JP6092250B2 - メチル４−アミノ−３−クロロ−６−（４−クロロ−２−フルオロ−３−メトキシフェニル）ピリジン−２−カルボキシレートを生成する方法 - Google Patents
メチル４−アミノ−３−クロロ−６−（４−クロロ−２−フルオロ−３−メトキシフェニル）ピリジン−２−カルボキシレートを生成する方法 Download PDFInfo
- Publication number
- JP6092250B2 JP6092250B2 JP2014550511A JP2014550511A JP6092250B2 JP 6092250 B2 JP6092250 B2 JP 6092250B2 JP 2014550511 A JP2014550511 A JP 2014550511A JP 2014550511 A JP2014550511 A JP 2014550511A JP 6092250 B2 JP6092250 B2 JP 6092250B2
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- fluoro
- methyl
- carboxylate
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161582166P | 2011-12-30 | 2011-12-30 | |
| US61/582,166 | 2011-12-30 | ||
| PCT/US2012/072071 WO2013102078A1 (en) | 2011-12-30 | 2012-12-28 | Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015504059A JP2015504059A (ja) | 2015-02-05 |
| JP6092250B2 true JP6092250B2 (ja) | 2017-03-08 |
Family
ID=48695351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014550511A Active JP6092250B2 (ja) | 2011-12-30 | 2012-12-28 | メチル４−アミノ−３−クロロ−６−（４−クロロ−２−フルオロ−３−メトキシフェニル）ピリジン−２−カルボキシレートを生成する方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8754110B2 (enExample) |
| EP (1) | EP2797890B1 (enExample) |
| JP (1) | JP6092250B2 (enExample) |
| KR (1) | KR102065543B1 (enExample) |
| AR (1) | AR089628A1 (enExample) |
| AU (1) | AU2012362268B2 (enExample) |
| BR (1) | BR112014015962B8 (enExample) |
| CA (1) | CA2861611C (enExample) |
| CO (1) | CO7010843A2 (enExample) |
| IL (1) | IL233412B (enExample) |
| IN (1) | IN2014DN05767A (enExample) |
| MX (1) | MX340947B (enExample) |
| NZ (1) | NZ627192A (enExample) |
| PL (1) | PL2797890T3 (enExample) |
| RU (1) | RU2616621C2 (enExample) |
| WO (1) | WO2013102078A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2797933B1 (en) * | 2011-12-30 | 2017-08-16 | Dow AgroSciences LLC | Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters and methods of using the same |
| US20140170058A1 (en) * | 2012-12-13 | 2014-06-19 | Dow Agrosciences Llc | Process for the removal of palladium from 4-amino-3-halo-5-fluoro-6-(aryl) pyridine-2-carboxylates and 4-amino-3-halo-6-(aryl)pyridine-2-carboxylates |
| EP3041849A4 (en) | 2013-09-05 | 2017-04-19 | Dow AgroSciences LLC | Methods for producing borylated arenes |
| TW201625354A (zh) | 2014-06-16 | 2016-07-16 | 陶氏農業科學公司 | 用於製備氧硼基化芳烴之方法 |
| MX2017011447A (es) * | 2015-05-22 | 2018-06-18 | Dow Agrosciences Llc | Recuperacion y / o reuso de un catalizador de paladio despues de una reaccion de acoplamiento suzuki. |
| CN105851037B (zh) * | 2016-05-17 | 2018-09-07 | 陕西上格之路生物科学有限公司 | 一种含氟氯吡啶酯的三元除草组合物 |
| US10087164B2 (en) | 2016-05-19 | 2018-10-02 | Dow Agrosciences Llc | Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct Suzuki coupling |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7145040B2 (en) * | 2004-07-02 | 2006-12-05 | Bristol-Myers Squibb Co. | Process for the preparation of amino acids useful in the preparation of peptide receptor modulators |
| WO2007082076A1 (en) | 2006-01-13 | 2007-07-19 | Dow Agrosciences Llc | 2-(poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides |
| CN101360713B (zh) * | 2006-01-13 | 2012-08-15 | 美国陶氏益农公司 | 6-(多取代芳基)-4-氨基吡啶甲酸酯及其作为除草剂的用途 |
| PL2327694T3 (pl) * | 2007-10-02 | 2013-12-31 | Dow Agrosciences Llc | Podstawione kwasy 4-aminopikolinowe i ich zastosowanie jako herbicydów |
| CN105254652A (zh) * | 2008-01-11 | 2016-01-20 | 陶氏益农公司 | 对1-氟-2-取代的-3-氯苯选择性脱质子化和官能化的方法 |
| GB0902474D0 (en) * | 2009-02-13 | 2009-04-01 | Syngenta Ltd | Chemical compounds |
| US8252938B2 (en) * | 2009-06-08 | 2012-08-28 | Dow Agrosciences, Llc. | Process for the preparation of 6-(aryl)-4-aminopicolinates |
| CA2780203A1 (en) * | 2009-11-19 | 2011-05-26 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
| EP2797933B1 (en) * | 2011-12-30 | 2017-08-16 | Dow AgroSciences LLC | Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters and methods of using the same |
| US20140170058A1 (en) * | 2012-12-13 | 2014-06-19 | Dow Agrosciences Llc | Process for the removal of palladium from 4-amino-3-halo-5-fluoro-6-(aryl) pyridine-2-carboxylates and 4-amino-3-halo-6-(aryl)pyridine-2-carboxylates |
-
2012
- 2012-12-28 BR BR112014015962A patent/BR112014015962B8/pt active IP Right Grant
- 2012-12-28 KR KR1020147020894A patent/KR102065543B1/ko active Active
- 2012-12-28 AU AU2012362268A patent/AU2012362268B2/en active Active
- 2012-12-28 PL PL12862450T patent/PL2797890T3/pl unknown
- 2012-12-28 JP JP2014550511A patent/JP6092250B2/ja active Active
- 2012-12-28 CA CA2861611A patent/CA2861611C/en active Active
- 2012-12-28 WO PCT/US2012/072071 patent/WO2013102078A1/en not_active Ceased
- 2012-12-28 RU RU2014131451A patent/RU2616621C2/ru active
- 2012-12-28 MX MX2014008019A patent/MX340947B/es active IP Right Grant
- 2012-12-28 US US13/729,995 patent/US8754110B2/en active Active
- 2012-12-28 EP EP12862450.9A patent/EP2797890B1/en active Active
- 2012-12-28 NZ NZ627192A patent/NZ627192A/en unknown
- 2012-12-28 IN IN5767DEN2014 patent/IN2014DN05767A/en unknown
-
2013
- 2013-01-02 AR ARP130100011A patent/AR089628A1/es active IP Right Grant
-
2014
- 2014-06-26 IL IL233412A patent/IL233412B/en active IP Right Grant
- 2014-07-18 CO CO14156063A patent/CO7010843A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012362268B2 (en) | 2016-11-17 |
| RU2014131451A (ru) | 2016-02-20 |
| BR112014015962B1 (pt) | 2019-12-17 |
| CA2861611C (en) | 2020-04-21 |
| RU2616621C2 (ru) | 2017-04-18 |
| EP2797890A4 (en) | 2015-09-23 |
| BR112014015962A2 (pt) | 2017-06-13 |
| KR20140117444A (ko) | 2014-10-07 |
| EP2797890A1 (en) | 2014-11-05 |
| IL233412A0 (en) | 2014-08-31 |
| PL2797890T3 (pl) | 2017-06-30 |
| US8754110B2 (en) | 2014-06-17 |
| WO2013102078A1 (en) | 2013-07-04 |
| NZ627192A (en) | 2015-09-25 |
| US20130172566A1 (en) | 2013-07-04 |
| JP2015504059A (ja) | 2015-02-05 |
| CA2861611A1 (en) | 2013-07-04 |
| AU2012362268A1 (en) | 2014-07-31 |
| AR089628A1 (es) | 2014-09-03 |
| KR102065543B1 (ko) | 2020-01-13 |
| BR112014015962B8 (pt) | 2022-10-11 |
| MX340947B (es) | 2016-08-01 |
| MX2014008019A (es) | 2014-12-08 |
| EP2797890B1 (en) | 2016-10-05 |
| CO7010843A2 (es) | 2014-07-31 |
| BR112014015962A8 (pt) | 2017-07-04 |
| IN2014DN05767A (enExample) | 2015-04-10 |
| IL233412B (en) | 2019-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2797933B1 (en) | Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters and methods of using the same | |
| JP2015504059A (ja) | メチル４−アミノ−３−クロロ−６−（４−クロロ−２−フルオロ−３−メトキシフェニル）ピリジン−２−カルボキシレートを生成する方法 | |
| US9376390B2 (en) | Methods of isolating (4-chloro-2-fluoro-3-substituted-phenyl)boronates and methods of using the same | |
| JP6505756B2 (ja) | ４−クロロ−２−フルオロ−３−置換−フェニルボロン酸を単離する方法 |
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