JP6162716B2 - 対象周波数多重経路長ミキサ - Google Patents
対象周波数多重経路長ミキサ Download PDFInfo
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- JP6162716B2 JP6162716B2 JP2014547315A JP2014547315A JP6162716B2 JP 6162716 B2 JP6162716 B2 JP 6162716B2 JP 2014547315 A JP2014547315 A JP 2014547315A JP 2014547315 A JP2014547315 A JP 2014547315A JP 6162716 B2 JP6162716 B2 JP 6162716B2
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
- B01F25/4323—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa using elements provided with a plurality of channels or using a plurality of tubes which can either be placed between common spaces or collectors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F21/00—Dissolving
- B01F21/02—Methods
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
- G01N2030/347—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient mixers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Accessories For Mixers (AREA)
Description
Claims (12)
- マイクロ流体分離システムで使用するためのミキサであって
混合ウェルと、
周知のノイズ特性を有する溶媒組成物の流入流を受けるための分配ウェルと、
分配および混合ウェルの間に設けられた輪郭表面と
を含み、
輪郭表面が、分配ウェルから混合ウェルまで延在する複数の流路を含み、各流路は対向して上方に傾斜した土手によって画定された異なる谷を通過し、溶媒組成の流れは分配ウェルにおいて流路と同じ数のストリームに分割し、流路は、流路の各々によって担持される溶媒組成物の流れの割合を決定する、異なるドエル容積を有し、流路のドエル容積は、溶媒組成物の流れにおいて周知のノイズ特性を対象にするように構成されており、ストリームは、ノイズ特性を減衰させた出力組成ストリームを生成するために流路のドエル容積によって決定された割合にしたがって、混合ウェルにおいて再結合し、
隣り合う谷が稜線で当接し、溶媒組成物は隣り合う谷の間の稜線からあふれることが可能な、ミキサ。 - 流路が異なる長さを有する、請求項1に記載のミキサ。
- 流路が異なる断面積を有する、請求項1に記載のミキサ。
- 任意の流路のドエル容積は、任意の流路の長さと断面積の関数である、請求項1に記載のミキサ。
- 周知のノイズ特性が、溶媒組成物の流れを提供する低圧勾配ポンプシステムによって生成される、請求項1に記載のミキサ。
- 周知のノイズ特性が、溶媒組成物の流れを提供する高圧勾配ポンプシステムによって意図的に生成される、請求項1に記載のミキサ。
- マイクロ流体分離システムであって、
周知のノイズ特性を有する溶媒組成物の流れをポンプ圧送するポンプシステムと、
混合ウェル、周知のノイズ特性を有する溶媒組成物の流れを受けるための分配ウェル、および分配および混合ウェルの間に設けられた輪郭表面を備えるミキサと
を含み、
輪郭表面が、分配ウェルから混合ウェルまで延在する複数の流路を備え、各流路は対向して上方に傾斜した土手によって画定された異なる谷を通過し、溶媒組成の流れは分配ウェルにおいて流路と同じ数のストリームに分割し、流路は、流路の各々によって担持される溶媒組成物の流れの割合を決定する、異なるドエル容積を有し、流路のドエル容積は、溶媒組成物の流れにおいて周知のノイズ特性を対象にするように構成されており、ストリームは、ノイズ特性を減衰させた出力組成ストリームを生成するために流路のドエル容積によって決定された割合にしたがって、混合ウェルにおいて再結合し、
隣り合う谷が稜線で当接し、溶媒組成物の流れは隣り合う谷の間の稜線からあふれることが可能な、マイクロ流体分離システム。 - 流路が異なる長さを有する、請求項7に記載のマイクロ流体分離システム。
- 流路が異なる断面積を有する、請求項7に記載のマイクロ流体分離システム。
- 任意の流路のドエル容積が、任意の流路の長さと断面積の関数である、請求項7に記載のマイクロ流体分離システム。
- ポンプシステムが、周知のノイズ特性を生成する低圧勾配ポンプシステムである、請求項7に記載のマイクロ流体分離システム。
- ポンプシステムが、周知のノイズ特性を生成するために意図的に動作させられる高圧勾配ポンプシステムである、請求項7に記載のマイクロ流体分離システム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161570487P | 2011-12-14 | 2011-12-14 | |
US61/570,487 | 2011-12-14 | ||
PCT/US2012/068438 WO2013090141A1 (en) | 2011-12-14 | 2012-12-07 | Targeted frequency multiple path length mixers |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015505732A JP2015505732A (ja) | 2015-02-26 |
JP6162716B2 true JP6162716B2 (ja) | 2017-07-12 |
Family
ID=48613091
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014547315A Active JP6162716B2 (ja) | 2011-12-14 | 2012-12-07 | 対象周波数多重経路長ミキサ |
Country Status (4)
Country | Link |
---|---|
US (1) | US9968894B2 (ja) |
EP (1) | EP2790821B1 (ja) |
JP (1) | JP6162716B2 (ja) |
WO (1) | WO2013090141A1 (ja) |
Families Citing this family (9)
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GB2524147B (en) * | 2014-02-06 | 2016-02-10 | Waters Technologies Corp | Method for high pressure gradient chromatography using pump stroke control |
US10712321B2 (en) * | 2016-11-02 | 2020-07-14 | Wyatt Technology Corporation | Method to eliminate periodic noise from data collected with a chromatography system |
US11185830B2 (en) | 2017-09-06 | 2021-11-30 | Waters Technologies Corporation | Fluid mixer |
WO2019050698A1 (en) | 2017-09-06 | 2019-03-14 | Waters Technologies Corporation | FLUID MIXER |
DE102018104840A1 (de) | 2018-03-02 | 2018-04-19 | Agilent Technologies Inc. | Fluidmischer mit nichtkreisförmigem Leitungsquerschnitt |
US11555805B2 (en) | 2019-08-12 | 2023-01-17 | Waters Technologies Corporation | Mixer for chromatography system |
CN116134312A (zh) | 2020-07-07 | 2023-05-16 | 沃特世科技公司 | 液相色谱用混合器 |
WO2022010666A1 (en) * | 2020-07-07 | 2022-01-13 | Waters Technologies Corporation | Combination mixer arrangement for noise reduction in fluid chromatography |
US11821882B2 (en) | 2020-09-22 | 2023-11-21 | Waters Technologies Corporation | Continuous flow mixer |
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-
2012
- 2012-12-07 JP JP2014547315A patent/JP6162716B2/ja active Active
- 2012-12-07 WO PCT/US2012/068438 patent/WO2013090141A1/en active Application Filing
- 2012-12-07 EP EP12857685.7A patent/EP2790821B1/en active Active
- 2012-12-07 US US14/362,750 patent/US9968894B2/en active Active
Also Published As
Publication number | Publication date |
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WO2013090141A1 (en) | 2013-06-20 |
EP2790821A1 (en) | 2014-10-22 |
EP2790821A4 (en) | 2015-11-04 |
EP2790821B1 (en) | 2023-07-26 |
JP2015505732A (ja) | 2015-02-26 |
US20140334251A1 (en) | 2014-11-13 |
US9968894B2 (en) | 2018-05-15 |
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