JP6088425B2 - チトクロームｐ４５０阻害剤およびその使用 - Google Patents

チトクロームｐ４５０阻害剤およびその使用 Download PDF

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JP6088425B2
JP6088425B2 JP2013513284A JP2013513284A JP6088425B2 JP 6088425 B2 JP6088425 B2 JP 6088425B2 JP 2013513284 A JP2013513284 A JP 2013513284A JP 2013513284 A JP2013513284 A JP 2013513284A JP 6088425 B2 JP6088425 B2 JP 6088425B2
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alkyl
alkenyl
alkynyl
halo
imidazol
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JP2013527238A (ja
JP2013527238A5 (enExample
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パニッカー，バイジョイ
オエレン，ラムベルタス．，ジェイ．ダブリュー．エム．
タラント，ジェイムス，ジー．
リム，ドン，スン
シュウ，シャオカン
ジュン，デウーン
ケイ． ミシュラ，ラマ，
ケイ． ミシュラ，ラマ，
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アンジオン バイオメディカ コーポレーション
アンジオン バイオメディカ コーポレーション
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biomedical Technology (AREA)
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  • Dermatology (AREA)
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  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
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JP2013513284A 2010-06-01 2011-06-01 チトクロームｐ４５０阻害剤およびその使用 Expired - Fee Related JP6088425B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39669610P 2010-06-01 2010-06-01
US61/396,696 2010-06-01
US201061460243P 2010-12-29 2010-12-29
US61/460,243 2010-12-29
PCT/US2011/038695 WO2011153192A2 (en) 2010-06-01 2011-06-01 Cytochrome p450 inhibitors and uses thereof

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JP2013527238A JP2013527238A (ja) 2013-06-27
JP2013527238A5 JP2013527238A5 (enExample) 2014-08-07
JP6088425B2 true JP6088425B2 (ja) 2017-03-01

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US (3) US8513291B2 (enExample)
EP (1) EP2576544A4 (enExample)
JP (1) JP6088425B2 (enExample)
CN (1) CN102985420B (enExample)
AU (1) AU2011261586B2 (enExample)
CA (1) CA2800664C (enExample)
IL (1) IL223056A (enExample)
WO (1) WO2011153192A2 (enExample)

Families Citing this family (12)

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US10414760B2 (en) 2016-11-29 2019-09-17 Angion Biomedica Corp. Cytochrome P450 inhibitors and uses thereof
US8809372B2 (en) 2011-09-30 2014-08-19 Asana Biosciences, Llc Pyridine derivatives
EP2760854B1 (en) * 2011-09-30 2017-08-30 Asana BioSciences, LLC Imidazole derivatives as cyp17 inhibitors for the treatment of cancer
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
MY167575A (en) 2011-10-14 2018-09-20 Ambit Biosciences Corp Heterocyclic compounds and use thereof as modulators of type iii receptor tyrosine kinases
WO2014015137A2 (en) * 2012-07-18 2014-01-23 Angion Biomedica Corp. Compositions and methods for treating dysproliferative diseases
JO3225B1 (ar) * 2012-11-27 2018-03-08 Lilly Co Eli 6-((s)-1-{1-[5-(2-هيدروكسي-إيثوكسي)-بيريدين-2-يل]-1h-بيرازول-3-يل}إيثيل)-3h-1 ، 3-بنزو ثيازول-2- أون باعتباره مضاد مستقبل ampa يعتمد على tarp- جاما 8
WO2014093960A1 (en) * 2012-12-16 2014-06-19 Angion Biomedica Corp. Compositions and methods for treating disease
EP3180335B1 (en) * 2014-08-11 2021-05-05 Angion Biomedica Corporation Cytochrome p450 inhibitors and uses thereof
CN107531631B (zh) * 2014-12-31 2021-09-03 安吉昂生物医药公司 用于治疗疾病的方法和药剂
GB201602572D0 (en) * 2016-02-12 2016-03-30 Eriksson Leif And Strid Ake And Sirsjö Allan New compound and uses
WO2018202487A1 (en) 2017-05-04 2018-11-08 Basf Se Substituted 5-(haloalkyl)-5-hydroxy-isoxazoles for combating phytopathogenic fungi

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EP0907650B1 (en) 1996-06-27 2002-12-04 Janssen Pharmaceutica N.V. N- 4-(heteroarylmethyl)phenyl]-heteroarylamines
WO2001057008A1 (en) * 2000-02-07 2001-08-09 Abbott Gesellschaft Mit Beschrankter Haftung & Company Kommanditgesellschaft 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors
JP2004509073A (ja) 2000-07-11 2004-03-25 ユニバーシティ・オブ・メリーランド，　ボルティモア 新規なｃ−４置換レチノイド
JP2004524289A (ja) * 2000-12-22 2004-08-12 アストラゼネカ・アクチエボラーグ 治療化合物
AR037797A1 (es) * 2001-12-12 2004-12-01 Tibotec Pharm Ltd Combinacion de inhibidores de proteasa dependientes del citocromo p450
CN1742007A (zh) * 2003-01-22 2006-03-01 伊莱利利公司 甾族激素核受体的吲哚衍生物调控剂
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BRPI0412424A (pt) * 2003-07-10 2006-09-05 Osi Pharm Inc composto, composição farmacêutica, método para tratar doenças dermatológicas ou cancerosas em um mamìfero, composição, e, método para tratar doenças relacionadas com a pele ou cancerosas
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Publication number Publication date
IL223056A (en) 2016-06-30
CA2800664A1 (en) 2011-12-08
US8513291B2 (en) 2013-08-20
WO2011153192A2 (en) 2011-12-08
WO2011153192A3 (en) 2012-04-19
IL223056A0 (en) 2013-02-03
EP2576544A4 (en) 2013-09-11
US8865752B2 (en) 2014-10-21
AU2011261586A1 (en) 2012-12-06
CN102985420B (zh) 2017-07-04
JP2013527238A (ja) 2013-06-27
CA2800664C (en) 2019-09-24
US20130102643A1 (en) 2013-04-25
US20150158853A1 (en) 2015-06-11
EP2576544A2 (en) 2013-04-10
CN102985420A (zh) 2013-03-20
AU2011261586B2 (en) 2015-08-27
US20140018401A1 (en) 2014-01-16

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