JP6059414B2 - イメージングに対する多重造影剤注入 - Google Patents

イメージングに対する多重造影剤注入 Download PDF

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Publication number
JP6059414B2
JP6059414B2 JP2008529750A JP2008529750A JP6059414B2 JP 6059414 B2 JP6059414 B2 JP 6059414B2 JP 2008529750 A JP2008529750 A JP 2008529750A JP 2008529750 A JP2008529750 A JP 2008529750A JP 6059414 B2 JP6059414 B2 JP 6059414B2
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Prior art keywords
contrast agent
administration
relaxation
tumor
relaxation rate
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JP2008529750A
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English (en)
Japanese (ja)
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JP2009507545A5 (enExample
JP2009507545A (ja
Inventor
ハンネス ダーンケ
ハンネス ダーンケ
トビアス スヒアエフテル
トビアス スヒアエフテル
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Koninklijke Philips NV
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Koninklijke Philips NV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/481—Diagnostic techniques involving the use of contrast agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/56366—Perfusion imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/50—NMR imaging systems based on the determination of relaxation times, e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Signal Processing (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Optics & Photonics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2008529750A 2005-09-13 2006-09-07 イメージングに対する多重造影剤注入 Expired - Fee Related JP6059414B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05108409 2005-09-13
EP05108409.3 2005-09-13
PCT/IB2006/053143 WO2007031910A2 (en) 2005-09-13 2006-09-07 Multiple contrast agent injection for imaging

Publications (3)

Publication Number Publication Date
JP2009507545A JP2009507545A (ja) 2009-02-26
JP2009507545A5 JP2009507545A5 (enExample) 2009-10-22
JP6059414B2 true JP6059414B2 (ja) 2017-01-11

Family

ID=37865329

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008529750A Expired - Fee Related JP6059414B2 (ja) 2005-09-13 2006-09-07 イメージングに対する多重造影剤注入

Country Status (5)

Country Link
US (2) US8175678B2 (enExample)
EP (1) EP1926425B1 (enExample)
JP (1) JP6059414B2 (enExample)
CN (1) CN101262817B (enExample)
WO (1) WO2007031910A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8173819B2 (en) 2005-09-02 2012-05-08 Visen Medical, Inc. Nicotinic and picolinic acid derived near-infrared fluorophores
US8175678B2 (en) 2005-09-13 2012-05-08 Koninklijke Philips Electronics N.V. Multiple contrast agent injection for imaging
CN101951839B (zh) * 2008-01-23 2013-11-06 M·阿韦基乌 利用超声造影剂的呼吸门控治疗评估
EP2247314A4 (en) * 2008-02-01 2013-11-27 Univ Boston CATIONIC CONTRASTING AGENTS AND METHOD FOR THEIR USE
JP5307453B2 (ja) * 2008-05-29 2013-10-02 株式会社日立メディコ 超音波診断装置
JP5360466B2 (ja) * 2008-07-11 2013-12-04 国立大学法人福井大学 Ｐｅｔ薬剤送出装置およびその作動方法
CN104519794B (zh) 2012-08-06 2018-05-22 皇家飞利浦有限公司 基于动态对比增强成像的渗透率度量
DE102015222853A1 (de) * 2015-11-19 2017-05-24 Siemens Healthcare Gmbh Verfahren zum automatischen Ermitteln eines Kontrastmittel-Injektionsprotokolls
WO2017147418A1 (en) 2016-02-24 2017-08-31 Ohio State Innovation Foundation Methods and devices for contrast agent magnetic resonance imaging
EP3382414B1 (de) * 2017-03-28 2024-09-18 Siemens Healthineers AG Verfahren zur durchführung einer angiographischen messung und erstellung einer angiographie
CN111458321B (zh) * 2020-05-22 2021-11-23 南京诺源医疗器械有限公司 一种基于病变部位荧光反馈的诊断系统

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA852979B (en) * 1984-04-27 1985-11-27 Vestar Research Inc Contrast agents for nmr imaging
US5164297A (en) * 1990-05-03 1992-11-17 Advanced Magnetics Inc. Solvent mediated relaxation assay system
US5304931A (en) * 1991-08-09 1994-04-19 Flamig Duane P Magnetic resonance imaging techniques
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
EP0814849A1 (en) * 1995-10-19 1998-01-07 BRACCO International B.V. Magnetically labeled chemoattractants as targeted contrast agents in the nmr imaging of living tissues
US6009342A (en) * 1997-02-28 1999-12-28 The Regents Of The University Of California Imaging method for the grading of tumors
WO2000019227A1 (en) 1998-09-28 2000-04-06 Nycomed Imaging As Method of magnetic resonance imaging
GB9821038D0 (en) * 1998-09-28 1998-11-18 Nycomed Imaging As Method
ATE309741T1 (de) 1999-03-26 2005-12-15 Leif Ostergaard System zur bestimmung hämodynamischer indizes mittels tomographischer daten
US6355225B1 (en) 1999-10-05 2002-03-12 Wm. Marsh Rice University Tda Research, Inc. Fullerene contrast agent for magnetic resonance imaging and spectroscopy
GB0007873D0 (en) * 2000-03-31 2000-05-17 Nycomed Imaging As Method
US6807441B2 (en) * 2000-05-19 2004-10-19 The Mcw Research Foundation Inc. Evaluation of tumor angiogenesis using magnetic resonance imaging
GB0117187D0 (en) * 2001-07-13 2001-09-05 Isis Innovations Ltd Magnetic resonance imaging
US20040073117A1 (en) * 2002-02-14 2004-04-15 Schwarz Karl Q. Method and system for delivering contrast agent
AU2003247379A1 (en) * 2002-05-17 2003-12-02 Case Western Reserve University Systems and methods for assessing blood flow in a target tissue
JP4013128B2 (ja) * 2002-09-12 2007-11-28 株式会社日立メディコ 血流動態解析装置、方法、及び画像診断装置
CN1802184A (zh) * 2003-03-18 2006-07-12 凯瑟罗斯医疗系统公司 用于从生理上传出的流体收集位置收回医用试剂的方法和装置
US7649981B2 (en) * 2003-10-15 2010-01-19 Varian Medical Systems, Inc. Multi-energy x-ray source
JP4446049B2 (ja) * 2003-11-06 2010-04-07 株式会社三重ティーエルオー 心筋血流の定量化装置
US7567832B2 (en) * 2004-08-13 2009-07-28 The Mcw Research Foundation MRI method for measuring tumor hemodynamic parameters in the presence of contrast agent extravasation
JP4192136B2 (ja) 2004-09-30 2008-12-03 株式会社小松製作所 画像表示システムおよび画像表示プログラム
JP5232473B2 (ja) * 2004-11-24 2013-07-10 メドラッド インコーポレーテッド 注入処理中に生成される圧力をモデル化するためのシステム及び装置
WO2006080022A2 (en) * 2005-01-31 2006-08-03 Yeda Research And Development Co. Ltd. Mri contrast agents for diagnosis and prognosis of tumors
US8175678B2 (en) 2005-09-13 2012-05-08 Koninklijke Philips Electronics N.V. Multiple contrast agent injection for imaging
EP1933706A2 (en) * 2005-10-05 2008-06-25 Koninklijke Philips Electronics N.V. Method and apparatus for predicting enhancement in angiography

Also Published As

Publication number Publication date
US20090130023A1 (en) 2009-05-21
EP1926425B1 (en) 2015-08-19
CN101262817A (zh) 2008-09-10
EP1926425A2 (en) 2008-06-04
WO2007031910A2 (en) 2007-03-22
CN101262817B (zh) 2011-09-07
JP2009507545A (ja) 2009-02-26
US20120253179A1 (en) 2012-10-04
US8175678B2 (en) 2012-05-08
WO2007031910A3 (en) 2007-10-18
US10154797B2 (en) 2018-12-18

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