JP6078076B2 - キナーゼ阻害剤多形体 - Google Patents

キナーゼ阻害剤多形体 Download PDF

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Publication number
JP6078076B2
JP6078076B2 JP2014541391A JP2014541391A JP6078076B2 JP 6078076 B2 JP6078076 B2 JP 6078076B2 JP 2014541391 A JP2014541391 A JP 2014541391A JP 2014541391 A JP2014541391 A JP 2014541391A JP 6078076 B2 JP6078076 B2 JP 6078076B2
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Japan
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acid
hcl
compound
cancer
pattern
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JP2014541391A
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Japanese (ja)
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JP2014533285A (ja
JP2014533285A5 (enExample
Inventor
ピンダ レン，
ピンダ レン，
マイケル マーティン，
マイケル マーティン，
クリストファー ピーター ウォーラル，
クリストファー ピーター ウォーラル，
スサナ デル リオ ガンセド，
スサナ デル リオ ガンセド，
Original Assignee
インテリカイン， エルエルシー
インテリカイン， エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2014541391A 2011-11-11 2012-11-12 キナーゼ阻害剤多形体 Active JP6078076B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161558962P 2011-11-11 2011-11-11
US61/558,962 2011-11-11
PCT/US2012/064729 WO2013071272A1 (en) 2011-11-11 2012-11-12 Kinase inhibitor polymorphs

Publications (3)

Publication Number Publication Date
JP2014533285A JP2014533285A (ja) 2014-12-11
JP2014533285A5 JP2014533285A5 (enExample) 2015-12-10
JP6078076B2 true JP6078076B2 (ja) 2017-02-08

Family

ID=48290672

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014541391A Active JP6078076B2 (ja) 2011-11-11 2012-11-12 キナーゼ阻害剤多形体

Country Status (5)

Country Link
US (1) US9403820B2 (enExample)
EP (1) EP2776428A4 (enExample)
JP (1) JP6078076B2 (enExample)
HK (1) HK1201271A1 (enExample)
WO (1) WO2013071272A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4903036B2 (ja) 2003-01-06 2012-03-21 アンジオケム・インコーポレーテッド 血液脳関門を通過する担体としてのアプロチニンおよび類似体
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
WO2009127072A1 (en) 2008-04-18 2009-10-22 Angiochem Inc. Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use
CA2740317A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Etoposide and doxorubicin conjugates for drug delivery
WO2010043047A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
US9914754B2 (en) 2008-12-05 2018-03-13 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
AU2009327267A1 (en) 2008-12-17 2011-07-14 Angiochem, Inc. Membrane type-1 matrix metalloprotein inhibitors and uses thereof
ES2729261T3 (es) 2009-04-20 2019-10-31 Angiochem Inc Tratamiento del cáncer de ovario utilizando un agente anticancerígeno conjugado con un análogo de Angiopep-2
WO2011000095A1 (en) 2009-07-02 2011-01-06 Angiochem Inc. Multimeric peptide conjugates and uses thereof
EP2792360A1 (en) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV
CN105745207A (zh) * 2013-10-03 2016-07-06 千年药物公司 使用PI3Kα抑制剂的增强的治疗方案
EP3307326B9 (en) 2015-06-15 2021-02-24 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis
JP2018039755A (ja) * 2016-09-08 2018-03-15 大塚化学株式会社 ナトリウム２α−メチル−２β−（１，２，３−トリアゾール−１−イル）−メチルペナム−３α−カルボン酸１，１−ジオキシド一水和物結晶の製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
DE10050663A1 (de) * 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
US20050043324A1 (en) 2003-06-03 2005-02-24 Tamas Koltai Polymorphic forms of ziprasidone HCI and processes for their preparation
EP1591625A1 (en) * 2004-04-30 2005-11-02 ALSTOM Technology Ltd Gas turbine blade shroud
US7745428B2 (en) * 2005-09-30 2010-06-29 Astrazeneca Ab Imidazo[1,2-A]pyridine having anti-cell-proliferation activity
MX358640B (es) * 2008-01-04 2018-08-29 Intellikine Llc Isoquinolin-1 (2h) -onas y tieno [2,3-d]pirimidin-4(3h) -onas substituidas, y metodos de uso de las mismas.
US8193182B2 (en) * 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8476431B2 (en) * 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
HRP20190016T1 (hr) * 2009-08-17 2019-03-08 Intellikine, Llc Heterociklički spojevi i njihova upotreba

Also Published As

Publication number Publication date
JP2014533285A (ja) 2014-12-11
WO2013071272A1 (en) 2013-05-16
HK1201271A1 (en) 2015-08-28
EP2776428A1 (en) 2014-09-17
US9403820B2 (en) 2016-08-02
EP2776428A4 (en) 2015-04-22
US20150005301A1 (en) 2015-01-01

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