JP6062674B2 - Liquid sweat enhancer - Google Patents
Liquid sweat enhancer Download PDFInfo
- Publication number
- JP6062674B2 JP6062674B2 JP2012163305A JP2012163305A JP6062674B2 JP 6062674 B2 JP6062674 B2 JP 6062674B2 JP 2012163305 A JP2012163305 A JP 2012163305A JP 2012163305 A JP2012163305 A JP 2012163305A JP 6062674 B2 JP6062674 B2 JP 6062674B2
- Authority
- JP
- Japan
- Prior art keywords
- mass
- liquid
- day
- less
- polymer catechins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007788 liquid Substances 0.000 title claims description 105
- 210000004243 sweat Anatomy 0.000 title claims description 30
- 239000003623 enhancer Substances 0.000 title claims description 9
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims description 66
- 235000005487 catechin Nutrition 0.000 claims description 66
- 229920000642 polymer Polymers 0.000 claims description 58
- 150000001765 catechin Chemical class 0.000 claims description 54
- 230000037396 body weight Effects 0.000 claims description 53
- 238000000034 method Methods 0.000 claims description 37
- 230000035900 sweating Effects 0.000 claims description 31
- 230000001737 promoting effect Effects 0.000 claims description 26
- 230000003204 osmotic effect Effects 0.000 claims description 22
- 235000013361 beverage Nutrition 0.000 claims description 21
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 12
- 229950001002 cianidanol Drugs 0.000 claims description 12
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical group OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims description 11
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000001569 carbon dioxide Substances 0.000 claims description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 33
- 244000269722 Thea sinensis Species 0.000 description 25
- 235000013616 tea Nutrition 0.000 description 24
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 21
- 238000012360 testing method Methods 0.000 description 15
- 239000000284 extract Substances 0.000 description 12
- 238000004458 analytical method Methods 0.000 description 11
- 235000003599 food sweetener Nutrition 0.000 description 11
- 239000003765 sweetening agent Substances 0.000 description 11
- 239000003792 electrolyte Substances 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 9
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 229960003975 potassium Drugs 0.000 description 9
- 239000011591 potassium Substances 0.000 description 9
- 229910052700 potassium Inorganic materials 0.000 description 9
- 239000011734 sodium Substances 0.000 description 9
- 229910052708 sodium Inorganic materials 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 150000001720 carbohydrates Chemical class 0.000 description 7
- 235000014633 carbohydrates Nutrition 0.000 description 7
- 235000015165 citric acid Nutrition 0.000 description 7
- 235000002639 sodium chloride Nutrition 0.000 description 7
- 108010038851 tannase Proteins 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 239000003651 drinking water Substances 0.000 description 6
- 235000020188 drinking water Nutrition 0.000 description 6
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000012141 concentrate Substances 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 239000012264 purified product Substances 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 description 4
- 206010019345 Heat stroke Diseases 0.000 description 4
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 239000008122 artificial sweetener Substances 0.000 description 4
- 235000021311 artificial sweeteners Nutrition 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 description 4
- 235000019225 fermented tea Nutrition 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- LVJJFMLUMNSUFN-UHFFFAOYSA-N gallocatechin gallate Natural products C1=C(O)C=C2OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C1OC(=O)C1=CC(O)=C(O)C(O)=C1 LVJJFMLUMNSUFN-UHFFFAOYSA-N 0.000 description 4
- 229940094952 green tea extract Drugs 0.000 description 4
- 235000020688 green tea extract Nutrition 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 238000005070 sampling Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 150000005846 sugar alcohols Chemical class 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 3
- 235000013376 functional food Nutrition 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- XMOCLSLCDHWDHP-SWLSCSKDSA-N (+)-Epigallocatechin Natural products C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-SWLSCSKDSA-N 0.000 description 2
- LSHVYAFMTMFKBA-PZJWPPBQSA-N (+)-catechin-3-O-gallate Chemical compound O([C@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-PZJWPPBQSA-N 0.000 description 2
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 description 2
- WMBWREPUVVBILR-GHTZIAJQSA-N (+)-gallocatechin gallate Chemical compound O([C@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-GHTZIAJQSA-N 0.000 description 2
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 description 2
- LSHVYAFMTMFKBA-TZIWHRDSSA-N (-)-epicatechin-3-O-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-TZIWHRDSSA-N 0.000 description 2
- PJVXUVWGSCCGHT-ZPYZYFCMSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;(3s,4r,5r)-1,3,4,5,6-pentahydroxyhexan-2-one Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO PJVXUVWGSCCGHT-ZPYZYFCMSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- LSHVYAFMTMFKBA-UHFFFAOYSA-N ECG Natural products C=1C=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-UHFFFAOYSA-N 0.000 description 2
- 239000004386 Erythritol Substances 0.000 description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000004376 Sucralose Substances 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 238000003321 atomic absorption spectrophotometry Methods 0.000 description 2
- 238000003287 bathing Methods 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 150000002016 disaccharides Chemical class 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 description 2
- 235000012734 epicatechin Nutrition 0.000 description 2
- 229940030275 epigallocatechin gallate Drugs 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
- 235000019414 erythritol Nutrition 0.000 description 2
- 229940009714 erythritol Drugs 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 235000009569 green tea Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000832 lactitol Substances 0.000 description 2
- 235000010448 lactitol Nutrition 0.000 description 2
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 2
- 229960003451 lactitol Drugs 0.000 description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 2
- 239000000845 maltitol Substances 0.000 description 2
- 235000010449 maltitol Nutrition 0.000 description 2
- 229940035436 maltitol Drugs 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 239000008239 natural water Substances 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 235000019408 sucralose Nutrition 0.000 description 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 235000018553 tannin Nutrition 0.000 description 2
- 229920001864 tannin Polymers 0.000 description 2
- 239000001648 tannin Substances 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 2
- 229940038773 trisodium citrate Drugs 0.000 description 2
- 235000019263 trisodium citrate Nutrition 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- KNIZBZYMVRWQKN-DMTCNVIQSA-N (3s)-3-amino-4-[[(2r)-1-amino-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC(O)=O KNIZBZYMVRWQKN-DMTCNVIQSA-N 0.000 description 1
- VMQCQYRHANDJBP-IUYQGCFVSA-N (3s)-3-amino-4-[[(2r)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](CO)C(N)=O VMQCQYRHANDJBP-IUYQGCFVSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- PVXPPJIGRGXGCY-TZLCEDOOSA-N 6-O-alpha-D-glucopyranosyl-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)C(O)(CO)O1 PVXPPJIGRGXGCY-TZLCEDOOSA-N 0.000 description 1
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- YZQCXOFQZKCETR-UWVGGRQHSA-N Asp-Phe Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 YZQCXOFQZKCETR-UWVGGRQHSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 241000209507 Camellia Species 0.000 description 1
- 241000723438 Cercidiphyllum japonicum Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 238000007696 Kjeldahl method Methods 0.000 description 1
- 241000134253 Lanka Species 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- HLCFGWHYROZGBI-JJKGCWMISA-M Potassium gluconate Chemical compound [K+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O HLCFGWHYROZGBI-JJKGCWMISA-M 0.000 description 1
- 239000001744 Sodium fumarate Substances 0.000 description 1
- 238000000944 Soxhlet extraction Methods 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- YPANSIUOCUYFAO-UHFFFAOYSA-L [Na+].[Na+].[Na+].[O-]C(=O)C(O)C(O)C([O-])=O Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C(O)C(O)C([O-])=O YPANSIUOCUYFAO-UHFFFAOYSA-L 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229940072107 ascorbate Drugs 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 238000004380 ashing Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 235000020279 black tea Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 235000018597 common camellia Nutrition 0.000 description 1
- 229940109275 cyclamate Drugs 0.000 description 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- MSJMDZAOKORVFC-SEPHDYHBSA-L disodium fumarate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C\C([O-])=O MSJMDZAOKORVFC-SEPHDYHBSA-L 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 235000020510 functional beverage Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000019534 high fructose corn syrup Nutrition 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 239000002444 monopotassium citrate Substances 0.000 description 1
- 235000015861 monopotassium citrate Nutrition 0.000 description 1
- 235000016337 monopotassium tartrate Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000020333 oolong tea Nutrition 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- -1 polyethylene terephthalate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 239000004224 potassium gluconate Substances 0.000 description 1
- 235000013926 potassium gluconate Nutrition 0.000 description 1
- 229960003189 potassium gluconate Drugs 0.000 description 1
- 229940086065 potassium hydrogentartrate Drugs 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- PHZLMBHDXVLRIX-UHFFFAOYSA-M potassium lactate Chemical compound [K+].CC(O)C([O-])=O PHZLMBHDXVLRIX-UHFFFAOYSA-M 0.000 description 1
- 239000001521 potassium lactate Substances 0.000 description 1
- 235000011085 potassium lactate Nutrition 0.000 description 1
- 229960001304 potassium lactate Drugs 0.000 description 1
- WKZJASQVARUVAW-UHFFFAOYSA-M potassium;hydron;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [K+].OC(=O)CC(O)(C(O)=O)CC([O-])=O WKZJASQVARUVAW-UHFFFAOYSA-M 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 235000019643 salty taste Nutrition 0.000 description 1
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940005573 sodium fumarate Drugs 0.000 description 1
- 235000019294 sodium fumarate Nutrition 0.000 description 1
- 239000000176 sodium gluconate Substances 0.000 description 1
- 235000012207 sodium gluconate Nutrition 0.000 description 1
- 229940005574 sodium gluconate Drugs 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000015870 tripotassium citrate Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Images
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Tea And Coffee (AREA)
- Non-Alcoholic Beverages (AREA)
Description
本発明は、液状発汗促進剤に関する。 The present invention relates to a liquid perspiration promoter.
熱中症は、夏場などの暑熱条件や運動による発汗で体水分や電解質が失われることにより発症する障害の総称であり、体温の上昇とともにめまいや頭痛、意識障害など様々な症状があらわれることで知られている。その対策として、適切な冷房の使用や、水分の摂取、特に電解質を含む飲料の摂取が推奨されている。 Heat stroke is a general term for disorders that develop due to loss of body water and electrolytes due to heat conditions such as summer and sweating due to exercise, and it is known that various symptoms such as dizziness, headache, and disturbance of consciousness appear as body temperature rises. It has been. As countermeasures, it is recommended to use appropriate air conditioning, intake of water, especially intake of beverages containing electrolytes.
体内に水分や電解質を速やかに補給する飲料として、例えば、電解質及び糖質を含有し、エネルギー量が２１０ｋｃａｌ／Ｌ以上、浸透圧が１００〜２５０ｍＯｓｍ／Ｌである電解質組成物（特許文献１）、電解質成分としてナトリウムイオン、カリウムイオン及び塩化物イオンを特定量含有し、ｐＨが４．２〜６、滴定酸度が３０未満、浸透圧が１６０〜１９０ｍＯｓｍ／Ｌである水分電解質補給飲料（特許文献２）が提案されている。 As a beverage that quickly replenishes the body with water and electrolyte, for example, an electrolyte composition containing an electrolyte and a sugar, having an energy amount of 210 kcal / L or more and an osmotic pressure of 100 to 250 mOsm / L (Patent Document 1), A water electrolyte supplemented beverage containing sodium ions, potassium ions and chloride ions as electrolyte components, having a pH of 4.2 to 6, a titratable acidity of less than 30, and an osmotic pressure of 160 to 190 mOsm / L (Patent Document 2) ) Has been proposed.
しかしながら、熱中症は、環境温度の変化に適切に体が順応できない場合や、加齢による体温調節機能の衰えにより、発汗量が低下した場合にも発症する。前記従来の電解質含有飲料は、水分や電解質を体内に補給するのに有効であるが、発汗の促進を意図するものではなく、前記特許文献にはそれを示唆する記載もない。
そこで、本発明は、発汗を促進することができる液状発汗促進剤、及び発汗促進方法を提供することを課題とする。
However, heat stroke also develops when the body cannot properly adapt to changes in the environmental temperature, or when the amount of sweating decreases due to a decline in body temperature regulation function due to aging. The conventional electrolyte-containing beverage is effective for replenishing the body with water and electrolytes, but does not intend to promote sweating, and the patent document does not have a description suggesting it.
Then, this invention makes it a subject to provide the liquid perspiration promoter which can promote perspiration, and the perspiration promotion method.
かかる状況に鑑み、本発明者らは、発汗を促進できる成分について検討を重ね、非重合体カテキン類を含有し、且つ浸透圧が体液よりも低い液剤を摂取することにより発汗を促進できることを見出した。 In view of such a situation, the present inventors have repeatedly investigated components capable of promoting sweating, and found that sweating can be promoted by ingesting a liquid agent containing non-polymer catechins and having a lower osmotic pressure than body fluid. It was.
すなわち、本発明は、（Ａ）非重合体カテキン類を０．０３〜０．３質量％含有し、かつ（Ｂ）浸透圧が１００〜２７０ｍＯｓｍ／Ｌである液状発汗促進剤、及び当該液状発汗促進剤を摂取する発汗促進方法を提供するものである。 That is, the present invention relates to (A) a non-polymer catechin containing 0.03 to 0.3% by mass and (B) a liquid perspiration promoter having an osmotic pressure of 100 to 270 mOsm / L, and the liquid perspiration The present invention provides a method of promoting sweating by taking an accelerator.
本発明によれば、発汗を促進することができる液状発汗促進剤が提供され、この液状発汗促進剤を経口摂取等することで発汗を促進することができる。したがって、本発明の液状発汗促進剤及び発汗促進方法は、発汗量の低下に伴う熱中症を始めとする諸症状の予防に有効である。 ADVANTAGE OF THE INVENTION According to this invention, the liquid perspiration promoter which can promote perspiration is provided, and perspiration can be accelerated | stimulated by ingesting this liquid perspiration promoter orally. Therefore, the liquid perspiration promoter and the perspiration promotion method of the present invention are effective in preventing various symptoms including heat stroke associated with a decrease in the perspiration amount.
本発明の液状発汗促進剤は、（Ａ）非重合体カテキン類を０．０３〜０．３質量％含有するが、より一層の発汗促進の観点から、（Ａ）非重合体カテキン類の含有量は、０．０５質量％以上が好ましく、０．０７質量％以上がより好ましく、０．０９質量％以上が更に好ましく、摂取しやすさ及び非重合体カテキン類の保存安定性の観点から、０．２５質量％以下が好ましく、０．２質量％以下がより好ましく、０．１５質量％以下が更に好ましい。（Ａ）非重合体カテキン類の含有量の範囲としては、好ましくは０．０５〜０．２５質量％、より好ましくは０．０７〜０．２質量％、更に好ましくは０．０９〜０．１５質量％である。 The liquid perspiration promoter of the present invention contains (A) non-polymer catechins in an amount of 0.03 to 0.3% by mass. From the viewpoint of further promoting perspiration, (A) the inclusion of non-polymer catechins The amount is preferably 0.05% by mass or more, more preferably 0.07% by mass or more, further preferably 0.09% by mass or more, from the viewpoint of easy intake and storage stability of non-polymer catechins, 0.25 mass% or less is preferable, 0.2 mass% or less is more preferable, and 0.15 mass% or less is still more preferable. (A) As content range of non-polymer catechin, Preferably it is 0.05-0.25 mass%, More preferably, it is 0.07-0.2 mass%, More preferably, it is 0.09-0. 15% by mass.
本発明において「（Ａ）非重合体カテキン類」とは、カテキン、カテキンガレート、ガロカテキン及びガロカテキンガレート等の非重合体カテキン類の非エピ体と、エピカテキン、エピガロカテキン、エピカテキンガレート及びエピガロカテキンガレート等の非重合体カテキン類のエピ体を併せての総称である。本発明においては、これら８種の非重合体カテキン類のうち少なくとも１種を含有すればよい。なお、非重合体カテキン類の含有量は、上記８種の合計量に基づいて定義される。 In the present invention, “(A) non-polymer catechins” means non-epimers of non-polymer catechins such as catechin, catechin gallate, gallocatechin and gallocatechin gallate, epicatechin, epigallocatechin, epicatechin gallate and It is a general term that includes epimers of non-polymer catechins such as epigallocatechin gallate. In this invention, what is necessary is just to contain at least 1 sort (s) among these 8 types of non-polymer catechins. The content of non-polymer catechins is defined based on the total amount of the above eight types.
（Ａ）非重合体カテキン類中の（Ｆ）非重合体カテキン類のエピ体の割合（以下、「エピ体率」とも称する。［（Ｆ）／（Ａ）］×１００）は、液状発汗促進剤による発汗促進及び非重合体カテキン類の保存安定性の観点から、７５質量％以上が好ましく、８０質量％以上がより好ましく、８４質量％以上が更に好ましく、９５質量％以下が好ましく、９２質量％以下がより好ましく、９０質量％以下が更に好ましい。エピ体率の範囲としては、好ましくは７５〜９５質量％、より好ましくは８０〜９２質量％、更に好ましくは８４〜９０質量％である。 (A) The ratio of epimer of (F) nonpolymer catechins in nonpolymer catechins (hereinafter also referred to as “epimer ratio” [[F) / (A)] × 100) is liquid sweating. From the viewpoint of promoting sweating by an accelerator and storage stability of non-polymer catechins, 75% by mass or more is preferable, 80% by mass or more is more preferable, 84% by mass or more is further preferable, and 95% by mass or less is preferable. More preferably, it is 90 mass% or less. The range of the epi fraction is preferably 75 to 95% by mass, more preferably 80 to 92% by mass, and still more preferably 84 to 90% by mass.
また、非重合体カテキン類には、エピガロカテキンガレート、ガロカテキンガレート、エピカテキンガレート及びカテキンガレートとからなるガレート体と、エピガロカテキンとガロカテキンとエピカテキン及びカテキンからなる非ガレート体が存在する。本発明に使用する（Ａ）非重合体カテキン類は、（Ａ）非重合体カテキン類中の（Ｇ）非重合体カテキン類のガレート体の割合（以下、「ガレート体率」とも称する。［（Ｇ）／（Ａ）］×１００）は、発汗促進の観点から、５質量％以上が好ましく、１０質量％以上がより好ましく、１５質量％以上が更に好ましく、２０質量％以上が更に好ましく、摂取しやすさ及び安定性の観点から、５５質量％以下が好ましく、５３質量％以下がより好ましく、５０質量％以下が更に好ましく、４６質量％以下が更に好ましい。ガレート体率の範囲としては、好ましくは５〜５５質量％、より好ましくは１０〜５３質量％、更に好ましくは１５〜５０質量％、更に好ましくは２０〜４６質量％である。 Non-polymer catechins include gallate bodies composed of epigallocatechin gallate, gallocatechin gallate, epicatechin gallate and catechin gallate, and non-gallate bodies composed of epigallocatechin, gallocatechin, epicatechin and catechin. . (A) Non-polymer catechins used in the present invention are ratios of gallate bodies of (G) non-polymer catechins in (A) non-polymer catechins (hereinafter also referred to as “gallate body ratio”). (G) / (A)] × 100) is preferably 5% by mass or more, more preferably 10% by mass or more, further preferably 15% by mass or more, and further preferably 20% by mass or more, from the viewpoint of promoting sweating. In light of ease of ingestion and stability, 55% by mass or less is preferable, 53% by mass or less is more preferable, 50% by mass or less is further preferable, and 46% by mass or less is more preferable. As a range of a gallate body rate, Preferably it is 5-55 mass%, More preferably, it is 10-53 mass%, More preferably, it is 15-50 mass%, More preferably, it is 20-46 mass%.
本発明に使用する（Ａ）非重合体カテキン類を入手する方法の例を以下に述べる。
（Ａ）非重合体カテキン類は、一般的には茶葉から抽出した茶抽出物、その濃縮物又はそれらの精製物（以下、これらを包括的に「茶抽出物等」とも称する）に含まれているため、これらから得られるものが好ましく使用される。ここで、「茶抽出物」とは、茶葉から水又は親水性有機溶媒を用いて抽出したものであって、濃縮や精製操作が行われていないものをいう。なお、水としては、例えば、水道水、天然水、蒸留水、膜ろ過水、イオン交換水等が挙げられ、親水性有機溶媒として、例えば、エタノール等のアルコールを挙げることができる。また、抽出方法としては、ニーダー抽出やカラム抽出等の公知の方法を採用することができる。
また、「茶抽出物の濃縮物」とは、上記茶抽出物から溶媒の少なくとも一部を除去して非重合体カテキン類濃度を高めたものをいう。茶抽出物の濃縮物は、例えば、特開昭５９−２１９３８４号公報、特開平４−２０５８９号公報、特開平５−２６０９０７号公報、特開平５−３０６２７９号公報等に記載の方法により調製することができるが、三井農林（株）の「ポリフェノン」、伊藤園（株）の「テアフラン」、太陽化学（株）の「サンフェノン」等の市販品を使用することもできる。
更に、「茶抽出物の精製物」は、茶抽出物又はその濃縮物を溶剤や吸着剤を用いて精製処理し固形分中の非重合体カテキン類の純度を高めたものをいい、例えば、特開２００４−１４７５０８号公報、特開２００７−２８２５６８号公報、特開２００６−１６０６５６号公報、特開２００８−０７９６０９号公報等に記載の方法により調製することができる。
An example of a method for obtaining (A) non-polymer catechins used in the present invention is described below.
(A) Non-polymer catechins are generally contained in a tea extract extracted from tea leaves, a concentrate thereof, or a purified product thereof (hereinafter, these are also collectively referred to as “tea extract etc.”). Therefore, those obtained from these are preferably used. Here, “tea extract” refers to a product extracted from tea leaves using water or a hydrophilic organic solvent, and has not been concentrated or purified. Examples of water include tap water, natural water, distilled water, membrane filtered water, and ion exchange water, and examples of the hydrophilic organic solvent include alcohols such as ethanol. As the extraction method, a known method such as kneader extraction or column extraction can be employed.
The “tea extract concentrate” refers to a product obtained by removing at least part of the solvent from the tea extract to increase the concentration of non-polymer catechins. The concentrate of tea extract is prepared by the method described in, for example, JP-A-59-219384, JP-A-4-20589, JP-A-5-260907, JP-A-5-306279, and the like. However, commercial products such as “Polyphenone” from Mitsui Norin Co., Ltd., “Theafuran” from ITO EN Co., Ltd., and “Sunphenon” from Taiyo Kagaku Co., Ltd. can also be used.
Furthermore, the “purified product of tea extract” refers to a product obtained by purifying a tea extract or a concentrate thereof using a solvent or an adsorbent to increase the purity of non-polymer catechins in the solid content, for example, It can be prepared by the methods described in JP-A-2004-147508, JP-A-2007-282568, JP-A-2006-160656, JP-A-2008-079609, and the like.
抽出に使用する茶葉としては、例えば、Camellia属、例えば、C.var.sinensis（やぶきた種を含む）、C.var.assamica及びそれらの雑種から選択される茶葉が挙げられる。茶葉は、その加工方法により、不発酵茶、半発酵茶、発酵茶に大別することができる。
不発酵茶としては、例えば、煎茶、番茶、玉露、てん茶、釜炒り茶等の緑茶が挙げられ、茎茶、棒茶、芽茶等も使用することができる。また、半発酵茶としては、例えば、鉄観音、色種、黄金桂、武夷岩茶などの烏龍茶が挙げられる。更に、発酵茶としては、ダージリン、アッサム、スリランカなどの紅茶が挙げられる。これらは単独で又は２種以上を組み合わせて用いることができる。中でも、非重合体カテキン類の含有量が高いという点から、緑茶が好ましい。
Examples of the tea leaves used for the extraction include tea leaves selected from the genus Camellia, for example, C. var. Sinensis (including Yabuta species), C. var. Assamica, and hybrids thereof. Tea leaves can be broadly classified into non-fermented tea, semi-fermented tea, and fermented tea depending on the processing method.
Examples of non-fermented tea include green tea such as sencha, bancha, gyokuro, tencha, and kettle roasted tea, and stem tea, stick tea, bud tea, and the like can also be used. Examples of the semi-fermented tea include oolong tea such as iron kannon, color type, golden katsura, and martial arts tea. Furthermore, examples of fermented tea include black teas such as Darjeeling, Assam, and Sri Lanka. These can be used alone or in combination of two or more. Among these, green tea is preferable from the viewpoint that the content of non-polymer catechins is high.
また、ガレート体率を上記範囲内に調整するために、茶抽出物等をタンナーゼ処理してもよい。ここで、「タンナーゼ処理」とは、茶抽出物等をタンナーゼ活性を有する酵素と接触させることをいう。なお、タンナーゼ処理における具体的な操作方法は公知の方法を採用することが可能であり、例えば、特開２００４−３２１１０５号公報に記載の方法を挙げることができる。 In order to adjust the gallate body ratio within the above range, the tea extract or the like may be tannase-treated. Here, “tannase treatment” refers to bringing a tea extract or the like into contact with an enzyme having tannase activity. In addition, the specific operation method in a tannase process can employ | adopt a well-known method, For example, the method of Unexamined-Japanese-Patent No. 2004-321105 can be mentioned.
本発明の液状発汗促進剤は、（Ｂ）浸透圧が１００〜２７０ｍＯｓｍ／Ｌであるが、より一層の発汗促進の観点から、１１０ｍＯｓｍ／Ｌ以上が好ましく、１２０ｍＯｓｍ／Ｌ以上がより好ましく、１３０ｍＯｓｍ／Ｌ以上が更に好ましく、１４０ｍＯｓｍ／Ｌ以上が更に好ましく、２３０ｍＯｓｍ／Ｌ以下が好ましく、２２０ｍＯｓｍ／Ｌ以下がより好ましく、２１０ｍＯｓｍ／Ｌ以下が更に好ましく、２００ｍＯｓｍ／Ｌ以下が更に好ましい。（Ｂ）浸透圧の範囲としては、好ましくは１１０〜２３０ｍＯｓｍ／Ｌ、より好ましくは１２０〜２２０ｍＯｓｍ／Ｌ、更に好ましくは１３０〜２１０ｍＯｓｍ／Ｌ、更に好ましくは１４０〜２００ｍＯｓｍ／Ｌである。ここで、本発明において「（Ｂ）浸透圧」は、氷点降下法により測定した値であり、浸透圧の測定には、例えば、浸透圧計ＯＭ８０２−Ｄ（朝日ライフサイエンス社製）を用いることができる。
（Ｂ）浸透圧は、液剤中の分子濃度により調整することができる。すなわち、（Ａ）非重合体カテキン類、並びに以下に述べる（Ｄ）甘味料、（Ｅ）酸味料、無機塩類等の任意成分の配合量を適宜変更することにより調整することができる。
The liquid perspiration promoter of the present invention has (B) an osmotic pressure of 100 to 270 mOsm / L. From the viewpoint of further promoting perspiration, it is preferably 110 mOsm / L or more, more preferably 120 mOsm / L or more, and 130 mOsm / L. L or more is more preferable, 140 mOsm / L or more is more preferable, 230 mOsm / L or less is preferable, 220 mOsm / L or less is more preferable, 210 mOsm / L or less is further preferable, and 200 mOsm / L or less is more preferable. (B) The range of osmotic pressure is preferably 110 to 230 mOsm / L, more preferably 120 to 220 mOsm / L, still more preferably 130 to 210 mOsm / L, still more preferably 140 to 200 mOsm / L. Here, in the present invention, “(B) osmotic pressure” is a value measured by the freezing point depression method. For the measurement of osmotic pressure, for example, an osmometer OM802-D (manufactured by Asahi Life Science Co., Ltd.) is used. it can.
(B) The osmotic pressure can be adjusted by the molecular concentration in the solution. That is, it can be adjusted by appropriately changing the blending amounts of (A) non-polymer catechins and optional components such as (D) sweeteners, (E) acidulants, inorganic salts described below.
また、本発明の液状発汗促進剤には、液状とするために（Ｃ）水が含まれている。（Ｃ）水としては、医薬又は飲食品の分野で通常使用されるものを適宜選択することができる。具体的には、水道水、天然水、蒸留水、膜ろ過水、イオン交換水等が挙げられる。
本発明の液状発汗促進剤中には、エタノール等、水以外の溶媒を含んでいてもよいが、水分吸収を促進し、発汗を効果的に促進するという観点より、（Ｃ）水の含有量は、８０質量％以上が好ましく、８５質量％以上がより好ましく、９０質量％以上が更に好ましく、９９．５質量％以下が好ましく、９９質量％以下がより好ましく、９８．５質量％以下が更に好ましい。（Ｃ）水の含有量の範囲としては、好ましくは８０〜９９．５質量％、より好ましくは８５〜９９質量％、更に好ましくは９０〜９８．５質量％である。
In addition, the liquid perspiration promoter of the present invention contains (C) water to make it liquid. (C) As water, what is normally used in the field | area of a pharmaceutical or food-drinks can be selected suitably. Specific examples include tap water, natural water, distilled water, membrane filtered water, and ion exchange water.
The liquid sweat accelerator of the present invention may contain a solvent other than water, such as ethanol, but from the viewpoint of promoting moisture absorption and effectively promoting sweating, (C) Water content Is preferably 80% by mass or more, more preferably 85% by mass or more, still more preferably 90% by mass or more, preferably 99.5% by mass or less, more preferably 99% by mass or less, and further 98.5% by mass or less. preferable. (C) As content range of water, Preferably it is 80-99.5 mass%, More preferably, it is 85-99 mass%, More preferably, it is 90-98.5 mass%.
また、本発明の液状発汗促進剤は、（Ｄ）甘味料を含有していてもよい。
（Ｄ）甘味料としては、例えば、炭水化物、糖アルコール、人工甘味料が挙げられる。これらは１種又は２種以上を組み合わせて使用することができる。
炭水化物は、単糖、二糖、多糖又はそれらの混合物を含むものである。単糖としては、例えば、グルコース、フルクトース等が挙げられ、二糖としては、例えば、スクロース、マルトース、イソマルツロース（商標名：パラチノース）等が挙げられ、多糖としては、例えば、澱粉、デキストリン等が挙げられ、混合物としては、例えば、ブドウ糖果糖液糖、果糖ブドウ糖液糖等が挙げられる。中でも、浸透圧の上昇抑制の観点から、多糖が好ましい。
糖アルコールとしては、例えば、グリセロール、エリスリトール、ソルビトール、キシリトール、マルチトール、ラクチトール、マンニトール、タガトース等を挙げることができる。
人工甘味料としては、例えば、スクラロース、サッカリン、シクラメート、アセスルフェーム−Ｋ、Ｌ−アスパルチル−Ｌ−フェニルアラニン低級アルキルエステル、Ｌ−アスパルチル−Ｄ−アラニンアミド、Ｌ−アスパルチル−Ｄ−セリンアミド、Ｌ−アスパルチル−ヒドロキシメチルアルカンアミド、Ｌ−アスパルチル−１−ヒドロキシエチルアルカンアミド、グリチルリチン等が挙げられる。
中でも、（Ｄ）甘味料としては、浸透圧の制御及びカロリー低減の観点から、炭水化物と、糖アルコール及び人工甘味料から選ばれる少なくとも１種との組み合わせが好ましい。
Moreover, the liquid perspiration promoter of this invention may contain the (D) sweetener.
Examples of (D) sweeteners include carbohydrates, sugar alcohols, and artificial sweeteners. These can be used alone or in combination of two or more.
Carbohydrates include monosaccharides, disaccharides, polysaccharides or mixtures thereof. Examples of monosaccharides include glucose and fructose. Examples of disaccharides include sucrose, maltose, and isomaltulose (trade name: palatinose). Examples of polysaccharides include starch and dextrin. Examples of the mixture include glucose fructose liquid sugar and fructose glucose liquid sugar. Among these, polysaccharides are preferable from the viewpoint of suppressing increase in osmotic pressure.
Examples of the sugar alcohol include glycerol, erythritol, sorbitol, xylitol, maltitol, lactitol, mannitol, tagatose and the like.
Examples of the artificial sweetener include sucralose, saccharin, cyclamate, acesulfame-K, L-aspartyl-L-phenylalanine lower alkyl ester, L-aspartyl-D-alanine amide, L-aspartyl-D-serine amide, L- Examples include aspartyl-hydroxymethylalkanamide, L-aspartyl-1-hydroxyethylalkanamide, and glycyrrhizin.
Among these, as the sweetener (D), a combination of a carbohydrate and at least one selected from sugar alcohols and artificial sweeteners is preferable from the viewpoint of controlling osmotic pressure and reducing calories.
本発明の液状発汗促進剤中の（Ｄ）甘味料の合計含有量は、（Ｂ）浸透圧が上記範囲内となるように適宜決定することが可能であるが、甘味のバランスの観点から、０．０００１質量％以上が好ましく、０．００１質量％以上がより好ましく、０．０１質量％以上が更に好ましく、１０質量％以下が好ましく、８質量％以下がより好ましく、６質量％以下が更に好ましい。（Ｄ）甘味料の合計含有量の範囲としては、好ましくは０．０００１〜１０質量％、より好ましくは０．００１〜８質量％、更に好ましくは０．０１〜６質量％である。 The total content of the (D) sweetener in the liquid sweat accelerator of the present invention can be appropriately determined so that the (B) osmotic pressure is within the above range, but from the viewpoint of the balance of sweetness, 0.0001 mass% or more is preferable, 0.001 mass% or more is more preferable, 0.01 mass% or more is further preferable, 10 mass% or less is preferable, 8 mass% or less is more preferable, and 6 mass% or less is further preferable. (D) As a range of the total content of a sweetener, Preferably it is 0.0001-10 mass%, More preferably, it is 0.001-8 mass%, More preferably, it is 0.01-6 mass%.
更に、本発明の液状発汗促進剤は、（Ｅ）酸味料を含有していてもよい。
（Ｅ）酸味料としては、アスコルビン酸、クエン酸、グルコン酸、コハク酸、酒石酸、乳酸、フマル酸、リン酸、リンゴ酸、アジピン酸及びそれらの塩類から選ばれる１種又は２種以上を含有することができる。塩類としては、例えば、アスコルビン酸ナトリウム等のアスコルビン酸塩；クエン酸三ナトリウム、クエン酸一カリウム、クエン酸三カリウム等のクエン酸塩；グルコン酸ナトリウム、グルコン酸カリウム等のグルコン酸塩；酒石酸ナトリウム、酒石酸三ナトリウム、酒石酸水素カリウム等の酒石酸塩；乳酸ナトリウム、乳酸カリウム等の乳酸塩；フマル酸ナトリウム等を挙げることができる。中でも、（Ｅ）酸味料としては、クエン酸及びクエン酸塩から選ばれる少なくとも１種が好ましく、クエン酸とクエン酸三ナトリウムの併用がより好ましい。塩類の併用により、ナトリウム、カリウム等の電解質を補給することができる。
Furthermore, the liquid perspiration promoter of the present invention may contain (E) a sour agent.
(E) As a sour agent, one or more selected from ascorbic acid, citric acid, gluconic acid, succinic acid, tartaric acid, lactic acid, fumaric acid, phosphoric acid, malic acid, adipic acid and salts thereof are contained. can do. Examples of salts include ascorbate such as sodium ascorbate; citrate such as trisodium citrate, monopotassium citrate and tripotassium citrate; gluconate such as sodium gluconate and potassium gluconate; sodium tartrate And tartrate salts such as trisodium tartrate and potassium hydrogen tartrate; lactates such as sodium lactate and potassium lactate; sodium fumarate and the like. Especially, as (E) acidulant, at least 1 sort (s) chosen from a citric acid and a citrate is preferable, and combined use of a citric acid and trisodium citrate is more preferable. By using the salts together, electrolytes such as sodium and potassium can be replenished.
本発明の液状発汗促進剤中の（Ｅ）酸味料の合計含有量は、適度な酸味による嗜好性向上の観点から、０．０１質量％以上が好ましく、０．０３質量％以上がより好ましく、０．０５質量％以上が更に好ましく、５質量％以下が好ましく、４．５質量％以下がより好ましく、４質量％以下が更に好ましい。（Ｅ）酸味料の合計含有量の範囲としては、好ましくは０．０１〜５質量％、より好ましくは０．０３〜４．５質量％、更に好ましくは０．０５〜４質量％である。 The total content of the (E) acidulant in the liquid sweat accelerator of the present invention is preferably 0.01% by mass or more, more preferably 0.03% by mass or more, from the viewpoint of improving palatability due to moderate acidity. 0.05 mass% or more is further preferable, 5 mass% or less is preferable, 4.5 mass% or less is more preferable, and 4 mass% or less is still more preferable. (E) As a range of the total content of a sour agent, Preferably it is 0.01-5 mass%, More preferably, it is 0.03-4.5 mass%, More preferably, it is 0.05-4 mass%.
更に、本発明の液状発汗促進剤は、無機塩類を含有していてもよい。無機塩類としては、塩化ナトリウム、塩化カリウム、塩化カルシウム、塩化マグネシウム、炭酸ナトリウム、炭酸カリウム、炭酸カルシウム、炭酸マグネシウム等から選ばれる１種又は２種以上を使用することができる。
本発明の液状発汗促進剤１００ｍＬ当たりのナトリウムの含有量は、１０ｍｇ／１００ｍＬ以上が好ましく、２０ｍｇ／１００ｍＬ以上がより好ましく、３０ｍｇ／１００ｍＬ以上が更に好ましく、８０ｍｇ／１００ｍＬ以下が好ましく、塩味の抑制の観点から、６０ｍｇ／１００ｍＬ以下がより好ましく、４０ｍｇ／１００ｍＬ以下がより好ましい。かかるナトリウム含有量の範囲としては、好ましくは１０〜８０ｍｇ／１００ｍＬ、より好ましくは２０〜６０ｍｇ／１００ｍＬ、更に好ましくは３０〜４０ｍｇ／１００ｍＬである。
また、本発明の液状発汗促進剤１００ｍＬ当たりのカリウムの含有量は、０．５ｍｇ／１００ｍＬ以上が好ましく、１ｍｇ／１００ｍＬ以上がより好ましく、２ｍｇ／１００ｍＬ以上が更に好ましく、４０ｍｇ／１００ｍＬ以下が好ましく、３０ｍｇ／１００ｍＬ以下がより好ましく、２０ｍｇ／１００ｍＬ以下がより好ましい。かかるカリウム含有量の範囲としては、好ましくは０．５〜４０ｍｇ／１００ｍＬ、より好ましくは１〜３０ｍｇ／１００ｍＬ、更に好ましくは２〜２０ｍｇ／１００ｍＬである。
なお、ナトリウム及びカリウムの含有量には、茶成分その他の配合成分由来のものも含まれる。
Furthermore, the liquid perspiration promoter of the present invention may contain inorganic salts. As the inorganic salt, one or more selected from sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium carbonate, potassium carbonate, calcium carbonate, magnesium carbonate and the like can be used.
The content of sodium per 100 mL of the liquid perspiration promoter of the present invention is preferably 10 mg / 100 mL or more, more preferably 20 mg / 100 mL or more, further preferably 30 mg / 100 mL or more, preferably 80 mg / 100 mL or less, and suppress salty taste. From the viewpoint, 60 mg / 100 mL or less is more preferable, and 40 mg / 100 mL or less is more preferable. The range of the sodium content is preferably 10 to 80 mg / 100 mL, more preferably 20 to 60 mg / 100 mL, and still more preferably 30 to 40 mg / 100 mL.
Further, the content of potassium per 100 mL of the liquid perspiration promoter of the present invention is preferably 0.5 mg / 100 mL or more, more preferably 1 mg / 100 mL or more, further preferably 2 mg / 100 mL or more, preferably 40 mg / 100 mL or less, 30 mg / 100 mL or less is more preferable, and 20 mg / 100 mL or less is more preferable. The range of the potassium content is preferably 0.5 to 40 mg / 100 mL, more preferably 1 to 30 mg / 100 mL, and still more preferably 2 to 20 mg / 100 mL.
The sodium and potassium contents include those derived from tea ingredients and other blending ingredients.
また、本発明の液状発汗促進剤は、口当たりの向上や爽快感の付与の観点から、炭酸ガスを含有することができる。圧入する炭酸ガスは、ガス容量比で０．５〜４．０が好ましく、１〜３．５がより好ましく、２〜３が更に好ましい。ここで、本発明において「ガス容量比（ガスボリューム）」とは、２０℃において液状発汗促進剤の容量に対する溶解している炭酸ガス容量の比率をいう。 Moreover, the liquid perspiration promoter of this invention can contain a carbon dioxide gas from a viewpoint of the improvement of mouthfeel or provision of a refreshing feeling. The carbon dioxide gas to be injected is preferably 0.5 to 4.0 in terms of gas volume ratio, more preferably 1 to 3.5, and still more preferably 2 to 3. Here, in the present invention, the “gas volume ratio (gas volume)” refers to the ratio of the volume of dissolved carbon dioxide gas to the volume of the liquid perspiration promoter at 20 ° C.
更に、本発明の液状発汗促進剤には、香料、果汁、ビタミン、酸化防止剤、エステル類、色素、乳化剤、保存料、調味料、野菜エキス、花蜜エキス、品質安定剤、苦味抑制剤等の添加剤を１種又は２種以上を組み合わせて配合してもよい。これら添加剤の含有量は、本発明の目的を損なわない範囲内で適宜決定することができる。 Further, the liquid perspiration promoter of the present invention includes flavors, fruit juices, vitamins, antioxidants, esters, pigments, emulsifiers, preservatives, seasonings, vegetable extracts, nectar extracts, quality stabilizers, bitterness inhibitors, etc. You may mix | blend an additive 1 type or in combination of 2 or more types. The content of these additives can be appropriately determined within a range that does not impair the object of the present invention.
本発明の液状発汗促進剤は、腸管での吸収促進の観点から、２５℃におけるｐＨが３〜６であること好ましく、３〜５がより好ましく、３〜４が更に好ましい。 From the viewpoint of promoting absorption in the intestinal tract, the liquid sweat accelerator of the present invention preferably has a pH at 25 ° C. of 3 to 6, more preferably 3 to 5, and still more preferably 3 to 4.
本発明の液状発汗促進剤の温度は特に限定されないが、摂取し易さの観点から、５〜４０℃が好ましく、５〜３５℃が更に好ましい。 Although the temperature of the liquid perspiration promoter of the present invention is not particularly limited, it is preferably 5 to 40 ° C, more preferably 5 to 35 ° C, from the viewpoint of ease of ingestion.
本発明の液状発汗促進剤は、過剰なカロリー摂取を防ぐ観点より、カロリーが２０ｋｃａｌ／１００ｍＬ以下であることが好ましく、１〜１５ｋｃａｌ／１００ｍＬがより好ましく、２〜１０ｋｃａｌ／１００ｍＬが更に好ましく、２〜５ｋｃａｌ／１００ｍＬが更に好ましい。カロリーは、「修正アトウォーター法」により求めることができる。すなわち、カロリーは、たんぱく質は１ｇにつき４ｋｃａｌで算出し、脂質は１ｇにつき９ｋｃａｌで算出し、炭水化物は１ｇにつき４ｋｃａｌで算出し、例えばソルビトール、キシリトール及びクエン酸は１ｇにつき３ｋｃａｌで算出し、例えばマルチトール及びラクチトールは１ｇにつき２ｋｃａｌで算出し、エリスリトール及びスクラロースは１ｇにつき０ｋｃａｌで算出して求めることができる。具体的な算出方法は、厚生労働省、新開発食品保険対策室通知の「栄養表示基準における栄養成分等の分析方法等について」の平成１１年４月２６日衛新第１３号新開発食品保険対策室通知「（別添）３４ 熱量」に記載されており、これらの記載を本明細書に援用する。 From the viewpoint of preventing excessive intake of calories, the liquid sweat accelerator of the present invention preferably has a calorie of 20 kcal / 100 mL or less, more preferably 1 to 15 kcal / 100 mL, still more preferably 2 to 10 kcal / 100 mL, 5 kcal / 100 mL is more preferable. The calorie can be obtained by the “corrected atwater method”. That is, calories are calculated at 4 kcal per gram for protein, 9 kcal per gram for lipid, 4 kcal per gram for carbohydrate, for example, 3 kcal per gram for sorbitol, xylitol and citric acid, for example maltitol And lactitol can be calculated at 2 kcal per gram, and erythritol and sucralose can be calculated at 0 kcal per gram. The specific calculation method is the Ministry of Health, Labor and Welfare and the Newly Developed Food Insurance Countermeasures Office “Analytical Methods for Nutritional Components, etc. in Nutrition Labeling Standards” April 26, 1999 Newly Developed Food Insurance Measures It is described in the room notification “(attachment) 34 calorie”, and these descriptions are incorporated in this specification.
本発明の液状発汗促進剤を摂取することで、発汗を促進することができる。
本発明の液状発汗促進剤の摂取量及び摂取回数は、摂取する対象の年齢、体重、症状の程度等によって適宜決定することができるが、体重１ｋｇ当たりの一日摂取量として、３ｍＬ／体重ｋｇ／日以上が好ましく、６ｍＬ／体重ｋｇ／日以上がより好ましく、８ｍＬ／体重ｋｇ／日以上が更に好ましく、３０ｍＬ／体重ｋｇ／日以下が好ましく、２５ｍＬ／体重ｋｇ／日以下がより好ましく、２０ｍＬ／体重ｋｇ／日以下が更に好ましい。当該摂取量の範囲としては、３〜３０ｍＬ／体重ｋｇ／日が好ましく、６〜２５ｍＬ／体重ｋｇ／日がより好ましく、８〜２０ｍＬ／体重ｋｇ／日が更に好ましい。
By ingesting the liquid perspiration promoter of the present invention, perspiration can be promoted.
The intake amount and the number of intakes of the liquid sweat accelerator of the present invention can be appropriately determined according to the age, weight, symptom level, etc. of the subject to be ingested, but the daily intake per 1 kg body weight is 3 mL / kg body weight. / ML or more, preferably 6 mL / kg body weight / day or more, more preferably 8 mL / kg body weight / day or more, preferably 30 mL / kg body weight / day or less, more preferably 25 mL / kg body weight / day or less, 20 mL More preferably / kg body weight / day or less. The intake range is preferably 3 to 30 mL / kg body weight / day, more preferably 6 to 25 mL / kg body weight / day, and still more preferably 8 to 20 mL / kg body weight / day.
また、本発明の液状発汗促進剤の摂取量は、体重１ｋｇ当たりの非重合体カテキン類の一日摂取量として、４ｍｇ／体重ｋｇ／日以上が好ましく、７ｍｇ／体重ｋｇ／日以上がより好ましく、１０ｍｇ／体重ｋｇ／日以上が更に好ましく、１２ｍｇ／体重ｋｇ／日以上が更に好ましく、３５ｍｇ／体重ｋｇ／日以下が好ましく、３０ｍｇ／体重ｋｇ／日以下がより好ましく、２５ｍｇ／体重ｋｇ／日以下が更に好ましく、２０ｍｇ／体重ｋｇ／日以下が更に好ましい。当該摂取量の範囲としては、４〜３５ｍｇ／体重ｋｇ／日が好ましく、７〜３０ｍｇ／体重ｋｇ／日がより好ましく、１０〜２５ｍｇ／体重ｋｇ／日が更に好ましく、１２〜２０ｍｇ／体重ｋｇ／日が更に好ましい。 In addition, the intake amount of the liquid sweat promoter of the present invention is preferably 4 mg / kg body weight / day or more, more preferably 7 mg / kg body weight / day or more as the daily intake of non-polymer catechins per 1 kg body weight. 10 mg / kg body weight / day or more is more preferred, 12 mg / kg body weight / day or more is more preferred, 35 mg / kg body weight / day or less is preferred, 30 mg / kg body weight / day or less is more preferred, 25 mg / kg body weight / day The following is more preferable, and 20 mg / kg body weight / day or less is more preferable. The intake range is preferably 4 to 35 mg / kg body weight / day, more preferably 7 to 30 mg / kg body weight / day, still more preferably 10 to 25 mg / kg body weight / day, and 12 to 20 mg / kg body weight / day. Day is even more preferred.
更に、本発明の液状発汗促進剤の一日摂取量は、１８０ｍＬ／日以上が好ましく、３００ｍＬ／日以上がより好ましく、４８０ｍＬ／日以上が更に好ましく、１８００ｍＬ／日以下が好ましく、１５００ｍＬ／日以下がより好ましく、１２００ｍＬ／日以下が更に好ましい。当該摂取量の範囲としては、１８０〜１８００ｍＬ／日が好ましく、３００〜１５００ｍＬ／日がより好ましく、４８０〜１２００ｍＬ／日が更に好ましい。 Further, the daily intake of the liquid sweat accelerator of the present invention is preferably 180 mL / day or more, more preferably 300 mL / day or more, further preferably 480 mL / day or more, preferably 1800 mL / day or less, preferably 1500 mL / day or less. Is more preferable, and 1200 mL / day or less is still more preferable. The range of the intake is preferably 180 to 1800 mL / day, more preferably 300 to 1500 mL / day, and still more preferably 480 to 1200 mL / day.
また、非重合体カテキン類の一日摂取量としては、２００ｍｇ／日以上が好ましく、３００ｍｇ／日以上がより好ましく、４００ｍｇ／日以上がより好ましく、５００ｍｇ／日以上が更に好ましい。また、２２００ｍｇ／日以下が好ましく、１８００ｍｇ／日以下がより好ましく、１５００ｍｇ／日以下が更に好ましく、１２００ｍｇ／日以下が更に好ましい。当該摂取量の範囲としては、２００〜２２００ｍｇ／日が好ましく、３００〜１８００ｍｇ／日がより好ましく、４００〜１５００ｍｇ／日が更に好ましく、５００〜１２００ｍｇ／日が更に好ましい。 The daily intake of non-polymer catechins is preferably 200 mg / day or more, more preferably 300 mg / day or more, more preferably 400 mg / day or more, and even more preferably 500 mg / day or more. Moreover, 2200 mg / day or less is preferable, 1800 mg / day or less is more preferable, 1500 mg / day or less is still more preferable, 1200 mg / day or less is still more preferable. The range of the intake is preferably 200 to 2200 mg / day, more preferably 300 to 1800 mg / day, still more preferably 400 to 1500 mg / day, and still more preferably 500 to 1200 mg / day.
本発明の液状発汗促進剤は、一日摂取量を１回で摂取しても、急激な水分摂取による利尿を抑制するために少量ずつ複数回に分けて摂取してもよい。少量ずつ複数回に分けて摂取する場合は、一日摂取量を１０分間以上、望ましくは２０分間以上、より望ましくは３０分間以上の間隔をあけて２〜１０回に分けて摂取することが好ましい。また、チューブ付き水筒、例えばハイドレーションシステム等を用いて連続的あるいは間欠的に摂取することが好ましい。
また、本発明の液状発汗促進剤の摂取時期は特に限定なく、食事時や食間等適宜選択することができる。
The liquid sweat enhancer of the present invention may be taken in a single daily dose, or may be taken in several small portions in order to suppress diuresis due to rapid water intake. When taking a small amount in multiple doses, the daily intake is preferably 10 minutes or more, preferably 20 minutes or more, more preferably 30 minutes or more at intervals of 2 to 10 times. . Moreover, it is preferable to ingest continuously or intermittently using a water bottle with a tube, for example, a hydration system.
Moreover, the intake time of the liquid perspiration promoter of the present invention is not particularly limited, and can be selected as appropriate during meals and between meals.
本発明の液状発汗促進剤は、汗腺を有する哺乳動物であれば特に限定されず、ヒトを含む任意の哺乳動物に投与することが可能であるが、ヒトが好ましい。 The liquid perspiration promoter of the present invention is not particularly limited as long as it is a mammal having sweat glands, and can be administered to any mammal including humans, but humans are preferred.
本発明の液状発汗促進剤は、後掲の実施例に示すように、水を摂取した場合に比して発汗量を有意に増加させる作用を有する。したがって、本発明の液状発汗促進剤は、発汗量の低下に伴う熱中症を始めとする諸症状の予防に有効である。 The liquid sweat enhancer of the present invention has an action of significantly increasing the amount of sweat as compared with the case of ingesting water, as shown in the Examples below. Therefore, the liquid perspiration promoter of the present invention is effective in preventing various symptoms including heat stroke associated with a decrease in the perspiration amount.
本発明の液状発汗促進剤を医薬品として使用する場合、通常経口摂取するが、経鼻的に、または経腸的に摂取することもできる。
また、本発明の液状発汗促進剤を飲食品として使用する場合には、機能性飲料として提供することができる。ここで、機能性飲料とは保健機能食品をいい、保健機能食品には日本国が定める特定保健用食品及び栄養機能食品等が包含される。
When the liquid sweat enhancer of the present invention is used as a pharmaceutical, it is usually taken orally, but can also be taken nasally or enterally.
Moreover, when using the liquid perspiration promoter of this invention as food-drinks, it can provide as a functional drink. Here, the functional beverage refers to a health functional food, and the health functional food includes a food for specified health and a nutritional functional food defined by Japan.
また、本発明の液状発汗促進剤は、ポリエチレンテレフタレートを主成分とする成形容器（いわゆるＰＥＴボトル）、金属缶、金属箔やプラスチックフィルムと複合された紙容器、瓶等の通常の包装容器に充填して提供することができる。その場合、例えば、金属缶のような容器に充填後、加熱殺菌できる場合にあっては適用されるべき法規（日本にあっては食品衛生法）に定められた殺菌条件で製造できる。ＰＥＴボトル、紙容器のようにレトルト殺菌できないものについては、あらかじめ上記と同等の殺菌条件、例えばプレート式熱交換器などで高温短時間殺菌後、一定の温度まで冷却して容器に充填する等の方法が採用できる。また無菌下で、充填された容器に別の成分を配合して充填してもよい。 In addition, the liquid perspiration promoter of the present invention fills ordinary packaging containers such as molded containers mainly composed of polyethylene terephthalate (so-called PET bottles), metal cans, paper containers combined with metal foil and plastic films, and bottles. Can be provided. In this case, for example, when the container can be heat sterilized after being filled in a container such as a metal can, it can be manufactured under the sterilization conditions stipulated in the applicable regulations (the Food Sanitation Law in Japan). For PET bottles and paper containers that cannot be sterilized by retort, sterilize under the same conditions as above, for example, after sterilizing at high temperature and short time with a plate heat exchanger, etc. The method can be adopted. Moreover, you may mix | blend another component with the filled container under aseptic conditions.
上述した実施形態に関し、本発明は更に以下の液状発汗促進剤、発汗促進方法を開示する。
＜１＞
（Ａ）非重合体カテキン類を０．０３〜０．３質量％含有し、かつ（Ｂ）浸透圧が１００〜２７０ｍＯｓｍ／Ｌである、液状発汗促進剤。
In relation to the above-described embodiment, the present invention further discloses the following liquid perspiration promoter and perspiration promotion method.
<1>
(A) A liquid perspiration promoter containing 0.03-0.3% by mass of non-polymer catechins and (B) an osmotic pressure of 100-270 mOsm / L.
＜２＞
当該液状発汗促進剤中の（Ａ）非重合体カテキン類の含有量が、好ましくは０．０５質量％以上、より好ましくは０．０７質量％以上、更に好ましくは０．０９質量％以上であって、好ましくは０．２５質量％以下、より好ましくは０．２質量％以下、更に好ましくは０．１５質量％以下である、前記＜１＞記載の液状発汗促進剤。
＜３＞
当該液状発汗促進剤中の（Ａ）非重合体カテキン類の含有量が、０．０５〜０．２５質量％、より好ましくは０．０７〜０．２質量％、更に好ましくは０．０９〜０．１５質量％である、前記＜１＞記載の液状発汗促進剤。
＜４＞
（Ａ）非重合体カテキン類中の（Ｆ）非重合体カテキン類のエピ体の割合（［（Ｆ）／（Ａ）］×１００）が、好ましくは７５質量％以上、より好ましくは８０質量％以上、更に好ましくは８４質量％以上であって、好ましく９５質量％以下、より好ましくは９２質量％以下、更に好ましくは９０質量％以下である、前記＜１＞〜＜３＞のいずれか一に記載の液状発汗促進剤。
＜５＞
（Ａ）非重合体カテキン類中の（Ｆ）非重合体カテキン類のエピ体の割合（［（Ｆ）／（Ａ）］×１００）が、好ましくは７５〜９５質量％、より好ましくは８０〜９２質量％、更に好ましくは８４〜９０質量％である、前記＜１＞〜＜３＞のいずれか一に記載の液状発汗促進剤。
＜６＞
（Ａ）非重合体カテキン類中の（Ｇ）非重合体カテキン類のガレート体の割合（［（Ｇ）／（Ａ）］×１００）が、好ましくは５質量％以上、より好ましくは１０質量％以上、更に好ましくは１５質量％以上、更に好ましくは２０質量％以上であって、好ましくは５５質量％以下、より好ましくは５３質量％以下、更に好ましくは５０質量％以下、更に好ましくは４６質量％以下である、前記＜１＞〜＜５＞のいずれか一に記載の液状発汗促進剤。
＜７＞
（Ａ）非重合体カテキン類中の（Ｇ）非重合体カテキン類のガレート体の割合（［（Ｇ）／（Ａ）］×１００）が、好ましくは５〜５５質量％、より好ましくは１０〜５３質量％、更に好ましくは１５〜５０質量％、更に好ましくは２０〜４６質量％である、前記＜１＞〜＜５＞のいずれか一に記載の液状発汗促進剤。
＜８＞
（Ｂ）浸透圧が、好ましくは１１０ｍＯｓｍ／Ｌ以上、より好ましくは１２０ｍＯｓｍ／Ｌ以上、更に好ましくは１３０ｍＯｓｍ／Ｌ以上、更に好ましくは１４０ｍＯｓｍ／Ｌ以上であって、好ましくは２３０ｍＯｓｍ／Ｌ以下、より好ましくは２２０ｍＯｓｍ／Ｌ以下、更に好ましくは２１０ｍＯｓｍ／Ｌ以下、更に好ましくは２００ｍＯｓｍ／Ｌ以下である、前記＜１＞〜＜７＞のいずれか一に記載の液状発汗促進剤。
＜９＞
（Ｂ）浸透圧が、好ましくは１１０〜２３０ｍＯｓｍ／Ｌ、より好ましくは１２０〜２２０ｍＯｓｍ／Ｌ、更に好ましくは１３０〜２１０ｍＯｓｍ／Ｌ、更に好ましくは１４０〜２００ｍＯｓｍ／Ｌである、前記＜１＞〜＜７＞のいずれか一に記載の液状発汗促進剤。
＜１０＞
（Ｃ）水を含有する、前記＜１＞〜＜９＞のいずれか一に記載の液状発汗促進剤。
＜１１＞
当該液状発汗促進剤中の（Ｃ）水の含有量が、好ましくは８０質量％以上、より好ましくは８５質量％以上、更に好ましくは９０質量％以上であって、好ましくは９９．５質量％以下、より好ましくは９９質量％以下、更に好ましくは９８．５質量％以下である、前記＜１０＞記載の液状発汗促進剤。
＜１２＞
当該液状発汗促進剤中の（Ｃ）水の含有量が、好ましくは８０〜９９．５質量％、より好ましくは８５〜９９質量％、更に好ましくは９０〜９８．５質量％である、前記＜１０＞記載の液状発汗促進剤。
<2>
The content of the (A) non-polymer catechins in the liquid sweat accelerator is preferably 0.05% by mass or more, more preferably 0.07% by mass or more, and further preferably 0.09% by mass or more. The liquid perspiration promoter according to the above <1>, preferably 0.25% by mass or less, more preferably 0.2% by mass or less, and still more preferably 0.15% by mass or less.
<3>
The content of (A) non-polymer catechins in the liquid perspiration promoter is 0.05 to 0.25% by mass, more preferably 0.07 to 0.2% by mass, and still more preferably 0.09 to The liquid sweat accelerator according to <1>, which is 0.15% by mass.
<4>
The proportion of epimer of (F) non-polymer catechins in (A) non-polymer catechins ([(F) / (A)] × 100) is preferably 75% by mass or more, more preferably 80% by mass. % Or more, more preferably 84% by mass or more, preferably 95% by mass or less, more preferably 92% by mass or less, and still more preferably 90% by mass or less. Any one of the above items <1> to <3> Liquid sweating promoter described in 1.
<5>
The ratio of the epimer of (F) non-polymer catechins in (A) non-polymer catechins ([(F) / (A)] × 100) is preferably 75 to 95% by mass, more preferably 80 -92 mass%, More preferably, it is 84-90 mass%, The liquid perspiration promoter as described in any one of said <1>-<3>.
<6>
(A) The ratio ([(G) / (A)] × 100) of the gallate form of (G) non-polymer catechins in the non-polymer catechins is preferably 5% by mass or more, more preferably 10% by mass. % Or more, more preferably 15% by weight or more, further preferably 20% by weight or more, preferably 55% by weight or less, more preferably 53% by weight or less, still more preferably 50% by weight or less, and further preferably 46% by weight. % Of the liquid perspiration promoter according to any one of <1> to <5>.
<7>
(A) The ratio ([(G) / (A)] × 100) of the gallate body of (G) non-polymer catechins in the non-polymer catechins is preferably 5-55% by mass, more preferably 10 -53 mass%, More preferably, it is 15-50 mass%, More preferably, it is 20-46 mass%, The liquid perspiration promoter as described in any one of said <1>-<5>.
<8>
(B) The osmotic pressure is preferably 110 mOsm / L or more, more preferably 120 mOsm / L or more, further preferably 130 mOsm / L or more, still more preferably 140 mOsm / L or more, preferably 230 mOsm / L or less, more preferably The liquid perspiration promoter according to any one of <1> to <7>, wherein is 220 mOsm / L or less, more preferably 210 mOsm / L or less, and even more preferably 200 mOsm / L or less.
<9>
(B) The osmotic pressure is preferably 110 to 230 mOsm / L, more preferably 120 to 220 mOsm / L, still more preferably 130 to 210 mOsm / L, still more preferably 140 to 200 mOsm / L, <1> to <7> The liquid perspiration promoter according to any one of 7>.
<10>
(C) The liquid perspiration promoter according to any one of <1> to <9>, containing water.
<11>
The content of (C) water in the liquid perspiration promoter is preferably 80% by mass or more, more preferably 85% by mass or more, still more preferably 90% by mass or more, and preferably 99.5% by mass or less. More preferably, it is 99 mass% or less, More preferably, it is 98.5 mass% or less, The liquid perspiration promoter of said <10> description.
<12>
The content of (C) water in the liquid perspiration promoter is preferably 80 to 99.5% by mass, more preferably 85 to 99% by mass, and still more preferably 90 to 98.5% by mass. 10> Liquid sweating promoter according to the above.
＜１３＞
更に、（Ｄ）甘味料を含有し、（Ｄ）甘味料が炭水化物と、糖アルコール及び人工甘味料から選ばれる少なくとも１種との組み合わせである、前記＜１＞〜＜１２＞のいずれか一に記載の液状発汗促進剤。
＜１４＞
当該液状発汗促進剤中の（Ｄ）甘味料の合計含有量が、好ましくは０．０００１質量％以上、より好ましくは０．００１質量％以上、更に好ましくは０．０１質量％以上であって、好ましくは１０質量％以下、より好ましくは８質量％以下、更に好ましくは６質量％以下である、前記＜１３＞記載の液状発汗促進剤。
＜１５＞
当該液状発汗促進剤中の（Ｄ）甘味料の合計含有量が、好ましくは０．０００１〜１０質量％、より好ましくは０．００１〜８質量％、更に好ましくは０．０１〜６質量％である、前記＜１３＞記載の液状発汗促進剤。
＜１６＞
更に、（Ｅ）酸味料を含有し、（Ｅ）酸味料がクエン酸及びクエン酸塩から選ばれる少なくとも１種である、前記＜１＞〜＜１５＞のいずれか一に記載の液状発汗促進剤。
＜１７＞
当該液状発汗促進剤中の（Ｅ）酸味料の合計含有量が、好ましくは０．０１質量％以上、より好ましくは０．０３質量％以上、更に好ましくは０．０５質量％以上であって、好ましくは５質量％以下、より好ましくは４．５質量％以下、更に好ましくは４質量％以下である、前記＜１６＞記載の液状発汗促進剤。
＜１８＞
当該液状発汗促進剤中の（Ｅ）酸味料の合計含有量が、好ましくは０．０１〜５質量％、より好ましくは０．０３〜４．５質量％、更に好ましくは０．０５〜４質量％である、前記＜１６＞記載の液状発汗促進剤。
＜１９＞
当該液状発汗促進剤１００ｍＬ当たりのナトリウムの含有量が、好ましくは１０ｍｇ／１００ｍＬ以上、より好ましくは２０ｍｇ／１００ｍＬ以上、更に好ましくは３０ｍｇ／１００ｍＬ以上であって、好ましくは８０ｍｇ／１００ｍＬ以下、より好ましくは６０ｍｇ／１００ｍＬ以下、更に好ましくは４０ｍｇ／１００ｍＬ以下である、前記＜１＞〜＜１８＞のいずれか一に記載の液状発汗促進剤。
＜２０＞
当該液状発汗促進剤１００ｍＬ当たりのナトリウムの含有量が、好ましくは１０〜８０ｍｇ／１００ｍＬ、より好ましくは２０〜６０ｍｇ／１００ｍＬ、更に好ましくは３０〜４０ｍｇ／１００ｍＬである、前記＜１＞〜＜１８＞のいずれか一に記載の液状発汗促進剤。
＜２１＞
当該液状発汗促進剤１００ｍＬ当たりのカリウムの含有量が、好ましくは０．５ｍｇ／１００ｍＬ以上、より好ましくは１ｍｇ／１００ｍＬ以上、更に好ましくは２ｍｇ／１００ｍＬ以上であって、好ましくは４０ｍｇ／１００ｍＬ以下、より好ましくは３０ｍｇ／１００ｍＬ以下、更に好ましくは２０ｍｇ／１００ｍＬ以下である、前記＜１＞〜＜２０＞のいずれか一に記載の液状発汗促進剤。
＜２２＞
当該液状発汗促進剤１００ｍＬ当たりのカリウムの含有量が、好ましくは０．５〜４０ｍｇ／１００ｍＬ、より好ましくは１〜３０ｍｇ／１００ｍＬ、更に好ましくは２〜２０ｍｇ／１００ｍＬである、前記＜１＞〜＜２０＞のいずれか一に記載の液状発汗促進剤。
＜２３＞
２５℃におけるｐＨが、好ましくは３〜６、より好ましくは３〜５、更に好ましくは３〜４である、前記＜１＞〜＜２２＞のいずれか一に記載の液状発汗促進剤。
＜２４＞
カロリーが、好ましくは２０ｋｃａｌ／１００ｍＬ以下、より好ましくは１〜１５ｋｃａｌ／１００ｍＬ、更に好ましくは２〜１０ｋｃａｌ／１００ｍＬ、更に好ましくは２〜５ｋｃａｌ／１００ｍＬである、前記＜１＞〜＜２３＞のいずれか一に記載の液状発汗促進剤。
<13>
Furthermore, any one of the above <1> to <12>, further comprising (D) a sweetener, wherein (D) the sweetener is a combination of a carbohydrate and at least one selected from a sugar alcohol and an artificial sweetener. Liquid sweating promoter described in 1.
<14>
The total content of the (D) sweetener in the liquid sweat accelerator is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, and further preferably 0.01% by mass or more, The liquid perspiration promoter according to <13>, which is preferably 10% by mass or less, more preferably 8% by mass or less, and still more preferably 6% by mass or less.
<15>
The total content of the (D) sweetener in the liquid sweat enhancer is preferably 0.0001 to 10% by mass, more preferably 0.001 to 8% by mass, and still more preferably 0.01 to 6% by mass. The liquid perspiration promoter according to the above <13>.
<16>
Furthermore, the liquid perspiration promotion as described in any one of the above items <1> to <15>, further comprising (E) an acidulant, wherein (E) the acidulant is at least one selected from citric acid and citrate. Agent.
<17>
The total content of the (E) acidulant in the liquid sweat accelerator is preferably 0.01% by mass or more, more preferably 0.03% by mass or more, still more preferably 0.05% by mass or more, The liquid perspiration promoter according to the above <16>, preferably 5% by mass or less, more preferably 4.5% by mass or less, and still more preferably 4% by mass or less.
<18>
The total content of (E) acidulant in the liquid sweat enhancer is preferably 0.01 to 5% by mass, more preferably 0.03 to 4.5% by mass, and still more preferably 0.05 to 4% by mass. %, The liquid perspiration promoter according to the above <16>.
<19>
The content of sodium per 100 mL of the liquid perspiration promoter is preferably 10 mg / 100 mL or more, more preferably 20 mg / 100 mL or more, still more preferably 30 mg / 100 mL or more, preferably 80 mg / 100 mL or less, more preferably The liquid perspiration promoter according to any one of <1> to <18>, which is 60 mg / 100 mL or less, more preferably 40 mg / 100 mL or less.
<20>
The content of sodium per 100 mL of the liquid sweat accelerator is preferably 10 to 80 mg / 100 mL, more preferably 20 to 60 mg / 100 mL, still more preferably 30 to 40 mg / 100 mL, <1> to <18> Liquid sweating promoter as described in any one of these.
<21>
The potassium content per 100 mL of the liquid perspiration promoter is preferably 0.5 mg / 100 mL or more, more preferably 1 mg / 100 mL or more, still more preferably 2 mg / 100 mL or more, preferably 40 mg / 100 mL or less, more The liquid perspiration promoter according to any one of <1> to <20>, preferably 30 mg / 100 mL or less, more preferably 20 mg / 100 mL or less.
<22>
The content of potassium per 100 mL of the liquid perspiration promoter is preferably 0.5 to 40 mg / 100 mL, more preferably 1 to 30 mg / 100 mL, still more preferably 2 to 20 mg / 100 mL, <1> to <20> The liquid perspiration promoter according to any one of 20>.
<23>
The liquid perspiration promoter according to any one of <1> to <22>, wherein the pH at 25 ° C is preferably 3 to 6, more preferably 3 to 5, and still more preferably 3 to 4.
<24>
Any one of <1> to <23>, wherein the calorie is preferably 20 kcal / 100 mL or less, more preferably 1 to 15 kcal / 100 mL, further preferably 2 to 10 kcal / 100 mL, and further preferably 2 to 5 kcal / 100 mL. The liquid perspiration promoter according to 1.
＜２５＞
前記液状発汗促進剤を摂取する、発汗促進方法。
<25>
A method for promoting perspiration, which comprises ingesting the liquid perspiration promoter.
＜２６＞
液状発汗促進剤の摂取量が、体重１ｋｇ当たりの一日摂取量として、好ましくは３ｍＬ／体重ｋｇ／日以上、より好ましくは６ｍＬ／体重ｋｇ／日以上、更に好ましくは８ｍＬ／体重ｋｇ／日以上であって、好ましくは３０ｍＬ／体重ｋｇ／日以下、より好ましくは２５ｍＬ／体重ｋｇ／日以下、更に好ましくは２０ｍＬ／体重ｋｇ／日以下である、前記＜２５＞記載の発汗促進方法。
＜２７＞
液状発汗促進剤の摂取量が、体重１ｋｇ当たりの一日摂取量として、好ましくは３〜３０ｍＬ／体重ｋｇ／日、より好ましくは６〜２５ｍＬ／体重ｋｇ／日、更に好ましくは８〜２０ｍＬ／体重ｋｇ／日である、前記＜２５＞記載の発汗促進方法。
＜２８＞
液状発汗促進剤の摂取量が、体重１ｋｇ当たりの非重合体カテキン類の一日摂取量として、好ましくは４ｍｇ／体重ｋｇ／日以上、より好ましくは７ｍｇ／体重ｋｇ／日以上、更に好ましくは１０ｍｇ／体重ｋｇ／日以上、更に好ましくは１２ｍｇ／体重ｋｇ／日以上であって、好ましくは３５ｍｇ／体重ｋｇ／日以下、より好ましくは３０ｍｇ／体重ｋｇ／日以下、更に好ましくは２５ｍｇ／体重ｋｇ／日以下、更に好ましくは２０ｍｇ／体重ｋｇ／日以下である、前記＜２５＞〜＜２７＞のいずれか一に記載の発汗促進方法。
＜２９＞
液状発汗促進剤の摂取量が、体重１ｋｇ当たりの非重合体カテキン類の一日摂取量として、好ましくは４〜３５ｍｇ／体重ｋｇ／日、より好ましくは７〜３０ｍｇ／体重ｋｇ／日、更に好ましくは１０〜２５ｍｇ／体重ｋｇ／日、更に好ましくは１２〜２０ｍｇ／体重ｋｇ／日である、前記＜２５＞〜＜２７＞のいずれか一に記載の発汗促進方法。
＜３０＞
液状発汗促進剤の摂取量が、一日当たり、好ましくは１８０ｍＬ／日以上、より好ましくは３００ｍＬ／日以上、更に好ましくは４８０ｍＬ／日以上であって、好ましくは１８００ｍＬ／日以下、より好ましくは１５００ｍＬ／日以下、更に好ましくは１２００ｍＬ／日以下である、前記＜２５＞〜＜２９＞のいずれか一に記載の発汗促進方法。
＜３１＞
液状発汗促進剤の摂取量が、一日当たり、好ましくは１８０〜１８００ｍＬ／日、より好ましくは３００〜１５００ｍＬ／日、更に好ましくは４８０〜１２００ｍＬ／日である、前記＜２５＞〜＜２９＞のいずれか一に記載の発汗促進方法。
＜３２＞
液状発汗促進剤の摂取量が、非重合体カテキン類の一日摂取量として、好ましくは２００ｍｇ／日以上、より好ましくは３００ｍｇ／日以上、更に好ましくは４００ｍｇ／日以上、更に好ましくは５００ｍｇ／日以上であって、好ましくは２２００ｍｇ／日以下、より好ましくは１８００ｍｇ／日以下、更に好ましくは１５００ｍｇ／日以下、更に好ましくは１２００ｍｇ／日以下である、前記＜２５＞〜＜３１＞のいずれか一に記載の発汗促進方法。
＜３３＞
液状発汗促進剤の摂取量が、非重合体カテキン類の一日摂取量として、好ましくは２００〜２２００ｍｇ／日が好ましく、３００〜１８００ｍｇ／日がより好ましく、４００〜１５００ｍｇ／日が更に好ましく、５００〜１２００ｍｇ／日である、前記＜２５＞〜＜３１＞のいずれか一に記載の発汗促進方法。
＜３４＞
液状発汗促進剤の一日摂取量を１回で摂取するか、又は１０分間以上、望ましくは２０分間以上、より望ましくは３０分間以上の間隔をあけて２〜１０回に分けて摂取する、前記＜２５＞〜＜３３＞のいずれか一に記載の発汗促進方法。
＜３５＞
好ましくは５〜４０℃、より好ましくは５〜３５℃の温度の液状発汗促進剤を摂取する、前記＜２５＞〜＜３４＞のいずれか一に記載の発汗促進方法。
<26>
The daily intake per kg body weight of the liquid sweat promoter is preferably 3 mL / kg body weight / day or more, more preferably 6 mL / kg body weight / day or more, and even more preferably 8 mL / kg body weight / day or more. And preferably 30 mL / kg body weight / day or less, more preferably 25 mL / kg body weight / day or less, and still more preferably 20 mL / kg body weight / day or less.
<27>
The daily intake per kg body weight of the liquid sweat promoter is preferably 3 to 30 mL / kg body weight / day, more preferably 6 to 25 mL / kg body weight / day, and still more preferably 8 to 20 mL / body weight. The perspiration promoting method according to <25>, wherein the perspiration is kg / day.
<28>
The daily intake of non-polymer catechins per kg body weight is preferably 4 mg / kg body weight / day, more preferably 7 mg / kg body weight / day, more preferably 10 mg. / Kg body weight / day or more, more preferably 12 mg / kg body weight / day or more, preferably 35 mg / kg body weight / day or less, more preferably 30 mg / kg body weight / day or less, more preferably 25 mg / kg body weight / day. The method for promoting perspiration according to any one of <25> to <27>, wherein the method is not more than a day, more preferably not more than 20 mg / kg of body weight / day.
<29>
The daily intake of non-polymer catechins per kg body weight of the liquid sweat promoter is preferably 4 to 35 mg / kg body weight / day, more preferably 7 to 30 mg / kg body weight / day, still more preferably Is 10 to 25 mg / kg body weight / day, more preferably 12 to 20 mg / kg body weight / day, according to any one of the above <25> to <27>.
<30>
The intake amount of the liquid perspiration promoter is preferably 180 mL / day or more, more preferably 300 mL / day or more, further preferably 480 mL / day or more, preferably 1800 mL / day or less, more preferably 1500 mL / day, per day. The method of promoting sweating according to any one of <25> to <29>, wherein the method is not more than a day, more preferably not more than 1200 mL / day.
<31>
Any of <25> to <29> above, wherein the intake amount of the liquid perspiration promoter is preferably 180 to 1800 mL / day, more preferably 300 to 1500 mL / day, still more preferably 480 to 1200 mL / day, per day. The method of promoting sweating according to claim 1.
<32>
The daily intake of the non-polymer catechins is preferably 200 mg / day or more, more preferably 300 mg / day or more, still more preferably 400 mg / day or more, and even more preferably 500 mg / day. Any one of the above <25> to <31>, which is preferably 2200 mg / day or less, more preferably 1800 mg / day or less, further preferably 1500 mg / day or less, more preferably 1200 mg / day or less. 2. A method for promoting perspiration described in 1.
<33>
The daily intake of the non-polymer catechins is preferably 200 to 2200 mg / day, more preferably 300 to 1800 mg / day, still more preferably 400 to 1500 mg / day, and more preferably 500 to 1500 mg / day. The method of promoting sweating according to any one of <25> to <31>, wherein the method is ~ 1200 mg / day.
<34>
The daily intake of the liquid sweat accelerator is taken once, or taken in 2-10 times at intervals of 10 minutes or more, desirably 20 minutes or more, more desirably 30 minutes or more, <25>-<33> The method for promoting perspiration according to any one of <33>.
<35>
Preferably, the method of promoting sweating according to any one of the above <25> to <34>, wherein a liquid sweat promoter at a temperature of 5 to 40 ° C., more preferably 5 to 35 ° C. is taken.
（１）浸透圧の測定
氷点降下法を用いた浸透圧計（朝日ライフサイエンス社製、ＯＭ８０２−Ｄ）で測定した。
(1) Measurement of osmotic pressure It measured with the osmometer (The Asahi Life Science company make, OM802-D) using the freezing point depression method.
（２）非重合体カテキン類の分析
各飲料をフィルター（０．４５μｍ）で濾過し、高速液体クロマトグラフ（型式ＬＣ−ＶＰ、島津製作所製）を用い、オクタデシル基導入液体クロマトグラフ用パックドカラム（Ｌ−カラムＴＭ ＯＤＳ、４．６ｍｍφ×２５０ｍｍ：財団法人 化学物質評価研究機構製）を装着し、カラム温度３５℃でグラジエント法により分析した。移動相Ａ液は酢酸を０．１ｍｏｌ／Ｌ含有する蒸留水溶液、Ｂ液は酢酸を０．１ｍｏｌ／Ｌ含有するアセトニトリル溶液とし、試料注入量は２０μＬ、ＵＶ検出器波長は２８０ｎｍの条件で行った。
(2) Analysis of non-polymer catechins Each beverage is filtered through a filter (0.45 μm), and a high-performance liquid chromatograph (model LC-VP, manufactured by Shimadzu Corporation) is used to form a packed column for an octadecyl group-introduced liquid chromatograph ( L-column TM ODS, 4.6 mmφ × 250 mm (manufactured by Chemical Substances Research Institute) was attached, and analysis was performed by a gradient method at a column temperature of 35 ° C. The mobile phase A solution was a distilled aqueous solution containing 0.1 mol / L of acetic acid, the B solution was an acetonitrile solution containing 0.1 mol / L of acetic acid, the sample injection amount was 20 μL, and the UV detector wavelength was 280 nm. .
（３）たんぱく質の分析
各飲料をケルダール法にて分析し、下記式により求めた。
窒素＝（ｇ／１００ｇ）＝（０．００１４×（Ｖ１−Ｖ０）×ｆ）／Ｓ1×１００
Ｖ１：試料滴定量（ｍＬ）
Ｖ０：ショ糖滴定量（ｍＬ）
ｆ：０．０５ｍｏｌ／Ｌ硫酸標準溶液のファクター
０．００１４：０．０５ｍｏｌ／Ｌ硫酸標準液１ｍＬに対する窒素量（ｇ）
Ｓ1：試料採取量（ｇ）
たんぱく質（ｇ／１００ｇ）＝窒素（ｇ／１００ｇ）×窒素・たんぱく質換算係数
(3) Protein analysis Each beverage was analyzed by the Kjeldahl method and determined by the following formula.
Nitrogen = (g / 100 g) = (0.0014 × (V1−V0) × f) / S 1 × 100
V1: Sample titration (mL)
V0: Sucrose titration (mL)
f: Factor of 0.05 mol / L sulfuric acid standard solution 0.0014: Nitrogen amount relative to 1 mL of 0.05 mol / L sulfuric acid standard solution (g)
S 1 : Sampling amount (g)
Protein (g / 100g) = Nitrogen (g / 100g) x Nitrogen / protein conversion factor
（４）脂質の分析
各飲料をソックスレー抽出法にて分析し、下記式により求めた。
脂質（ｇ／１００ｇ）＝（Ｗ−Ｗ０）／Ｓ2×１００
Ｗ：恒量（抽出後、ｇ）
Ｗ０：恒量（抽出前、ｇ）
Ｓ2：試料採取量（ｇ）
(4) Analysis of lipid Each beverage was analyzed by a Soxhlet extraction method, and determined according to the following formula.
Lipid (g / 100g) = (W−W0) / S 2 × 100
W: constant weight (after extraction, g)
W0: Constant weight (before extraction, g)
S 2 : Sampling amount (g)
（５）炭水化物の分析
各飲料について下記式により求めた。
炭水化物（ｇ／１００ｇ）＝１００×比重−（水分＋たんぱく質＋脂質＋灰分＋タンニン）
比重：振動式密度計法で測定
水分：減圧加熱乾燥法で測定
灰分：直接灰化法で測定
タンニン：ＦＯＬＩＮ‐ＤＥＮＩＳ法で測定
(5) Analysis of carbohydrate It calculated | required by the following formula about each drink.
Carbohydrate (g / 100 g) = 100 × specific gravity− (water + protein + lipid + ash content + tannin)
Specific gravity: measured by vibrating densitometer method Moisture: measured by reduced pressure heating drying method Ash content: measured by direct ashing method Tannin: measured by FOLIN-DENIS method
（６）ナトリウムの分析
各飲料を原子吸光光度法にて分析し、下記式により求めた。
ナトリウム含量（ｍｇ／１００ｇ）＝Ａ1×Ｖ1×Ｐ1／Ｗ1／１０
Ａ1：検量線から求めたナトリウムの濃度（μｇ／ｍＬ）
Ｖ1：最終液量（ｍＬ）
Ｐ1：分取率
Ｗ1：試料採取量（ｇ）
(6) Analysis of sodium Each beverage was analyzed by atomic absorption spectrophotometry and determined by the following formula.
Sodium content (mg / 100g) = A 1 × V 1 × P 1 / W 1/10
A 1 : Sodium concentration determined from a calibration curve (μg / mL)
V 1 : Final liquid volume (mL)
P 1 : Fractionation rate W 1 : Sampling amount (g)
（７）カリウムの分析
各飲料を原子吸光光度法にて分析し、下記式により求めた。
カリウム含量（ｍｇ／１００ｇ）＝Ａ2×Ｖ2×Ｐ2／Ｗ2／１０
Ａ2：検量線から求めたカリウムの濃度（μｇ／ｍＬ）
Ｖ2：最終液量（ｍＬ）
Ｐ2：分取率
Ｗ2：試料採取量（ｇ）
(7) Analysis of potassium Each beverage was analyzed by atomic absorption spectrophotometry and determined by the following formula.
Potassium content (mg / 100g) = A 2 × V 2 × P 2 / W 2/10
A 2 : Potassium concentration (μg / mL) determined from the calibration curve
V 2 : Final liquid volume (mL)
P 2 : Fractionation rate W 2 : Sampling amount (g)
（８）クエン酸の分析
各飲料を高速液体クロマトグラフ法にて分析した。
試料を５０ｍＬ容メスフラスコに約５ｇ精密に量り、５％過塩素酸を５ｍＬ、精製水を２０ｍＬ添加し、１０分間振とうした。その後、精製水にて５０ｍＬに定容し、０．４５μｍのメンブランフィルターでろ過したものを試験溶液とした。高速液体クロマトグラフで分析し、検量線からクエン酸濃度を求めた。
(8) Analysis of citric acid Each beverage was analyzed by high performance liquid chromatography.
About 5 g of a sample was accurately measured in a 50 mL volumetric flask, 5 mL of 5% perchloric acid and 20 mL of purified water were added, and the mixture was shaken for 10 minutes. Thereafter, the test solution was made up to 50 mL with purified water and filtered through a 0.45 μm membrane filter. Analysis was performed with a high performance liquid chromatograph, and the citric acid concentration was determined from a calibration curve.
＜実施例＞
市販の緑茶抽出物の濃縮物（三井農林（株）「ポリフェノンＨＧ」）１００ｇを９０．０質量％エタノール９００ｇに分散させ、３０分熟成し、２号濾紙及び孔径０．２μｍの濾紙で濾過し、水２００ｍＬを加えて減圧濃縮することによって緑茶抽出物の精製物を得た。得られた緑茶抽出物の精製物は、（Ａ）非重合体カテキン類濃度が１５．２質量％、非重合体カテキン類中のガレート体率が５８．１質量％であった。緑茶抽出物の精製物をタンナーゼ処理し、非重合体カテキン類濃度が１５．０質量％、非重合体カテキン類中のガレート体率が４４．２質量％、非重合体カテキン類中のエピ体率が８５．４質量％のタンナーゼ処理物を得た。
得られたタンナーゼ処理物、水、甘味料、酸味料、無機塩類等を用い、浸透圧１６２ｍＯｓｍ／Ｌの液状発汗促進剤を調製した。調製した液状発汗促進剤を、次の試験例において「カテキン含有低張飲料水」として用いた。分析値を表１に示す。
<Example>
100 g of a commercially available concentrate of green tea extract (Mitsui Norin Co., Ltd. “Polyphenone HG”) was dispersed in 900 g of 90.0% by mass ethanol, aged for 30 minutes, and filtered through No. 2 filter paper and 0.2 μm pore size filter paper. Then, 200 mL of water was added and concentrated under reduced pressure to obtain a purified product of green tea extract. The purified product of the green tea extract obtained had (A) a non-polymer catechin concentration of 15.2% by mass, and a gallate body ratio in the non-polymer catechins of 58.1% by mass. A purified product of green tea extract is treated with tannase, the non-polymer catechin concentration is 15.0% by mass, the gallate content in the non-polymer catechins is 44.2% by mass, and the epimer in the non-polymer catechins A tannase-treated product having a rate of 85.4% by mass was obtained.
Using the obtained tannase-treated product, water, sweetener, acidulant, inorganic salts and the like, a liquid sweating accelerator having an osmotic pressure of 162 mOsm / L was prepared. The prepared liquid perspiration promoter was used as “catechin-containing hypotonic drinking water” in the following test examples. The analytical values are shown in Table 1.
＜試験例＞
暑熱環境下での下腿温浴中に、浸透圧の異なる飲料水を摂取させた時の発汗量について検討した。
<Test example>
We examined the amount of sweat when ingesting drinking water with different osmotic pressures during warm bathing in the lower leg.
（１）被験飲料
各被験飲料の分析結果を表１に、カテキン含有低張飲料水中の非重合体カテキン類の組成を表２に、それぞれ示す。
１）水（ミネラルウォーター，２ｍＯｓｍ／Ｌ）
２）カテキン含有低張飲料水（１６２ｍＯｓｍ／Ｌ）
３）市販等張飲料水（３２４ｍＯｓｍ／Ｌ）
(1) Test beverage Table 1 shows the analysis results of each test beverage, and Table 2 shows the composition of non-polymer catechins in the catechin-containing hypotonic drinking water.
1) Water (mineral water, 2 mOsm / L)
2) Hypotonic drinking water containing catechin (162 mOsm / L)
3) Commercially isotonic drinking water (324 mOsm / L)
（２）試験方法
成人男性８名（年齢２５．８±５．９歳、体重６２．３±１０．１、平均値±標準偏差）を被験者（解析対象者）とした。各被験者に対し試験前日の暴飲暴食と飲酒を禁止し、試験当日に朝食（ゼリーとミネラルウォーター５００ｍＬ）と昼食（弁当と麦茶２５０ｍＬ）のみを摂取させ、各飲料は全て飲みきるよう指示した。１４：３０以降は実験開始（１６：００）まで絶食、絶飲するように指示した。
各被験者にＴシャツと水着に更衣させた後、室温３５℃、相対湿度７５％に設定した人工気候室内にて、水温４０℃の下腿温浴を９０分間行った。その際、上記１）〜３）の被験飲料を各被験者に対し、下腿温浴開始直後、試験開始から３０分経過後及び６０分経過後に４ｍＬ／体重ｋｇずつ３分以内に摂取させ、上腕部局所発汗量を連続測定した。
本試験は、被験者８名に対し、上記１）〜３）の被験飲料のそれぞれについて行った。
各飲料の影響をなくすために、被験飲料ごとに２〜１０日の間隔を空けて試験を実施した。なお、各飲料の温度は、室温と同じ３５℃とした。
被験者の体重、飲料摂取量、及び非重合体カテキン類摂取量を表３に示す。
試験開始から９０分後まで一定時間経過ごとに測定した上腕部局所発汗量を図１に、試験終了時の上腕部局所発汗量を図２及び表４に、それぞれ示す。
(2) Test method Eight adult males (age 25.8 ± 5.9 years old, body weight 62.3 ± 10.1, mean value ± standard deviation) were used as subjects (analytical subjects). Each subject was prohibited from eating and drinking on the day before the test, and only breakfast (jelly and 500 ml of mineral water) and lunch (lunch and 250 ml of barley tea) were ingested on the day of the test. After 14:30, they were instructed to fast and drink until the start of the experiment (16:00).
Each subject was dressed in a T-shirt and a bathing suit, and then a lower leg warm bath at a water temperature of 40 ° C. was performed for 90 minutes in an artificial climate room set at a room temperature of 35 ° C. and a relative humidity of 75%. At that time, the test drinks 1) to 3) above were given to each subject immediately after the start of the lower leg warm bath, after 30 minutes and 60 minutes from the start of the test within 4 minutes each with 4 mL / kg body weight. The amount of sweating was measured continuously.
This test was conducted for each of the test beverages 1) to 3) above for 8 subjects.
In order to eliminate the influence of each beverage, the test was performed with an interval of 2 to 10 days for each test beverage. In addition, the temperature of each drink was 35 degreeC which is the same as room temperature.
Table 3 shows the subject's weight, beverage intake, and non-polymer catechin intake.
FIG. 1 shows the amount of local sweating of the upper arm part measured every predetermined time from the start of the test to 90 minutes later, and FIG. 2 and Table 4 show the amount of local sweating of the upper arm part at the end of the test.
本発明の液状発汗促進剤（カテキン含有低張飲料水）は、暑熱環境下、下腿温浴負荷時の摂取において、発汗量が水摂取群よりも有意に高値を示すことが分かった。
したがって、本発明の液状発汗促進剤は、発汗を効率よく促し、体温制御に寄与すると推察される。
It was found that the liquid sweat enhancer (catechin-containing hypotonic drinking water) of the present invention showed a significantly higher sweating value than the water intake group when ingested in a hot environment under a warm bath.
Therefore, it is speculated that the liquid perspiration promoter of the present invention promotes sweating efficiently and contributes to body temperature control.
Claims (15)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012163305A JP6062674B2 (en) | 2012-07-24 | 2012-07-24 | Liquid sweat enhancer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012163305A JP6062674B2 (en) | 2012-07-24 | 2012-07-24 | Liquid sweat enhancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014019691A JP2014019691A (en) | 2014-02-03 |
| JP6062674B2 true JP6062674B2 (en) | 2017-01-18 |
Family
ID=50194986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012163305A Active JP6062674B2 (en) | 2012-07-24 | 2012-07-24 | Liquid sweat enhancer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6062674B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6393524B2 (en) * | 2014-06-05 | 2018-09-19 | ロート製薬株式会社 | Moisturizer |
| US20220062318A1 (en) | 2018-12-28 | 2022-03-03 | Hayashibara Co., Ltd. | Heat stress relieving agent |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004123642A (en) * | 2002-10-04 | 2004-04-22 | Shimizu Pharmaceutical Co Ltd | Electrolyte composition |
| JP2006158379A (en) * | 2004-11-15 | 2006-06-22 | Kao Corp | Packed drink for promoting burning of lipid |
| JP4811576B2 (en) * | 2005-03-31 | 2011-11-09 | 味の素株式会社 | Moisture electrolyte supplement drink |
| JP4512013B2 (en) * | 2005-09-07 | 2010-07-28 | 和光堂株式会社 | Liquid beverage composition and method for producing the same |
| JP5297649B2 (en) * | 2006-12-27 | 2013-09-25 | 花王株式会社 | Container drink |
| JP2011088880A (en) * | 2009-10-23 | 2011-05-06 | Shigeharu Inoue | New fragrant distilled water and application thereof |
-
2012
- 2012-07-24 JP JP2012163305A patent/JP6062674B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014019691A (en) | 2014-02-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8088429B2 (en) | Package drink | |
| US7981449B2 (en) | Production process of purified green tea extract | |
| JP4884003B2 (en) | Container oolong tea drink | |
| JP2004041186A (en) | Bottled black tea drink | |
| JP2009247215A (en) | Bottled drink | |
| JP3590028B2 (en) | Semi-fermented tea or fermented tea beverage with high catechin content | |
| JP4181982B2 (en) | Containerized beverage containing purified green tea extract | |
| JP4247178B2 (en) | Method for producing purified green tea extract | |
| JP4768534B2 (en) | Containerized green tea beverage | |
| JP6062674B2 (en) | Liquid sweat enhancer | |
| JP4383337B2 (en) | High concentration catechin-containing container-packed oolong tea drink | |
| JP2005270094A (en) | Method for producing refined green tea extract | |
| JP6310625B1 (en) | Beverages containing tiliroside and chlorogenic acids | |
| JP4751205B2 (en) | Method for producing purified green tea extract | |
| JP4201760B2 (en) | Container drink | |
| JP2003304811A (en) | Method for producing green tea polyphenol | |
| JP6782866B1 (en) | Beverage composition | |
| ES2349643T3 (en) | PACKED DRINK. | |
| JP2015000054A (en) | Container-packed beverage | |
| JP4838204B2 (en) | Container drink | |
| JP2003230358A (en) | Method for producing fermented tea beverage or semi- fermented tea beverage | |
| JP2009055813A (en) | Packed non-tea drink | |
| JP5550274B2 (en) | Container drink | |
| JP2006182737A (en) | Packed drink for improving hepatic function | |
| JP5902461B2 (en) | Container drink |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150617 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160426 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160620 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20161122 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20161215 |
|
| R151 | Written notification of patent or utility model registration |
Ref document number: 6062674 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R151 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |