JP6100575B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition.

  In recent years, dry mouth syndrome that feels dry is increasing due to a decrease in salivation due to stress, aging, side effects of drugs, and the like.

  As a technique for improving dry mouth syndrome, for example, an oral composition that suppresses dryness in the oral cavity has been proposed (Patent Document 1).

Special table 2010-519279 gazette

  However, according to the conventional technique, the moistening effect in the oral cavity has not been fully realized, and the persistence of the moistening effect has been poor.

  The subject of this invention is providing the composition for oral cavity which is excellent in the wet effect in an oral cavity, and its sustainability.

The present invention provides the following [1] to [8].
[1] Component (A): pyrrolidone carboxylic acid or a salt thereof,
(B) Component: Composition for oral cavity containing water-soluble polymer.
[2] The composition for oral cavity according to [1], wherein the content of the component (A) is 0.1% by mass to 10% by mass with respect to the total amount of the oral composition.
[3] The composition for oral cavity according to [1] or [2], wherein the content of the component (B) is 0.1% by mass to 5% by mass with respect to the total amount of the oral composition.
[4] The composition for oral cavity according to any one of [1] to [3], wherein the component (B) is nonionic or anionic.
[5] The oral cavity according to any one of [1] to [4], wherein the component (B) is a water-soluble polymer selected from the group consisting of carrageenan, alginic acid and salts thereof, carboxymethylcellulose, and hydroxypropylmethylcellulose. Composition.
[6] Component (A): pyrrolidone carboxylic acid or salt thereof and (C) component: perfluoropolyether derivative, hydrogenated lecithin, hydroxylated lecithin, 1,1′-methylenebis (4-isocyanatocyclohexane) and poly An oral composition containing a compound selected from the group consisting of copolymers with alkylene glycol.
[7] The composition for oral cavity according to any one of [1] to [6], which is a toothpaste or a mouthwash.
[8] The composition for oral cavity according to any one of [1] to [6], which is a toothpaste.

  ADVANTAGE OF THE INVENTION According to this invention, the composition for oral cavity which is excellent in the wetting effect in an oral cavity and its sustainability can be provided.

  Hereinafter, the present invention will be described in detail with reference to preferred embodiments thereof.

[Oral composition]
In one embodiment, the composition for oral cavity of the present invention contains (A) component: pyrrolidone carboxylic acid or a salt thereof, and (B) component: water-soluble polymer.
Hereinafter, such an oral composition may be referred to as “the oral composition of the first embodiment”.

<(A) component>
(A) component contained in the composition for oral cavity of this invention is pyrrolidone carboxylic acid or its salt.

  Pyrrolidone carboxylic acid or a salt thereof is generally a moisturizing ingredient used in skin cosmetics. Pyrrolidone carboxylic acid or a salt thereof is one of skin extracts and is known to have an effect of moisturizing the skin. However, knowledge about the action in the oral cavity of pyrrolidonecarboxylic acid or a salt thereof has not been obtained.

  The present inventors examined the action of such pyrrolidone carboxylic acid or a salt thereof in the oral cavity, but pyrrolidone carboxylic acid or a salt thereof alone does not provide a sufficient oral moistening effect. ((B) component: water-soluble polymer, (C) component: perfluoropolyether derivative, hydrogenated lecithin, hydroxylated lecithin, and 1,1′-methylenebis (4-isocyanatocyclohexane) and polyalkylene glycol When used in combination with a copolymer, it has been found to be significantly superior in the moistness of the oral cavity and the sustainability of the moisture content in the oral cavity, compared to conventional moisturizing ingredients (such as carrageenan). It came to complete the composition for oral cavity of this invention.

  Pyrrolidone carboxylic acid is produced by dehydrating glutamic acid extracted from seaweed, wheat, sugarcane, etc., and has a structure represented by the following formula (1).

  The salt of pyrrolidone carboxylic acid is not particularly limited as long as it is a pharmacologically acceptable salt. Examples of pharmacologically acceptable salts include acid addition salts, base addition salts, and amino acid salts. Specific examples thereof include inorganic acid salts such as hydrochloride, hydrobromide, sulfate, hydroiodide, nitrate, phosphate; citrate, oxalate, acetate, formate, propion Acid salt, benzoate salt, trifluoroacetate salt, maleate salt, tartrate salt, methanesulfonate salt, benzenesulfonate salt, paratoluenesulfonate salt, etc .; sodium salt, potassium salt, calcium salt, magnesium Inorganic base salts such as salts, copper salts, zinc salts, aluminum salts, ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, diisopropylammonium salts; lysine salts, arginine salts, histidine salts, asparagine And amino acid salts such as acid salts and glutamates. Among them, the salt of pyrrolidone carboxylic acid is preferably a water-soluble salt, more preferably a water-soluble inorganic salt, and more preferably an alkali metal salt such as a sodium salt or a potassium salt because of its excellent oral moisturizing effect.

  A commercially available product may be used as the pyrrolidone carboxylic acid. As a commercial item of pyrrolidone carboxylic acid, "AJIDEW A-100 (registered trademark)" by Ajinomoto Co., Inc. is mentioned, for example. As a commercial item of sodium pyrrolidone carboxylate, "AJIDEW NL-50 (registered trademark)" manufactured by Ajinomoto Co., Inc. may be mentioned, for example.

  (A) A component may be used individually by 1 type and may use 2 or more types together.

  The content of the component (A) in the oral composition of the first embodiment is preferably 0.1% by mass or more based on the total amount of the oral composition from the viewpoint of enhancing the wet effect in the oral cavity. The content is more preferably 0.5% by mass or more, and further preferably 1% by mass or more. The upper limit of the content of the component (A) is not particularly limited, but even if added in a large amount, the contribution to improving the wetting effect is limited and results in poor dispersibility. It is preferably 10% by mass or less, more preferably 7.5% by mass or less, and further preferably 5% by mass or less.

  Therefore, the content of the component (A) in the oral composition of the first embodiment is preferably 0.1% by mass to 10% by mass and more preferably 0.5% with respect to the total amount of the oral composition. It is from 0.5% to 7.5% by mass, more preferably from 0.5% to 5% by mass, and even more preferably from 1% to 5% by mass.

  In addition, in this invention, content of each component in an oral composition is based on the preparation amount of each component at the time of manufacturing a composition.

<(B) component>
The component (B) contained in the oral composition of the present invention is a water-soluble polymer.

  As described above, by using such a component (B) in combination with the component (A), it is possible to achieve an oral moisturizing effect excellent enough for the user to realize, The persistence of the wetting effect can be significantly improved.

  In the present invention, the “water-soluble polymer” refers to a polymer that can be dissolved in 1 g or more in 100 g of water at 20 ° C.

As for (B) component, the viscosity (25 degreeC) of 1 mass% aqueous solution becomes like this. Preferably it is 0.1-10000 mPa * s, More preferably, it is 1-5000 mPa * s.
In addition, the viscosity (25 degreeC) of 1% aqueous solution of (B) component uses the B-type viscometer (The rotor of No.1-No.5 is used suitably according to a viscosity), and the rotation speed is 10 per minute It can be measured appropriately at 100 revolutions.

  The water-soluble polymer used as the component (B) is nonionic or anionic from the viewpoint of realizing a composition for oral cavity that is excellent in the oral moisturizing effect and its sustainability in combination with the component (A). It is preferable.

  The water-soluble polymer used as the component (B) may be a natural polymer, a semi-synthetic polymer or a synthetic polymer. Here, “semi-synthetic polymer” refers to a polymer obtained by chemically modifying a natural polymer.

  Examples of natural polymers that can be suitably used as the component (B) include carrageenan, alginic acid and salts thereof, agar, farseleran, and xanthan gum. Here, examples of the salt of alginic acid include alkali metal salts, and sodium salts are preferable.

  Examples of the semisynthetic polymer that can be suitably used as the component (B) include sodium carboxymethylcellulose, hydroxypropylmethylcellulose, methylcellulose, and ethylcellulose.

  Examples of the synthetic polymer that can be suitably used as the component (B) include carboxyvinyl polymer, polyacrylic acid and its salt, polymethacrylic acid and its salt, and polyvinylpyrrolidone. Here, as a salt of polyacrylic acid and a salt of polymethacrylic acid, an alkali metal salt is mentioned, for example, A sodium salt is preferable.

  From the viewpoint of realizing a composition for oral cavity that is particularly excellent in the wetting effect in the oral cavity and its sustainability in combination with the component (A), the component (B) is preferably a natural polymer or a semi-synthetic polymer, Carrageenan, alginic acid and its salt, carboxymethylcellulose, and hydroxypropylmethylcellulose are more preferable. Above all, by using carrageenan, alginic acid and a salt thereof that can be gelled by reacting with calcium ions contained in saliva as a component (B), an oral composition that is extremely excellent in the oral moisturizing effect and its sustainability. Can be realized. The most preferred component (B) is carrageenan from the viewpoint of enhancing the moisturizing effect in the oral cavity and its sustainability.

  (B) A commercial item may be used for a component. Examples of the commercially available carrageenan include “Carrageenan” (product name) manufactured by CP Kelco. Examples of commercially available products of sodium alginate include “Duck Algin” manufactured by Kimika Co., Ltd., and “Na Alginate” manufactured by Kibun Food Chemical Co., Ltd. Examples of commercially available hydroxypropyl methylcellulose include “Metros” manufactured by Shin-Etsu Chemical Co., Ltd. and “Methocel” manufactured by Dow Chemical Co., Ltd.

  (B) A component may be used individually by 1 type and may use 2 or more types together.

  Content of (B) component in the composition for oral cavity of 1st Embodiment is from the viewpoint which can fully realize the wet effect in an oral cavity, and raises the sustainability of the wet effect in an oral cavity with respect to the oral composition whole quantity. It is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and further preferably 1% by mass or more. The upper limit of the content of the component (B) is not particularly limited, but even if it is added in a large amount, the contribution to improving the moisturizing effect in the oral cavity is limited. From the viewpoint of realizing good extrudability in the case of a dentifrice composition, it is preferably 5% by mass or less.

  Therefore, the content of the component (B) in the oral composition of the first embodiment is preferably 0.1% by mass to 10% by mass and more preferably 0.1% with respect to the total amount of the oral composition. It is 5 mass%-5 mass%, More preferably, it is 0.5 mass%-5 mass%, More preferably, it is 1 mass%-5 mass%.

  The composition for oral cavity of 1st Embodiment may contain the (C) component mentioned later in addition to the said (A) component and (B) component.

  When the component (C) is used in the oral composition of the first embodiment, the total content of the component (B) and the component (C) in the oral composition of the first embodiment has a moisturizing effect in the oral cavity. From the viewpoint of being able to fully realize and enhancing the persistence of the moisturizing effect in the oral cavity, it is preferably 0.1% by mass or more, more preferably 0.5% by mass or more with respect to the total amount of the oral composition. Preferably, it is 1 mass% or more. The upper limit of the total content of the component (B) and the component (C) is not particularly limited. However, even if a large amount is added, the contribution to improving the moistening effect in the oral cavity is limited. On the other hand, it is usually 10% by mass or less, and preferably 5% by mass or less from the viewpoint of realizing good extrudability when a dentifrice composition is used.

  When the component (C) is used in the oral composition of the first embodiment, the total content of the component (B) and the component (C) in the oral composition of the first embodiment is the total amount of the oral composition. On the other hand, it is preferably 0.1% by mass to 10% by mass, more preferably 0.1% by mass to 5% by mass, still more preferably 0.5% by mass to 5% by mass, and even more preferably. Is 1% by mass to 5% by mass.

In another embodiment, the oral composition of the present invention comprises (A) component: pyrrolidone carboxylic acid or a salt thereof, and (C) component: perfluoropolyether derivative, hydrogenated lecithin, hydroxylated lecithin, and 1, It contains a compound selected from the group consisting of a copolymer of 1′-methylenebis (4-isocyanatocyclohexane) and polyalkylene glycol.
Hereinafter, such an oral composition may be referred to as “the oral composition of the second embodiment”.

  (A) A component is as having demonstrated the composition for oral cavity of 1st Embodiment, The suitable content in the suitable example and composition for oral cavity is also as having demonstrated previously.

<(C) component>
(C) component contained in the composition for oral cavity of this invention is perfluoropolyether derivative, hydrogenated lecithin, hydroxylated lecithin, 1,1'-methylenebis (4-isocyanatocyclohexane), polyalkylene glycol, It is a compound chosen from the group which consists of a copolymer.

  As described above, by using such a component (C) in combination with the component (A), it is possible to achieve an excellent oral moisturizing effect that can be fully realized by the user. The persistence of the wetting effect can be significantly improved.

  Component (C) is a water-insoluble compound having an amount that can be dissolved in 100 g of water at 20 ° C. of less than 1 g.

  The perfluoropolyether derivative that can be used as the component (C) is not particularly limited as long as it is a perfluorinated polyether compound, and a preferred example is polyperfluoromethylisopropyl ether.

  In the copolymer of 1,1′-methylenebis (4-isocyanatocyclohexane) and polyalkylene glycol that can be used as the component (C), the number of carbon atoms of the oxyalkylene unit contained in the polyalkylene glycol is preferably 1 to 1. 6, more preferably 1-4, even more preferably 2 or 3, and even more preferably 3. Therefore, a preferred specific example of such a copolymer is a copolymer of 1,1'-methylenebis (4-isocyanatocyclohexane) and polypropylene glycol.

  From the viewpoint of realizing a composition for oral cavity that is particularly excellent in the oral moisturizing effect and its sustainability in combination with the component (A), the component (C) includes polyperfluoromethylisopropyl ether and 1,1′-methylenebis. A copolymer of (4-isocyanatocyclohexane) and polyalkylene glycol is particularly preferred.

  (C) A commercial item may be used for a component. Examples of commercially available products of polyperfluoromethyl isopropyl ether include “FOMBLIN HC / 01”, “FOMBLIN HC / 02”, “FOMBLIN HC / 03”, “FOMBLIN HC / 04”, “Nikko Chemicals Corporation”, “ “FOMBLIN HC / 25” and “FOMBLIN HC / R”. Examples of commercially available hydrogenated lecithin include “NIKKOL Resinol S-10” and “NIKKOL Resinol S-PIE” manufactured by Nikko Chemicals Corporation. Examples of commercially available products of lecithin hydroxide include “NIKKOL Resinol SH50” and “NIKKOL Resinol WS-50” manufactured by Nikko Chemicals Corporation. Examples of commercially available copolymers of 1,1′-methylenebis (4-isocyanatocyclohexane) and polypropylene glycol include, for example, “Polyol polymer-2”, “Polyol polymer-14”, “Polyol polymer” manufactured by Nikko Chemicals Co., Ltd. -15 ".

  (C) A component may be used individually by 1 type and may use 2 or more types together.

  The content of the component (C) in the composition for oral cavity of the second embodiment is based on the total amount of the composition for oral cavity from the viewpoint of sufficiently realizing the wet effect in the oral cavity and enhancing the persistence of the wet effect in the oral cavity. It is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and further preferably 1% by mass or more. The upper limit of the content of the component (C) is not particularly limited, but even if it is added in a large amount, the contribution to improving the moisturizing effect in the oral cavity is limited. From the viewpoint of realizing good extrudability in the case of a dentifrice composition, it is preferably 5% by mass or less.

  Therefore, the content of the component (C) in the oral composition of the second embodiment is preferably 0.1% by mass to 10% by mass, more preferably 0.1% with respect to the total amount of the oral composition. It is 5 mass%-5 mass%, More preferably, it is 0.5 mass%-5 mass%, More preferably, it is 1 mass%-5 mass%.

  Regardless of whether the first embodiment or the second embodiment, the shape and dosage form of the oral composition of the present invention are not particularly limited. For example, it can be prepared in various shapes such as a liquid system (liquid, liquid, paste) and a solid system (solid, solid). Examples of dosage forms include toothpastes, liquid dentifrices, liquid dentifrices, toothpaste compositions such as powder dentifrices, mouthwash compositions, coating compositions, oral pasta, mouth freshener compositions, Food forms (for example, chewing gum, tablet candy, candy, gummi, film, troche, etc.) can be mentioned.

  It is preferable that the composition for oral cavity of the present invention is a dentifrice composition or a mouthwash composition because the effect of wetting in the oral cavity can be further enhanced. When the composition for oral cavity of this invention is a dentifrice composition, it is especially preferable that it is a toothpaste.

  Regardless of whether the first embodiment or the second embodiment is used, the composition for oral cavity of the present invention can be used for the composition for oral cavity in addition to the above components, as long as the effects of the present invention are not impaired. Known additive components can be blended. Examples of such additional components include abrasives, thickeners, surfactants, sweeteners, preservatives, fragrances, medicinal ingredients, colorants, brighteners, pH adjusters, solvents, and excipients. It can be appropriately selected depending on the dosage form. Although the specific example of an additional component is shown below, the component which can be mix | blended with the composition for oral cavity of this invention is not restrict | limited to these.

  Examples of the abrasive include silica-based abrasives such as silicic anhydride, crystalline silica, amorphous silica, silica gel, aluminosilicate, zeolite, calcium hydrogen phosphate anhydrous, calcium hydrogen phosphate dihydrate, Examples thereof include calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tertiary calcium phosphate, hydroxyapatite, tetracalcium phosphate, and a synthetic resin abrasive.

  An abrasive | polishing agent may be used individually by 1 type, and may use 2 or more types together. When mix | blending an abrasive | polishing agent, it is preferable that the compounding quantity is 2-40 mass% of the whole composition in a dentifrice, and it is more preferable that it is 5-20 mass%. In a mouthwash, it is preferable that it is 0-10 mass% of the whole composition, and it is more preferable that it is 0-5 mass%.

  Examples of the thickening agent include sorbitol (sorbit), propylene glycol, butylene glycol, glycerin, polyethylene glycol and the like. A thickener may be used individually by 1 type and may use 2 or more types together. When the composition for oral cavity contains a thickener, the content thereof can be determined within a range not hindering the effects of the present invention, and is usually 1 to 60% by mass with respect to the total amount of the composition for oral cavity. .

  As the surfactant, for example, an anionic surfactant, a nonionic surfactant, an amphoteric surfactant and the like can be used.

  Examples of the anionic surfactant include N-acyl amino acid salts, α-olefin sulfonates, N-acyl sulfonates, alkyl sulfates, sulfates of glycerol fatty acid esters, and the like. Of these, N-acylamino acid salts, α-olefin sulfonates, alkyl sulfates and the like are preferable from the viewpoint of versatility, and lauroyl sarcosine sodium, alkyl chain carbon chain length from the viewpoint of foamability and hard water resistance. More preferred are sodium α-olefin sulfonates having 10 to 16 carbon atoms, sodium lauryl sulfate, and the like.

  Nonionic surfactants include, for example, polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated castor oil, glycerin ester polyoxyethylene ether, sucrose fatty acid ester, alkylolamide And glycerin fatty acid ester. Of these, polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, alkylolamide, sorbitan fatty acid ester and the like are preferably used from the viewpoint of versatility. The polyoxyethylene alkyl ether preferably has a carbon chain length of 14 to 18 carbon atoms. The polyoxyethylene alkyl ether preferably has an average ethylene oxide addition mole number of 15 to 30. The polyoxyethylene hydrogenated castor oil preferably has an ethylene oxide average addition mole number (average addition EO) of 20 to 100. The alkylolamide preferably has an alkyl chain with a carbon chain length of 12 to 14 carbon atoms. The sorbitan fatty acid ester preferably has 12 to 18 carbon atoms in the fatty acid. The polyoxyethylene sorbitan fatty acid ester preferably has 16 to 18 carbon atoms in the fatty acid. In addition, the polyoxyethylene sorbitan fatty acid ester preferably has an average ethylene oxide addition mole number of 10 to 40.

  Examples of amphoteric surfactants include alkyl betaine surfactants, amine oxide surfactants, and imidazolinium betaine surfactants. Specific examples of the amphoteric surfactant include coconut oil fatty acid amide alkyl betaine, and coconut oil fatty acid amide propyl betaine is preferable.

  Surfactant may be used individually by 1 type and may use 2 or more types together. When an oral composition contains surfactant, the content is 0-10 mass% normally with respect to oral composition whole quantity, and it is preferable that it is 0.01-5 mass%.

  Examples of the sweetening agent include saccharin sodium, stevioside, neohesperidin hydrochalcone, glycyrrhizin, perilartin, p-methoxycinnamic aldehyde, thaumatin, palatinose, maltitol, xylitol, arabitol and the like. A sweetener may be used individually by 1 type and may use 2 or more types together. When a sweetener is used, the blending amount can be appropriately determined within a range not impairing the effects of the present invention.

  Examples of the preservative include paraoxybenzoic acid esters such as sodium benzoate, methylparaben, ethylparaben, and butylparaben, ethylenediaminetetraacetate, benzalkonium chloride, and the like. A preservative may be used individually by 1 type, and may use 2 or more types together. When the preservative is used, the blending amount can be appropriately determined within a range not impairing the effects of the present invention.

  Examples of the fragrances include natural fragrances, synthetic fragrances (single fragrances), and blended fragrances (oil and fat fragrances (oil-based fragrances), powder fragrances, etc.). A fragrance | flavor may be used individually by 1 type and may use 2 or more types together.

  Natural flavors include, for example, mastic oil, parsley oil, anise oil, eucalyptus oil, winter green oil, cassia oil, menthol oil, spearmint oil, peppermint oil, lemon oil, coriander oil, orange oil, mandarin oil, lime oil , Lavender oil, laurel oil, chamomile oil, cardamom oil, caraway oil, bay oil, lemongrass oil, pine needle oil, neroli oil, rose oil, jasmine oil, Iris concrete, peppermint absolute, rose absolute, orange flower, citrus Oil, mixed fruit oil, strawberry oil, cinnamon oil, clove oil, grape oil, clove oil, thyme oil, sage oil, peppermint oil, rosemary oil, marjoram oil, origanum oil, grapefruit oil, sweetie oil, palm oil, ma Go absolute, orange flower absolute, capsicum extract, ginger oleoresin, pepper oleoresin, and capsicum oleoresin and the like.

  Single flavors include, for example, carvone, anethole, methyl salicylate, cinnamaldehyde, linalool, linalyl acetate, limonene, menthone, menthyl acetate, pinene, octyl aldehyde, citral, pregon, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate Rate, allylcyclohexanepropionate, methylanthranilate, ethylmethylanthranilate, vanillin, undecalactone (γ-undecalactone, δ-undecalactone, etc.), hexanal (trans-2-hexenal, etc.), ethi Non-alcohol, propyl alcohol, butanol, isoamyl alcohol, hexenol (such as cis-3-hexenol), dimethylsulfide, cycloten, furfural, Limethylpyrazine, ethyl lactate, ethyl lioacetate, cineol (1,8-cineole, etc.), mensofuran, linalool oxide, vanillyl butyl ether, isopulegol, furaneol, ethylcyclopentenolone, 2-methylbutyric acid, propionic acid , Decalactone (γ-decalactone, δ-decalactone etc.), nonalactone (γ-nonalactone, δ-nonalactone etc.), hexalactone (γ-hexalactone, δ-hexalactone etc.), isoamyl acetate, benzaldehyde, hexyl acetate, ethyl- 2-methylbutyrate, benzyl alcohol, α-terpineol, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, methyl cinnamate, ethyl β- methylthio propionate, cis-6-nonenol, Caron, methyl jasmonate like.

  The single item fragrance may be a cooling agent. As the cooling sensation agent, menthol, N-ethyl-p-menthane-3-carboxamide, N- (ethoxycarbonylmethyl) -3-p-menthane carboxamide, N, 2,3-trimethyl-2-isopropylbutanamide , 3- (L-methoxy) propane-1,2-diol, menthyl lactate (menthyl lactate), monomenthyl succinate, menthose glycerol acetal, 3-l-menthoxypropane-1,2-diol, menthose glycerol ether, spiranthol And monomenthyl succinate.

  The blended fragrance is a fragrance made by blending a single fragrance and / or a natural fragrance. Examples include menthol micron, strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, tropical fruit flavor, butter flavor, milk flavor, yogurt flavor, fruit mix flavor, herbal mint flavor and the like.

  The form of the fragrance is not limited, and any of essential oil, extract, solid, and powder obtained by spray-drying any of these may be used. When the composition for oral cavity contains a fragrance | flavor raw material, it is preferable that the content is 0.000001-1 mass% with respect to the composition for oral cavity. Moreover, when the flavoring fragrance | flavor which uses the said fragrance | flavor raw material is contained, it is preferable that the content is 0.1-2.0 mass% with respect to the composition for oral cavity.

  Examples of medicinal ingredients include bactericidal or antibacterial agents such as chlorohexidine, triclosan, isopropylmethylphenol, cetylpyridinium chloride, zinc gluconate, and zinc citrate; anticalculus agents such as condensed phosphate and ethane hydroxydiphosphonate; Anti-inflammatory agents such as tranexamic acid, glycyrrhizic acid dipotassium salt, ε-aminocaproic acid, agate extract; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; Astringents such as sodium chloride and allantoin; hypersensitivity inhibitors such as strontium chloride; dentin enhancers such as sodium fluoride, hexafluorosilicic acid and salts thereof; sodium polyphosphate, Stain removing agent sodium phosphate and the like. One medicinal component may be used alone, or two or more medicinal components may be used in combination. The compounding amount in the case of using a medicinal component can be appropriately set within a pharmaceutically acceptable range for each medicinal component.

  Examples of the colorant include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red potato pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, spirulina pigment, and coumarindo pigment. Red 3, No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1 and other legal dyes, riboflavin, copper chlorofin sodium, titanium dioxide and the like. . When the oral composition contains a colorant, the content is preferably 0.00001 to 3% by mass with respect to the total amount of the oral composition.

  Examples of the brightener include waxes such as shellac, carnauba wax, and candelilla wax, and calcium stearate. When the oral composition contains a brightener, the content is preferably 0.01 to 5% by mass with respect to the total amount of the oral composition.

  The pH (20 ° C.) of the oral composition of the present invention is usually 6 to 10, preferably 6 to 9. Examples of the pH adjuster include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, Examples include acids and alkalis such as sodium citrate, sodium hydrogen citrate, sodium phosphate, and sodium dihydrogen phosphate, and buffers. When a pH adjuster is blended, the blending amount can be appropriately determined within a range not impairing the effects of the present invention.

  Examples of the solvent include water and lower alcohols having 3 or less carbon atoms such as ethanol and propanol. The solvent is usually blended in a liquid oral composition. When the composition for oral cavity contains water as a solvent, the content is preferably 20 to 95% by mass with respect to the total amount of the composition for oral cavity. When the oral composition contains a lower alcohol as a solvent, the content is preferably 1 to 20% by mass with respect to the total amount of the oral composition.

  Examples of the excipient include syrup, glucose, fructose, invert sugar, dextrin, oligosaccharide and the like. When the oral composition is a food preparation, an excipient is usually added. When the excipient is blended, the blending amount can be appropriately determined within a range not impairing the effects of the present invention.

  EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to such examples. In the following, “%” means “mass%” unless otherwise specified.

Examples 2-4 , 6, 7, 9-11, 13, 14, 16-18, 20, 21, 23-25, 27, 28, 30-32, 34 and 35 described below , Reference Example 1, The main raw materials used in 5, 8, 12, 15, 19, 22, 26, 29 and 33 and Comparative Examples 1 to 3 are collectively described below.
[Main raw materials used in Examples and Comparative Examples]
<(A) component>
(A-1): Pyrrolidonecarboxylic acid “AJIDEW A-100 (registered trademark)” manufactured by Ajinomoto Co., Inc.
<(B) component>
(B-1): Hydroxypropyl methylcellulose “Metroze” manufactured by Shin-Etsu Chemical Co., Ltd.
(B-2): Carrageenan “Carrageenan” manufactured by CP Kerco
(B-3): Sodium alginate “Duck Argin” manufactured by Kimika Co., Ltd.
<(C) component>
(C-1): Polyperfluoromethyl isopropyl ether “FOMBLIN HC / R” manufactured by Nikko Chemicals Co., Ltd.
(C-2): Hydrogenated lecithin “NIKKOL Resinol S-PIE” manufactured by Nikko Chemicals Co., Ltd.
<Other additive components>
Sodium fluoride (medicinal ingredient), sodium polyphosphate (medicinal ingredient), propylene glycol (viscous agent), 70% by weight sorbitol (viscous agent), sodium lauryl sulfate (surfactant), palm oil fatty acid amidopropyl betaine ( Surfactant), polyoxyethylene hydrogenated castor oil (surfactant), saccharin sodium (sweetener), abrasive silica (abrasive), ε-aminocaproic acid (medicinal ingredient), methyl paraoxybenzoate (preservative), paraoxy Butyl benzoate (preservative), titanium oxide (colorant), red No. 106 (colorant), fragrance, purified water (solvent)
As the additive component, a component conforming to the quasi-drug raw material standard 2006 was used.

Examples 2-4, 6, 7, 9-11, 13, 14, 16-18, 20, 21, 23-25, 27, 28, 30-32, 34 and 35, Reference Examples 1, 5, 8, 12, 15, 19, 22, 26, 29 and 33, and Comparative Examples 1-3
Examples 2 to 4, 6, 7, 9 to 11, 13, 14, 16 to 18, 20, 21, 23 using the components described above and according to the following preparation methods according to the blending amounts shown in Tables 1 to 6. The dentifrice compositions of 25, 27, 28, 30-32, 34 and 35, Reference Examples 1 , 5, 8, 12, 15, 19, 22, 26, 29 and 33 and Comparative Examples 1 to 3 were prepared. . In addition, the compounding quantity of each component shown to Tables 1-6 is the value (AI) converted into a pure part except 70 mass% sorbitol. The compounding quantity of 70 mass% sorbitol is a value as 70 mass% sorbitol. In Tables 1 to 6, “3E-05” means 3 × 10 ⁻⁵ (that is, 0.00003).
About the prepared dentifrice composition, the moisturizing effect in the oral cavity was evaluated according to the following procedure. The evaluation results are shown in Tables 1-6.

(Method for preparing dentifrice composition)
An X phase was prepared by mixing and dissolving the following “(i) useful component for X phase” and “(ii) other additional components for X phase” in purified water. On the other hand, a Y phase was prepared by dissolving or dispersing the following “(iii) Y phase additive component” in propylene glycol at room temperature. Next, the Y phase was added and mixed into the stirring X phase to prepare the Z phase. Finally, in the Z phase, the following “(iv) Z phase additive component” is mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Works), defoamed to 4 kPa, and dentifrice. 1.0 kg (100 parts by mass) was obtained.

(Useful ingredients blended in X phase, Y phase, Z phase and other additive ingredients)
(I) Useful component for X phase: pyrrolidone carboxylic acid (ii) Other additive components for X phase: sodium fluoride, sodium polyphosphate, 70% by mass sorbitol, sodium saccharin (iii) Additive component for Y phase: propylene Additives for glycol, hydroxypropyl methylcellulose, carrageenan, sodium alginate, polyperfluoromethylisopropyl ether, hydrogenated lecithin (iv) Z phase: sodium lauryl sulfate, coconut oil fatty acid amidopropyl betaine, polyoxyethylene hydrogenated castor oil, increased Viscous silica, abrasive silica, ε-aminocaproic acid, methyl paraoxybenzoate, butyl paraoxybenzoate, titanium oxide, red No. 106, fragrance

(Evaluation of actual feeling of moisturizing effect in the oral cavity)
In 10 subjects, a questionnaire was conducted about the actual feeling of the moistening effect in the oral cavity when brushing with a dentifrice composition, and a score (1 to 4 points) was given based on the following score criteria, and the average value Was calculated. Based on the average value of the calculated scores, the degree of actual feeling of the moistening effect in the oral cavity was evaluated based on the following evaluation criteria.
Toothbrushing was carried out by taking about 1 g of the dentifrice composition on a toothbrush and brushing for 3 minutes in each subject.

[Score standard]
4 points: I felt strong moisture in the oral cavity 3 points: I felt moisture in the oral cavity 2 points: I hardly felt moisture in the oral cavity 1 point: I did not feel moisture in the oral cavity

〔Evaluation criteria〕
◎: Average value of 3.5 points or more ○: Average value of 3.0 points or more and less than 3.5 points △: Average value of 2.0 points or more and less than 3.0 points ×: Average value of less than 2.0 points

(Evaluation of water content in the oral cavity)
In 10 subjects, the moisture content of the oral mucosa when dentifrice was brushed using the dentifrice composition was measured with an oral moisture meter (“Mucus” manufactured by Live Co., Ltd.). The measurement was performed for (1) right cheek and (2) left cheek, and the average value of (1) and (2) was calculated for each subject. Furthermore, the average value about 10 test subjects was computed, and the moisture content in the oral cavity was evaluated based on the following evaluation criteria from the average value.
Toothbrushing was carried out by taking about 1 g of the dentifrice composition on a toothbrush and brushing for 3 minutes in each subject. The first measurement was performed immediately after rinsing twice after brushing (“immediately after use”). After 15 minutes, a second measurement was performed (“after 15 minutes”).

〔Evaluation criteria〕
◎: 29% or more ○: 27% or more and less than 29% △: 25% or more and less than 27% × less than 25%

Claims (4)

Component (A): Pyrrolidone carboxylic acid or a salt thereof (excluding N-lauryl-L-arginine ethyl ester / pyrrolidone carboxylate and N-coconut oil fatty acid acyl-L-arginine ethyl-DL-pyrrolidone carboxylate). 1 % by mass to 7.5 % by mass relative to the total amount of the oral composition,
(B) component: Carrageenan, alginic acid and its salt, agar, far celerane, xanthan gum, sodium carboxymethylcellulose, hydroxypropylmethylcellulose, methylcellulose, ethylcellulose, carboxyvinyl polymer, polyacrylic acid and its salt, polymethacrylic acid and its salt, and polyvinyl The composition for oral cavity containing 1 mass%-5 mass% with respect to the oral composition whole quantity of 1 or more types selected from the group which consists of pyrrolidone. The oral composition according to claim 1, wherein the component (B) is at least one selected from the group consisting of carrageenan, alginic acid and salts thereof, carboxymethylcellulose, and hydroxypropylmethylcellulose. The composition for oral cavity of Claim 1 or 2 which is a dentifrice or a mouthwash. The composition for oral cavity of Claim 1 or 2 which is a toothpaste.