JP6224615B2 - 抗血管新生およびがん処置のためのα５β１のアンタゴニストの投与 - Google Patents

抗血管新生およびがん処置のためのα５β１のアンタゴニストの投与 Download PDF

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JP6224615B2
JP6224615B2 JP2014549212A JP2014549212A JP6224615B2 JP 6224615 B2 JP6224615 B2 JP 6224615B2 JP 2014549212 A JP2014549212 A JP 2014549212A JP 2014549212 A JP2014549212 A JP 2014549212A JP 6224615 B2 JP6224615 B2 JP 6224615B2
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angiogenesis
administration
cancer
treatment
vlo4
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JP2015506352A (ja
JP2015506352A5 (cg-RX-API-DMAC7.html
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フェン，シャオドン
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California Northstate College of Pharmacy LLC
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California Northstate College of Pharmacy LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1891—Angiogenesic factors; Angiogenin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2014549212A 2011-12-22 2012-12-18 抗血管新生およびがん処置のためのα５β１のアンタゴニストの投与 Active JP6224615B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/374,369 US8946159B2 (en) 2011-12-22 2011-12-22 Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment
US13/374,369 2011-12-22
PCT/US2012/070399 WO2013096335A1 (en) 2011-12-22 2012-12-18 Administration of an antagonist of alpha 5 beta 1 for anti-antiogenesis and cancer treatment

Publications (3)

Publication Number Publication Date
JP2015506352A JP2015506352A (ja) 2015-03-02
JP2015506352A5 JP2015506352A5 (cg-RX-API-DMAC7.html) 2016-05-19
JP6224615B2 true JP6224615B2 (ja) 2017-11-01

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JP2014549212A Active JP6224615B2 (ja) 2011-12-22 2012-12-18 抗血管新生およびがん処置のためのα５β１のアンタゴニストの投与

Country Status (5)

Country Link
US (6) US8946159B2 (cg-RX-API-DMAC7.html)
EP (2) EP2793924B1 (cg-RX-API-DMAC7.html)
JP (1) JP6224615B2 (cg-RX-API-DMAC7.html)
CN (1) CN104159596B (cg-RX-API-DMAC7.html)
WO (1) WO2013096335A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110319335A1 (en) 2010-06-23 2011-12-29 Xiaodong Feng Combined administration of integrin receptor antagonists for anti-angiogenic therapy
US8946159B2 (en) 2011-12-22 2015-02-03 California Northstate College Of Pharmacy, Llc Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment
WO2016029131A1 (en) * 2014-08-22 2016-02-25 National Cheng Kung University Disintegrin variants and pharmaceutical uses thereof
AU2019234836A1 (en) * 2018-03-13 2020-09-17 The Regents Of The University Of California Inhibitors of integrin alpha 2 beta 1 and methods of use
CN115916176A (zh) 2020-05-01 2023-04-04 加利福尼亚大学董事会 α2β1整联蛋白的抑制剂和其使用方法
WO2022178218A1 (en) 2021-02-19 2022-08-25 Mevion Medical Systems, Inc. Gantry for a particle therapy system

Family Cites Families (21)

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AU3734693A (en) 1992-03-17 1993-10-21 Board Of Regents, The University Of Texas System Neurotrophic peptides
JP2002514605A (ja) * 1998-05-08 2002-05-21 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア 血管形成を検出および阻害する方法
US6852318B1 (en) * 1998-05-08 2005-02-08 The Regents Of The University Of California Methods for detecting and inhibiting angiogenesis
CA2400040A1 (en) * 2000-02-25 2001-08-30 Immunex Corporation Integrin antagonists
US20040121031A1 (en) 2002-12-09 2004-06-24 Muhammed Majeed Novel topical skin care and nutraceutical applications of Glabridin or extracts containing a defined amount (4-90%) of Glabridin
US7101707B2 (en) 2002-12-23 2006-09-05 Cedars-Sinai Medical Center Secondary sprouting for isolation and expansion of endothelial sprout cells and endothelial precursor cells from a mixed population and for screening substances
UA88294C2 (ru) * 2004-03-24 2009-10-12 Фейсит Биотек Корпорейшен ПРИМЕНЕНИЕ АНТИ-α5β1 АНТИТЕЛ ДЛЯ УГНЕТЕНИЯ ПРОЛИФЕРАЦИИ РАКОВЫХ КЛЕТОК
CA2560508A1 (en) 2004-03-24 2005-10-06 Pdl Biopharma, Inc. Use of anti-alpha5beta1 antibodies to inhibit cancer cell proliferation
EP1898940A4 (en) * 2005-06-07 2010-05-26 Univ Pennsylvania Alpha2beta1 / GPIa IIA INTEGRIN INHIBITORS
KR101201886B1 (ko) 2006-01-19 2012-11-15 아이진 주식회사 펩타이드를 유효성분으로 하는 혈관 관련 질환 치료제 조성물
US20070287664A1 (en) 2006-03-23 2007-12-13 Schering Corporation Combinations of HCV protease inhibitor(s) and CYP3A4 inhibitor(s), and methods of treatment related thereto
US8008256B2 (en) * 2006-05-01 2011-08-30 University Of Southern California Combination therapy for treatment of cancer
US20080267978A1 (en) 2006-08-28 2008-10-30 Mary Zutter Anti-angiogenic targets for cancer therapy
EP2268317B1 (en) 2008-03-14 2020-02-26 VisEn Medical, Inc. Integrin targeting agents and in vivo and in vitro imaging methods using the same
US20100105644A1 (en) 2008-10-27 2010-04-29 The Regents Of The University Of Michigan Botanical composition for enhanced skin repair and uses thereof
JP2012510466A (ja) 2008-12-01 2012-05-10 ライラ ファーマシューティカルズ ピーブイティ．エルティディ． 炎症、皮膚異常及び粘膜異常並びに他の皮膚疾病及び粘膜疾病の治療のための局部用製剤
US8987493B2 (en) 2010-05-20 2015-03-24 Temple University—Of the Commonwealth System of Higher Education Process for synthesis of silane dipeptide analogs
US20110311335A1 (en) * 2010-06-21 2011-12-22 Douglas Wike Removable fastener
US20110319335A1 (en) 2010-06-23 2011-12-29 Xiaodong Feng Combined administration of integrin receptor antagonists for anti-angiogenic therapy
IL210587A0 (en) 2011-01-12 2011-03-31 Adel Jamil Hidmi Natural preparation for treatment of skin sores and lesions
US8946159B2 (en) 2011-12-22 2015-02-03 California Northstate College Of Pharmacy, Llc Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment

Also Published As

Publication number Publication date
EP2793924A1 (en) 2014-10-29
CN104159596A (zh) 2014-11-19
WO2013096335A1 (en) 2013-06-27
EP3777877B1 (en) 2024-08-07
HK1203391A1 (en) 2015-10-30
US20150105320A1 (en) 2015-04-16
US20130225495A1 (en) 2013-08-29
CN104159596B (zh) 2017-03-08
US20220226431A1 (en) 2022-07-21
US12053504B2 (en) 2024-08-06
EP3777877A1 (en) 2021-02-17
US8815805B2 (en) 2014-08-26
EP2793924A4 (en) 2015-08-26
US20200397856A1 (en) 2020-12-24
US10722555B2 (en) 2020-07-28
WO2013096335A8 (en) 2014-03-27
US20240342240A1 (en) 2024-10-17
US11318184B2 (en) 2022-05-03
JP2015506352A (ja) 2015-03-02
US8946159B2 (en) 2015-02-03
US20130165380A1 (en) 2013-06-27
EP2793924B1 (en) 2020-11-04

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