c having a size capable of forming a liquid pool is provided at a portion facing the sealing member 4 a attached to the piston 4. The recess 6c is formed and is connected to the channel 6a. The concave portion 6c will be described later.

  The nozzle portion 6 can be mass-produced by resin molding, and is formed so that it can be replaced with a new nozzle portion every time injection liquid is injected. As a result, the user can always use the new nozzle portion 6 every time the injection of the injection solution is performed, and a sanitary injection is realized. The shape and size of the flow path 6a are factors that determine the behavior of the injection liquid injected from the syringe 1 after injection. Therefore, by forming the nozzle portion 6 to be exchangeable as described above, it is possible to select the nozzle portion 6 having a flow path suitable for feeding an injection solution to be injected into a target region in a living body. The injection of the injection solution can be suitably realized.

As described above, when the nozzle portion 6 and the nozzle holder 5, the piston 4 and the piston holder 3, and the igniter holder 12 are arranged in the housing 2, the piston 1 in the state before use of the syringe 1 shown in FIG. An accommodation space 13 capable of accommodating the injection solution is formed between the sealing member 4 a attached to the nozzle 4 and the recess 6 c of the nozzle 6. In the syringe 1 shown in FIG. 1, the injection solution is loaded into the storage space 13 when the syringe 1 is assembled. In the configuration shown in FIG. 1, the injection solution is not sealed in a completely closed space, and the tip end of the syringe is open. However, since the inside diameter of the opening 6b of the nozzle portion 6 is extremely small (for example, 100 μm), the injection solution is stored in the storage space 13 due to the surface tension of the injection solution even when the storage space 13 is a semi-closed space. State can be maintained. Then, as described later, the loaded injection liquid is ejected from the opening 6b of the nozzle unit 6 by being pressurized by energy generated by combustion of the igniter 22 in the igniter 20.

  Here, the order of assembling the components into the syringe 1 will be described with reference to FIGS. First, the nozzle holder 5 holding the nozzle portion 6 is inserted from the rear end side of the housing 2. At this time, the concave portion 6c in the nozzle portion 6 is in a state where the injection solution is loaded. In FIG. 3, the nozzle holder 5 and the nozzle unit 6 are shown in a separated state so that the presence of each component can be easily grasped. At this time, the nozzle holder 5 is inserted into the housing 2 until the stepped portion formed by the body 51 and the neck 52 of the nozzle holder 5 abuts on the step 2c of the housing 2. With the stepped portion abutting the stepped portion 2c, the opening 6b of the nozzle portion 6 held by the nozzle holder 5 is exposed to the front end side of the housing 2.

  Next, the piston holder 3 with the piston 4 held in the through hole 31 is inserted from the rear end side of the housing 2. In FIG. 3, the piston holder 3 and the piston 4 are shown in a separated state so that the presence of each component can be easily grasped. At this time, the neck portion 33 of the piston holder 3 is inserted into the inner hole 5a of the nozzle holder 5, and a stepped portion formed by the body portion 32 and the neck portion 33 of the piston holder 3 is formed at the rear end of the nozzle holder 5. The piston holder 3 is inserted into the housing 2 until it abuts. With the stepped portion abutting on the rear end of the nozzle holder 5, an accommodation space 13 is formed between the sealing member 4 a attached to the piston 4 and the recess 6 c of the nozzle 6. Become. Note that the inner diameter of the concave portion 6c coincides with the inner diameter of the through hole 31, and the piston 4 (or the sealing member 4a attached to the piston 4) can be propelled to the inside of the concave portion 6c. When 4a comes into contact with the bottom surface (the inner wall surface on the tip end side) of recess 6c, the volume of accommodation space 13 becomes substantially zero.

  Next, the igniter holder 12 is inserted from the rear end side of the housing 2. As described above, in order to improve the sealing performance of the combustion chamber 11 from which the combustion products generated by the igniter 20 are released, the rear end surface of the piston holder 3 and the front end surface of the igniter holder 12 are formed. An O-ring 9 is arranged between them. Here, in order to efficiently transmit the combustion energy from the igniter 20 to the piston 4, the inner diameter (φA) of the combustion chamber 11 is slightly larger than the outer diameter of the piston 4 (or the inner diameter of the through hole 31) (φB). Largely designed. Therefore, the rear end surface of the piston holder 3 is exposed to the combustion chamber 11, and there is a pressure receiving surface 34 that can receive the pressure by the combustion energy from the igniter 20.

  After the insertion of the igniter holder 12, the igniter 20 is disposed on the igniter holder 12, and then the cap 30 is connected to the housing 2 side, whereby the assembly of the syringe 1 is completed.

  Here, in the syringe 1 according to the present embodiment, in the state shown in FIG. 1, the front end surface of the neck 33 of the piston holder 3 and the rear end surface of the nozzle portion 6 held in the nozzle holder 5. A non-contact state in which no direct contact occurs is formed. In the non-contact state, a predetermined distance Δd is secured between the front end surface of the neck portion 33 and the rear end surface of the nozzle portion 6, and this Δd can be set to, for example, 0.1 mm. Then, due to the distance Δd between the front end surface of the neck 33 and the rear end surface of the nozzle portion 6, the isolation space 8 that is a space for forming the non-contact state exists.

Here, the isolated space 8 can be said to be an annular space provided between the piston holder 3 and the nozzle portion 6, and the space has an opening on the accommodation space 13 side and the piston holder 3 and the nozzle holder 5. To the contact surface 8a. It should be noted that the opening is accommodated so that the injection solution in the accommodation space 13 does not flow into the isolation space 8 when the syringe 1 is used, that is, when the opening 6b of the nozzle portion 6 is brought into contact with the injection target. The space 13 is provided at a position near the piston 4. More specifically, when the maximum amount of the injection solution that can be accommodated in the accommodation space 13 is stored in the syringe 1, the position of the opening of the isolation space 8 is determined so that the injection solution does not flow into the isolation space 8. Have been. 1, the piston holder 3 and the nozzle holder 5 are depicted without a gap in FIG. 1 showing a schematic configuration of the syringe 1. However, from a microscopic viewpoint, the unevenness of the surface of the piston holder 3 and the nozzle holder 5 are shown. Due to the unevenness of the surface, a completely closed space cannot be formed. For this reason, it can be said that a small flow path is formed on the contact surface 8a between the piston holder 3 and the nozzle holder 5 such that air can flow from a micro viewpoint. This is the same for the contact surface 8b between the nozzle holder 5 and the housing 2. Therefore, the isolation space 8 connects the housing space 13 and the outside of the housing space 13 (for example, the space by the minute air flow path in the contact surfaces 8a and 8b, the outside space of the syringe 1, and the like) so that air communication is possible. The isolation space 8 corresponds to an air passage according to the present invention.

  In the syringe 1 configured as described above, a power supply unit is connected to the igniter 20, and the igniter 20 is operated by a current from the power supply unit. Then, the combustion of the ignition charge 22 fills the combustion chamber 11 with combustion products, and transmits the pressure to the piston 4 as energy for injection injection injection. Upon receiving the energy, the piston 4 pushes the through-hole 31 and applies pressure to the injection solution stored in the storage space 13 so as to move toward the injection target via the flow path 6 a of the nozzle unit 6. The injection will be injected. Since the injected injection liquid is pressurized, the injection liquid penetrates the surface of the injection target and reaches the inside thereof, so that the purpose of injection in the syringe 1 can be achieved.

  When the piston 4 pushes the through hole 31 for injection of such an injection solution and attempts to enter the accommodation space 13, air present together with the injection solution in the accommodation space 13 is pressurized by the piston 4, Part of it flows into the isolation space 8. Here, as described above, the isolation space 8 flows into the isolation space 8 because the isolation space 8 is connected to the outside of the housing space 13 so as to be able to communicate with the outside by the micro air flow path microscopically existing on the contact surfaces 8a and 8b. The pressurized air is discharged to the outside of the accommodation space 13 through the minute air flow path. The discharge of the pressurized air is performed when the sealing member 4a integrated with the piston 4 (that is, the sealing member 4a that is a part of the piston 4) reaches the opening position of the isolated space 8 on the housing space 13 side. The opening is continued until the side surface of the sealing member 4a is closed. Note that, once the opening of the isolated space 8 is closed by the sealing member 4a, the closed state is continued until the injection of the injection solution is completed.

  As described above, in the initial stage of the propulsion of the piston 4, the air in the storage space 13 is discharged to the outside through the isolation space 8, and thereafter, the injection of the injection liquid is mainly performed. When the injection is injected, the opening of the isolated space 8 is closed by the piston 4 (the sealing member 4a), so that the injection can be prevented from flowing into the isolated space 8. Therefore, it is possible to inject the injection liquid in a state where the ratio of the air existing in the storage space 13 to the injection liquid injected from the opening 6b of the nozzle portion 6 is reduced as much as possible. Become. When the injection liquid is ejected from the opening 6b with air mixed therein, the injection liquid tends to diffuse due to the air, and as a result, the penetration energy of the injection target by the injection liquid decreases, and the injection liquid drops to a desired site. It is difficult to reach the injection solution. However, in the syringe 1 of the present invention, since the amount of air mixed in the injection solution can be suppressed by discharging air through the isolation space 8, the function of the syringe 1 can be suitably maintained.

In addition, the isolated space 8 can be said to be a useful structure from the viewpoint of protection of the nozzle portion 6. The nozzle section 6 has a flow path 6a for forming a flow of the injection liquid at the time of injection. If the flow path 6a is deformed by the energy generated by the igniter 20 for injection, it is preferable that the flow path 6a be deformed. It becomes difficult to inject the injection solution. For example, since the pressure receiving surface 34 is formed on the rear end surface of the piston holder 3, the energy generated by the igniter 20 at the time of injection of the injection liquid causes the piston holder 3 to move the piston holder 3 toward the distal end side of the syringe 1. Acts as a pushing force. At this time, if the piston holder 3 is in contact with the nozzle 6 held in the nozzle holder 5, the energy received by the pressure receiving surface 34 is transmitted to the nozzle 6 unnecessarily, As a result, the nozzle portion 6 may be deformed or damaged.

  However, in the syringe 1, the presence of the isolation space 8 prevents the piston holder 3 from directly contacting the nozzle portion 6. That is, the non-contact state between the piston holder 3 and the nozzle portion via the distance Δd is formed by the isolation space 8. The distance Δd is set so that the tip end surface of the neck portion 33 and the rear end surface of the nozzle portion 6 are not in contact with each other even in the slight deformation and movement of the piston holder 3 that may occur when the pressure receiving surface 34 receives combustion energy. Is set to a value that can be maintained. Therefore, in the syringe 1, the non-contact state between the front end surface of the neck portion 33 and the rear end surface of the nozzle portion 6 is maintained before and after the generation of the combustion energy in the igniter 20. As described above, the non-contact state between the front end surface of the neck portion 33 and the rear end surface of the nozzle portion 6 can be maintained before and after the generation of the combustion energy in the igniter 20, that is, before and after the injection of the injection liquid. By designing the syringe 1 so that the nozzle unit 6 is not deformed, it is possible to avoid deformation, breakage, and the like of the nozzle unit 6 caused by unnecessary external force being applied to the nozzle unit 6. In particular, when the nozzle portion 6 is formed of a material having a relatively low strength such as a resin from the viewpoint of productivity or the like, the flow path in the nozzle portion 6 is easily deformed by an external force, so that an appropriate injection solution may be used. It is considered that the structure of the syringe 1 according to the present embodiment is extremely useful also from the viewpoint of ensuring injection of the syringe.

<Modification 1>
Here, in the syringe 1 shown in FIG. 1, the rear end face 6d of the nozzle part 6 is formed in a flat shape as shown in FIG. Therefore, the rear end face 6 d defines a part of the isolation space 8. On the other hand, instead of such a configuration shown in FIG. 4, a nozzle portion 6 having a rear end face 6d shown in FIG. 5 can be employed. In detail, on the rear end surface 6d of the nozzle portion 6, a groove portion 6e is provided from the concave portion 6c located at the center of the nozzle portion 6 to the outer surface thereof, and the nozzle portion 6 is incorporated in the syringe 1. Sometimes, the piston holder 3, the nozzle holder 5, and the nozzle part 6 may be designed such that the rear end face 6d is in contact with the front end face of the neck 33 of the piston holder 3. As described above, even when the rear end surface 6d of the nozzle portion 6 is in contact with the front end surface of the neck portion 33, the groove portion 6e is arranged so as to allow air communication between the housing space 13 and the outside. Thus, as described above, the amount of air mixed in the injection solution can be suppressed by discharging air through the isolation space 8. A configuration corresponding to the groove 6e shown in FIG. 5 may be provided on the piston holder 3 side.

<Modification 2>
In the syringe 1 shown in FIG. 1, the pressure receiving surface 34 is formed on the rear end surface of the piston holder 3. However, even when such a pressure receiving surface is not formed, that is, the inner diameter of the combustion chamber 11 ( Even when the outer diameter (φB) of the piston 4 is smaller than the outer diameter (φB) of the piston 4, the above-described configuration of “maintaining a non-contact state between the front end surface of the neck 33 and the rear end surface of the nozzle portion 6” is as follows. Useful. When the piston 4 receives the combustion energy from the igniter 20 and propels the inside of the through hole 31 toward the distal end, the piston holder 3 receives a frictional force from the piston 4, and the force is similarly applied to the distal end of the piston holder 3. This is because it acts as a pushing force to the part side. Even in such a case, by adopting a configuration of “maintaining a non-contact state between the front end surface of the neck portion 33 and the rear end surface of the nozzle portion 6”, deformation of the nozzle portion 6 is avoided, It is possible to ensure proper injection of the injection solution. At the same time, since the air can be exhausted through the isolation space 8, diffusion of the injection solution due to air mixing can be suppressed.

Second Embodiment A syringe 1 according to a second embodiment of the present invention will be described with reference to FIG. FIG. 6 is a sectional view illustrating a schematic configuration of the syringe 1 according to the present embodiment. The syringe 1 has a housing 102, and a central portion of the syringe main body 102 is provided with a through hole 131 extending in the axial direction and having a constant diameter along the axial direction. One end of the through hole 131 communicates with the combustion chamber 111 having a diameter larger than the diameter of the through hole 131, and the other end reaches the front end of the housing 102. Further, an igniter 120 is attached to the housing 102 via the cap 130 so that the ignition portion of the combustion chamber 111 is opposite to the communication portion with the through-hole 131 so that the ignition portion faces the communication portion. . Note that the igniter 120 is substantially the same as the igniter 20 shown in FIG. In the through hole 131 of the housing 102, the metal piston 104 is disposed so as to be slidable in the through hole 131 along the axial direction, and one end thereof is exposed to the combustion chamber 111 side. .

  Further, the nozzle portion 106 is attached to the housing 102 via a cap 110. Inside the nozzle portion 106, a concave portion 106c that forms a storage space 113 for storing the injection solution, a flow path 106a for injecting the injection solution to the outside, and an opening 106b thereof are provided. Then, the housing space 113 is sealed with the sealing member 104 a in a state where the injection liquid is housed in the housing space 113 in the nozzle portion 106, and in this state, the nozzle portion 106 is fixed to the housing 102. At this time, the end surface of the sealing member 104a comes into contact with the end surface of the piston 104 held in the through hole 131. Therefore, the injection liquid stored in the storage space 113 is propelled by the piston 104 due to the generation of combustion energy in the igniter 20 and is pressed by the sealing member 104a to be ejected from the nozzle portion 106.

  The syringe 1 configured as described above has a configuration in which the housing 102 itself also functions as a piston holder as compared with the syringe 1 shown in FIG. 1, and further has a configuration in which the configuration of the nozzle holder is omitted. . Here, in the nozzle portion 106, an air passage 108 is formed to connect the housing space 113 and the outside of the syringe 1 so that air communication is possible. The air passage 108 is similar to that of the first embodiment in that the injection liquid contained in the storage space 113 is opened at a position where the injection liquid does not flow into the air passage 108 when the syringe 1 is used. Therefore, in the initial stage of the propulsion of the piston 104, the air in the housing space 113 is discharged to the outside through the air passage 108, and thereafter, the injection liquid is mainly injected. When the injection is injected, the opening of the air passage 108 is closed by the sealing member 104a, so that the injection can be prevented from flowing into the air passage 108. As described above, the amount of air mixed in the injection solution is suppressed by discharging the air through the air passage 108, and a suitable injection solution can be injected.

<Modification>
A modification of the syringe 1 shown in FIG. 6 will be described with reference to FIG. In the syringe 1 shown in FIG. 7, the sealing member 104a is integrally attached to the piston 104, and is held in the through hole 131 of the housing 2. Then, the nozzle portion 106 in which the injection solution is stored in the storage space 113 is attached to the housing 102 via the cap 110. In this state, the sealing member 104a faces the injection solution stored in the storage space 113. Here, an air passage 108 formed as a groove as shown in FIG. 5 is provided on the rear end surface of the nozzle portion 106. One end of the air passage 108 is opened at a position where the injection liquid does not flow into the air passage 108 when the syringe 1 is used, and the other end is opened at a gap between the cap 110 and the nozzle portion 106. doing. Therefore, in the initial stage of the propulsion of the piston 104, the air in the housing space 113 is discharged to the outside through the air passage 108, and thereafter, the injection liquid is mainly injected. When the injection is injected, the opening of the air passage 108 is closed by the sealing member 104a, so that the injection can be prevented from flowing into the air passage 108. As described above, the amount of air mixed in the injection solution is suppressed by discharging the air through the air passage 108, and a suitable injection solution can be injected.

<Other Examples>
According to the syringe 1 according to the present invention, in addition to the case of injecting the above-mentioned injection solution into the skin structure, for example, in the field of regenerative medicine, cells to be injected, scaffold tissues / scaffolds, cultured cells and stem cells Etc. can be sown. For example, as disclosed in JP-A-2008-206777, cells that can be appropriately determined by those skilled in the art according to the site to be transplanted and the purpose of recellularization, such as endothelial cells, endothelial progenitor cells, bone marrow cells, and prebones It is possible to inject the blast cells, chondrocytes, fibroblasts, skin cells, muscle cells, liver cells, kidney cells, intestinal cells, stem cells, and any other cells considered in the field of regenerative medicine with the syringe 1. .

  Furthermore, the syringe 1 according to the present invention can be used for delivery of DNA and the like to cells, scaffold tissues, scaffolds and the like as described in JP-T-2007-525192. In this case, it can be said that the use of the syringe 1 according to the present invention is more preferable than the case of using a needle for delivery because the influence on the cells, the scaffold tissue, the scaffold, and the like can be suppressed.

  Furthermore, the syringe 1 according to the present invention is also suitable for delivering various genes, tumor suppressor cells, lipid envelopes, etc. directly to a target tissue, or administering an antigen gene to enhance immunity against a pathogen. Used for In addition, the field of various disease treatments (the fields described in JP-T-2008-508681, JP-T-2010-503616, etc.), the immunomedicine field (the fields described in JP-T-2005-523679, etc.), etc. The syringe 1 can be used, and the usable field is not limited intentionally.

1 ··· Syringe 2, 102 ··· Housing 2a ··· Inner hole 2b ··· Through hole 2c ··· Step 2d ··· Projection 3 ··· Piston holder 4 · · · · · · Piston 4a, 104a · · · sealing member 5 · · · nozzle holder 5a · · · inner hole 5b · · · tapered portion 6, 106 · · · nozzle portion 6a, 106a ··· Channels 6b and 106b ··· Openings 6c and 106c ··· Depressions 8 ··· Isolation space 9 ··· O-rings 10 and 110 ··· Caps 11 and 111 ··· ··· Combustion chamber 12 ··· Ignitioner holders 13 and 113 ··· Storage space 20 and 120 ··· Ignitioners 31 and 131 ··· Through hole 32 ··· Body 33 ··· · Neck 34 ··· Pressure receiving surface 51 ··· Body 52 ··· Neck 108 ··· Empty Passage

Claims (3)

A syringe for injecting an injection target substance into an injection target area,
A driving unit that generates energy for injecting the injection target substance,
A piston holder that defines the path of a piston propelled by energy generated by the drive;
A nozzle portion that includes a flow path through which the injection target substance pressurized by the piston flows, and that ejects the injection target substance to an injection target region from an open end of the flow path,
Before energy is generated by the driving unit, an accommodation space for accommodating the injection target substance is formed inside the nozzle unit on the side of the piston in the traveling direction,
The syringe is
It housed in the housing space when the energy that will be generated by the drive unit in the accommodation space open end of the flow path of the nozzle portion even before being transmitted to the piston is in contact with the injection target area An opening provided at a position where the substance to be injected does not flow in, the opening being closed by a part of the piston when the piston is propelled by the energy from the driving unit and enters the accommodation space. Further comprising an air passage connecting the housing space and the outside of the housing space so that air communication can be performed therebetween.
Syringe. Until the piston is propelled by the energy from the drive unit and closes the opening after the drive unit is actuated, the air in the storage space pressurized by the piston passes through the air passage and passes through the air passage. Discharged to the outside,
The syringe according to claim 1. The nozzle portion is formed of a resin,
The syringe according to claim 1 or 2.

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