JP6170498B2 - 関連する物体の走査顕微鏡撮像のための光学顕微鏡プローブ - Google Patents

関連する物体の走査顕微鏡撮像のための光学顕微鏡プローブ Download PDF

Info

Publication number
JP6170498B2
JP6170498B2 JP2014540586A JP2014540586A JP6170498B2 JP 6170498 B2 JP6170498 B2 JP 6170498B2 JP 2014540586 A JP2014540586 A JP 2014540586A JP 2014540586 A JP2014540586 A JP 2014540586A JP 6170498 B2 JP6170498 B2 JP 6170498B2
Authority
JP
Japan
Prior art keywords
probe
optical
lens
housing
microscope
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2014540586A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015504530A5 (https=
JP2015504530A (ja
Inventor
ベルナルドス ヘンドリクス ウィルヘルムス ヘンドリクス
ベルナルドス ヘンドリクス ウィルヘルムス ヘンドリクス
ワルテルス コルネリス ヨゼフ ビールホフ
ワルテルス コルネリス ヨゼフ ビールホフ
ネナド ミハイロヴィチ
ネナド ミハイロヴィチ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips NV filed Critical Koninklijke Philips NV
Publication of JP2015504530A publication Critical patent/JP2015504530A/ja
Publication of JP2015504530A5 publication Critical patent/JP2015504530A5/ja
Application granted granted Critical
Publication of JP6170498B2 publication Critical patent/JP6170498B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00174—Optical arrangements characterised by the viewing angles
    • A61B1/00177—Optical arrangements characterised by the viewing angles for 90 degrees side-viewing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00174—Optical arrangements characterised by the viewing angles
    • A61B1/00179—Optical arrangements characterised by the viewing angles for off-axis viewing
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2423—Optical details of the distal end
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/26—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes using light guides
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
    • G02B26/10—Scanning systems
    • G02B26/103—Scanning systems having movable or deformable optical fibres, light guides or waveguides as scanning elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096—Optical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/02—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices involving prisms or mirrors
    • G02B23/06—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices involving prisms or mirrors having a focussing action, e.g. parabolic mirror
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2446—Optical details of the image relay

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Astronomy & Astrophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Microscoopes, Condenser (AREA)
  • Endoscopes (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)
  • Mechanical Optical Scanning Systems (AREA)
JP2014540586A 2011-11-14 2012-10-31 関連する物体の走査顕微鏡撮像のための光学顕微鏡プローブ Expired - Fee Related JP6170498B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161559179P 2011-11-14 2011-11-14
US61/559,179 2011-11-14
PCT/IB2012/056039 WO2013072796A1 (en) 2011-11-14 2012-10-31 Optical microscopy probe for scanning microscopy of an associated object

Publications (3)

Publication Number Publication Date
JP2015504530A JP2015504530A (ja) 2015-02-12
JP2015504530A5 JP2015504530A5 (https=) 2015-11-26
JP6170498B2 true JP6170498B2 (ja) 2017-07-26

Family

ID=47295100

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014540586A Expired - Fee Related JP6170498B2 (ja) 2011-11-14 2012-10-31 関連する物体の走査顕微鏡撮像のための光学顕微鏡プローブ

Country Status (5)

Country Link
US (1) US11051698B2 (https=)
EP (1) EP2753967B1 (https=)
JP (1) JP6170498B2 (https=)
CN (2) CN113397455B (https=)
WO (1) WO2013072796A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113397455B (zh) 2011-11-14 2024-08-16 皇家飞利浦有限公司 用于相关联的对象的扫描显微镜检查的光学显微镜检查探头
CN105455767A (zh) * 2015-12-22 2016-04-06 佛山市南海区欧谱曼迪科技有限责任公司 一种显微内窥镜系统
EP3719557B1 (en) * 2017-11-30 2025-01-08 Fundació Institut de Ciències Fotòniques Optical endoscope

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4932490A (https=) * 1972-07-24 1974-03-25
US4905082A (en) 1987-05-06 1990-02-27 Olympus Optical Co., Ltd. Rigid video endoscope having a detachable imaging unit
WO1990000754A1 (en) * 1988-07-13 1990-01-25 Martin Russell Harris Scanning confocal microscope
GB8817672D0 (en) * 1988-07-25 1988-09-01 Sira Ltd Optical apparatus
JPH0387804A (ja) 1989-07-13 1991-04-12 Martin R Harris スキャニング共焦点顕微鏡
US6564087B1 (en) * 1991-04-29 2003-05-13 Massachusetts Institute Of Technology Fiber optic needle probes for optical coherence tomography imaging
US6485413B1 (en) * 1991-04-29 2002-11-26 The General Hospital Corporation Methods and apparatus for forward-directed optical scanning instruments
US5445142A (en) * 1994-03-15 1995-08-29 Ethicon Endo-Surgery, Inc. Surgical trocars having optical tips defining one or more viewing ports
US5865725A (en) * 1995-09-13 1999-02-02 Moritex Corporation Image capture instrument with side view angle
JP2001515382A (ja) 1997-03-06 2001-09-18 マサチューセッツ インスティチュート オブ テクノロジー 生体組織の光学走査用機器
WO2001050947A1 (en) * 2000-01-14 2001-07-19 Intuitive Surgical, Inc. Endoscope
AU2001272261A1 (en) * 2000-07-10 2002-01-21 University Health Network Method and apparatus for high resolution coherent optical imaging
FR2836727B1 (fr) * 2002-03-04 2006-02-24 Vincent Lauer Dispositif de balayage optique confocal
US6891984B2 (en) * 2002-07-25 2005-05-10 Lightlab Imaging, Llc Scanning miniature optical probes with optical distortion correction and rotational control
JP4550048B2 (ja) * 2003-05-01 2010-09-22 ギブン イメージング リミテッド パノラマ視野の撮像装置
EP1683074A1 (en) * 2003-11-10 2006-07-26 Technology Innovations, LLC Digital imaging assembly and methods thereof
US20110178409A1 (en) * 2004-02-27 2011-07-21 Optiscan Pty Ltd Optical Element
US9182577B2 (en) 2005-01-21 2015-11-10 Karl Storz Imaging, Inc. Variable direction of view instrument with distal image sensor
JP2006329973A (ja) 2005-04-28 2006-12-07 Hitachi Ltd 走査プローブ顕微鏡およびこれを用いた試料観察方法およびデバイス製造方法
CN1854793A (zh) * 2005-04-28 2006-11-01 株式会社日立制作所 扫描探针显微镜、使用其的试样观察方法及装置制造方法
US7329860B2 (en) * 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
WO2007084849A1 (en) * 2006-01-18 2007-07-26 The General Hospital Corporation System and methods for generating data using one or more endoscopic microscopy techniques
DE102006046554A1 (de) * 2006-09-28 2008-04-03 Jenlab Gmbh Miniaturisierter optischer Kopf für mikroskopische Abbildung und/oder Bearbeitung
JPWO2008081653A1 (ja) * 2006-12-28 2010-04-30 テルモ株式会社 光プローブ
US20080221388A1 (en) * 2007-03-09 2008-09-11 University Of Washington Side viewing optical fiber endoscope
US7999945B2 (en) * 2007-07-18 2011-08-16 The George Washington University Optical coherence tomography / acoustic radiation force imaging probe
US8437587B2 (en) * 2007-07-25 2013-05-07 University Of Washington Actuating an optical fiber with a piezoelectric actuator and detecting voltages generated by the piezoelectric actuator
TWI350368B (en) * 2007-11-16 2011-10-11 Univ Southern Taiwan Tech 3-dof optical measurement probe with in-line beams
GB0809037D0 (en) * 2008-05-19 2008-06-25 Renishaw Plc Video Probe
JP5731389B2 (ja) * 2008-10-22 2015-06-10 コーニンクレッカ フィリップス エヌ ヴェ 光学的な走査プローブのアセンブリ
CN102216828B (zh) * 2008-11-14 2014-04-02 皇家飞利浦电子股份有限公司 光纤扫描探测器
JP2011043793A (ja) * 2009-07-23 2011-03-03 Hoya Corp 走査用対物レンズ、走査型プローブ、及び走査型内視鏡
WO2011059833A2 (en) * 2009-10-29 2011-05-19 California Institute Of Technology Dual-mode raster point scanning/light sheet illumination microscope
JP2011099963A (ja) * 2009-11-05 2011-05-19 Hideaki Ishizuki 高被写界深度マイクロ単レンズ
EP2575597B1 (en) * 2010-05-25 2022-05-04 The General Hospital Corporation Apparatus for providing optical imaging of structures and compositions
CN113397455B (zh) 2011-11-14 2024-08-16 皇家飞利浦有限公司 用于相关联的对象的扫描显微镜检查的光学显微镜检查探头
JPWO2018051439A1 (ja) * 2016-09-14 2019-08-15 オリンパス株式会社 光ファイバスキャナ、照明装置および観察装置

Also Published As

Publication number Publication date
CN103930816A (zh) 2014-07-16
CN113397455B (zh) 2024-08-16
US20140316282A1 (en) 2014-10-23
EP2753967B1 (en) 2023-04-12
EP2753967A1 (en) 2014-07-16
US11051698B2 (en) 2021-07-06
CN113397455A (zh) 2021-09-17
WO2013072796A1 (en) 2013-05-23
JP2015504530A (ja) 2015-02-12

Similar Documents

Publication Publication Date Title
JP6500774B2 (ja) レーザ走査型内視鏡装置
Lee et al. Scanning fiber endoscopy with highly flexible, 1 mm catheterscopes for wide‐field, full‐color imaging
US8705184B2 (en) Multi-path, multi-magnification, non-confocal fluorescence emission endoscopy apparatus and methods
Piyawattanametha et al. In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract
US20130324858A1 (en) Multi-path, multi-magnification, non-confocal fluorescence emission endoscopy apparatus and methods
CN103462645B (zh) 前视光声内窥镜
JPWO2014157645A1 (ja) レーザ走査型観察装置及びレーザ走査方法
CA2850068A1 (en) Scanning optical systems
US12585108B2 (en) Image generating device
JP2011508889A (ja) 光学プローブ
US20200345206A1 (en) Image generating device
JP6170498B2 (ja) 関連する物体の走査顕微鏡撮像のための光学顕微鏡プローブ
Kim et al. Objective-lens-free confocal endomicroscope using Lissajous scanning lensed-fiber
JPWO2017170662A1 (ja) 光学イメージング装置
WO2017070146A1 (en) High resolution microendoscope employing differential structured illumination and method of using same
JP5864105B2 (ja) 光プローブ
Osdoit et al. In vivo fibered confocal reflectance imaging: totally non-invasive morphological cellular imaging brought to the endoscopist
Pivawattanametha MEMS based fiber-optical microendoscopy
Ouzounov et al. High resolution, large field-of-view endomicroscope with optical zoom capability
Huland et al. Compact & Portable In Vivo Multiphoton GRIN Endoscope
JP2006204505A (ja) 生体観察装置
Pattanasak et al. Light microendoscopy with MEMS technology
Zhang et al. Nonlinear Imaging of Intrinsic Tissue Contrast with a Fiberoptic Scanning Endomicroscope
Ge et al. The theoretical and experimental research on endoscopic confocal imaging system
Tearney et al. Spectral Encoding for Endoscopic Confocal Microscopy and Miniature Endoscopy

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151002

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151002

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160816

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161116

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170210

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20170214

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170606

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170630

R150 Certificate of patent or registration of utility model

Ref document number: 6170498

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees