JP6211905B2 - Method for producing ionized metal liquid capable of binding to nutritional components - Google Patents

Description

  The present invention relates to an ionized metal solution that can easily bind a metal (mineral) to proteins (amino acids, etc.), fats (fatty acids), carbohydrates (monosaccharides to polysaccharides) and vitamins that are nutritional components for the human body. And a method of binding a metal to a nutritional component using an ionized metal solution produced by this method.

  Currently, various products including amino acids, hyaluronic acid, and other nutritional components are supplied to the market in the fields of drugs, supplements, cosmetics and the like. Nutrient ingredients for the human body such as amino acids and hyaluronic acid have a certain effect even when ingested alone, but the terminal groups of those organic acids have sodium, potassium, calcium, magnesium, iron, zinc, copper, It is known that when a metal such as manganese is bonded, the absorption efficiency and functionality to the human body can be further improved.

  There are several ways to bond metals to the end groups of organic acids, for example by using sodium hydroxide when binding sodium and using potassium hydroxide when binding potassium. In general, a method is used in which hydrogen of a carboxyl group of an organic acid is replaced with sodium or potassium, that is, acetylation is performed once and sodium ions or potassium ions are bonded in the second stage.

JP 2005-41851 A

  However, it is easy to bind sodium or potassium to the terminal group of the amino acid, but since dihydric or higher hydroxide is insoluble in water, divalent or higher calcium, magnesium, iron, copper, zinc In the case of manganese, etc., there is a problem that it cannot be well bonded by the above method. Moreover, there are various problems in using a strongly alkaline substance in the manufacturing process of drugs, supplements, and cosmetics.

  The present invention is intended to solve the above-described problems in the prior art, and a method for producing an ionized metal liquid capable of binding various metals to various nutritional components including amino acids and hyaluronic acid, And it aims at providing the method of couple | bonding a metal with a nutrient component using the ionized metal liquid manufactured by the said method.

  The method for producing an ionized metal liquid according to the present invention includes, as a main raw material, any one or two or more kinds of dried and crushed loquat, plum fruit, apricot fruit and loquat leaves. While preparing, as an auxiliary material, any one kind or two or more kinds of eggshells, pearls, corals, and shells are prepared, and further, one kind or two or more kinds of target metal powders or foils Prepare the body, mix the main raw material, 3 to 10% by weight of the main raw material and the powder or foil of the target metal, and put them in 200 to 300% by weight of the main raw material water , Sterilize by heating until boiling, then transfer to a fermentation tank after cooling, add 10-30% by weight of koji of the main raw material, maintain the temperature at 41-42 ° C., primary fermentation, then In addition to adding 200-500% water by weight of the main raw material to the fermentation tank Add organic acid-producing bacteria, maintain the temperature at 40-45 ° C., ferment and mature by secondary fermentation, transfer the secondary fermented in the fermentation tank to a metal container, heat and sterilize Then, it is cooled and filtered.

  In addition, when performing heat sterilization, it is preferable to immerse electrodes in water and to apply a low frequency vibration voltage of about 45 to 70 Hz with a supply voltage amplitude of 70 to 130 V to these electrodes, A means for generating an electrostatic magnetic field, a means for supplying electrons to the liquid in the tank by applying an electric potential, and a means for irradiating a sound wave or an ultrasonic wave of 24 to 44 kHz or more are arranged close to each other. Under the influence of the above, it is preferable to mature while supplying electrons and irradiating with sound waves or ultrasonic waves. Furthermore, as an organic acid generating bacterium to be added to the fermentation tank, one or more of citric acid bacteria, citrate enzyme, malic acid bacteria, malic enzyme, acetic acid bacteria, and lactic acid bacteria are used. It is preferable to select and use.

  The method for binding a metal to a nutrient component of the present invention is to prepare an ionized metal solution of a target metal produced by the above-described method for producing an ionized metal solution and an aqueous solution of the nutrient component to be bound, and in the aqueous solution of the nutrient component An amount of ionized metal liquid containing a number of metal ions corresponding to the number of terminals of the nutritional component is added to the aqueous solution of the nutritional component, and the mixed solution is 22 to 44 kHz at a speed of 50 to 100 revolutions per minute. It is characterized by stirring in a magnetic field while applying ultrasonic waves and applying a potential of 1000 to 10000V.

  According to the method of the present invention, it is possible to produce an ionized metal liquid capable of binding various metals to nutritional components such as amino acids and hyaluronic acid, and by treating with this ionized metal liquid, nutrition can be achieved. Various metals can be suitably bonded to the component.

  1st embodiment of this invention is a manufacturing method of an ionized metal liquid, and is implemented by the following procedures. First, as the main raw material, either one kind or two or more kinds of loquat fruit, plum fruit, apricot fruit, loquat leaves (both dry and crushed) are prepared, As an auxiliary material, any one kind or two or more kinds of eggshells, pearls, corals, and shells (all dried and crushed) are prepared. In addition, the target metal (metal to be bound to nutrients such as amino acids and hyaluronic acid) (target metal) powder (calcium powder, magnesium powder, iron powder, zinc powder, copper powder, manganese powder, etc.) Prepare pure metal powder) or metal foil.

  Next, the main raw material, auxiliary raw material (3 to 10% by weight of the main raw material), and metal powder (or metal foil) are mixed, and these are put into water (200 to 300% by weight of the main raw material) and boiled. And sterilize by heating at a temperature of 100 ° C. for 20 minutes or more. When heat sterilization is performed, electrodes are immersed in water, and a low frequency oscillation voltage (AC or DC pulsation voltage) of about 45 to 70 Hz with a supply voltage amplitude of 70 to 130 V is applied to these electrodes. The main raw material and auxiliary raw material in a dry state are usually in a state where oxidation has progressed, but this activates the oxidation-reduction reaction and can be reduced.

  When the heat sterilization is completed, the mixture is cooled to about 40 ° C., transferred to a fermentation tank, and koji (10 to 30% by weight of the main raw material) is added. As the koji added here, mixed koji is preferably used. For example, sake koji, shochu, mirin koji, soy sauce koji, miso, baker's yeast and the like can be used. Once the koji is added, the temperature is maintained at 41-42 ° C. and allowed to sleep for 3-4 weeks to promote fermentation (primary fermentation).

  When the primary fermentation is completed, water is added to the tank (200 to 500% by weight of the main raw material) and organic acid-producing bacteria (10 to 30% by weight of the main raw material) are added to maintain the temperature at 40 to 45 ° C. Let lay for 1-2 weeks, ripen by promoting fermentation (secondary fermentation).

  In the tank, a means for generating an electrostatic magnetic field, a means for supplying an electron (-e) to the liquid in the tank by applying a potential, and a means for irradiating a sound wave or an ultrasonic wave of 24 to 44 kHz or more are arranged close to each other. Then, the liquid in the tank is aged while supplying electrons and irradiating with sound waves or ultrasonic waves under the influence of an electrostatic magnetic field. By such means, the degree of ripening can be increased by about 2 to 3 times, and the time required for ripening is reduced to less than half that of the prior art (more specifically, the time required for 2 months is 1 month) (~ 1 to 2 weeks).

  Examples of organic acid generating bacteria added to the tank include, for example, citric acid bacteria that generate citric acid, citrate enzymes (group I), malic acid bacteria that generate malic acid, and malic enzymes (group II). And acetic acid bacteria (Group III) that generate acetic acid, various other lactic acid bacteria (Group IV), etc., and also a mixture of Group I and Group II, a mixture of Group I and Group III, A mixture of Group I and Group IV, a mixture of Group II and Group III, or a mixture of Group II and Group IV can be mixed and used in various combinations. When applied to cosmetic applications, the group I generating citric acid, and when applied to food applications, the group II generating malic acid, the group III generating acetic acid, apples Acid and acetic acid Mixtures of the above group II and III group to be, or, the group IV, also when applied to a plastic product, the III group that generates acid, or, it is preferable to use the IV group.

  Finally, what was subjected to secondary fermentation in the tank (secondary fermentation liquor) was transferred to a metal container and heated, and sterilized by heating at a temperature of 100 ° C. (center temperature) for 10 minutes or more. Cool to 0 C and filter.

  The ionized metal liquid produced by the method described above has a composition (organic acid metal aqueous solution) composed of a metal, an organic acid, and an electrolyte, and has characteristics such as an electrolyte, ionization, water solubility, and dissociability. For example, when calcium powder is used as the metal powder to be mixed with the main material and the auxiliary material, citrate Ca, citrate acetate Ca, malate Ca, malate acetate Ca, lactate Ca, lactate acetate Ca, and acetate acetate It becomes the form of acetic acid lactate malate Ca and the like. In addition, by using magnesium powder, iron powder, zinc powder, copper powder, manganese powder, etc. as the metal powder to be mixed (replaced with calcium in the above example), organic acid generation added after the end of primary fermentation Various ionized metal solutions (organic acid metal aqueous solutions) can be produced by appropriately selecting the type of bacteria.

  In terms of molecular structure, when calcium powder is used as the metal powder to be mixed with the main raw material and auxiliary raw material, and malic acid bacteria that generate DL-malic acid are used as organic acid generating bacteria added after the end of primary fermentation It becomes as follows.

  In the above example, when calcium is replaced with another metal, it may be chelated and precipitated.

  In addition, as a metal powder to be mixed with the main raw material and the auxiliary raw material, calcium acid is used, and as an organic acid generating bacterium to be added after the end of primary fermentation, malic acid bacterium generating DL-malic acid, and acetic acid bacterium generating acetic acid When mixed and used, the results are as follows.

  Further, when magnesium powder is used as the metal powder to be mixed with the main raw material and the auxiliary raw material, and citric acid bacteria that generate citric acid are used as the organic acid generating bacteria added after the end of the primary fermentation, the following results.

  In this case, the magnesium is chelated but does not precipitate. In the above example (when citric acid bacteria are used), precipitation occurs when calcium is used. Moreover, when iron is used, it is difficult to melt.

  Also, iron powder is used as the metal powder to be mixed with the main raw material and auxiliary raw material, and citric acid bacteria that generate citric acid and acetic acid bacteria that generate acetic acid are mixed as organic acid generating bacteria added after the end of primary fermentation. When used as follows:

  Further, when calcium powder is used as the metal powder to be mixed with the main raw material and the auxiliary raw material, and acetic acid bacteria that generate acetic acid are used as the organic acid generating bacteria added after the end of primary fermentation, the following results.

  In addition, when zinc powder is used as the metal powder to be mixed with the main raw material and auxiliary raw material and acetic acid bacteria that generate acetic acid and lactic acid bacteria are mixed and used as the organic acid generating bacteria added after the end of primary fermentation, It becomes as follows.

  The second embodiment of the present invention is a method of binding a metal to a nutrient component using the ionized metal liquid produced by the method for producing an ionized metal liquid described as the first embodiment, and is carried out by the following procedure. The

  Prepare an aqueous solution of the nutrient component to be combined and an ionized metal solution manufactured using the metal to be combined (target metal), and the number of metal ions corresponding to the number of nutrient components in the aqueous solution Is added to the aqueous solution of nutrient components, and the mixture is stirred at a speed of 50 to 100 revolutions per minute. In addition, stirring is performed in a magnetic field (1000 gauss × 100 to 300) while applying ultrasonic waves of 22 to 44 kHz and applying a potential of 1000 to 10000 V at room temperature of 20 to 40 ° C. Do.

  In addition, the number of the terminal of the nutrient component in the aqueous solution of the nutrient component can be calculated in terms of molecular weight based on the type of the nutrient component, the concentration of the aqueous solution, and the like. Further, the amount of the ionized metal liquid containing the corresponding number of metal ions can be calculated from the amount of the raw material used during the production of the ionized metal liquid.

  If said procedure is implemented, it will be in the state which the ionized metal in an ionized metal liquid couple | bonded with the terminal of the nutrient component in aqueous solution. Hereinafter, a specific example will be described.

  When calcium is bound to cysteine, which is a kind of amino acid, for example, a cysteine solution having a concentration of 10% and an ionized metal solution of calcium (ionized metal as shown in the above “chemical formula 1”, “chemical formula 2”, and “chemical formula 5”) And an ionized metal solution containing a quantity of calcium ions corresponding to the number of cysteine ends in the solution (for example, 5 to 8% by weight of the cysteine solution) is added to the cysteine solution, The mixture is stirred under the conditions described above. If it does so, it will be in the state which the calcium ion couple | bonded with the terminal (carboxyl group) of cysteine as follows.

  In addition, when an appropriate amount of an ionized metal solution is added to an aqueous solution of arginine (Arg), which is a kind of amino acid, and stirred under the above-described conditions, a metal ion is formed at the terminal (carboxyl group) of arginine as described below. It becomes a combined state.

  In “Chemical Formula 8”, the ionized metal in the added ionized metal liquid is inserted into the blank part surrounded by the broken line. For example, when an ionized metal liquid produced using calcium is added, calcium ions are bound to the terminal, and similarly, sodium, potassium, magnesium, iron, copper, zinc, manganese, germanium, titanium, vanadium, In addition to chromium and cobalt, lithium, beryllium, aluminum, silicon, nickel, gallium, selenium, yttrium, zirconium, niobium, molybdenum, ruthenium, rhodium, palladium, silver, indium, tin, barium, tungsten, osmium, iridium, platinum, When an ionized metal liquid produced using gold, lead, bismuth, radium, neodymium, or samarium is added, these ions are bonded to the terminal.

  In addition, when manufacturing an ionized metal liquid, the metal used as a raw material is not limited to one type, It is also possible to use a mixture of two or more of the above metals. Multiple types of metals can be combined. Therefore, the metal can be appropriately selected according to the purpose and can be bound to the target nutrient component.

  In addition, the nutritional component to be a metal binding target is not limited to amino acids as shown in the above “Chemical Formula 7” and “Chemical Formula 8”, but other organic acids (mucopolysaccharide, mucin, keratin, elastin, collagen, Chondroitin, sericin, fibroin, chitosan, etc.), vitamins, carbohydrates, fatty acids, or their conjugates can also be used to easily form the above metals by carrying out the method of this embodiment. It is possible to produce ionized metal-binding nutrients (drugs and supplements) or cosmetics that can be combined and can be expected to have extremely high effects in terms of absorption efficiency and functionality in the human body.

Claims (5)

Prepare one or more kinds of dried and crushed loquat, plum, apricot and loquat leaves as main ingredients, and eggshell, pearls as auxiliary ingredients Prepare one or two or more of corals and shells, and further prepare one or two or more types of target metal powders or foils,
The main raw material, 3 to 10% by weight of the main raw material, and the powder or foil of the target metal are mixed, put in 200 to 300% by weight of the main raw material, and heated until boiling. And sterilize
Then, after cooling, move to the fermentation tank,
Add 10-30 wt% koji of the main raw material, and maintain the temperature at 41-42 ° C for primary fermentation,
Then, in the fermentation tank, 200 to 500% by weight of water as the main raw material is added, and organic acid generating bacteria are added, and the temperature is maintained at 40 to 45 ° C., secondary fermentation is performed, and the product is aged.
Production of ionized metal liquid capable of binding the target metal to nutritional components, characterized by transferring the secondary fermented product in the fermentation tank to a metal container, sterilizing by heating, and then cooling and filtering. Method. 2. The nutrition according to claim 1, wherein when performing heat sterilization, electrodes are immersed in water, and a low-frequency oscillation voltage of about 45 to 70 Hz is applied to these electrodes at a supply voltage amplitude of 70 to 130 V. 3. A method for producing an ionized metal liquid capable of binding a target metal to a component . A means for generating an electrostatic magnetic field, a means for supplying an electron to a liquid in the tank by applying an electric potential, and a means for irradiating a sound wave or an ultrasonic wave of 24 to 44 kHz or more are disposed close to the tank for fermentation. The liquid is aged while supplying electrons and irradiating with sound waves or ultrasonic waves under the influence of an electrostatic magnetic field, and the target metal is added to the nutrient component according to claim 1 or 2. A method for producing a bondable ionized metal liquid. Select one or more of citric acid bacteria, citrate enzyme, malic acid bacteria, malic enzyme, acetic acid bacteria, and lactic acid bacteria as organic acid generating bacteria to be added to the fermentation tank The method for producing an ionized metal liquid capable of binding a target metal to a nutrient component according to claim 1 , wherein the target metal is bound to the nutrient component according to claim 1. Preparing an ionized metal liquid of a target metal produced by a method for producing an ionized metal liquid capable of binding the target metal to the nutritional component according to any one of claims 1 to 4, and an aqueous solution of the nutritional component to be bound;
An amount of ionized metal liquid containing a number of metal ions corresponding to the number of terminals of the nutritional component in the aqueous solution of the nutritional component is added to the aqueous solution of the nutritional component, and the mixture is rotated at a speed of 50 to 100 revolutions per minute. A method of binding a metal to a nutritional component, characterized by stirring in a magnetic field while applying an ultrasonic wave of 22 to 44 kHz and applying a potential of 1000 to 10,000 V.