JP4811576B2 - Moisture electrolyte supplement drink - Google Patents

Description

  The present invention relates to a water electrolyte replenishing beverage that is replenished for the purpose of improving the dehydration state or preventing dehydration symptoms, and particularly relates to a water electrolyte replenishing beverage that can replenish water and electrolyte components quickly and in a well-balanced manner.

  Conventionally, oral replenishers mainly used for the treatment of acute diarrhea in infants have been used containing electrolyte components, carbohydrates, and organic acids in order to achieve quick water and electrolyte component replenishment. (For example, refer to Patent Document 1). The subject who should take this oral replenisher is not limited to children, and recently, the demand for ingestion of oral replenisher is increasing in the elderly. In other words, it is known that elderly people are prone to chronic dehydration due to a decrease in fluid volume due to aging, and dehydration in elderly people is said to be closely related to nutritional disorders and cerebrovascular disorders. . In particular, the importance of hydration and fluid retention for the body has been recognized for the prevention of cerebrovascular disorders.

  Therefore, it is important to improve and prevent such symptoms, and various oral fluid replacement solutions or electrolyte beverages in liquid or granule dosage forms have been proposed so far. However, the liquid or granule oral replenishers or electrolyte beverages that have been proposed so far are still not sufficient from the viewpoint of quick replenishment of water and electrolyte components, and are particularly hydrated for the elderly, Each has its advantages and disadvantages when it comes to holding body fluids.

  For example, in oral replenishers of granules, various electrolyte compositions prepared in the form of granules are dissolved in water at the time of use to prepare and ingest oral replenishers, but the electrolyte composition at the time of dissolution, solution pH The osmotic pressure is appropriate for absorbing moisture and electrolyte components from the intestinal tract, but there is a concern that preparation during use is time-consuming and accurate dilution is not performed.

  In addition, the liquid oral replenisher or the electrolyte beverage solves the above-mentioned problems and can be easily ingested as it is, and the electrolyte composition is also appropriate, but the osmotic pressure of the solution is slightly high, and the solution pH Is prepared as low as less than 4.2 from the conditions of the sterilization process when filling the container. The oral replenisher or electrolyte beverage prepared at this low pH places an excessive burden on intestinal absorption of water and electrolyte components in the intestinal tract of neutral environment, and there is a concern that water and electrolyte components cannot be replenished quickly. .

  Accordingly, there is a need for a water electrolyte supplemented beverage that can solve these problems simultaneously, has a composition that allows efficient and physiological hydration and electrolyte component replenishment, and can be consumed without the need for preparation at the time of use.

So far, the present inventors have proposed an electrolyte beverage composition capable of efficiently performing quick hydration / electrolyte component replenishment and sufficient energy replenishment simultaneously as a solution to the above-mentioned problems (Patent Document 2). ). The electrolyte beverage composition proposed by the present inventors is excellent in that it can efficiently and physiologically replenish hydration / electrolyte components, but improves the cerebrovascular disorder by retaining fluid and preventing dehydration in the elderly. However, it has not been sufficient for prevention, and further improvement has been demanded.
JP 52-41273 A JP 2004-123642 A

  Therefore, the present invention is a water electrolyte replenishing beverage that can efficiently and physiologically replenish hydration and electrolyte components, and is particularly effective in improving and preventing cerebrovascular disorders by retaining body fluids and preventing dehydration in the elderly. It is an object of the present invention to provide a water electrolyte supplement beverage that can be taken ready-to-use without the need for preparation at the time of use.

  In order to solve such problems, the present inventors have made various studies on water electrolyte supplemented beverages, selected the concentration of electrolyte components suitable for electrolyte component supplementation, and solutions suitable for absorption of water and electrolyte components in the intestinal tract. Various characteristics were studied. And as a water electrolyte replenishing drink, we obtained knowledge that it is necessary to study not only solution osmotic pressure and pH but also the titrated acidity of the solution. We have found a water electrolyte supplement beverage. Furthermore, the present inventors have studied the most suitable conditions in order to provide a water electrolyte supplement beverage based on such a composition as a solution that does not need to be prepared at the time of use, and have completed the present invention.

That is, the present invention has the following basic aspects:
(1) As an electrolyte component, it contains sodium ions 30 to 40 mEq / L, potassium ions 15 to 25 mEq / L, chloride ions 25 to 35 mEq / L, pH 4.2 to 6.0, and titration acidity is less than 30 A hydrated electrolyte supplemented drink characterized by having an osmotic pressure of 160 to 190 mOsm / L;
It is.

Furthermore, the present invention provides a more specific embodiment as follows:
(2) The water electrolyte replenishing beverage according to 1 above, wherein the titratable acidity is 15 or less;
(3) The water electrolyte supplement drink according to 1 or 2 above, further containing calcium ions 3 to 7 mEq / L and magnesium ions 2 to 5 mEq / L as an electrolyte component;
(4) The water electrolyte supplemented beverage according to the above 1 or 3, characterized by containing 3 w / v% or less of a disaccharide as a saccharide;
(5) The water electrolyte-supplemented beverage according to 4 above, wherein the disaccharide is sucrose;
(6) The water electrolyte supplemented beverage according to the above 1, 2, 3 or 4, further comprising 15 to 79 mEq / L of citrate ion and 2 to 10 mEq / L of phosphate ion;
(7) The water electrolyte supplemented beverage according to any one of 1 to 6 above, which has a total volume of 200 mL or less;
(8) The water electrolyte supplemented beverage according to any one of 1 to 7 above, wherein an aseptic sterilization filling method is used as a method for sterilizing and filling the container;
It is.

That is, the present invention is a water electrolyte supplement beverage, while maintaining a high electrolyte concentration, the solution pH is set in the range of 4.2 to 6.0, the titrated acidity is less than 30, and the solution permeation thereon. It has one feature in that the pressure is set to 160 to 190 mOsm / L and hypotonic.
In particular, since the titratable acidity of conventional water electrolyte supplemented beverages is high, there was a difficulty in the absorption of water and electrolyte components in the intestinal tract, but the water electrolyte supplemented beverage of the present invention solved this point. As a thing, it is particularly effective.

The water electrolyte replenishment drink proposed by the present invention is a water electrolyte replenishment drink capable of efficiently performing water replenishment and electrolyte component replenishment.In particular, as a result of emphasizing the relation between titration acidity and absorbability at the intestinal tract, Replenishment / electrolyte component replenishment can be performed quickly in a balanced manner.
Thus, the water / electrolyte supplemented beverage of the present invention quickly absorbs water and electrolyte components, and as a result, is particularly effective in improving and preventing cerebrovascular disorders by retaining body fluids and preventing dehydration in the elderly. It is.
Furthermore, since there is no need for preparation at the time of use, there is an advantage that it can be easily ingested with a ready-to-use solution, eliminating the concern that accurate dilution seen in granular preparations is not performed. ing.

  As described above, the present inventors conducted various studies on the water electrolyte supplemented beverage, and as a result, among the various properties of the solution, each of the titratable acidity, pH, osmotic pressure, electrolyte concentration, and sugar content was determined. The present invention has been completed by studying it so as to be suitable for replenishment of moisture and electrolyte components.

Further, based on the composition having the best solution titration acidity, pH, osmotic pressure, electrolyte concentration, and sugar content selected as described above, the most suitable method for filling the container is selected to complete the present invention. It has been made.
These points will be described in detail below.

The solution pH in the water / electrolyte supplement beverage provided by the present invention is one factor affecting the absorption rate of water / electrolyte components from the digestive tract. Water or electrolyte components taken orally are absorbed in the intestine after passing through the stomach. Since the pH environment of the intestinal tract, which is the absorption site, is weakly acidic to neutral, it is physiological that the pH of the ingested beverage is also weakly acidic to neutral, and quick water and electrolyte components It can be said that it is preferable for absorption.
Considering this point, in the water electrolyte supplemented beverage proposed by the present invention, the pH range of the solution is preferably 4.2 to 6.0.
In fact, as can be seen from the test examples described later, the water electrolyte supplemented beverage of the present invention has a quicker water / electrolyte component from the intestinal tract than the water electrolyte supplemented beverage having a lower value than pH 4.2. Absorption was observed.

Furthermore, based on the knowledge that the titrated acidity in the water electrolyte supplemented beverage provided by the present invention is an important factor affecting the rate of water absorption from the digestive tract, the appropriate titrated acidity was examined.
By the way, the pH of the solution only indicates the hydrogen ion concentration, that is, the acid dissociated in the solution, and does not provide information on the amount of the acid not dissociated which is a reservoir of hydrogen ions. On the other hand, titratable acidity indicates the total acidity including not only dissociated acid but also undissociated acid, and the sodium hydroxide necessary for neutralizing the solution to pH 7.4, which is the pH of blood. It is expressed as a quantity (mEq number of OH ⁻ ). Even in a solution having the same pH, the higher the titratable acidity, the higher the buffer capacity.

Therefore, the lower the titrated acidity of the ingested beverage, the less the buffering action that occurs in the intestinal tract that is the absorption site and the buffering action that occurs in the blood that arrives after absorption from the intestinal tract, and the quick absorption of water Therefore, it can be said that it is preferable.
Considering this point, in the water electrolyte supplemented beverage proposed by the present invention, the titrated acidity of the solution is preferably less than 30, more preferably 15 or less.
In fact, as the water electrolyte supplemented beverage of the present invention clearly shows from the test examples to be described later, the lower the titrated acidity, the faster the water absorption from the intestinal tract is recognized, and the water absorption is the titrated acidity of the solution. An inversely proportional relationship was recognized.

In the water electrolyte supplemented beverage provided by the present invention, the osmotic pressure of the solution is hypotonic than the physiological osmotic pressure of 285 mOsm / L. Is important to. On the other hand, the presence of appropriate electrolytes and carbohydrates is also an important factor that promotes rapid absorption of moisture and electrolyte components from the intestinal tract, because the electrolyte and carbohydrate contents are too low. On the other hand, when the osmotic pressure is low, the absorption rate of water and electrolyte components from the intestinal tract is suppressed. Therefore, the existence of the optimum osmotic pressure range and the above-described factors influence the moisture and electrolyte absorption into the intestinal tract.
A preferable osmotic pressure range is 160 to 190 mOsm / L, and an osmotic pressure range of 170 to 180 mOsm / L is particularly preferable.

Among the sugars contained in the water electrolyte supplemented beverage, glucose (glucose) in particular is an energy source and has an important function in the absorption of sodium ions from the intestinal tract. That is, sodium ions are absorbed simultaneously with the absorption of glucose by the sodium-glucose symporter present in the small intestine.
Sucrose, a disaccharide, is finally broken down into glucose and absorbed from the intestinal tract. Therefore, in the present invention, by containing disaccharides, particularly sucrose in a well-balanced manner without containing glucose in advance, the taste is improved and moisture absorption and sodium ion absorption from the intestinal tract are promoted. .
A preferable sugar concentration is 3 w / v% or less of sucrose, and particularly preferably 2 to 2.5 w / v%. The water electrolyte supplemented beverage of the present invention having such a sugar concentration has a sufficient sugar concentration necessary to promote water absorption and sodium ion absorption from the intestinal tract, and at the same time suppresses an excessive increase in solution osmotic pressure, In addition, the calorie intake is kept low.

  In the water electrolyte supplement beverage provided by the present invention, in order to efficiently absorb the electrolyte component lost by dehydration and sweating from the intestinal tract by oral ingestion, as an electrolyte component, sodium ion, potassium ion, chloride ion, etc. It is preferable to contain. Specifically, sodium ions are preferably contained in an amount of 30 to 40 mEq / L. Potassium ions are preferably contained in an amount of 15 to 25 mEq / L, and chloride ions are preferably contained in an amount of 25 to 35 mEq / L.

  Calcium and magnesium are involved in many enzyme reactions in the living body and work on metabolism of a large amount of minerals including sodium ions and potassium ions. Therefore, in the present invention, it is preferable to further contain calcium ions and magnesium ions as the electrolyte component.

  The concentration of calcium ions is preferably 3 to 7 mEq / L, and more preferably 4 to 6 mEq / L. Further, in the case of magnesium ions, it is preferable to contain 1 to 5 mEq / L, more preferably 2 to 4 mEq / L.

In the water electrolyte supplement beverage provided by the present invention, it is necessary to appropriately control a plurality of factors that affect the absorbability from the intestinal tract, and it is preferable to use citrate ions from various electrolyte components. . Such citrate ions have characteristics that can be appropriately adjusted to the intended pH and titration acidity of the water electrolyte supplemented beverage of the present invention, and can be used for calcium salts and magnesium salts contained in the water electrolyte supplemented beverage of the present invention. It also plays a role of solubilization.
The concentration is preferably 15 to 70 mEq / L, and more preferably 20 to 50 mEq / L.

  By combining the above electrolyte components in a well-balanced manner, the electrolyte concentration required for electrolyte component replenishment is maintained, and in addition, the solution pH, titration acidity, and osmotic pressure ranges necessary for quick and sufficient water replenishment are maintained. It becomes possible to set to.

  In addition, in the water electrolyte supplemented beverage of the present invention, for example, sweeteners such as stevia, sucralose, aspartame, and fruit-based fragrances can be added and blended in order to give moderate sweetness and further improve ease of drinking. . Especially for elderly people, plum flavor and tea flavor are preferable, and the addition of the citrate ion is particularly preferable for bringing it closer to a natural flavor.

  In addition, amino acids or amino acid analogs such as cystine, theanine, and arginine can be included as a component that increases immunity, which is particularly necessary in children and elderly people with low immunity, and is useful for the prevention of cerebrovascular disorders. As an essential component, an antioxidant component, a component having a function of suppressing the formation of thrombus, and the like can be contained. In the above-described water electrolyte supplemented beverage of the present invention, these components can be contained. It is included in the technical scope of the present invention.

Furthermore, the water electrolyte supplement beverage of the present invention may contain vitamins. As vitamins, there are vitamin A, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin B ₁₂ , vitamin C, vitamin D, vitamin E, vitamin K, biotin, folic acid, pantothenic acid and nicotinic acids, Involved in various metabolisms such as sugar metabolism, lipid metabolism and amino acid metabolism. In particular, vitamin B ₁ and its derivatives are those related to glucose metabolism as a coenzyme of the glycolytic system, she serves to convert the carbohydrates contained in the water electrolyte supplement drink efficiently energy can be expected.
In particular, among the various metabolic functions in the case of elderly is declining, it is preferable to formulate the water-soluble vitamins from the vitamin group, and more preferably to incorporate vitamin B ₁ and vitamin C.

  The water electrolyte supplemented beverage provided by the present invention is filled with a container such as a plastic bottle, a PET bottle, a paper container (cart can, tetra pack, etc.), an aluminum pouch, or a metal can, for example. In addition, since the pH of the solution of the water electrolyte reinforced beverage of the present invention is 4.2 or more, it is preferable to perform aseptic sterilization filling.

  The application amount of the water-electrolyte supplemented beverage of the present invention is appropriately determined according to the degree of dehydration and sweating. However, as a preferable application method, avoiding a rapid large-scale intake as much as possible and taking a small amount frequently. preferable. Therefore, the volume is preferably 200 mL or less as the total amount. The dose is usually taken orally, but can also be taken nasally or enterally. In addition, because of the characteristics of the water electrolyte supplemented beverage of the present invention, it is particularly effective for elderly people who are prone to vomiting and gastroesophageal reflux.

  Hereinafter, the present invention will be described in more detail with reference to test examples describing examples, but the present invention is not limited to these examples.

Test Example 1:
Sodium chloride (reagent special grade), potassium chloride (reagent special grade), calcium chloride (reagent special grade), magnesium chloride (reagent special grade), potassium dihydrogen phosphate (reagent special grade), sodium citrate (reagent special grade), citric acid (reagent) (Special grade) and sucrose (special reagent grade) were weighed according to the composition shown in Table 1 below and dissolved in water for injection to prepare 100 mL of the water electrolyte supplemented beverage of the present invention (Examples 1-2).
Further, as a comparative example, a 100 mL water electrolyte supplemented beverage was prepared with the composition shown in Table 1 containing 315 mg of citric acid (special reagent grade) and having a pH of less than 4.2 (Comparative Example 1).

  The electrolyte concentration and sugar concentration based on the compositions of Examples 1 and 2 and Comparative Example 1 are as shown in Table 2 below.

The units in the table are as follows.
Na, K, Cl, Mg, Ca, citric acid: mEq / L
PO ₄ : mmol / L
Sucrose: g / L

The pH, titratable acidity, and osmotic pressure of the water electrolyte supplemented beverages of Examples 1-2 and Comparative Example 1 were measured (osmometer OM-6030, manufactured by Kyoto Daiichi Chemical Co., Ltd.).
For titrated acidity, 100 mL of each water electrolyte supplemented beverage was dispensed into a beaker, and a pH meter (D-52, manufactured by HORIBA, Ltd.) was used, and 0.1N NaOH solution until pH 7.4 was obtained. In addition, the amount required was indicated as titrated acidity.
The results were as shown in Table 3 below.

Test example 2:
Using the water electrolyte supplemented beverages of Examples 1 and 2 and Comparative Example 1, animal tests were performed as follows (each group n = 3).
Using Wistar male rats fasted overnight, laparotomy was performed under urethane (Aldrich, 1.4 g / kg, subcutaneous administration) anesthesia and into the duodenum (5 cm below the pyloric ostium) and ileum (5 cm above the cecum). A Tygon tube (R3603, duodenum side: inside diameter 0.79 mm, ileum side: inside diameter 1.59 mm) was inserted. Using an infusion pump (high-precision syringe pump KDS-100, manufactured by Muromachi Co., Ltd.), three types of the present invention solution and comparative example solution were each flowed at a flow rate of 0.5 mL / min from the Tygon tube on the duodenum side, and perfusion started. From 1 hour later, 10 minutes of perfusate was collected from the ileum side.
The collected perfusate was centrifuged (centrifuge H-3P, manufactured by Kokusan Co., Ltd., 3000 rpm / 10 minutes), and the supernatant was collected and stored at 4 ° C. until measurement. After completion of perfusion, the intestinal tract from the duodenum to the ileum was removed and collected.
The collected intestinal tract was dried overnight at 60 ° C. using a dryer (manufactured by Toyo Corporation), and then the dry weight was measured using a balance for organ measurement (JP-300W, Chyo Balance).

The amount of water absorption was determined from the change in absorbance due to the change in the concentration of phenol red in the perfusate with respect to the test solution using the fact that phenol red (reagent grade, 20 mg / L) added in advance to the solution of the present invention was not absorbed into the intestinal tract. . Take 0.1 mL each of the test solution and perfusate, add 0.9 mL of 1% sodium carbonate aqueous solution to this, and stir well. Then, using an ultraviolet / visible absorptiometer (UV-2400PC, manufactured by Shimadzu Corporation), the wavelength Absorbance at 560 nm, 520 nm, and 600 nm was measured.
Using each measured value, the water absorption amount (μL / g / min) into the intestinal tract was calculated according to the following calculation formula.

  Further, the sodium ion concentration was measured using an automatic electrolyte analyzer (EA06T, manufactured by A & T). From the measured value, the amount of electrolyte absorption (μmol / g / min) into the intestinal tract was calculated according to the following formula.

Using the average value of the perfusate collected three times as a measurement value, the mean ± standard error (mean ± SE) of each group was determined.
The balance of water and sodium ions in each specimen was as shown in Table 4 and FIGS.

表中の値は、平均±標準誤差を表す。

The values in the table represent mean ± standard error.

From the above results, when comparing the water electrolyte supplemented beverages of Examples 1 and 2 of the present invention and the supplemented beverage of Comparative Example 1 having a pH of less than 4.2 with increased citric acid content, the water absorption amount was 1, Example 2 and Comparative Example 1 were decreased in this order, and the water absorption amount showed an inversely proportional relationship with the titratable acidity of the solution.
The sodium ion absorption amount of the supplemental beverages of Example 1 and Example 2 was higher than that of the supplemental beverage of Comparative Example 1.
From the above, it can be understood that the water electrolyte supplement beverages of Examples 1 and 2 of the present invention have improved water absorbability from the intestinal tract when the titrated acidity of the solution is less than 30. By setting the solution pH to 4.2 or higher (Example 1: 5.17, Example 2: 4.42), compared with Comparative Example 1 (3.93) having a pH of less than 4.2, sodium from the intestinal tract It is understood that the ion absorption is remarkably improved.

Test Example 3:
The water electrolyte supplemented beverage of Example 1 of the present invention was compared with a commercially available electrolyte supplemented beverage (specimen A) and water using a rat dehydration model, and the change over time in the dehydration correcting action was examined by oral administration. .
The electrolyte concentration and sugar concentration of the electrolyte-supplemented beverage used in the test are as shown in Table 5 below.

The units in the table are as follows.
Na, K, Cl, Ca, Mg, citric acid, lactic acid: mEq / L
PO ₄ : mmol / L
Sugar: g / L

  Wistar male rats (8.5 weeks old) were fasted for 24 hours and watered for 24 hours before administration to induce dehydration. After the 24-hour fasting and fasting treatment, the water electrolyte supplemented beverage of the present invention (Example 1: 20 administration groups), a commercially available electrolyte supplement beverage (Sample A: 20 administration groups) and water were used as the respective water electrolyte supplemented beverages. (Administration group: 13 animals) was administered by oral bolus using an oral sonde in an amount of 10 mL. Urine volume was measured and collected in the following manner before and after administration.

(1) Urine volume measurement:
Urine volume was measured 6 hours after administration.
(2) Urine collection and urine parameter measurement:
Urine was collected immediately before administration and 6 hours after administration, and sodium ion concentration and potassium ion concentration were measured using an automatic electrolyte analyzer (EA06T, A & T).
(3) Balance of sodium ion and balance of potassium ion The balance of sodium ion and balance of potassium ion 6 hours after administration were calculated.
The value is the mean ± standard deviation (mean ± SD) of each group.

  The urine volume of each test group 6 hours after administration is shown in Table 6 below and FIG.

  As can be seen from the results shown in Table 6 and FIG. 3, the administration group of the water electrolyte supplement drink of the present invention is significantly more urine than the commercially available electrolyte supplement drink (specimen A) and the water administration group. It was something that decreased. This indicates that the water electrolyte replenishing beverage of the present invention significantly promotes water replenishment and body fluid retention.

  Table 7 below shows the urinary sodium ion concentration and urine potassium ion concentration of each test group before administration (that is, after dehydration) and 6 hours after administration.

  The balance of sodium ions and potassium ions in each test group was as shown in Table 8 and FIGS.

  As can be seen from the results shown in Tables 7 and 8 and FIGS. 4 and 5, the administration of the hydrated electrolyte supplemented beverage of the present invention was significantly compared to the commercial electrolyte supplemented beverage (Sample A) and the administration of water. This is a person who has good balance of sodium ions and potassium ions, and this shows that the water electrolyte replenishing beverage of the present invention has very good electrolyte replenishment.

  As described above, the present invention provides a water electrolyte replenishing beverage that can efficiently perform quick water replenishment and electrolyte component replenishment when used as an oral replenisher. In addition, it contains a high electrolyte concentration and moderate sugar, and the hypotonicity of the solution allows quick absorption of water and electrolyte components from the intestinal absorption site. It is effective for the improvement and prevention of cerebrovascular disorders caused by the above, and its industrial contribution is great.

It is the bluff which compared the balance of the water about 3 persons of Examples 1 and 2 in Experiment 2, and the reinforced drink of Comparative Example 1. It is the bluff which compared the balance of the sodium ion about 3 persons of Example 1 and 2 in Experiment 2, and the reinforced drink of Comparative Example 1. 10 is a graph comparing the amount of urine after administration of Example 1, Sample A and water in a dehydration symptom model rat in Test Example 3. FIG. FIG. 5 is a bluff comparing the balance of sodium ions after administration of Example 1, Specimen A and water in a dehydration symptom model rat in Test Example 3. FIG. FIG. 4 is a bluff comparing the balance of potassium ions after administration of Example 1, Specimen A and water in a dehydration symptom model rat in Test Example 3. FIG.

Claims (5)

As electrolyte components, sodium ions 30 to 40 mEq / L, potassium ions 15 to 25 mEq / L, chloride ions 25 to 35 mEq / L, calcium ions 3 to 7 mEq / L, magnesium ions 1 to 5 mEq / L, citrate ions 20 to It contains 50 mEq / L, pH is 4.2 to 6.0, titration acidity is 15 or less , its osmotic pressure is 160 to 180 mOsm / L, and it contains disaccharides of 3 w / v% or less as carbohydrate. A water electrolyte supplement drink characterized by the above. The water electrolyte-supplemented beverage according to claim 1, wherein the disaccharide is sucrose. Furthermore, 2-10 mEq / L of phosphate ion is contained, The water electrolyte supplement drink of Claim 1 or 2 characterized by the above-mentioned. The water electrolyte supplement drink according to any one of claims 1 to 3 , which has a volume of 200 mL or less as a total amount. Water electrolyte supplement drink of claims 1, characterized by using the aseptic sterilization filling method as a sterile filling method of the container according to any one of 4.

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